Article
Medicine, General & Internal
Abir Nagata, Toshio Masumoto, Hidekazu Nishigori, Takatoshi Nakagawa, Shinji Otani, Youichi Kurozawa
Summary: This study investigates the association between in utero exposure to corticosteroids and beta 2-adrenergic agonists and offspring neurodevelopmental milestones during the first 3 years of life.
Article
Medicine, Research & Experimental
Kirti Singh, Razan L. Teyani, Nader H. Moniri
Summary: Asthma and other airway obstructive disorders are characterized by heightened inflammation and oxidative environment, while beta 2-adrenergic receptor (beta 2AR) agonists are still the first-line treatment option for asthma, chronic use may lead to increased tolerance to bronchorelaxant effects possibly due to hyperoxidation of beta 2AR to S-sulfinic acids.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Anne Paakinaho, Miia Tiihonen, Heikki Koskela, Marjaana Koponen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen
Summary: The long-term use of long-acting I32AR agonists may be associated with a reduced risk of Parkinson's disease, especially among patients with both asthma and chronic obstructive pulmonary disease. However, the findings of this study might be influenced by confounding factors.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Respiratory System
Joseph Emil Amegadzie, John-Michael Gamble, Jamie Farrell, Zhiwei Gao
Summary: In this study, the use of β2-agonists was not associated with the risk of pneumonia in patients with asthma, COPD, or asthma-COPD overlap, but was associated with an increased risk of all-cause mortality in COPD patients compared to ICS use.
RESPIRATORY RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Jinhee H. Hwang, Michael E. Spurlock, John C. Kube, Xiang Z. Li, Stephen B. Smith
Summary: The study revealed that lubabegron fumarate is highly selective for the beta(3)-adrenergic receptor subtype and has minimal agonistic activity at the beta(2)-adrenergic receptor. Differences in mRNA expression levels of beta(1)-, beta(2)-, and beta(3)-AR were observed between subcutaneous and intramuscular adipose tissues. The response to beta-adrenergic ligands, especially agonists for the beta(1)- and beta(3)-receptor subtypes, was found to be lower in intramuscular adipose tissue compared to subcutaneous adipose tissue.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Allergy
Chih-Cheng Lai, Chao-Hsien Chen, Ya-Hui Wang, Cheng-Yi Wang, Hao-Chien Wang
Summary: The study found that overuse of SABAs is associated with an increased risk of sepsis and septic shock in patients with asthma in Taiwan.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Donghwa Kim, Alina Tokmakova, Lauren K. Lujan, Hannah R. Strzelinski, Nicholas Kim, Maliheh Najari Beidokhti, Marc A. Giulianotti, Amirhossein Mafi, Jung-A A. Woo, Steven S. An, William A. Goddard, Stephen B. Liggett
Summary: The study identified a potentially beneficial β(2)-adrenergic receptor agonist, C1-S, for treating asthma, which diverges from the influence of β-arrestin by retaining Gas signaling, resulting in biologically relevant biasing effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Catalina M. Carvajal Gonczi, Mehri Hajiaghayi, Fatemeh Gholizadeh, Maria Auxiliadora Xavier Soares, Fadi Touma, Carolina Lopez Naranjo, Amanda J. Rios, Chelsea Pozzebon, Tina Daigneault, Kelly Burchell-Reyes, Peter J. Darlington
Summary: The study found that terbutaline can increase memory Th17 cells in lymphocytes from healthy individuals, thus exacerbating autoimmune diseases or asthma. This effect may be related to cAMP and PKA.
Article
Respiratory System
Miriam R. Bennett, Catherina L. Chang, Chris Tuffery, Sandra Hopping, Robert J. Hancox
Summary: The study investigated the impact of cardio-selective beta(1)-blocker bisoprolol on the response to salbutamol in patients with asthma. The results showed that there was no significant difference in the bronchodilator response to salbutamol after bronchoconstriction induced by mannitol between bisoprolol treatment and placebo.
