Improvement of cognitive function in Alzheimer’s disease model mice by genetic and pharmacological inhibition of the EP4 receptor

Identification of EP4 as a Potential Target for the Treatment of Castration-Resistant Prostate Cancer Using a Novel Xenograft Model

(2010) N. Terada et al.   CANCER RESEARCH

The Prostaglandin E2 E-Prostanoid 4 Receptor Exerts Anti-Inflammatory Effects in Brain Innate Immunity

(2010) J. Shi et al.   JOURNAL OF IMMUNOLOGY

Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

(2009) A. Savonenko et al.   EXPERIMENTAL NEUROLOGY

Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

(2009) Paramita Chakrabarty et al.   FASEB JOURNAL

Prostaglandin E2Stimulates the Production of Amyloid-β Peptides through Internalization of the EP4Receptor

(2009) Tatsuya Hoshino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

(2008) Linda A. Kotilinek et al.   BRAIN