Article
Clinical Neurology
Diana A. Olszewska, Alfonso Fasano, Renato P. Munhoz, Carolina Candelaria Ramirez Gomez, Anthony E. Lang
Summary: This retrospective cohort study aimed to investigate the difference in the time between initial levodopa and dopamine agonist (DA) treatment and the development of disabling motor complications (MCs) in Parkinson's disease (PD) patients who underwent deep brain stimulation (DBS). The results showed no significant difference in the duration from the first treatment to DBS assessment or surgery between patients who received levodopa and those who received a DA.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Behavioral Sciences
Gabriella E. DiCarlo, Mark T. Wallace
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and restricted interests/repetitive behaviors. Over 1000 genes and 2000 copy number variants have been implicated in ASD. It is believed that there is not a single genetic cause or neurobiological basis for ASD, but rather multiple subtypes with different genetic and neurobiological perturbations. Dopamine dysfunction may be one potential subtype associated with ASD. This research provides a framework for subcategorizing ASD based on genetic changes, neurobiological differences, and behavioral features.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Song
Summary: This study examines the pharmacological properties of selective reuptake inhibitors for dopamine, norepinephrine, and serotonin and finds antagonistic effects when they are used in combination. Furthermore, it suggests the presence of a potential secondary inhibitor binding site that affects inhibition.
Article
Biochemistry & Molecular Biology
Mu Li, Xintong Zhang, Sixiang Chen, Hanhe Liu, Yuan-Wei Zhang
Summary: This study reveals a novel structural characteristic of the neurotransmitter sodium symporter (NSS) family, specifically in TuriSERT, and demonstrates the unique substrate binding site and 1:1 stoichiometry of sodium-substrate binding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
John Sebastiani, Allyson Sabatelli, M. Danielle McDonald
Summary: Mild hypoxia in toadfish results in increased 5-HT uptake and degradation in peripheral tissues, leading to reduced plasma 5-HT levels. The gill appears to play a major role in the clearance of 5-HT.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Chemistry, Analytical
Jordan Holmes, Thorsten Lau, Rachel Saylor, Nadine Fernandez-Novel, Melinda Hersey, Deanna Keen, Lena Hampel, Sandra Horschitz, Julia Ladewig, Brenna Parke, Michael C. Reed, H. Frederik Nijhout, Janet Best, Philipp Koch, Parastoo Hashemi
Summary: Depression is a pressing public health crisis, and better diagnostics and therapeutics are urgently needed. Researchers have developed a chemical model using human-derived stem cells to investigate serotonin neurotransmission, which has the potential to be a translational tool for neuropsychopharmacology.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Haelim Jeong, Jun Young Park, Ji-Hyun Lee, Ja-Hyun Baik, Chae-Yeon Kim, Jin-Young Cho, Monica Driscoll, Young-Ki Paik
Summary: The discovery of rcat-1 as a novel negative transcriptional regulator for dopamine metabolism genes has provided insights into the regulation of food search-associated locomotion. The mutants of rcat-1 exhibit abnormal movement behaviors and potential deficiencies in food sensing or locomotion toward food. This finding not only identifies a new subtype of dopamine-related behaviors but also suggests a potential therapeutic target in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Gita Vita Soraya, Zulvikar Syambani Ulhaq, Syifaus Shodry, Muhammad A'raaf Sirojan Kusuma, Sarah Herawangsa, Maharani Oryza Sativa, Aridin Gustaf, Dzakky Avecienna Nur Faridwazdi, Shinta Wulandari Florentia, Neila Raisa, Andi Kurnia Bintang, Muhammad Akbar
Summary: This study conducted a systematic review and meta-analysis on the pharmacogenetic association between levodopa-induced dyskinesia (LID) and motor fluctuations (MF) with common genetic variants of the dopamine metabolic and signaling pathways. The results showed strong associations between polymorphisms of genes regulating dopamine metabolism and the occurrence of LID and MF. The MAO-B rs1799836 may be a potential pharmacogenetic marker for MLIC, while the COMT rs4680 and rs4633 may be markers for LID in Asian ethnicities.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Ryul Kim, Sangmin Park, Dallah Yoo, Jin-Sun Jun, Beomseok Jeon
Summary: The study found that the APOE ?4 allele has a negative impact on cognitive function in early Parkinson's disease patients; over 5 years of follow-up, APOE ?4 carriers showed steeper declines in the Montreal Cognitive Assessment score and semantic fluency test score, with no significant differences observed in other motor and nonmotor functions or DAT imaging variables.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Psychiatry
Simeng Gu, Zhengming He, Qiuyue Xu, Jie Dong, Tingwei Xiao, Fei Liang, Xianjun Ma, Fushun Wang, Jason H. Huang
Summary: Post-stroke depression is a common and serious consequence of stroke, but many aspects related to it are still unclear. The monoamine hypothesis suggests that three monoamines play a key role in depression, and current antidepressants target these monoamines for the treatment of post-stroke depression. Recent studies have also shown potential effects of monoamine-related emotional intervention in the treatment and prevention of post-stroke depression.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Chemistry, Medicinal
Jianping Chen, Erik J. Garcia, Christina R. Merritt, Joshua C. Zamora, Andrew A. Bolinger, Konrad Pazdrak, Susan J. Stafford, Randy C. Mifflin, Eric A. Wold, Christopher T. Wild, Haiying Chen, Noelle C. Anastasio, Kathryn A. Cunningham, Jia Zhou
Summary: In this study, novel oleamide analogues were designed and synthesized as selective 5-HT2CR agonists or dual 5-HT2CR/5-HT2AR positive allosteric modulators using a fragment-based discovery approach. Compound 13 (JPC0323) showed on-target properties, acceptable plasma exposure and brain penetration, and negligible displacement to orthosteric sites of over 50 GPCRs and transporters. Moreover, compound 13 suppressed novelty-induced locomotor activity in a 5-HT2CR-dependent manner, indicating 5-HT2CR agonist activity at the whole organism level at the employed doses of 13. This research discovered new selective 5-HT2CR agonists and first-in-class 5-HT2CR/5-HT2AR dual positive allosteric modulators, expanding the pharmacological toolbox for exploring the biology of these important receptors.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Urszula Adamiak-Giera, Wojciech Jawien, Anna Pierzchlinska, Monika Bialecka, Jan Dariusz Kobierski, Tomasz Janus, Barbara Gawronska-Szklarz
Summary: This study aimed to investigate the pharmacokinetic characteristics of levodopa in Parkinson's disease patients, finding that ropinirole does not influence the concentrations of levodopa and its metabolite 3-OMD, while higher 3-OMD levels play a role in inducing motor complications during long-term therapy.