Article
Physiology
Kaveh Moghbeli, Eleanor Valenzi, Rachel Naramore, John Charles Sembrat, Kong Chen, Mauricio M. Rojas, Sally E. Wenzel, Robert Lafyatis, Brian Modena, Nathaniel M. Weathington
Summary: The study analyzed BAL samples from Severe Asthma patients and found suppression of the BALcAMP gene module, influenced by various factors. The results showed that the BALcAMP gene network expression was suppressed in multiple cell populations, particularly significantly in macrophages.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Chemistry, Medicinal
Jianfang Chen, Jiangting Liu, Yuan Yuan, Xin Chen, Fuhui Zhang, Xuemei Pu
Summary: This study explores the molecular mechanisms of biased activation induced by structural differences between different agonists. It reveals that G-protein-biased agonists and fi-arrestin-biased agonists achieve biased signaling through different conformational changes. In addition, the study also identifies specific conformations of ICL3 under specific agonists and the roles of key residues. These findings contribute to a better understanding of biased activation mechanisms and provide guidance for the design of biased drugs.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Allergy
Hao-Chien Wang, Susanthy Djajalaksana, Latha Sharma, Theerakorn Theerakittikul, Hui Fang Lim, Kwang Ha Yoo, Andrea Ban Yu-Lin, Dina V. Diaz, Lala Yang, Maarten J. H. I. Beekman
Summary: The study reveals the problem of SABA overprescription in at least 25% of asthma patients in Asia, which is associated with poor clinical outcomes. These findings demonstrate the importance of adhering to updated asthma treatment recommendations in the region.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Review
Veterinary Sciences
Alison P. Pfau, Elizabeth A. Shepherd, M. Gabbi Martin, Sophia Ascolese, Katie M. Mason, Amanda M. Egert-McLean, Brynn H. Voy, Phillip R. Myer
Summary: The beef industry is facing the challenge of increasing protein supply to a growing global population. Improving nutrient use efficiency and addressing the rumen microbial community are important for enhancing the sustainability of the industry. Beta-adrenergic agonists and dietary protein play critical roles in beef cattle production, with beta-agonists enhancing growth and feed efficiency, and dietary protein providing necessary nutrients. By optimizing rumen fermentation, diet, and growth-promoting technologies, the industry can improve energy capture and performance. Research and development in this field can lead to innovative solutions that benefit both producers and the environment.
VETERINARY SCIENCES
(2023)
Article
Health Care Sciences & Services
Zineb Jeddi, Ihsane Gryech, Mounir Ghogho, Maryame EL Hammoumi, Chafiq Mahraoui
Summary: The study used machine learning models to predict childhood asthma and identified 19 significant risk factors associated with the disease. Random forest was found to be the best predictive model. Maternal and prenatal risk factors play important roles in childhood asthma and most of them are avoidable, emphasizing the need for raising awareness about prenatal risk factors.
Review
Urology & Nephrology
Jin K. Kim, Mark Jason De Jesus, Min Joon Lee, Joana Dos Santos, Jun S. Dy, Jessica M. Ming, Mandy Rickard, Armando J. Lorenzo, Michael E. Chua
Summary: The use of beta 3 agonists in pediatric patients with neurogenic detrusor overactivity (NDO) or overactive bladder (OAB) shows promising, effective, and safe outcomes, with improvements in urodynamics parameters and self-reported outcomes.
JOURNAL OF UROLOGY
(2022)
Article
Behavioral Sciences
Gayle C. Windham, Michelle Pearl, Meredith C. Anderson, Victor Poon, Darryl Eyles, Karen L. Jones, Kristen Lyall, Martin Kharrazi, Lisa A. Croen
Article
Behavioral Sciences
Jennifer L. Ames, Gayle C. Windham, Kristen Lyall, Michelle Pearl, Martin Kharrazi, Cathleen K. Yoshida, Judy Van de Water, Paul Ashwood, Lisa A. Croen
Article
Behavioral Sciences
Kristen Lyall, Lanxin Song, Kelly Botteron, Lisa A. Croen, Stephen R. Dager, M. Daniele Fallin, Heather C. Hazlett, Elizabeth Kauffman, Rebecca Landa, Christine Ladd-Acosta, Daniel S. Messinger, Sally Ozonoff, Juhi Pandey, Joseph Piven, Rebecca J. Schmidt, Robert T. Schultz, Wendy L. Stone, Craig J. Newschaffer, Heather E. Volk
Article
Behavioral Sciences
Emily E. Joyce, Jorge E. Chavarro, Juliette Rando, Ashley Y. Song, Lisa A. Croen, M. Daniele Fallin, Irva Hertz-Picciotto, Rebecca J. Schmidt, Heather Volk, Craig J. Newschaffer, Kristen Lyall
Summary: This study examined the relationship between pesticide exposure from residues in the diet during pregnancy and child autism-related traits. The findings suggest that pesticide residues in the diet were not related to child autism-related outcomes at age three. However, higher prenatal fruit and vegetable intake was associated with reductions in child autism-related traits.
