Article
Neurosciences
Jung-Eun Lee, So-Young Park, Pyung-Lim Han
Summary: Aging leads to alterations in gene expression in the hippocampus, affecting the ability to cope with stress in mice. Downregulation of SUV39H1 and subsequent changes in its signaling pathways may increase susceptibility to stress in aging individuals. Additionally, the phenolic compound rosmarinic acid shows promise in reversing stress-induced changes and producing antidepressant effects via a distinct mechanism from traditional antidepressants.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Johana Spies, Adriana Covarrubias-Pinto, Constanza Carcamo, Yennyfer Arancibia, Fernanda Salazar, Carolina Paredes-Martinez, Carola Otth, Maite Castro, Angara Zambrano
Summary: Huntington's disease (HD) is characterized by degeneration of brain nerve cells. The link between DNA damage and impaired signaling related to neurodegeneration is unclear. The study found that DSBs differentially impact the gene expression patterns of plasticity genes in normal cells compared to the HD model.
NEUROCHEMICAL RESEARCH
(2023)
Article
Reproductive Biology
Bin Liu, Yongjie Liu, Shuman Li, Pingping Chen, Jun Zhang, Liping Feng
Summary: This study investigated the reproductive outcomes of BDNF treatment and potential mechanisms in aged mice. The results showed that BDNF treatment could improve ovarian function and fertility in aged mice by promoting ovarian cell proliferation and activating the TrkB and cyclin D1-creb signaling pathways. Therefore, targeting the BDNF-TrkB signaling pathway may be a potential novel therapeutic strategy to reverse ovarian aging.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Environmental Sciences
Yi-Zhou Li, Zi-Yao Wu, Bi-Qi Zhu, Yu-Xiao Wang, Ya-Qi Kan, Huai-Cai Zeng
Summary: In this study, the role of the BDNF-TrkB-CREB signaling pathway in bisphenol S (BPS)-induced neurotoxicity was investigated. The results showed that BPS damaged the hippocampal ultrastructure and reduced the number of synapses in male mice. Additionally, BPS increased the methylation rate of BDNF promoter IV and altered the expression of various proteins involved in the pathway. These findings suggest that the BDNF-TrkB-CREB pathway may play a role in BPS-induced neurotoxicity through methylation regulation.
Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Article
Psychiatry
Barbara Risse Quaioto, Aline Ribeiro Borcoi, Suzanny Oliveira Mendes, Paola Cerbino Doblas, Tamires dos Santos Vieira, Ivana Alece Arantes Moreno, Joaquim Gasparini dos Santos, Andre Willian Hollais, Amanda Sgrancio Olinda, Marcele Lorentz Mattos de Souza, Flavia Vitorino Freitas, Julia Assis Pinheiro, Ester Ribeiro Cunha, Bruna Pereira Sorroche, Lidia Maria Rebolho Batista Arantes, Adriana Madeira Alvares-da-Silva
Summary: This study investigated the methylation of the BDNF gene in individuals with depression who were tobacco users. A total of 384 adults from southeastern Brazil were recruited for the study. The results showed a significant interaction between depression and tobacco use on BDNF methylation levels. Individuals with depression and tobacco use had lower levels of BDNF methylation compared to those with or without depression who did not use tobacco. The findings suggest that tobacco use may interfere with BDNF gene methylation in depressed individuals.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuki Tomiga, Kazuya Sakai, Song-Gyu Ra, Masaki Kusano, Ai Ito, Yoshinari Uehara, Hirokazu Takahashi, Kentaro Kawanaka, Hidenobu Soejima, Yasuki Higaki
Summary: This study found that relatively short-term running exercise can reduce anxiety-like behaviors, increase brain-derived neurotrophic factor (BDNF), and decrease neuronal nitric oxide synthase (nNOS) levels through epigenetic modifications in the brain. These effects mainly occur in the ventral hippocampal region, suggesting a potential mechanism for mood regulation via alterations in epigenetic mechanisms after a brief period of exercise.
Article
Medicine, Research & Experimental
Pedro S. Marra, Yoshitaka Nishizawa, Takehiko Yamanashi, Eleanor J. Sullivan, Katie R. Comp, Kaitlyn J. Crutchley, Nadia E. Wahba, Kazuki Shibata, Tsuyoshi Nishiguchi, Kyosuke Yamanishi, Nicolas O. Noiseux, Matthew D. Karam, Gen Shinozaki
Summary: This study suggests a potential role of epigenetics in the mechanisms of action of NSAIDs. The analysis of DNA methylation profiles revealed several biological pathways related to NSAIDs' function. However, due to the lack of statistically significant findings, these results should be interpreted with caution as exploratory and hypothesis-generating.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jianbo Xiu, Jiayu Li, Zeyue Liu, Hui Wei, Caiyun Zhu, Rongrong Han, Zijing Liu, Wanwan Zhu, Yan Shen, Qi Xu
Summary: Major depressive disorder (MDD) is a prevalent and devastating mental illness. The diagnosis of MDD currently lacks reliable biomarkers. This study identified and validated a potential DNA methylation biomarker for MDD in the Chinese Han population, and investigated its functional implications, which could improve the diagnosis and treatment of MDD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Hansi Pathak, Anton Borchert, Sara Garaali, Alexandra Burkert, Helge Frieling
Summary: This study investigates the interaction and mechanisms between BDNF exon IV promoter methylation and antidepressant treatment. The results show that antidepressant treatment increases promoter methylation and specific CpG methylation affects transcriptional activity. Furthermore, overexpression of DNMT3a also enhances transcription of BDNF exon IV.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Curtis L. Petersen, Brock C. Christensen, John A. Batsis
Summary: The study found a significant association between decreased biological age using DNA methylation clocks and increased physical functional ability in older obese adults, suggesting the utility of DNA methylation clocks in assessing interventions to improve health in this population.
