期刊
JOURNAL OF NEUROCHEMISTRY
卷 129, 期 4, 页码 637-648出版社
WILEY-BLACKWELL
DOI: 10.1111/jnc.12636
关键词
cannabinoid; CB1 receptor; developing cerebral cortex; post-mitotic migrating neurons; prenatal exposure
资金
- Argentine Agency for Promotion of Science and Technology (ANPCyT) [PICT2007-01080]
- National Research Council (CONICET) [PIP-00774]
- University of Buenos Aires [UBACyT 20020100100093]
- CONICET
During corticogenesis, the endocannabinoid system plays an important role in neural progenitor proliferation, specification, neuronal migration, and differentiation. Children prenatally exposed to marijuana have a significant impairment of higher cognitive functions. We showed in the present study that Prenatal WIN55,212-2 exposure alters radial and tangential migration and induces a delay in glutamatergic neurons differentiation in the embryonic rat cerebral cortex. The present results contribute to the knowledge on neurobiological substrates that determine neurobehavioral changes that will persist through post-natal life.
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