Article
Cell Biology
Jian Luo
Summary: Astrocytes are highly polarized neuroglial cells that play diverse roles in the brain. In response to pathological insults, they transition from a dormant state to a reactive and migratory state, known as reactive astrogliosis. Dysregulation of cell polarity proteins during astrogliosis may impact astrocyte reactivity and disease progression, making them potential therapeutic targets.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Alejandro Villarreal, Tanja Vogel
Summary: Astrocytes are a type of neuroglial cells that provide metabolic and structural support to neurons in the nervous system. In pathological conditions, astrocytes can undergo reactive astrogliosis, leading to phenotypic and transcriptional changes. The heterogeneity of astrocyte subpopulations in response to injury or other pathological conditions may be influenced by altered cellular signaling and cell type specification during development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka M. Jurga, Martyna Paleczna, Justyna Kadluczka, Katarzyna Z. Kuter
Summary: This review discusses the crucial communication between neurons and neuroglia for functional efficiency and quick response to danger. It focuses on identifying markers for different astroglial phenotypes related to various physiological and pathological conditions, aiming to facilitate future experimental studies and diagnostics.
Review
Biochemistry & Molecular Biology
Steven A. Hill, Marissa Fu, A. Denise R. Garcia
Summary: Astrocytes are complex cells performing essential functions in the nervous system. The Sonic hedgehog (Shh) signaling pathway plays a crucial role in regulating the molecular identity and functional properties of astrocytes, and is active in specific subpopulations of these cells throughout the brain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Won-Seok Lee, Ji-Hye Kang, Jung-Hwan Lee, Yoo Sung Kim, Jongmin Joseph Kim, Han-Sem Kim, Hae-Won Kim, Ueon Sang Shin, Bo-Eun Yoon
Summary: The study utilized carbon nanotube platforms to enhance astrocyte functions, such as improving cell adhesion, proliferation, and gliotransmission, by increasing resting Ca2+ levels.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Cell Biology
Sarah A. Neely, David A. Lyons
Summary: Glia are a diverse collection of cells that play essential roles in the nervous system. Recent advances in animal models, particularly using zebrafish, have provided important insights into the function and interactions of glial cells, contributing to our understanding of their complex roles in development and throughout life.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sheau-Ling Lee, Michelle Hui-Hsin Lee, Kuo-Jen Wu, Chia-Wen Chiang, Yun-Xuan Chang, Jung-Da Fang, Hsiu-Hui Tung, Li-Wei Kuo, Yun Wang
Summary: This study found that human recombinant hepatocyte growth factor (HGF) can mitigate motor impairment and cortical infarction in a rat model of ischemic stroke. HGF reduces the expression of inflammatory cytokines and alleviates cell activation. The therapeutic effects of HGF are dependent on the inhibition of a type II transmembrane serine protease called matriptase (MTP).
Review
Cell Biology
A. Denise R. Garcia
Summary: The Sonic hedgehog (Shh) molecular signaling pathway is a key regulator of neurodevelopment, with diverse functions in various cell types and developmental stages. In addition to its roles in development, Shh signaling continues into adulthood and is now recognized as an important regulator of astrocyte function. Astrocytes play essential roles in nervous system functions, including synapse formation, coordination of CNS inflammatory responses, and Shh signaling mediates communication between neurons and astrocytes, influencing astrocyte identity, synaptic organization, and inflammation regulation.
Review
Cell Biology
Kathryn M. Markey, Jillian C. Saunders, Jana Smuts, Catherine R. von Reyn, A. Denise R. Garcia
Summary: In the past 15-20 years, our understanding of astrocyte contributions to central nervous system function has significantly changed. Astrocytes are now recognized as key elements in a broad array of CNS functions, including synapse formation and function and blood brain barrier maintenance. However, the basic biology of astrocyte development remains poorly understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Physiology
David S. Bouvier, Sonja Fixemer, Tony Heurtaux, Felicia Jeannelle, Katrin B. M. Frauenknecht, Michel Mittelbronn
Summary: Astrocytes play multiple roles in the central nervous system, but in age-related neurodegenerative diseases, they may exhibit neurotoxic phenotypes that contribute to disease progression. Chronic inflammation, oxidative stress, impaired phagocytosis, and altered physiological roles are the main manifestations of astrocytic toxicity. However, the involvement of astrocytes in brain deterioration in patients with neurodegenerative diseases is still controversial due to overlapping pathologies and technical challenges in studying human brain samples. This review provides an overview of astrocyte neurotoxicity from in vitro findings to animal models and patient-related research, and discusses the role of aging in astrocytes and potential therapeutic strategies.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Malte Borggrewe, Corien Grit, Ilia D. Vainchtein, Nieske Brouwer, Evelyn M. Wesseling, Jon D. Laman, Bart J. L. Eggen, Susanne M. Kooistra, Erik W. G. M. Boddeke
Summary: Astrocytes play various roles in the CNS, with different subtypes exhibiting morphological and functional heterogeneity. The local brain environment influences the transcriptional programs of astrocyte subtypes, which also show distinct responses in neuroinflammatory conditions.
