Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

(2013) Julius Popp et al.   BIOCHEMICAL PHARMACOLOGY

Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function

(2013) Brian P. Head et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Embedding Aβ42 in Heterogeneous Membranes Depends on Cholesterol Asymmetries

(2013) Nicoletta Liguori et al.   BIOPHYSICAL JOURNAL

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

(2013) Nathalie Pierrot et al.   EMBO Molecular Medicine

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis

(2013) C van de Kraats et al.   Multiple Sclerosis Journal

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression

(2013) Valerio Leoni et al.   NEUROBIOLOGY OF DISEASE

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical Identification of a Linear Cholesterol-Binding Domain within Alzheimer’s β Amyloid Peptide

(2012) Coralie Di Scala et al.   ACS Chemical Neuroscience

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients

(2012) Adina N. Lazar et al.   ACTA NEUROPATHOLOGICA

Disorders of sterol synthesis: Beyond Smith-Lemli-Opitz syndrome

(2012) Gail E. Herman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The link between altered cholesterol metabolism and Alzheimer's disease

(2012) Paola Gamba et al.   Annals of the New York Academy of Sciences

The Intermediate Enzymes of Isoprenoid Metabolism as Anticancer Targets

(2012) Andrew Wiemer et al.   Anti-Cancer Agents in Medicinal Chemistry

AP-2β regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes

(2012) Ximena S. Rossello et al.   BRAIN RESEARCH

Reciprocal regulation of cholesterol and beta amyloid at the subcellular level in Alzheimer’s disease

(2012) Elena Posse de Chaves   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Heart Disease and Stroke Statistics—2013 Update

(2012) Alan S. Go et al.   CIRCULATION

Neuronal Membranes are Key to the Pathogenesis of Alzheimers Disease: the Role of Both Raft and Non-Raft Membrane Domains

(2012) R. Williamson et al.   Current Alzheimer Research

Cochrane review on ‘Statins for the treatment of dementia’

(2012) Bernadette McGuinness et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease

(2012) Jiaqi Yao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease

(2012) Julius Popp et al.   JOURNAL OF NEUROCHEMISTRY

 -Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage

(2012) A. Mohamed et al.   JOURNAL OF NEUROSCIENCE

Mevalonate-suppressive dietary isoprenoids for bone health

(2012) Huanbiao Mo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effects of cyclodextrin in two patients with Niemann–Pick Type C disease

(2012) Muneaki Matsuo et al.   MOLECULAR GENETICS AND METABOLISM

Brain Isoprenoids Farnesyl Pyrophosphate and Geranylgeranyl Pyrophosphate are Increased in Aged Mice

(2012) Gero P. Hooff et al.   MOLECULAR NEUROBIOLOGY

Isoprenoids and Related Pharmacological Interventions: Potential Application in Alzheimer’s Disease

(2012) Ling Li et al.   MOLECULAR NEUROBIOLOGY

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

(2012) M. Maulik et al.   MOLECULAR NEUROBIOLOGY

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS)

(2011) Melissa K. Passarelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lamin A, farnesylation and aging

(2011) Sita Reddy et al.   EXPERIMENTAL CELL RESEARCH

Cholesterol Modulates the Rate and Mechanism of Acetylcholine Receptor Internalization

(2011) Virginia Borroni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A

(2011) D. J. Christensen et al.   JOURNAL OF IMMUNOLOGY

Cholesterol asymmetry in synaptic plasma membranes

(2011) W. Gibson Wood et al.   JOURNAL OF NEUROCHEMISTRY

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Cholesterol metabolism in Huntington disease

(2011) Joanna M. Karasinska et al.   Nature Reviews Neurology

Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation

(2011) R.A. Mans et al.   NEUROSCIENCE

Epidemiological link between low cholesterol and suicidality: A puzzle never finished

(2011) Jian Zhang   NUTRITIONAL NEUROSCIENCE

Control of synapse development and plasticity by Rho GTPase regulatory proteins

(2011) Kimberley F. Tolias et al.   PROGRESS IN NEUROBIOLOGY

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Biological membranes: the importance of molecular detail

(2011) Anthony G. Lee   TRENDS IN BIOCHEMICAL SCIENCES

Intracellular cholesterol homeostasis and amyloid precursor protein processing

(2010) Mark P. Burns et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Isoprenoids, small GTPases and Alzheimer's disease

(2010) Gero P. Hooff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid Membranes and β-Amyloid: A Harmful Connection

(2010) G.P. Eckert et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Binding of amyloid β peptide to β2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

(2010) Dayong Wang et al.   FASEB JOURNAL

Regulation of Synaptic Rac1 Activity, Long-Term Potentiation Maintenance, and Learning and Memory by BCR and ABR Rac GTPase-Activating Proteins

(2010) D. Oh et al.   JOURNAL OF NEUROSCIENCE

Astrocytic β2-adrenergic receptors: From physiology to pathology

(2010) Guy Laureys et al.   PROGRESS IN NEUROBIOLOGY

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Increased Membrane Cholesterol Might Render Mature Hippocampal Neurons More Susceptible to  -Amyloid-Induced Calpain Activation and Tau Toxicity

(2009) A. M. Nicholson et al.   JOURNAL OF NEUROSCIENCE

Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene

(2009) Pi-Lin Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

(2009) Gunter P. Eckert et al.   NEUROBIOLOGY OF DISEASE

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Amyloid β-protein stimulates trafficking of cholesterol and caveolin-1 from the plasma membrane to the Golgi complex in mouse primary astrocytes

(2009) U. Igbavboa et al.   NEUROSCIENCE

Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease

(2009) Alina Solomon et al.   NEUROSCIENCE LETTERS

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

(2009) R. W. Halford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis

(2008) Qiu-Lan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure

(2008) Ning Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

(2008) Denise M.O. Ramirez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Lipid rafts, cholesterol, and the brain

(2008) Zeljka Korade et al.   NEUROPHARMACOLOGY

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

(2008) T. Kotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE

Diverse roles of Rho family GTPases in neuronal development, survival, and death

(2007) Daniel et al.   Frontiers in Bioscience-Landmark