Article
Neurosciences
Chao-Ji Yu, Meng Wang, Rui-Yang Li, Tao Wei, Han-Chen Yang, Yun-Si Yin, Ying-Xin Mi, Qi Qin, Yi Tang
Summary: This review summarizes the main characteristics of synapses and synaptic plasticity under physiological and pathological conditions. It elaborates on the role of microglia and the signaling pathways involved in regulating synaptic plasticity. The review also highlights the unique role of TREM2 in microglia-mediated regulation of synaptic plasticity and its relationship with AD, as well as proposing four possible ways in which TREM2 is involved in regulating synaptic plasticity.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marjan Talebi, Mohsen Talebi, Eleni Kakouri, Tahereh Farkhondeh, Ali Mohammad Pourbagher-Shahri, Petros A. Tarantilis, Saeed Samarghandian
Summary: Neurodegenerative diseases are age-related disorders characterized by progressive neuronal loss, with the most prevalent being Alzheimer's disease, Parkinson's disease, and Huntington's disease. The etiology remains largely ambiguous, but p53 is considered to play a significant role, regulating various cellular pathways including apoptosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Clinical Neurology
Joshua D. Samuels, Katelyn A. Moore, Hannah E. Ennerfelt, Alexis M. Johnson, Adeline E. Walsh, Richard J. Price, John R. Lukens
Summary: Mutations in the INPP5D gene have been associated with an increased risk of late-onset Alzheimer's disease. Deletion of SHIP-1 in microglia leads to improved neuronal health and enhanced clearance of amyloid beta plaques, suggesting that targeting SHIP-1 may be a promising strategy for treating Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Review
Geriatrics & Gerontology
Shenrui Guo, Hui Wang, Yafu Yin
Summary: Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases, and microglia can be categorized into M1 and M2 types with opposite functions. Modulating microglia M1/M2 polarization shows promising therapeutic potential in neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Cell Biology
Menbere Y. Wendimu, Shelley B. Hooks
Summary: Neuroinflammation plays a fundamental role in neurodegenerative diseases, and microglia, as the immune guardians of the central nervous system, are central drivers of this inflammation. Microglia exhibit complex and often contradictory activation patterns in different pathological states, playing both detrimental and protective roles.
Article
Neurosciences
Wei-Shi Liu, Ya-Ru Zhang, Yi-Jun Ge, Hui-Fu Wang, Wei Cheng, Jin-Tai Yu
Summary: This study identified the association between TREM2, temporal lobe, and AD using genetic and transcriptomic data, and explored the complex associations among inflammation, brain structure, and neurodegenerative disorders, particularly AD.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cristina Russo, Maria Stella Valle, Antonella Russo, Lucia Malaguarnera
Summary: Numerous studies have shown that microglia play a role in promoting inflammatory processes within the central nervous system by producing chemokines. These cells share similarities with macrophages, suggesting they are involved in innate immune responses in the brain. Neuroinflammation leads to changes in neuro-metabolism and increased energy consumption. Recent research has focused on the role of Ghre signaling in microglia activity and its impact on neurodegenerative diseases. Understanding this role could provide strategies to downregulate neuroinflammation and reduce negative neurological outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Ankit Tandon, Sangh J. Singh, Rajnish K. Chaturvedi
Summary: Alzheimer's and Parkinson's are two common neurodegenerative disorders, with existing treatments limited in their ability to halt disease progression. Nanotechnology has enabled the development of novel nano-therapeutics for these diseases, allowing for efficient and targeted drug delivery to the brain. Nanoparticles are also being explored for their role in precise diagnosis, with challenges such as route of administration and toxicity needing to be addressed for successful therapeutic outcomes.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Multidisciplinary Sciences
