Article
Pharmacology & Pharmacy
Sabrina Giofre, Antonio Renda, Silvia Sesana, Beatrice Formicola, Barbara Vergani, Biagio Eugenio Leone, Vanna Denti, Giuseppe Paglia, Serena Groppuso, Valentina Romeo, Luca Muzio, Andrea Balboni, Andrea Menegon, Antonia Antoniou, Arianna Amenta, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
Summary: Dual functionalized liposomes with modified peptides and MMP-sensitive moieties have the ability to cross BBB and release drugs in MMP-rich microenvironment. These liposomes display good biocompatibility and efficiently release encapsulated fluorescent dyes.
Review
Biochemistry & Molecular Biology
Milton H. Hamblin, Jean-Pyo Lee
Summary: Neural stem cell transplantation shows promise in treating ischemic stroke by potentially therapeutic actions against neurovascular injury. By secreting factors that stimulate endogenous repair mechanisms, NSCs can promote self-recovery in early-stage ischemic stroke and improve short-term and long-term stroke outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Gary A. Rosenberg
Summary: Binswanger disease is a type of vascular cognitive impairment and dementia. Biomarkers can aid in early diagnosis, such as using magnetic resonance imaging and cerebrospinal fluid or positron emission tomography to detect vascular disease-related proteins. Vascular disease accelerates cognitive decline, which is associated with misfolded proteins and inflammation. Early detection and treatment of dementia can be improved by advancements in plasma biomarker detection techniques and technologies like machine learning.
Article
Environmental Sciences
Ziyang Guo, Zhengzheng Ruan, Dongdong Zhang, Xiaohui Liu, Liyan Hou, Qingshan Wang
Summary: This study reveals that rotenone induces cognitive impairments in mice through microglia-mediated blood brain barrier disruption and neuronal apoptosis via MMP-2/-9, providing a novel aspect for the pathogenesis of pesticide-induced neurotoxicity and Parkinson's disease-related dementia.
Review
Biochemistry & Molecular Biology
Milosz Caban, Katarzyna Owczarek, Urszula Lewandowska
Summary: Eye diseases are linked to visual impairment and reduced quality of life. Current treatments for these diseases are not satisfactory, highlighting the need for new therapeutic approaches. Matrix metalloproteinases and tissue inhibitors of metalloproteinases play crucial roles in eye diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Diede W. M. Broekaart, Till S. Zimmer, Sophie T. Cohen, Rianne Tessers, Jasper J. Anink, Helga E. de Vries, Jan A. Gorter, Roger Prades, Eleonora Aronica, Erwin A. van Vliet
Summary: The gelatinase inhibitor ACT-03 has shown disease-modifying effects in epilepsy models by reducing neuroinflammation and preserving blood-brain barrier integrity. Further evaluation of its effects in clinical trials is warranted.
Article
Immunology
Caio Andreeta Figueiredo, Johannes Steffen, Lorena Morton, Sushmitha Arumugam, Oliver Liesenfeld, Maria A. Deli, Andrea Kroeger, Thomas Schueler, Ildiko Rita Dunay
Summary: Our study demonstrates that T. gondii initially infects endothelial cells in the choroid plexus, triggering early local immune responses and barrier disturbances which ultimately affect BCSFB function.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Surgery
Guang Yang, Yingya Cao, Ping Wang, Lin Mei, Jinbao Chen, Weihua Lu
Summary: The study aimed to investigate the mechanism by which minocycline protects the blood-brain barrier (BBB) in septic rats. The results showed that minocycline pretreatment could inhibit microglial activation, decrease MMP-9 expression, increase the expression of ZO-1 and occludin, and improve the permeability of the BBB.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Medicine, Research & Experimental
Lorena Cayetano-Salazar, Dania A. Nava-Tapia, Kevin D. Astudillo-Justo, Adan Arizmendi-Izazaga, Cesar Sotelo-Leyva, Mayra Herrera-Martinez, Socrates Villegas-Comonfort, Napoleon Navarro-Tito
Summary: Cancer is a leading cause of death globally, with invasion and metastasis being directly responsible. Current therapeutic approaches for cancer suffer from toxicity and chemoresistance, highlighting the need for alternative treatment options. Natural products, particularly flavonoids, have shown promise as they possess antitumor properties in various study models. This review discusses the regulation of tissue inhibitors of metalloproteinases (TIMPs) expression and the role of flavonoids as therapeutic molecules that target TIMPs. Flavonoids exhibit chemopreventive and cytotoxic effects against different types of cancer through various mechanisms and also regulate crucial signaling pathways involved in cancer cell migration, invasion, and metastasis.
