Article
Immunology
Mahsa Tanha, Mahmood Bozorgmehr, Mohammad-Reza Shokri, Haleh Edalatkhah, Mahya Tanha, Amir-Hassan Zarnani, Shohreh Nikoo
Summary: The study suggests that TCDD may impact inflammatory immune mediators involved in the development of endometriosis through AHR activation, potentially promoting the progression of the disease.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Arfa Tahir, Muhammad Umar Ijaz, Huma Naz, Tayyaba Afsar, Ali Almajwal, Houda Amor, Suhail Razak
Summary: TCDD is a potent environmental toxicant that can negatively impact the male reproductive system by inducing oxidative stress. However, the use of DDM showed promise in ameliorating these damages through its antioxidant, anti-apoptotic, and androgenic properties.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Wurood Hantoosh Neamah, Alex Rutkovsky, Osama Abdullah, Kiesha Wilson, Ryan Bloomquist, Prakash Nagarkatti, Mitzi Nagarkatti
Summary: This study demonstrates that Resveratrol (RSV), an AhR antagonist, reduces the induction and function of murine myeloid-derived suppressor cells (MDSCs) induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). RSV reverses the effects of TCDD on macrophages and dendritic cells, as well as the upregulation of critical molecules involved in TCDD-mediated induction and immunosuppressive functions of MDSCs. RSV treatment decreases the energetic demands induced by TCDD. These findings suggest the potential use of RSV to attenuate the immunosuppressive properties of MDSCs.
Article
Cell Biology
Yuan-Yuan Xie, Ting-Ting Pan, De-en Xu, Xin Huang, Yong Tang, Wenhui Huang, Rui Chen, Li Lu, Hao Chi, Quan-Hong Ma
Summary: Clemastine, an H1-antihistamine, has the potential to induce OPC differentiation and myelin formation under different neuropathological conditions. In aged APPSwe/PS1dE9 mice, chronic clemastine treatment reduced brain amyloid-beta deposition, improved short-term memory deficit, enhanced OPC density, and prevented OPCs from entering cellular senescence, showing therapeutic potential in Alzheimer's disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Jae Gon Park, Hisato Iwata, Nguyen Minh Tue, Tatsuya Kunisue, Eun-Young Kim
Summary: Researchers have discovered a naturally occurring dioxin called 1,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD) in the marine environment, synthesized by red algae. They investigated the effects of this compound on bird embryos and found that 1,3,7-TriBDD exposure may lead to health issues such as diabetes and cancer. Compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,3,7-TriBDD had different impacts on the phenotype and transcriptome of chicken embryos, potentially resulting in different severity of effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Toxicology
Muhammad Umar Ijaz, Shama Mustafa, Qurat Ul Ain, Ali Hamza, Shafaqat Ali
Summary: This study aimed to determine the mitigative role of rhamnazin against TCDD-induced damage to the male reproductive tract. The results showed that rhamnazin can improve the damage caused by TCDD through its antioxidant, anti-apoptotic, and androgenic properties.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Michela Novelli, Pascale Beffy, Matilde Masini, Chiara Vantaggiato, Luisa Martino, Lorella Marselli, Piero Marchetti, Vincenzo De Tata
Summary: Exposure to environmental pollutant TCDD affects pancreatic islets, especially beta cells, leading to cell death, ultrastructural alterations, decreased insulin secretion, and changes in gene expression. TCDD exposure significantly reduces cell survival and insulin secretion, causes ultrastructural changes in beta cells, and alters gene expression profiles in isolated islets.
Article
Gastroenterology & Hepatology
Yongliang Yang, David Filipovic, Sudin Bhattacharya
Summary: This study utilized a multiscale computational model to investigate the mechanisms underlying spatially restricted gene expression induced by the environmental pollutant TCDD. The findings reveal that a negative feedback loop and cooperative gene induction are key factors contributing to the localized gene induction pattern.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Cell Biology
Juliane Bauch, Andreas Faissner
Summary: Oligodendrocytes play an important role in myelination in the central nervous system. The glycoproteins tenascin-C (Tnc) and tenascin-R (Tnr) regulate the differentiation and regeneration of oligodendrocytes, affecting the formation and thickness of myelin sheaths. Results from experiments using Tnc and Tnr knockout mice show increased number of myelin sheaths and thickness in the absence of these proteins.
