Article
Biochemistry & Molecular Biology
Qi-Qi Li, Jia-Ying Li, Ming Zhou, Zheng-Hong Qin, Rui Sheng
Summary: Cerebral ischemia is a disease caused by intracranial artery stenosis or occlusion, leading to ischemic necrosis of brain tissue, where neuroinflammation plays a key role.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Yuanyuan Li, Xiaokun Cheng, Xinying Liu, Le Wang, Jing Ha, Zibin Gao, Xiaoliang He, Zhuo Wu, Aibing Chen, Linda L. Jewell, Yongjun Sun
Summary: This article reviews the role of NMDA receptors in cerebral ischemia, especially the role of metabotropic signaling. Studies have shown that ion flow interacts with metabotropic signaling to regulate ischemic injury. NMDA receptor antagonists may have important implications for the treatment of cerebral ischemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Sahra Amel Belambri, Viviana Marzaioli, Margarita Hurtado-Nedelec, Coralie Pintard, Shiyu Liang, Yezhou Liu, Tarek Boussetta, Marie-Anne Gougerot-Pocidalo, Richard D. Ye, Pham My-Chan Dang, Jamel El-Benna
Summary: This study discovered that p67phox and p40phox are novel regulators of p47phox phosphorylation at specific sites, which is essential for superoxide production by phagocytes and immune response.
Article
Biochemistry & Molecular Biology
Kathryn A. Schiel
Summary: The hypothesis suggests that increased extracellular glutamate in ALS and cerebral ischemia might be beneficial by stimulating glutamate utilization as metabolic fuel. The role of extracellular glutamate in ischemia is debated, with its potential for excitotoxicity in early in vitro studies in contrast to its oxidation in later in vivo studies. The activity of NMDA glutamate receptors may determine whether extracellular glutamate is detrimental or beneficial.
Article
Chemistry, Medicinal
Xing Xing Zheng, Ying Chun Li, Kai Lin Yang, Zhou Xiao He, Zhao Liang Wang, Xing Wang, Hui Ling Jing, Yan Jun Cao
Summary: Icariin demonstrated protective effects against Glu-induced excitatory neurotoxicity, enhancing cell viability and reducing apoptosis, oxidative stress, and other negative impacts. These findings suggest that Icariin could be a potential therapeutic candidate for neurological disorders associated with glutamate toxicity.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Edna Bechor, Anat Zahavi, Yevgeny Berdichevsky, Edgar Pick
Summary: This study identified a novel mechanism of inhibiting NADPH oxidase activity using self-assembled peptides, which bind specifically to p67(phox) and deplete it, leading to the inhibition of oxidase activity.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Clinical Neurology
Osama Khojah, Seraj Makkawi, Saeed Alghamdi
Summary: This study aimed to systematically review reported cases of anti-mGluR1 encephalitis and summarize their clinical presentation, management, outcomes, and case reports. The study found that anti-mGluR1 encephalitis manifests as symptoms of cerebellar pathology, and early diagnosis with prompt initiation of immunotherapy is crucial for patient recovery.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christina A. Gates, Donald S. Backos, Philip Reigan, Nicholas R. Natale
Summary: Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) were found to selectively positively modulate metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no cross-reactivity at mGluR1a, mGluR5, or mGluR8. Additional analogs were prepared to increase binding affinity, resulting in successful selective lateral metalation and electrophilic quenching at the C3 position.
Review
Cell Biology
Falko Lange, Julia Hoernschemeyer, Timo Kirschstein
Summary: The progression of glioblastomas and tumor-associated epilepsy is closely linked through various pathophysiological mechanisms involving the neurotransmitter glutamate. Current research focuses on the role of glutamate receptors in these diseases and discusses future interventions to interfere with the glutamatergic network.