Article
Chemistry, Analytical
Akshata Anchan, Graeme Finlay, Catherine E. Angel, James J. W. Hucklesby, Scott E. Graham
Summary: Previous studies have shown that human melanoma cells can weaken the brain endothelial barrier, but the expression of MMPs and proteases released by melanoma cells may not directly contribute to the initial disruption of the brain endothelium.
Review
Biochemistry & Molecular Biology
Kathryn E. Sanchez, Gary A. Rosenberg
Summary: COVID-19 primarily affects the peripheral symptoms, but it can also impact the central nervous system (CNS). The association between stroke and COVID-19 suggests overlapping molecular mechanisms. This study proposes that SARS-CoV-2 infection leads to the upregulation of inflammatory proteins in peripheral macrophages, resulting in various negative effects on endothelial function, leading to disruption of the blood-brain barrier (BBB). This disruption alters CNS function by affecting astrocyte function and inflammasome activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Taylor E. Branyan, Amutha Selvamani, Min Jung Park, Kriti E. Korula, Kelby F. Kosel, Rahul Srinivasan, Farida Sohrabji
Summary: The study identifies miR-20a-3p as a potential therapeutic for stroke and reveals different expression levels of this microRNA in astrocytes of different genders and age groups. Results show that miR-20a-3p has more neuroprotective effects when expressed in neurons, and intravenous injections of miR-20a-3p mimic significantly improve stroke outcomes.
TRANSLATIONAL STROKE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Christian Behm, Michael Nemec, Fabian Weissinger, Marco Aoqi Rausch, Oleh Andrukhov, Erwin Jonke
Summary: The systematic review revealed that orthodontic forces induce increased expression levels of MMPs and TIMPs in the PDL during orthodontic tooth movement. However, the exact effect may vary depending on intervention and sample parameters as well as subject characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Peripheral Vascular Disease
Carlos Escudero, Ellen Kupka, Belen Ibanez, Hermes Sandoval, Felipe Troncoso, Anna-Karin Wikstroem, Daniela Lopez-Espindola, Jesenia Acurio, Pablo Torres-Vergara, Lina Bergman
Summary: Preeclampsia is a maternal syndrome characterized by hypertension and proteinuria after 20 weeks of gestation with brain complications being the main cause of morbidity and mortality, especially in low- and middle-income countries. In addition to the cardiovascular effects, women with preeclampsia have higher risk of stroke, dementia, white matter lesions, epilepsy, and cognitive decline postpartum, and evidence also links preeclampsia with similar cognitive and cerebral disorders in offspring. However, the mechanistic links between these associations remain unresolved. This article summarizes the current knowledge and potential pathophysiological mechanisms of cerebrovascular complications in preeclampsia.
Review
Clinical Neurology
Yang Liu, Lingxiao Qi, Zhe Li, V. Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a disease caused by cerebrovascular damage, leading to hematoma enlargement, brain edema, and physical injury in the brain parenchyma. Matrix metalloproteinases (MMPs) are a group of endopeptidases that can degrade components of the extracellular matrix and promote neuroinflammation. After ICH, several MMPs are upregulated and may have different functions at different stages. The glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) induces the production of MMPs. The interactions between MMPs and EMMPRIN/CD147 in ICH are complex.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neurosciences
Rajat Sandhir, Namita Mahajan, Arpit Mehrotra, Aanchal Aggarwal, Aditya Sunkaria
Article
Biochemistry & Molecular Biology
Olusegun L. Adebayo, Alka Khera, Rajat Sandhir, Gbenga A. Adenuga
CELL BIOCHEMISTRY AND FUNCTION
(2016)
Article
Biochemistry & Molecular Biology
Aanchal Aggarwal, Inderjit Singh, Rajat Sandhir
NEUROCHEMISTRY INTERNATIONAL
(2018)
Article
Ophthalmology
Surinder Singh Pandav, Partha Chakma, Alka Khera, Neera Chugh, Parul Chawla Gupta, Faisal Thattaruthody, Natasha Gautam Seth, Srishti Raj, Sushmita Kaushik, Madhu Khullar, Jagat Ram
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Bhupindervir Kaur, Alka Khera, Rajat Sandhir
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Bhuvaneshwari Sundaram, Aanchal Aggarwal, Rajat Sandhir
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Rajat Sandhir, Neha Sethi, Aanchal Aggarwal, Alka Khera
NEUROCHEMISTRY INTERNATIONAL
(2014)
Article
Pharmacology & Pharmacy
Aanchal Aggarwal, Nishtha Sharma, Rajat Sandhir, Vikas Rishi
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Gerontology
Alka Khera, Poonam Kanta, Jaswinder Kalra, Dheeraj Dumir, M. Thungapathra
JOURNAL OF WOMEN & AGING
(2019)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)