Article
Behavioral Sciences
Irva Hertz-Picciotto, Susan A. Korrick, Christine Ladd-Acosta, Margaret R. Karagas, Kristen Lyall, Rebecca J. Schmidt, Anne L. Dunlop, Lisa A. Croen, Dana Dabelea, Julie L. Daniels, Cristiane S. Duarte, M. Daniele Fallin, Catherine J. Karr, Barry Lester, Leslie D. Leve, Yijun Li, Monica McGrath, Xuejuan Ning, Emily Oken, Sharon K. Sagiv, Sheela Sathyanaraya, Frances Tylavsky, Heather E. Volk, Lauren S. Wakschlag, Mingyu Zhang, T. Michael O'Shea, Rashelle J. Musci
Summary: This study examined the association between maternal prenatal smoking and autism spectrum disorder (ASD) in children. The findings suggest a modest association between maternal smoking and ASD diagnosis, as well as an increase in ASD-related traits. However, the study also acknowledges the heterogeneity of results and limitations in data collection and confounders.
Article
Biochemistry & Molecular Biology
Alexandra Ramirez-Celis, Lisa A. Croen, Cathleen K. Yoshida, Stacey E. Alexeeff, Joseph Schauer, Robert H. Yolken, Paul Ashwood, Judy van de Water
Summary: Maternal autoantibody-related ASD (MAR ASD) is a subtype of autism where maternal autoantibodies cross the placenta and affect the developing brain, leading to neurodevelopmental alterations and autism-associated behaviors in the offspring. This study validated previously identified MAR ASD patterns and their accuracy in predicting ASD risk.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Ashley Y. Song, Kelly Bakulski, Jason Feinberg, Craig Newschaffer, Lisa A. Croen, Irva Hertz-Picciotto, Rebecca J. Schmidt, Homayoon Farzadegan, Kristen Lyall, M. Daniele Fallin, Heather E. Volk, Christine Ladd-Acosta
Summary: This study found that accelerated epigenetic aging in mothers was associated with lower cognitive ability and function in offspring at 12 months, while accelerated maternal epigenetic aging was marginally associated with increased odds of ASD in offspring at 36 months. On the other hand, father's accelerated aging was marginally associated with decreased ASD risk in their offspring. This suggests that epigenetic aging in parents may play a role in neurodevelopment and ASD risk.
Article
Behavioral Sciences
Frances L. Lynch, Joanna E. Bulkley, Alexandra Varga, Phillip Crawford, Lisa A. Croen, Yihe G. Daida, Eric Fombonne, Brigit Hatch, Maria Massolo, John F. Dickerson
Summary: Parents of children with autism spectrum disorder (ASD) and other chronic health conditions face challenges in maintaining employment. This study aimed to understand the specific impact of these health conditions on parent employment in order to provide support for families.
Article
Biochemistry & Molecular Biology
Jason I. I. Feinberg, Rose Schrott, Christine Ladd-Acosta, Craig J. J. Newschaffer, Irva Hertz-Picciotto, Lisa A. A. Croen, M. Daniele Fallin, Andrew P. P. Feinberg, Heather E. E. Volk
Summary: There is a need to consider the paternal contributions to autism spectrum disorder (ASD) and explore the association between paternal autistic traits, sperm epigenome, and autistic traits in children. This study analyzed the genetic and epigenetic data of fathers and children from the Early Autism Risk Longitudinal Investigation (EARLI) cohort. The results showed significant associations between differentially methylated regions (DMRs) in the sperm epigenome and autistic traits in 3-year-old offspring. These findings highlight the potential importance of sperm epigenetic mechanisms in the development of autism.