Article
Marine & Freshwater Biology
Monica S. Yue, Shannon E. Martin, Nathan R. Martin, Michael R. Taylor, Jessica S. Plavicki
Summary: Exposure to TCDD in zebrafish disrupts the development of the subintestinal venous plexus (SIVP) which vascularizes the liver, kidney, gut, and pancreas, as well as the superficial annular vessel (SAV) crucial for retinal vasculature. TCDD exposure also increases the expression of bmp4, a key molecular mediator of SIVP morphogenesis.
AQUATIC TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Hui-Ting Huang, Chia-Hsin Ho, Hsin-Yu Sung, Li-Ya Lee, Wan-Ping Chen, Yu-Wen Chen, Chin-Chu Chen, Chung-Shi Yang, Shun-Fen Tzeng
Summary: The extract from Hericium erinaceus mycelium (HEM) and its components HeA and HeS promote differentiation of oligodendrocyte precursor cells (OPCs) into oligodendrocytes (OLs) and enhance myelin basic protein (MBP) expression on neuronal fibers. These findings suggest promising functional effects of HEM and its ingredients in promoting OL maturation and potential for myelination in neurodevelopmental disorders.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Alexandria N. Hughes
Summary: Building a functional nervous system requires coordinated actions of many glial cells, including oligodendrocytes, microglia, and astrocytes. These non-neuronal, non-oligodendroglial cells play important roles in modifying myelination patterns in the CNS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Carlie L. Cullen, Megan O'Rourke, Shannon J. Beasley, Loic Auderset, Yilan Zhen, Renee E. Pepper, Robert Gasperini, Kaylene M. Young
Summary: Primary cilia play a crucial role in the myelination process of oligodendrocyte progenitor cells, with their assembly regulated by the gene Kif3a. Deletion of Kif3a leads to decreased OPC proliferation and oligodendrogenesis, affecting fine motor coordination in specific brain regions.
Article
Environmental Sciences
Michelle E. Kossack, Katherine E. Manz, Nathan R. Martin, Kurt D. Pennell, Jessica Plavicki
Summary: Dioxin and dioxin-like compounds are environmental contaminants that induce toxicity by binding to the aryl hydrocarbon receptor (AHR). The zebrafish model has been used to study developmental toxicity caused by exposure to AHR ligands such as dioxin. In this study, targeted gas chromatography (GC) and non-targeted liquid chromatography (LC) were used to quantify TCDD uptake, model its elimination dynamics, and determine its impact on the zebrafish metabolome. The results showed that environmentally relevant body burdens of TCDD were produced in zebrafish through different waterborne exposures, and TCDD exposure affected metabolic pathways associated with AHR signaling and brain development.
