Article
Developmental Biology
Shizheng Zhao, Ao Zhang, Hao Zhu, Zilong Wen
Summary: The study reports the identification and characterization of a new member of the ETS transcription factors, Spi2, in ray-finned fish. It shows that Spi2 is crucial for hematopoietic stem and progenitor cell development and myeloid lineage differentiation. A reporter line is created to track these cells from early development to adulthood.
Article
Biochemistry & Molecular Biology
Federica Petrillo, Dmitry Chernyakov, Cristina Esteva-Font, Soren B. Poulsen, Bayram Edemir, Robert A. Fenton
Summary: Water homeostasis is regulated by the kidneys through urine concentration. The antidiuretic hormone AVP enhances water reabsorption through binding to V2R in the kidney. ELF5 and NFAT5 are transcription factors that regulate Aqp2 expression and play important roles in renal water handling. The absence of NFAT5 leads to nephrogenic diabetes insipidus.
Review
Medicine, Research & Experimental
Liwei Du, Yuchen Liu, Chenxi Li, Jinkuang Deng, Yi Sang
Summary: In this review, the authors discuss the role and progress of ETS factors and miRNAs in cancer research, with a focus on their interactions with ceRNAs, posttranslational modifications, and the tumor microenvironment. They find that the interplay between ETS factors and miRNAs offers new insights into tumorigenesis and development, as well as novel therapeutic approaches for malignant tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Jing Ma, Li-yue Wang, Jia-xi Dai, Ying Wang, Duo Lin
Summary: CaNAC46 is an important transcription factor that regulates plant resistance to abiotic stresses such as drought and salinity by activating ROS-scavenging enzymes and enhancing root formation. The regulatory mechanisms controlling this NAC transcription factor appear to be conserved between Arabidopsis thaliana and pepper.
Article
Cell Biology
Umair W. Khan, Phillip A. Newmark
Summary: The mechanisms required for female germ cell development and regeneration in planarians involve neurotransmitter-biosynthetic enzymes and regionally enriched genes, which regulate germ cell development and regeneration in somatic gonadal cells.
Article
Clinical Neurology
Rasha Alqdwah-Fattouh, Sara Rodriguez-Martin, Diana Barreira-Hernandez, Laura Izquierdo-Esteban, Miguel Gil, Diana Gonzalez-Bermejo, Encarnacion Fernandez-Anton, Antonio Rodriguez-Miguel, Alberto Garcia-Lledo, Francisco Bolumar, Francisco J. de Abajo
Summary: A study found that the use of selective serotonin reuptake inhibitors (SSRIs) is not associated with an increased risk of noncardioembolic ischemic stroke. In fact, SSRIs appear to be protective compared to other antidepressants.
Article
Plant Sciences
Hongjie Wang, Cheng Li, Lidan Wang, Hongying Zhong, Xin Xu, Yanbo Cheng, Hai Nian, Wenhua Liu, Pei Chen, Aixia Zhang, Qibin Ma
Summary: In this study, the GmABR1 gene from soybean was investigated for its aluminum tolerance. The results showed that GmABR1 gene was constitutively expressed in root tip, stem, and leaf tissues, and its transcript increased significantly under aluminum stress. GmABR1 may regulate plant resistance to aluminum stress through genes related to aluminum stress response and ABA response pathways.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Genetics & Heredity
Michaela A. Boti, Panagiotis G. Adamopoulos, Panagiotis Tsiakanikas, Andreas Scorilas
Summary: Elf-3, a member of the ETS family, is crucial in epithelial cell differentiation, development, and cancer. This study identified 25 new ELF3 mRNA transcript variants and two novel exons, laying the foundation for further research on the biological function of these variants and protein isoforms.
Article
Plant Sciences
Yongli Li, Zhihong Hou, Weiwei Li, Haiyang Li, Sijia Lu, Zhuoran Gan, Hao Du, Tai Li, Yuhang Zhang, Fanjiang Kong, Yuhan Cheng, Milan He, Lixin Ma, Chunmei Liao, Yaru Li, Lidong Dong, Baohui Liu, Qun Cheng
Summary: The E1 gene in soybean plays an important role in leaf development, with E1 overexpression resulting in smaller and curlier leaves. E1 negatively regulates the expression of leaf development-related genes by binding to their promoters, affecting leaf development.
Article
Clinical Neurology
Ya-Mei Tzeng, I-Hsun Li, Hui-Han Kao, Jui-Hu Shih, Chin-Bin Yeh, Yi-Hsien Chen, Li-Ting Kao
Summary: This study found that antidepressants can reduce the subsequent risk of psoriasis in patients with major depressive disorder, particularly selective serotonin reuptake inhibitors and low-dose antidepressants have significant protective effects.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Physiology
Maja Zupancic, Evgenii Tretiakov, Zoltan Mate, Ferenc Erdelyi, Gabor Szabo, Frederic Clotman, Tomas Hokfelt, Tibor Harkany, Erik Keimpema
Summary: This study maps the positions and connectivity of Onecut3(+) neuronal populations in the developing and adult mouse brain. The study found that Onecut3 marks a previously undescribed neuronal cohort in the lateral hypothalamus, which expresses thyrotropin-releasing hormone. The Onecut3(+) neurons in the lateral hypothalamus have both intra- and extrahypothalamic efferents, with projections to the septal complex, habenula, neocortex, and hippocampus.
Article
Pharmacology & Pharmacy
Joachim Neumann, Tom Seidler, Charlotte Fehse, Margareta Marusakova, Britt Hofmann, Ulrich Gergs
Summary: The study revealed that metoclopramide had a partial agonist effect on human cardiac 5-HT4 receptors, while domperidone had no effect at all.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Benjamin P. Song, Michelle F. Ragsac, Krissie Tellez, Granton A. Jindal, Jessica L. Grudzien, Sophia H. Le, Emma K. Farley
Summary: By conducting high-throughput screens on genomic elements in developing Ciona embryos, this study identifies an enhancer near Lama gene that is critical for notochord development. Transcription factors Zic and ETS regulate enhancer activity and their binding sites are conserved in Lama1 introns in mouse and human. Furthermore, a similar binding site logic is observed in other Ciona and vertebrate Bra enhancers. The study uncovers the importance of enhancer grammar and discovers conserved signatures of enhancer logic and grammar in chordates.
Article
Multidisciplinary Sciences
Swapnalee Sarmah, Matthew R. Hawkins, Priyadharshini Manikandan, Mark Farrell, James A. Marrs
Summary: The E26 transformation specific (ETS) family transcription factor ELF3 plays a critical role in the development of epidermal, mesenchymal, and neural tissues in zebrafish. Loss of Elf3 function leads to defects in notochord, craniofacial cartilage, and fin development, as well as neural abnormalities. Disruption of extracellular matrix organization and dysregulation of genes encoding ECM proteins and matrix metalloproteases (MMP) may contribute to the observed phenotypes in Elf3-morphants.
Article
Cell Biology
Laura Pezze, Erna Marija Meskyte, Mattia Forcato, Stefano Pontalti, Kalina Aleksandra Badowska, Dario Rizzotto, Ira-Ida Skvortsova, Silvio Bicciato, Yari Ciribilli
Summary: The study revealed a new role for ETV7 in promoting plasticity and resistance in breast cancer stem-like cells. By reprogramming gene expression, ETV7 influenced the proliferation and treatment sensitivity of breast cancer stem cells.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Paul R. Albert, Faranak Vahid-Ansari
Editorial Material
Neurosciences
Paul R. Albert
Editorial Material
Neurosciences
Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2020)
Article
Psychiatry
Amin Zahrai, Faranak Vahid-Ansari, Mireille Daigle, Paul R. Albert
TRANSLATIONAL PSYCHIATRY
(2020)
Review
Clinical Neurology
Shawn Hayley, Antoine M. Hakim, Paul R. Albert
Summary: Major depression may be a precursor to cognitive decline and dementia, with chronic stress and inflammation compromising brain function and leading to depression and mild cognitive impairment. Treating inflammatory changes in depression can reverse the condition, and anti-inflammatory and antidepressant treatments may reduce or prevent dementia in individuals with depression. Chronic stress and inflammation may increase brain permeability and cytokine production, eventually manifesting as depression, cognitive impairment, and potentially dementia.
Editorial Material
Neurosciences
Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2021)
Review
Psychiatry
Faranak Vahid-Ansari, Paul R. Albert
Summary: Serotonin plays key roles in wiring the developing brain and synaptic reorganization during adulthood, mediated by 14 different 5-HT receptors. The 5-HT system has the capacity to regrow and reinnervate brain regions following insults, often leading to depression, anxiety, and cognitive impairment. Chronic treatment with antidepressants can accelerate the rewiring processes and potentially improve recovery from injury-induced mental illness or cognitive impairment.
FRONTIERS IN PSYCHIATRY
(2021)
Editorial Material
Neurosciences
Paul R. Albert, Lena Palaniyappan, Patricia Boksa
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Neurosciences
S. Hayley, F. Vahid-Ansari, H. Sun, P. R. Albert
Summary: Parkinson's disease is a complex illness influenced by environmental factors and genetic vulnerability. Many studies focus on the disease's motor symptoms and overlook the debilitating non-motor features that occur early in the disease process. Comorbid psychiatric features, such as clinical depression, anxiety, and sleep disorders, are believed to emerge before prominent motor deficits. This review explores the prodromal stage of PD, the unfolding of early neuropsychiatric pathology, and later motor disturbances, as well as the complexity captured by animal models of PD.
NEUROBIOLOGY OF DISEASE
(2023)
Meeting Abstract
Neurosciences
Faranak Vahid-Ansari, Amin Zahrai, Mireille Daigle, Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Meeting Abstract
Neurosciences
Min Zhang, Faranak Vahid-Ansari, Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Meeting Abstract
Clinical Neurology
F. Vahid-Ansari, A. Zahrai, P. Albert
INTERNATIONAL JOURNAL OF STROKE
(2021)
Meeting Abstract
Clinical Neurology
Faranak Vahid-Ansari, Amin Zahrai, Paul Albert
INTERNATIONAL JOURNAL OF STROKE
(2019)
Meeting Abstract
Clinical Neurology
Min Zhang, Faranak Vahid-Ansari, Paul Albert
INTERNATIONAL JOURNAL OF STROKE
(2019)
Meeting Abstract
Neurosciences
Amin Zahrai, Faranak Vahid-Ansari, Paul R. Albert
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)