MOLECULAR PSYCHIATRY
(2023)
Article
Behavioral Sciences
Beth A. Malow, Yinge Qian, Jennifer L. Ames, Stacey Alexeeff, Lisa A. Croen
Summary: Compared to non-autistic adults, autistic adults have higher rates of medical and psychiatric conditions. This study examines the longitudinal trajectory of health conditions in autistic youth compared to non-autistic youth as they transition from adolescence to early adulthood in a large healthcare system. The study found that the prevalence of common medical and psychiatric conditions increased from age 14 to 22 in autistic youth, with higher rates compared to non-autistic youth. Obesity, neurological disorders, anxiety, and ADHD were the most prevalent conditions in autistic youth. The findings highlight the importance of screening and health education for autistic youth to prevent adverse health outcomes in adulthood.
Article
Psychology, Developmental
Jeroen Dewinter, Morenike Giwa Onaiwu, Maria L. Massolo, Reid Caplan, Els Van Beneden, Nikki Broermann, Eileen T. Crehan, Lisa A. Croen, Susan Faja, Dena L. Gassner, Laura Graham Holmes, Cat Hughes, Morrigan Hunter, Monique Huysamen, Paola Jelonche, Meng-Chuan Lai, Ilse Noens, Heta Pukki, Mark A. Stokes, John F. Strang, Anna I. R. Van der Miesen
Summary: This report presents recommendations to promote the health and well-being of autistic individuals in terms of their sexuality and gender diversity. The recommendations were developed based on the latest scientific knowledge and community involvement. A group of international experts in autism, sexuality, and gender diversity, along with autistic advocates, collaborated to develop the initial recommendations. These recommendations were then reviewed by the wider community through an online survey. Eight out of the original 11 recommendations received consensus support. The final recommendations focus on providing education and information, improving healthcare accessibility, and including the autism community in future research related to sexuality, relationships, and gender diversity.
Article
Neurosciences
Lisa A. Croen, Jennifer L. Ames, Yinge Qian, Stacey Alexeeff, Paul Ashwood, Erica P. Gunderson, Yvonne W. Wu, Andrew S. Boghossian, Robert Yolken, Judy Van de Water, Lauren A. Weiss
Summary: Inflammatory conditions during pregnancy, such as asthma and obesity, are associated with an increased risk of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). However, there doesn't seem to be a shared genetic risk factor for these conditions and ASD. Children whose mothers have both asthma and obesity during pregnancy may benefit from earlier screening and intervention.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2024)
Article
Environmental Sciences
Kimberly Berger, Patrick T. Bradshaw, Victor Poon, Marty Kharrazi, Darryl Eyles, Paul Ashwood, Kristen Lyall, Heather E. Volk, Jenn Ames, Lisa A. Croen, Gayle C. Windham, Michelle Pearl
Summary: Over two-thirds of pregnant women in the U.S. have insufficient Vitamin D concentrations, which may be associated with prenatal exposure to environmental chemical mixtures. Some pollutants are associated with decreased Vitamin D concentrations, while others are associated with increased concentrations. Overall mixture exposure is associated with lower Vitamin D concentrations.
ENVIRONMENTAL POLLUTION
(2024)
Article
Psychology, Developmental
Christina Nicolaidis, Kelly Y. Zhen, Junghee Lee, Dora M. Raymaker, Steven K. Kapp, Lisa A. Croen, Anna Urbanowicz, Joelle Maslak, Mirah Scharer
Summary: There is a pressing need for interventions to improve healthcare for autistic adults, but there is a lack of validated measures to evaluate such interventions. Through community-based participatory research, a set of patient- and proxy-reported instruments were created to measure healthcare outcomes and intervention targets in autistic adults, showing good psychometric characteristics. Future research should focus on assessing whether these interventions effectively improve healthcare outcomes in autistic adults.
Article
Behavioral Sciences
Gayle C. Windham, Michelle Pearl, Victor Poon, Kimberly Berger, Jasmine W. Soriano, Darryl Eyles, Kristen Lyall, Martin Kharrazi, Lisa A. Croen