Article
Cell Biology
M. Crespo, D. A. Leon-Navarro, M. Martin
Summary: Febrile seizures in children can lead to epilepsy in adults, with glutamate playing a key role in the development of neurological disorders. In the short term after seizures, GLT-1 levels increase and glutamate concentration decreases, while mGlu(5)R levels remain unchanged. However, in the long term, an increase in mGlu(5)R levels and decreases in GLT-1 and glutamate levels are observed, associated with the development of an anxious phenotype and potentially increased vulnerability to epileptic events in adults.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Deepa Gautam, Ulhas P. Naik, Meghna U. Naik, Santosh K. Yadav, Rameshwar Nath Chaurasia, Debabrata Dash
Summary: This paper explores the role of platelets in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as the critical role of glutamate receptors in the pathophysiology of these diseases. By reviewing data from clinical trials, animal models, and cellular studies, it reveals the involvement of glutamate receptor dysfunction in neurodegenerative processes and provides an overview of current treatments, including glutamate receptor antagonists, for AD and PD.
Article
Neurosciences
Xin Sui, Hideyuki Yoshioka, Yuichiro Fukumoto, Kazuya Kanemaru, Hiroyuki Kinouchi
Summary: HAX-1 is a mitochondrial protein that plays a neuroprotective role against ischemic neuronal injury, and the downregulation of HAX-1 by NOX2-produced ROS can induce apoptosis after cerebral ischemia.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Neurosciences
David Ramos-Vicente, Seth G. N. Grant, Alex Bayes
Summary: Glutamate is the major excitatory neurotransmitter in both vertebrate and invertebrate nervous systems. The evolution of glutamate receptors is more complex than anticipated, with recent research proposing a new classification system for ionotropic glutamate receptors. Additionally, the evolution of animal metabotropic glutamate receptors has resulted in the formation of four classes instead of three previously recognized.
Article
Cell Biology
Yuliya Filina, Aida Gabdoulkhakova, Albert Rizvanov, Valentina Safronova
Summary: Phagocytes' functional activity and inflammation's development and resolution are determined by formylpeptide receptors (FPRs) signaling. Research has shown that different types of formylpeptide receptors, FPR1 and FPR2, activate distinct patterns of MAP kinase activity, with JNK involved in both Fpr1 and Fpr2 mediated activation of ROS production, while p38 MAPK and ERK are only involved in Fpr1 induced ROS generation.
CELLULAR SIGNALLING
(2022)
Article
Endocrinology & Metabolism
Akos Menyhart, Rita Frank, Attila E. Farkas, Zoltan Sule, Viktoria E. Varga, Adam Nyul-Toth, Anne Meiller, Orsolya Ivankovits-Kiss, Coline L. Lemale, Irisz Szabo, Reka Toth, Daniel Zolei-Szenasi, Johannes Woitzik, Stephane Marinesco, Istvan A. Krizbai, Ferenc Bari, Jens P. Dreier, Eszter Farkas
Summary: Acute brain swelling impairs astroglial glutamate clearance and leads to extracellular glutamate accumulation and the occurrence of SiD, a pathological spreading depolarization associated with astrocyte swelling and neuronal death. Preventive osmotherapy may be necessary in acute brain injury to mitigate the effects of SiD.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Agriculture, Multidisciplinary
Kazutoshi Murotomi, Aya Umeno, Mayu Yasunaga, Mototada Shichiri, Noriko Ishida, Taisuke Koike, Toshiki Matsuo, Hiroko Abe, Yasukazu Yoshida, Yoshihiro Nakajima
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2015)
Article
Biotechnology & Applied Microbiology
Mayu Yasunaga, Kazutoshi Murotomi, Hiroko Abe, Tomomi Yamazaki, Shigeaki Nishii, Tetsuya Ohbayashi, Mitsuo Oshimura, Takako Noguchi, Kazuki Niwa, Yoshihiro Ohmiya, Yoshihiro Nakajima
