Is the mTOR-signalling cascade disrupted in Schizophrenia?

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

(2013) Sean J. Humphrey et al.   Cell Metabolism

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

Sex-dependent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steroid hormones

(2013) Rachel A. Hill et al.   JOURNAL OF NEUROCHEMISTRY

A recollection of mTOR signaling in learning and memory

(2013) T. E. Graber et al.   LEARNING & MEMORY

Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway

(2013) J Iafrati et al.   MOLECULAR PSYCHIATRY

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons

(2013) Miou Zhou et al.   NEURON

BDNF-induced local protein synthesis and synaptic plasticity

(2013) Graciano Leal et al.   NEUROPHARMACOLOGY

Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia

(2013) Jian-Ping Zhang et al.   SCHIZOPHRENIA RESEARCH

Rethinking schizophrenia in the context of normal neurodevelopment

(2013) Vibeke S. Catts et al.   Frontiers in Cellular Neuroscience

Sex-specific and region-specific changes in BDNF–TrkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice

(2012) YeeWen Candace Wu et al.   BRAIN RESEARCH

5-HT6receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

(2012) Julie Meffre et al.   EMBO Molecular Medicine

Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History

(2012) J. Annelies E. Polman et al.   ENDOCRINOLOGY

Mammalian Target of Rapamycin Complex 1 (mTORC1) and 2 (mTORC2) Control the Dendritic Arbor Morphology of Hippocampal Neurons

(2012) Malgorzata Urbanska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse

(2012) Justin T Rogers et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Stress makes its molecular mark

(2012) Eric J. Nestler   NATURE

The involvement of Reelin in neurodevelopmental disorders

(2012) Timothy D. Folsom et al.   NEUROPHARMACOLOGY

Glucocorticoid regulation of brain-derived neurotrophic factor: Relevance to hippocampal structural and functional plasticity

(2012) D. Suri et al.   NEUROSCIENCE

Altered N-methyl-d-aspartate receptor function in reelin heterozygous mice: Male–female differences and comparison with dopaminergic activity

(2012) Maarten van den Buuse et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neurodevelopmental hypothesis of schizophrenia

(2011) Michael J. Owen et al.   BRITISH JOURNAL OF PSYCHIATRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

DISC1-binding proteins in neural development, signalling and schizophrenia

(2011) Nicholas J. Bradshaw et al.   NEUROPHARMACOLOGY

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies

(2011) Anouk Marsman et al.   SCHIZOPHRENIA BULLETIN

Cognition in schizophrenia: core psychological and neural mechanisms

(2011) Deanna M. Barch et al.   TRENDS IN COGNITIVE SCIENCES

5-HT6 Receptor Antagonists as Potential Therapeutics for Cognitive Impairment

(2010) Gerard Rosse et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

An inverse relationship between cortisol and BDNF levels in schizophrenia: Data from human postmortem and animal studies

(2010) George Issa et al.   NEUROBIOLOGY OF DISEASE

Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice

(2010) Michael A. Siuta et al.   PLOS BIOLOGY

mTORC1 signalling and mRNA translation: Figure 1

(2009) Christopher G. Proud   BIOCHEMICAL SOCIETY TRANSACTIONS

Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively

(2009) M.H. Grider et al.   JOURNAL OF NEUROSCIENCE RESEARCH

BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation

(2009) Leandro Slipczuk et al.   PLoS One

Modeling the Positive Symptoms of Schizophrenia in Genetically Modified Mice: Pharmacology and Methodology Aspects

(2009) M. van den Buuse   SCHIZOPHRENIA BULLETIN

Extinction Memory Is Impaired in Schizophrenia

(2008) Daphne J. Holt et al.   BIOLOGICAL PSYCHIATRY

Regulation of Proline-rich Akt Substrate of 40 kDa (PRAS40) Function by Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation

(2008) Lifu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity

(2008) M. D. Antion et al.   LEARNING & MEMORY

mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice

(2008) M. D. Antion et al.   MOLECULAR AND CELLULAR BIOLOGY

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia

(2008) Anilkumar Pillai et al.   SCHIZOPHRENIA RESEARCH

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS