Review
Cell Biology
Bazhena Bahatyrevich-Kharitonik, Rafael Medina-Guzman, Alicia Flores-Cortes, Marta Garcia-Cruzado, Edel Kavanagh, Miguel Angel Burguillos
Summary: Cell death related (CDR) proteins were originally known for their role in apoptotic cell death signaling, but recent studies have revealed their diverse non-apoptotic functions in the CNS, including inflammasome and non-apoptotic cell death, cytoskeleton reorganization, synaptic plasticity, mitophagy, neurodegeneration, and calcium signaling. Proteomic techniques have evolved to predict caspase substrates, which may explain the non-apoptotic roles of CDR proteins. Furthermore, there are new concepts in the field, such as the impact of sexual dimorphism on non-apoptotic CDR protein function and the emergence of zymogen-specific caspase functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Jiyeon Ha, Hana Jang, Namjeong Choi, Jagyeong Oh, Chanhyuk Min, Davide Pradella, Da-Woon Jung, Darren R. Williams, Daeho Park, Claudia Ghigna, Xuexiu Zheng, Haihong Shen
Summary: SRSF9 is identified as a novel regulatory protein for alternative splicing (AS) of Caspase-2 exon 9, affecting cellular apoptosis by regulating a subset of apoptosis related genes.
Article
Environmental Sciences
Abdullah Aslan, Seda Beyaz, Ozlem Gok, Gozde Parlak, Muhammed Ismail Can, Can Ali Agca, Ibrahim Hanifi Ozercan, Akif Evren Parlak
Summary: This study aimed to investigate whether royal jelly can prevent fluoride-induced brain tissue damage and explore the underlying molecular mechanisms. The results showed that royal jelly prevented brain tissue damage caused by fluoride through its antioxidant activities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Graciliana Lopes, Elisabete Gomes, Mariana Barbosa, Joao Bernardo, Patricia Valentao
Summary: This study reports the potential medicinal properties of aqueous and hydroethanol extracts of camel grass in the RAW 264.7 cell model of inflammation and neurologically related conditions for the first time, and establishes a relationship between the chemical profiles of the extracts and their biological activities.
Article
Neurosciences
Serena Petry, Behnaz Nateghi, Remi Keraudren, Nicolas Sergeant, Emmanuel Planel, Sebastien S. Hebert, Isabelle St-Amour
Summary: This study investigates the alternative splicing of tau protein in HD patients and identifies abnormal splicing events in the putamen. Differences in exon 2 splicing coincide with increased tau hyperphosphorylation, aggregation, and markers of neurodegeneration, suggesting a potential biomarker or therapeutic target.
Review
Neurosciences
Mohammad Rafi Khezri, Morteza Ghasemnejad-Berenji
Summary: Alzheimer's disease is the most common neurodegenerative disorder worldwide and its main cause is still unknown. Neuronal death due to various pathologic changes is considered to be the main cause. Caspases, a group of proteases involved in cellular apoptosis and other cellular responses, have been found to play a central role in the pathophysiology of Alzheimer's disease. Targeting caspases may be a suitable therapeutic option to slow the progression of the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Jason P. Fernandes, William G. Branton, Eric A. Cohen, Gerrit Koopman, Ivanela Kondova, Benjamin B. Gelman, Christopher Power
Summary: Despite effective antiretroviral therapies, a significant proportion of treated HIV infection cases develop a neurodegenerative syndrome called HIV-associated neurocognitive disorder (HAND). This study investigates the mechanisms underlying neuronal damage and death in HAND and identifies a novel mechanism by which HIV triggers pyroptotic death in neurons. Targeting this mechanism could offer new diagnostic and therapeutic strategies for HAND and other neurodegenerative disorders.
Article
Biochemistry & Molecular Biology
Donglin Yang, Liujun He, Shuiqing Ma, Shiqiang Li, Yajun Zhang, Chunsheng Hu, Jiuhong Huang, Zhigang Xu, Dianyong Tang, Zhongzhu Chen
Summary: Compound 6d, a spiroindoline compound, inhibits CRC growth by acting as an inhibitor of Bcl-2 and inducing caspase 3-mediated intrinsic apoptosis. Caspase 3 activation by compound 6d directly cleaves HDAC6, with cleavage occurring at D1088 in the DMAD-S motif. Compound 6d-induced apoptosis promotes autophagy initiation by disrupting the interaction between Bcl-2 and Beclin 1, resulting in the accumulation of ubiquitinated proteins and reduction of autophagic flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu-Kai Huang, Kun-Che Chang, Chia-Yang Li, Ann-Shung Lieu, Chih-Lung Lin
Summary: This study investigated the role of AKR1B1 in glioma cell proliferation and apoptosis signaling. AKR1B1 expression was measured in different cell lines and tissues. The effects of AKR1B1 overexpression or knockdown, as well as p38 MAPK activation and inhibition, were evaluated. AKR1B1 was found to regulate glioma cell proliferation through the activation of p38 MAPK and apoptosis signaling. Therefore, AKR1B1 may be a potential therapeutic target for glioma therapy.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Neurosciences
Xiangjun Yang, Qun Zeng, Gulgun Tezel
Summary: This study investigated the importance of caspase-8 in different fates of glaucomatous RGCs and astroglia, revealing cell type-specific distinct processes that regulate caspase-8 functions in experimental glaucoma. Deletion of caspase-8 in astroglia protected RGCs against glia-driven inflammatory injury, while inhibition of caspase-8 cleavage inhibited apoptosis in RGCs themselves, suggesting the multi-target potential of caspase-8 regulation in providing neuroprotection and immunomodulation in glaucoma.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Immunology
Shuling Zhang, Ning Liu, Mingxing Ma, Hai Huang, Mike Handley, Xueli Bai, Fengping Shan
Summary: The study demonstrated that MENK regulates the biological behavior of lung cancer cells by enhancing apoptosis and immunogenicity while promoting NK cell-driven tumor immunity, potentially inhibiting the proliferation of lung cancer cells through the activation of key signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Environmental
Ives Charlie-Silva, Amanda P. C. Araujo, Abraao T. B. Guimaraes, Flavio P. Veras, Helyson L. B. Braz, Leticia G. de Pontes, Roberta J. B. Jorge, Marco A. A. Belo, Bianca H. V. Fernandes, Rafael H. Nobrega, Giovane Galdino, Antonio Condino-Neto, Jorge Galindo-Villegas, Glaucia M. Machado-Santelli, Paulo R. S. Sanches, Rafael M. Rezende, Eduardo M. Cilli, Guilherme Malafaia
Summary: The study evaluated the aquatic toxicity of SARS-CoV-2 Spike protein peptides on tadpoles, finding that these peptides can increase oxidative stress and acetylcholinesterase activity, indicating potential environmental and biological harm.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Neurosciences
Shuqiang Zhang, Junjie Zhong, Lian Xu, Yue Wu, Jie Xu, Jianhua Shi, Zhikai Gu, Xiaoyu Li, Nana Jin
Summary: Dyrk1A promotes neuronal apoptosis by suppressing ASF-mediated Bcl-x splicing, and the truncated form of Dyrk1A aggravates neuronal apoptosis by inhibiting ASF-mediated Bcl-x splicing.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Plant Sciences
Shuai Zhao, Daihong Wan, Yaoyao Zhong, Xiwei Xu
Summary: This study reveals the protective effects of 1,25-D3 against H. pylori-induced apoptosis in gastric mucosa epithelial cells and elucidates its underlying mechanisms.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meng-Jie Zhao, Xiao Yao, Ping Wei, Chen Zhao, Meng Cheng, Dong Zhang, Wen Xue, Wen-Tian He, Weili Xue, Xinxin Zuo, Lei-Lei Jiang, Zhiyuan Luo, Jiaqi Song, Wen-Jie Shu, Han-Ye Yuan, Yi Liang, Hui Sun, Yan Zhou, Yu Zhou, Ling Zheng, Hong-Yu Hu, Jiwu Wang, Hai-Ning Du
Summary: Research has shown that O-GlcNAc transferase OGT-mediated O-GlcNAcylation of TDP-43 can suppress ALS-related proteinopathies and enhance TDP-43's splicing function. This study further demonstrates the importance of TDP-43 O-GlcNAcylation in maintaining neuronal health and function.
Article
Biochemical Research Methods
Anne Arnold, Markus Persike, Jan Gorka, Eleanor J. Dommett, Martina Zimmermann, Michael Karas
JOURNAL OF MASS SPECTROMETRY
(2015)
Article
Polymer Science
Gokhan Yilmaz, Lea Messager, Anne S. Gleinich, Daniel A. Mitchell, Giuseppe Battaglia, C. Remzi Becer
Article
Chemistry, Multidisciplinary
Daniel A. Mitchell, Qiang Zhang, Lenny Voorhaar, David M. Haddleton, Shan Herath, Anne S. Gleinich, Harpal S. Randeva, Max Crispin, Hendrik Lehnert, Russell Wallis, Steven Patterson, C. Remzi Becer
Article
Education, Scientific Disciplines
Martina Zimmermann
AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
(2013)
Review
Pharmacology & Pharmacy
M. Zimmermann
BRITISH JOURNAL OF PHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Markus H. Hillert, Imran Imran, Martina Zimmermann, Helene Lau, Stefanie Weinfurter, Jochen Klein
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Neurosciences
Franziska Mohr, Martina Zimmermann, Jochen Klein
Article
Neurosciences
Ute Burkhardt, Bartosch Wojcik, Martina Zimmermann, Jochen Klein
Article
Neurosciences
G. Li, J. Klein, M. Zimmermann
Article
Multidisciplinary Sciences
Franziska Mohr, Eric Krejci, Martina Zimmermann, Jochen Klein
Article
Cell Biology
Ting Wang, Zheng Wang, Lauriane de Fabritus, Jinglian Tao, Essa M. Saied, Ho-Joon Lee, Bulat R. Ramazanov, Benjamin Jackson, Daniel Burkhardt, Mikhail Parker, Anne S. Gleinich, Zhirui Wang, Dong Eun Seo, Ting Zhou, Shihao Xu, Irina Alecu, Parastoo Azadi, Christoph Arenz, Thorsten Hornemann, Smita Krishnaswamy, Serge A. van de Pavert, Susan M. Kaech, Natalia B. Ivanova, Fabio R. Santori
Summary: 1-Deoxysphingosines have been identified as modulators of NR2F1 and NR2F2 activity, binding to their ligand-binding domains and regulating their transcriptional activity at physiological concentrations. Inhibition of sphingolipid biosynthesis phenocopies NR2F1/2 deficiency in endothelium and cardiomyocytes, while increased levels of 1-Deoxysphingosines activate NR2F1/2-dependent differentiation programs. These findings suggest that 1-Deoxysphingosines are physiological regulators of NR2F1/2-mediated transcription.
DEVELOPMENTAL CELL
(2021)
Article
Microbiology
Sarah Welbourn, Srirupa Chakraborty, Jie E. Yang, Anne S. Gleinich, Sailaja Gangadhara, Salar Khan, Courtney Ferrebee, Bhrugu Yagnik, Samantha Burton, Tysheena Charles, S. Abigail Smith, Danielle Williams, Rohini Mopuri, Amit A. Upadhyay, Justin Thompson, Matt A. Price, Shiyu Wang, Zhaohui Qin, Xiaoying Shen, LaTonya D. Williams, Nathan Eisel, Tiffany Peters, Lu Zhang, William Kilembe, Etienne Karita, Georgia D. Tomaras, Steven E. Bosinger, Rama R. Amara, Parastoo Azadi, Elizabeth R. Wright, Sandrasegaram Gnanakaran, Cynthia A. Derdeyn
Summary: Transmitted/founder (T/F) HIV-1 envelope proteins possess features desirable for vaccine immunogen design and can elicit neutralizing antibody responses in rhesus macaques (RM). The serum neutralizing activity in RM was found to be dependent on the gp120 V5 region, which was also targeted by a neutralizing monoclonal antibody (nmAb) isolated from the infected individual. The results demonstrate the potential of using T/F Envs as a starting point to drive neutralizing antibody breadth in vaccine design.
Article
Oncology
Jingyu Zhan, Dong Lin, Nathan Watson, Lothar Esser, Wai Kwan Tang, Alex Zhang, Xiufen Liu, Raffit Hassan, Anne Gleinich, Asif Shajahan, Parastoo Azadi, Ira Pastan, Di Xia
Summary: Mesothelin, a tumor-associated antigen, is highly expressed on the cell surface of many human cancers and has limited expression in normal tissues. Binding of mesothelin to CA-125 can facilitate cell adhesion and tumor metastasis. Immunotherapeutic strategies targeting mesothelin are actively being studied.
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Joji Tanaka, Anne S. Gleinich, Qiang Zhang, Richard Whitfield, Kristian Kempe, David M. Haddleton, Thomas P. Davis, Sebastien Perrier, Daniel A. Mitchell, Paul Wilson
Article
Humanities, Multidisciplinary
Martina Zimmermann
JOURNAL OF MEDICAL HUMANITIES
(2013)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)