JOURNAL OF BIOTECHNOLOGY
(2015)
Article
Chemistry, Applied
Aya Umeno, Mizuki Takashima, Kazutoshi Murotomi, Yoshihiro Nakajima, Taisuke Koike, Toshiki Matsuo, Yasukazu Yoshida
JOURNAL OF OLEO SCIENCE
(2015)
Review
Chemistry, Applied
Yasukazu Yoshida, Aya Umeno, Yoko Akazawa, Mototada Shichiri, Kazutoshi Murotomi, Masanori Hone
JOURNAL OF OLEO SCIENCE
(2015)
Review
Biochemistry & Molecular Biology
Aya Umeno, Masanori Horie, Kazutoshi Murotomi, Yoshihiro Nakajima, Yasukazu Yoshida
Article
Multidisciplinary Sciences
Kazutoshi Murotomi, Shigeyuki Arai, Satoko Uchida, Shin Endo, Hitoshi Mitsuzumi, Yosuke Tabei, Yasukazu Yoshida, Yoshihiro Nakajima
SCIENTIFIC REPORTS
(2016)
Article
Food Science & Technology
Yosuke Tabei, Kazutoshi Murotomi, Aya Umeno, Masanori Horie, Yoshio Tsujino, Bumbu Masutani, Yasukazu Yoshida, Yoshihiro Nakajima
FOOD AND CHEMICAL TOXICOLOGY
(2017)
Article
Chemistry, Analytical
Katsuhiro Uno, Kazutoshi Murotomi, Yasuhiro Kazuki, Mitsuo Oshimura, Yoshihiro Nakajima
Article
Biochemistry & Molecular Biology
K. Murotomi, A. Umeno, M. Yasunaga, M. Shichiri, N. Ishida, H. Abe, Y. Yoshida, Y. Nakajima
FREE RADICAL RESEARCH
(2015)
Article
Food Science & Technology
Kazutoshi Murotomi, Shigeyuki Arai, Aki Suyama, Akira Harashima, Yoshihiro Nakajima
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Biochemistry & Molecular Biology
Aya Umeno, Mami Sakashita, Sakiko Sugino, Kazutoshi Murotomi, Kentaro Tomii, Yuko Tsuchiya, Kazuhiko Yamasaki, Masanori Horie, Kentaro Takahara, Yasukazu Yoshida, Tsugumi Okuzawa, Naoki Morita
BIOSCIENCE REPORTS
(2020)
Article
Medicine, Research & Experimental
Kazutoshi Murotomi, Hirosuke Tawara, Mitsuko Sutoh, Mayu Yasunaga
Summary: Non-alcoholic steatohepatitis (NASH) is influenced by the complex interaction between the liver and other organs. This study found that iron-accumulating splenocytes can induce inflammation and exacerbate NASH. Therefore, the regulation of iron metabolism in the spleen is crucial for the development of novel therapeutic targets for NASH.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yoshiki Hayashi, Soshiro Kashio, Kazutoshi Murotomi, Shinjiro Hino, Woojin Kang, Kenji Miyado, Mitsuyoshi Nakao, Masayuki Miura, Satoru Kobayashi, Masakazu Namihira
Summary: Tissue aging is a major factor contributing to disabilities and shortened lifespan. The mechanism of tissue aging is not completely understood, but this study suggests that the biosynthesis of S-adenosyl-methionine (SAM) can accelerate aging-related defects during Drosophila oogenesis. The study also reveals an aging-related increase in SAM levels in mouse reproductive tissue and the brain.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Mayu Yasunaga, Fumiko Kobayashi, Yu Sogo, Kazutoshi Murotomi, Motohiro Hirose, Yuki Hara, Masashi Yamazaki, Atsuo Ito
Summary: This study demonstrated the enhancing effects of low-molecular-weight heparin (LMWH) incorporated into fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers on the biological activity of FGF-2 in vitro. The presence of LMWH increased the stability and amount of FGF-2 in the composite layers, leading to enhanced mitogenic and endothelial tube-forming activities, as well as osteogenic differentiation gene expression. These findings suggest that the LMWH-FGF-2-calcium phosphate composite layer holds promise as a coating for orthopedic and dental implants.
ACTA BIOMATERIALIA
(2022)
Article
Veterinary Sciences
Masanori Horie, Takamasa Miura, Satomi Hirakata, Akira Hosoyama, Sakiko Sugino, Aya Umeno, Kazutoshi Murotomi, Yasukazu Yoshida, Taisuke Koike
EXPERIMENTAL ANIMALS
(2017)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)