Review
Multidisciplinary Sciences
Baljit S. Khakh, Steven A. Goldman
Summary: Huntington's disease (HD) is a fatal neurodegenerative disease caused by a mutation in the huntingtin gene. Astrocytes in the striatum, a brain region affected in HD, play a role in the pathology of the disease. Dysfunctions in astrocytes contribute to cellular and metabolic abnormalities in HD, suggesting the potential for therapeutic targeting of these cells to restore normal function.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Neurosciences
Kjell Heuser, Rune Enger
Summary: Epilepsy is a common neurological disorder affecting millions worldwide, with current research focusing on neuronal discharges and the role of astrocytes in releasing signaling substances that interact with neurons. The central role of astrocytic Ca2+ signals in promoting ictogenesis and epileptogenesis is increasingly recognized and studied.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Leonardo A. Perez, Aysha Rashid, J. Dale Combs, Pascal Schneider, Andres Rodriguez, Khalid Salaita, Lisette Leyton
Summary: Astrocyte reactivity is influenced by mechanical and chemical stimuli, with integrins playing a key role in triggering cell contraction and adhesion in response to Thy-1 engagement. This study highlights the potential of targeting alpha(V)beta(3) Integrin mechanoreceptor to regulate astrocyte behavior in neuronal healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Linda Frintrop, Stefanie Trinh, Jochen Seitz, Markus Kipp
Summary: Eating behavior is regulated by hypothalamic circuits, with glia cells potentially playing a role in this process. Recent studies have shown a reduction in the number of astrocytes in an experimental anorexia nervosa model. Anorexia nervosa is associated with brain volume loss and neuropsychological deficits, and the underlying pathophysiology is still unknown. Understanding the role of glia cells in eating disorders, including anorexia nervosa, may lead to the identification of new drug targets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Diego Baronio, Guilherme Bauer-Negrini, Kamila Castro, Gustavo Della-Flora Nunes, Rudimar Riesgo, Daniella Areas Mendes-da-Cruz, Wilson Savino, Carmem Gottfried, Victorio Bambini-Junior
NEUROIMMUNOMODULATION
(2018)
Review
Endocrinology & Metabolism
Renata Torres Abib, Alexandru Gaman, Aroldo A. Dargel, Ryad Tamouza, Flavio Kapczinski, Carmem Gottfried, Marion Leboyer
NEUROIMMUNOMODULATION
(2018)
Article
Behavioral Sciences
Mellanie Fontes-Dutra, Gustavo Della-Flora Nunes, Julio Santos-Terra, Walquiria Souza-Nunes, Guilherme Bauer-Negrini, Mauro Mozael Hirsch, Lily Green, Rudimar Riesgo, Carmem Gottfried, Victorio Bambini
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Neurosciences
Mauro Mozael Hirsch, Iohanna Deckmann, Julio Santos-Terra, Gabriela Zanotto Staevie, Mellanie Fontes-Dutra, Giovanna Carello-Collar, Marilia Korbes-Rockenbach, Gustavo Brum Schwingel, Guilherme Bauer-Negrini, Bruna Rabelo, Maria Carolina Bittencourt Goncalves, Juliana Correa-Velloso, Yahaira Naaldijk, Ana Regina Geciauskas Castillo, Tomasz Schneider, Victorio Bambini-Junior, Henning Ulrich, Carmem Gottfried
Review
Developmental Biology
Julio Santos-Terra, Iohanna Deckmann, Mellanie Fontes-Dutra, Gustavo Brum Schwingel, Victorio Bambini-Junior, Carmem Gottfried
Summary: Neurodevelopmental disorders are a diverse and prevalent group of psychiatric conditions characterized by impairments in the nervous system that onset during gestation and continue throughout postnatal life. Transcription factors play a critical role in different risk factors, organizing key developmental processes in a time and location-dependent manner, potentially serving as important mediators in the context of genome-environment interactions.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2021)
Article
Developmental Biology
Iohanna Deckmann, Julio Santos-Terra, Mellanie Fontes-Dutra, Marilia Korbes-Rockenbach, Guilherme Bauer-Negrini, Gustavo Brum Schwingel, Rudimar Riesgo, Victorio Bambini-Junior, Carmem Gottfried
Summary: The study evaluated various physiological indicators related to the brain in an animal model of autism spectrum disorder, demonstrating significant changes in blood-brain barrier permeability and brain water content. Resveratrol was found to have an impact on these indicators and could prevent some of the alterations, providing insights into the pathophysiology of autism spectrum disorder.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Guilherme Bauer-Negrini, Iohanna Deckmann, Gustavo Brum Schwingel, Mauro Mozael Hirsch, Mellanie Fontes-Dutra, Giovanna Carello-Collar, Diane E. Halliwell, Maria Paraskevaidi, Camilo L. M. Morais, Francis L. Martin, Rudimar Riesgo, Carmem Gottfried, Victorio Bambini-Junior