Article
Pharmacology & Pharmacy
Qian Zhang, XiangTing Chen, FeiFei Chen, SiYuan Wen, ChangQing Zhou
Summary: Compared with levodopa, dopamine agonists (DAs) as initial treatment are associated with lower incidences of motor complications in early Parkinson's disease (PD). There is no strong evidence that a given DA is more potent in lower incidences of motor complications than another. We performed a network meta-analysis of levodopa versus DAs as monotherapy in early PD to assess the risk of motor complications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Miguel A. Labrador-Espinosa, Michel J. Grothe, Daniel Macias-Garcia, Silvia Jesus, Astrid Adarmes-Gomez, Laura Munoz-Delgado, Paula Fernandez-Rodriguez, Juan Francisco Martin-Rodriguez, Ismael Huertas, David Garcia-Solis, Pablo Mir
Summary: The study found that reductions in DAT levels in the sensorimotor striatal subregion were most pronounced in PD patients who developed LID, providing a potentially sensitive tool for early detection and improved prognosis of this common complication in PD.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
John Sebastiani, M. Danielle McDonald
Summary: This experiment showed that transporter-mediated 5-HT uptake plays an important role in controlling circulating 5-HT and whole body 5-HT homeostasis in Gulf toadfish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Irene Sebastianutto, Maria Angela Cenci
CURRENT OPINION IN PHARMACOLOGY
(2018)
Review
Clinical Neurology
M. Angela Cenci, Henrik Jorntell, Per Petersson
JOURNAL OF NEURAL TRANSMISSION
(2018)
Review
Clinical Neurology
M. Angela Cenci, Alan R. Crossman
MOVEMENT DISORDERS
(2018)
Article
Multidisciplinary Sciences
T. Fieblinger, L. Zanetti, I. Sebastianutto, L. S. Breger, L. Quintino, M. Lockowandt, C. Lundberg, M. A. Cenci
SCIENTIFIC REPORTS
(2018)
Article
Neurosciences
Per Petersson, Par Halje, M. Angela Cenci
JOURNAL OF PARKINSONS DISEASE
(2019)
Article
Clinical Neurology
Veronica Francardo, Michal Geva, Francesco Bez, Quentin Denis, Lilach Steiner, Michael R. Hayden, M. Angela Cenci
Article
Clinical Neurology
Elena Espa, Erik K. H. Clemensson, Kelvin C. Luk, Andreas Heuer, Tomas Bjoerklund, M. Angela Cenci
MOVEMENT DISORDERS
(2019)
Article
Medicine, Research & Experimental
Irene Sebastianutto, Elise Goyet, Laura Andreoli, Joan Font-Ingles, David Moreno-Delgado, Nathalie Bouquier, Celine Jahannault-Talignani, Enora Moutin, Luisa Di Menna, Natallia Maslava, Jean-Philippe Pin, Laurent Fagni, Ferdinando Nicoletti, Fabrice Ango, M. Angela Cenci, Julie Perroy
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Editorial Material
Clinical Neurology
M. Angela Cenci, Sara Riggare, Rajesh Pahwa, David Eidelberg, Robert A. Hauser
MOVEMENT DISORDERS
(2020)
Article
Multidisciplinary Sciences
Erik K. H. Clemensson, Morteza Abbaszadeh, Silvia Fanni, Elena Espa, M. Angela Cenci
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Multidisciplinary Sciences
Sara Hestehave, Klas S. P. Abelson, Tina Bronnum Pedersen, David P. Finn, Daniel R. Andersson, Gordon Munro
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Elena Espa, Lu Song, Katrine Skovgard, Silvia Fanni, M. Angela Cenci
Summary: This study investigated the impact of adjunct treatment with the D2/3 agonist ropinirole on levodopa-induced dyskinesia (LID)-related neuroplasticity and drug responses. The results showed distinct differences in neuroplasticity and pharmacological responses between rats receiving levodopa monotherapy and those receiving levodopa-ropinirole combination therapy. These findings suggest that the adjuvant dopamine agonist treatment should be considered when studying and treating LID in both clinical and experimental settings.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Chang Li, Osama F. Elabi, Tim Fieblinger, M. Angela Cenci
Summary: The dendritic arbour of striatal projection neurons undergoes atrophic changes in Parkinson's disease. In a mouse model of dopamine denervation, spiny projection neurons in the direct pathway show coordinated changes in dendritic morphology, intrinsic excitability, and Kir conductances at 28 days post-lesion, which may interfere with their normal movement-related output.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Editorial Material
Medicine, Research & Experimental
Anders Bjorklund, M. Angela Cenci
RECENT ADVANCES IN PARKINSON'S DISEASE
(2020)
Letter
Clinical Neurology
Robert A. Hauser, David Eidelberg, Rajesh Pahwa, Sara Riggare, M. Angela Cenci
MOVEMENT DISORDERS
(2020)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)