Article
Multidisciplinary Sciences
JoAnn Buchanan, Leila Elabbady, Forrest Collman, Nikolas L. Jorstad, Trygve E. Bakken, Carolyn Ott, Jenna Glatzer, Adam A. Bleckert, Agnes L. Bodor, Derrick Brittain, Daniel J. Bumbarger, Gayathri Mahalingam, Sharmishtaa Seshamani, Casey Schneider-Mizell, Marc M. Takeno, Russel Torres, Wenjing Yin, Rebecca D. Hodge, Manuel Castro, Sven Dorkenwald, Dodam Ih, Chris S. Jordan, Nico Kemnitz, Kisuk Lee, Ran Lu, Thomas Macrina, Shang Mu, Sergiy Popovych, William M. Silversmith, Ignacio Tartavull, Nicholas L. Turner, Alyssa M. Wilson, William Wong, Jingpeng Wu, Aleksandar Zlateski, Jonathan Zung, Jennifer Lippincott-Schwartz, Ed S. Lein, H. Sebastian Seung, Dwight E. Bergles, R. Clay Reid, Nuno Macarico da Costa
Summary: Neurons in the developing brain undergo structural refinement through the engulfment and degradation of axonal branches and synapses by glial cells. In the mouse visual cortex, oligodendrocyte precursor cells (OPCs) were found to surround small branches of axons and engage in axon pruning. Compared to microglia, OPCs were more abundant in phagosomes and phagolysosomes, suggesting their substantial contribution to neuronal circuit refinement during cortical development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Critical Care Medicine
Mercedes Fernandez, Vito Antonio Baldassarro, Rita Capirossi, Roberto Montevecchi, Jacopo Bonavita, Maura Cescatti, Tiziana Giovannini, Giulia Giovannini, Mariella Uneddu, Gordini Giovanni, Luciana Giardino, Laura Calza
JOURNAL OF NEUROTRAUMA
(2020)
Article
Pharmacology & Pharmacy
A. Giuliani, L. Lorenzini, V. A. Baldassarro, M. Pannella, M. Cescatti, M. Fernandez, G. Alastra, A. Flagelli, G. Villetti, B. P. Imbimbo, L. Giardino, L. Calza
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2020)
Article
Neurosciences
Alexandria Beland-Millar, Masaki Takimoto, Taku Hamada, Claude Messier
Article
Biochemistry & Molecular Biology
Rita Capirossi, Beatrice Piunti, Mercedes Fernandez, Elisa Maietti, Paola Rucci, Stefano Negrini, Tiziana Giovannini, Carlotte Kiekens, Laura Calza
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Mercedes Fernandez, Micaela Pannella, Vito Antonio Baldassarro, Alessandra Flagelli, Giuseppe Alastra, Luciana Giardino, Laura Calza
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Veterinary Sciences
Andrea Corsini, Francesco Dondi, Daria G. Serio, Silvia Zamagni, Stefania Golinelli, Mercedes Fernandez, Federico Fracassi
Summary: The study evaluated calcium and phosphate metabolism in dogs with hypercortisolism, showing higher serum phosphate concentrations, FECa, and wPTH concentrations in dogs with NOHC, and lower 25-(OH)D concentrations, as well as lower plasma FGF-23 concentrations compared to controls.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Computer Science, Artificial Intelligence
Flavio Bertini, Davide Allevi, Gianluca Lutero, Laura Calza, Danilo Montesi
Summary: Alzheimer's disease is the main form of dementia worldwide, with current pharmacological treatments only able to alleviate symptoms rather than halt the degenerative process. Research suggests that speech changes may be an early indication of cognitive defects, and an automated method using speech features has been proposed for classifying Alzheimer's disease patients.
COMPUTER SPEECH AND LANGUAGE
(2022)
Article
Biochemistry & Molecular Biology
Andrea Alogna, Valentina Gentili, Claudio Trapella, Supandeep Singh Hallan, Maddalena Sguizzato, Giovanni Strazzabosco, Mercedes Fernandez, Rita Cortesi, Roberta Rizzo, Daria Bortolotti
Summary: Liposomes have been utilized in various fields due to their versatility and easy production. This study evaluated the use of liposomes as a vehicle for delivering active components from snail mucus, showing promising effects on wound healing reconstitution. Specifically, the HC-loaded liposomes demonstrated superior cell monolayer reconstruction compared to untreated and HC-treated samples, indicating a novel delivery strategy for the HelixComplex mucus.
Article
Microbiology
Daria Bortolotti, Valentina Gentili, Sabrina Rizzo, Giovanna Schiuma, Silvia Beltrami, Giovanni Strazzabosco, Mercedes Fernandez, Francesca Caccuri, Arnaldo Caruso, Roberta Rizzo
Summary: (3) Our study demonstrated that both TLR3 and TLR7 play a role in regulating innate immunity during lung SARS-CoV-2 infection. Activation of TLRs led to the production of pro-inflammatory cytokines and interferons, indicating their potential as targets for early-stage infection control.
Article
Microbiology
Daria Bortolotti, Valentina Gentili, Alessandra Bortoluzzi, Marcello Govoni, Giovanna Schiuma, Silvia Beltrami, Sabrina Rizzo, Eleonora Baldi, Elisabetta Caselli, Maura Pugliatti, Massimiliano Castellazzi, Mercedes Fernandez, Enrico Fainardi, Roberta Rizzo
Summary: In patients with multiple sclerosis, there is an increased susceptibility to human herpesvirus infections, particularly EBV and HHV-6. These viral infections may induce immune activation and trigger autoimmune responses, leading to tissue damage and the development of multiple sclerosis lesions.
Article
Developmental Biology
Giovanna Schiuma, Silvia Beltrami, Erica Santi, Gennaro Scutiero, Juana Maria Sanz, Chiara Marina Semprini, Sabrina Rizzo, Mercedes Fernandez, Ines Zidi, Roberta Gafa, Angelina Passaro, Pantaleo Greco, Daria Bortolotti, Roberta Rizzo
Summary: Recent studies have shown differential expression of ACE2 and CD147 in pregnant women with SARS-CoV-2 placental infection. This study aimed to investigate placental SARSCoV-2 infection and its potential effect on protein expression. The results revealed a higher percentage of SARS-CoV-2 NP positive placental samples in the group positive for SARS-CoV-2 at delivery compared to the negative group.
Article
Pharmacology & Pharmacy
Giada Lodi, Valentina Gentili, Fabio Casciano, Arianna Romani, Giorgio Zauli, Paola Secchiero, Enrico Zauli, Carolina Simioni, Silvia Beltrami, Mercedes Fernandez, Roberta Rizzo, Rebecca Voltan
Summary: SARS-CoV viruses downregulate antiviral defenses by manipulating p53, a key molecule for cell homeostasis and immune control. Using MDM2 inhibitors to raise p53 levels can inhibit cell cycle and virus release, as well as reduce the expression of inflammatory cytokines. Therefore, p53 and MDM2 inhibitors may be potential therapies against SARS-CoV-2.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Agnese Stanzani, Anna Sansone, Cinzia Brenna, Vito Antonio Baldassarro, Giuseppe Alastra, Luca Lorenzini, Chryssostomos Chatgilialoglu, Ilaria Laface, Carla Ferreri, Luca Maria Neri, Laura Calza
Summary: The study analyzed changes in lipid composition due to inflammatory conditions. The fatty acid composition was measured in erythrocytes and spinal cord tissue of mice affected by experimental allergic encephalomyelitis (EAE). The results showed a decrease in PUFAs and an increase in SFAs in the membrane during the acute phase of EAE, while PUFAs decreased in the spinal cord tissue.
Article
Cell Biology
Marzia Moretti, Riccardo Caraffi, Luca Lorenzini, Ilaria Ottonelli, Michele Sannia, Giuseppe Alastra, Vito Antonio Baldassarro, Alessandro Giuliani, Jason Thomas Duskey, Maura Cescatti, Barbara Ruozi, Luigi Aloe, Maria Angela Vandelli, Luciana Giardino, Giovanni Tosi, Laura Calza
Summary: Spinal cord injury (SCI) causes sensory and motor disabilities without any cure. To improve myelin repair and limit degeneration, a multitherapy using nanomedicines loaded with T3, ibuprofen, and mNGF was developed. In vitro experiments confirmed the efficacy of T3-NMeds in promoting oligodendrocyte precursor cell differentiation. In vivo rat experiments showed short-term anti-inflammatory effects and long-term improvements in myelination, suggesting the potential effectiveness of this multiple treatment for SCIs.
Review
Pharmacology & Pharmacy
Mercedes Fernandez, Manuela Nigro, Alessia Travagli, Silvia Pasquini, Fabrizio Vincenzi, Katia Varani, Pier Andrea Borea, Stefania Merighi, Stefania Gessi
Summary: The blood-brain barrier (BBB) is a biological barrier that protects the central nervous system (CNS) and regulates the permeability of drugs. Activation of adenosine receptors (ARs) may modulate BBB permeability, which has potential implications for treating CNS disorders.
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)