CLINICAL EPIGENETICS
(2021)
Article
Biology
Anna Kankaanpaeae, Asko Tolvanen, Aino Heikkinen, Jaakko Kaprio, Miina Ollikainen, Elina Sillanpaeae
Summary: This study found that an unhealthy lifestyle during adolescence is associated with accelerated biological aging in young adulthood, which may be explained by genetic factors.
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: The study showed that cilostazol could alleviate prenatal VPA exposure-related hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety, while significantly increasing biochemical markers such as BDNF, pCREB, IL-10, and GSH in the assessed brain regions.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Psychiatry
Oluwagbenga Dada, Christopher Adanty, Nasia Dai, Richie Jeremian, Sauliha Alli, Philip Gerretsen, Ariel Graff, John Strauss, Vincenzo De Luca
Summary: The study found evidence of epigenetic age acceleration associated with psychosis severity in individuals with schizophrenia, using two different algorithms for DNAm age analysis.
PSYCHIATRY RESEARCH
(2021)
Article
Oncology
Yun-Hsiang Lo, Wan-Yu Lin
Summary: This study comprehensively investigates the associations between cardiovascular health and four epigenetic clocks. The findings suggest that ideal cardiovascular health is associated with lower levels of biological aging, reducing the risk of aging-related disorders.
CLINICAL EPIGENETICS
(2022)
Article
Psychiatry
Hiren R. Modi, Kaizong Ma, Lisa Chang, Mei Chen, Stanley I. Rapoport
PSYCHIATRY RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Yewon Cheon, Hyung-Wook Kim, Miki Igarashi, Hiren R. Modi, Lisa Chang, Kaizong Ma, Deanna Greenstein, Mary Wohltmann, John Turk, Stanley I. Rapoport, Ameer Y. Taha
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2012)
Article
Biochemistry & Molecular Biology
Hiren R. Modi, Mireille Basselin, Arneer Y. Taha, Lei O. Li, Rosalind A. Coleman, Meir Bialer, Stanley I. Rapoport
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2013)
Article
Clinical Neurology
Hiren R. Modi, Mireille Basselin, Stanley I. Rapoport
Article
Clinical Neurology
Jae Hyuk Yang, Amit Wasudeo Bhandarkar, Byung Gun Lim, Hitesh N. Modi, Seung Woo Suh
EUROPEAN SPINE JOURNAL
(2013)
Article
Clinical Neurology
Jae Hyuk Yang, Amit Wasudeo Bhandarkar, Barani Rathanvelu, Jin Ho Hwang, Jae Young Hong, Hitesh N. Modi, Seung Woo Suh
EUROPEAN SPINE JOURNAL
(2014)
Article
Biochemistry & Molecular Biology
Honey Modi, Marion Cornu, Bernard Thorens
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Orthopedics
Jae Hyuk Yang, Seung Woo Suh, Hitesh N. Modi, Easwar T. Ramani, Jae Young Hong, Jin Ho Hwang, Woon Yong Jung
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2013)
Article
Biochemistry & Molecular Biology
Hiren R. Modi, Ameer Y. Taha, Hyung-Wook Kim, Lisa Chang, Stanley I. Rapoport, Yewon Cheon
JOURNAL OF NEUROCHEMISTRY
(2013)
Article
Multidisciplinary Sciences
Hiren R. Modi, Qihong Wang, G. D. Sahithi, David Sherman, Elliot Greenwald, Alena V. Savonenko, Romergryko G. Geocadin, Nitish V. Thakor
Article
Biochemistry & Molecular Biology
Ameer Y. Taha, Mireille Basselin, Epolia Ramadan, Hiren R. Modi, Stanley I. Rapoport, Yewon Cheon
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2012)
Article
Neurosciences
Hyung-Wook Kim, Yewon Cheon, Hiren R. Modi, Stanley I. Rapoport, Jagadeesh S. Rao
PSYCHOPHARMACOLOGY
(2012)
Article
Biotechnology & Applied Microbiology
Hiren R. Modi, Qihong Wang, Sarah J. Olmstead, Elizabeth S. Khoury, Nirnath Sah, Yu Guo, Payam Gharibani, Rishi Sharma, Rangaramanujam M. Kannan, Sujatha Kannan, Nitish V. Thakor
Summary: This study demonstrates that early intervention with dendrimer-N-acetylcysteine conjugate (D-NAC) can improve post-cardiac arrest survival rate, motor deficits, and neurological recovery by targeting activated microglial cells and attenuating neuroinflammation. Early therapeutic intervention with a single dose of D-NAC shows sustained improvement in long-term outcomes, providing a promising approach for treating post-cardiac arrest syndrome.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Orthopedics
Jae Hyuk Yang, Rathinavelu Barani, Amit Wasudeo Bhandarkar, Seung Woo Suh, Jae Young Hong, Hitesh N. Modi, Jae Hyuk Yang
CLINICAL JOURNAL OF SPORT MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)