Summary: This study investigated the impact of T-cell immunodeficiency on behaviors relevant to neurodevelopmental and neuropsychiatric disorders and characterized related alterations through multidisciplinary approaches. Results showed that BALB/c nude mice displayed impaired sociability, a complex pattern of repetitive behaviors, and increased sensitivity to thermal nociception, along with a different CNS spectrochemical signature compared to their heterozygous littermates. These findings highlight potential neuroimmunological influences involved with the observed alterations.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Julio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Andre Vinicius Contri Paz, Clarissa S. Gama, Victorio Bambini-Junior, Mellanie Fontes-Dutra, Carmem Gottfried
Summary: This study investigated histological parameters and interneuron sub-populations in the hippocampus of an autism animal model induced by VPA, showing the protective effect of RSV. The research also demonstrated long-term effects of prenatal exposure to ASD on hippocampal structure and associated proteins.
Article
Biochemistry & Molecular Biology
Julio Santos-Terra, Iohanna Deckmann, Giovanna Carello-Collar, Gustavo Della-Flora Nunes, Guilherme Bauer-Negrini, Gustavo Brum Schwingel, Mellanie Fontes-Dutra, Rudimar Riesgo, Carmem Gottfried
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by brain alterations and E/I imbalance. This study investigates the inhibitory components associated with ASD and suggests that prenatal treatment with resveratrol (RSV) may have preventive effects on ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Behavioral Sciences
Patricia Pelufo Silveira, Lorenzo More, Carmem Gottfried
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Clinical Neurology
Josemar Marchezan, Iohanna Deckmann, Guilherme Cordenonsi da Fonseca, Rogerio Margis, Rudimar Riesgo, Carmem Gottfried
Summary: This study aimed to evaluate the efficacy and safety of trans-resveratrol (RSV) in pediatric subjects with Autism Spectrum Disorder (ASD). The results showed that RSV treatment significantly improved behavioral impairments, increased miR-195-5p levels associated with the immune system, and had no adverse effects.
CLINICAL NEUROPHARMACOLOGY
(2022)
Article
Neurosciences
Mellanie Fontes-Dutra, Joseane Righes Marafiga, Julio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Bruna Rabelo, Rafael Kazmierzak de Moraes, Marilia Rockenbach, Mayara Vendramin Pasquetti, Carmem Gottfried, Maria Elisa Calcagnotto
Summary: Prenatal exposure to valproic acid (VPA) leads to autism spectrum disorder (ASD), but resveratrol (RSV) can prevent these impairments. This study found that prenatal VPA exposure reduced synaptic inhibition in the somatosensory area, resulting in behavioral and electroencephalogram changes. However, RSV prevented these synaptic inhibition alterations and improved behavioral and electroencephalogram abnormalities.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Marina C. Leite, Fabiana Galland, Maria Cristina Guerra, Leticia Rodrigues, Jessica Taday, Priscila T. Monteforte, Hanko Hirata, Carmem Gottfried, Rosario Donato, Soraya Smaili, Carlos-Alberto Goncalves
Summary: The secretion of S100B by astrocytes is triggered by the increase in intracellular Ca2+, which is caused by the mobilization of Ca2+ from the endoplasmic reticulum. The widely used solvent DMSO acts as a secretagogue for S100B, promoting its secretion both in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Mellanie Fontes-Dutra, Julio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Gustavo Della-Flora Nunes, Mauro Mozael Hirsch, Guilherme Bauer-Negrini, Rudimar S. Riesgo, Victorio Bambini-Junior, Cecilia Hedin-Pereira, Carmem Gottfried
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Mauro Mozael Hirsch, Iohanna Deckmann, Mellanie Fontes-Dutra, Guilherme Bauer-Negrini, Gustavo Della-Flora Nunes, Walquiria Nunes, Bruna Rabelo, Rudimar Riesgo, Rogerio Margis, Victorio Bambini-Junior, Carmem Gottfried
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)