Ping-Chieh Pao, Jinsoo Seo, Audrey Lee, Oleg Kritskiy, Debasis Patnaik, Jay Penney, Ravikiran M. Raju, Ute Geigenmuller, M. Catarina Silva, Diane E. Lucente, James F. Gusella, Bradford C. Dickerson, Anjanet Loon, Margaret X. Yu, Michael Bula, Melody Yu, Stephen J. Haggarty, Li-Hue Tsai
Summary: In this study, a 12-amino-acid-long peptide fragment derived from Cdk5 (Cdk5i) was identified. The Cdk5i showed high binding affinity toward the Cdk5/p25 complex and reduced Cdk5/p25 kinase activity, offering therapeutic potential for neurodegenerative diseases associated with Cdk5 hyperactivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Oscar M. Munoz M. Herrera, Angela M. M. Zivkovic
Summary: Cholesterol plays a crucial role in brain function and structure, and its dysregulation has been associated with neurodegenerative diseases such as Alzheimer's disease. While the regulation and dysregulation of cholesterol metabolism and transport in neurons and astrocytes are well-studied, less is known about how microglia, the immune cells of the brain, handle cholesterol and how this affects their functions. This review discusses the role of cholesterol in regulating microglia phenotype and function, the effects of statins on microglia, and highlights areas for future research to develop novel therapies for the prevention and treatment of Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Stefania Merighi, Manuela Nigro, Alessia Travagli, Stefania Gessi
Summary: Neuroinflammation may be a crucial avenue for treating and preventing Alzheimer's disease, with microglia playing a key role in the disease process but potentially becoming impaired in later stages. It is important to identify new biomarkers to assess microglial activity and develop novel therapies to restore their physiological function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Oscar Munoz M. Herrera, Brian V. V. Hong, Ulises Ruiz Mendiola, Izumi Maezawa, Lee-Way Jin, Carlito B. Lebrilla, Danielle J. Harvey, Angela M. Zivkovic
Summary: Research has shown that specific genes in microglia are highly associated with Alzheimer's disease (AD) and microglia play a critical role in the development of AD. Therefore, microglia are an important target for novel AD treatment approaches. A study used a multi-stimulant approach to examine the human microglia cell 3 (HMC3) cell line's ability to replicate dysfunctional microglia characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Dieli
Summary: The inflammatory response in Alzheimer's disease has both protective and harmful effects. Microglia initially play a protective role but can become overactivated, leading to impaired clearance of β-amyloid peptides and neurodegeneration. Microglia also contribute to the spread of tau pathology. Elevated levels of soluble TREM2 in cerebrospinal fluid are associated with amyloid plaque burden, neurodegeneration, and cognitive decline. Understanding the relationship between innate immunity and Alzheimer's disease could lead to new diagnostic and therapeutic approaches, but further studies are needed for effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Eun Sun Jung, Kyujin Suh, Jihui Han, Heyyoung Kim, Hyung-Sik Kang, Won-Seok Choi, Inhee Mook-Jung
Summary: The study reveals that amyloid-beta activates the NLRP3 inflammasome in microglia by activating Syk and inhibiting AMPK, leading to neuroinflammation. Additionally, flufenamic acid (FA), a non-steroidal anti-inflammatory drug, effectively inhibits microglial activation of the NLRP3 inflammasome by regulating Syk and AMPK, offering a potential treatment for AD.
Article
Neurosciences
Lee-Way Jin, Jacopo di Lucente, Ulises Ruiz Mendiola, Xinyu Tang, Angela M. Zivkovic, Carlito B. Lebrilla, Izumi Maezawa
Summary: FUT8-catalyzed core fucosylation plays a significant role in microglial activation induced by amyloid-beta oligomer (AβO). Inhibition of fucosylation reduces the induction of pro-inflammatory cytokines and rectifies phagocytic deficits in AβO-stimulated microglia. FUT8 is a component of the p53 signaling cascade regulating microglial behavior.
Article
Neurosciences
Wan-Chen Lin, Ming-Chi Tsai, Christopher M. Davenport, Caleb M. Smith, Julia Veit, Neil M. Wilson, Hillel Adesnik, Richard H. Kramer
Article
Biochemistry & Molecular Biology
Richard H. Kramer, Christopher M. Davenport
Article
Biochemistry & Molecular Biology
Wan-Chen Lin, Christopher M. Davenport, Alexandre Mourot, Devaiah Vytla, Caleb M. Smith, Kathryne A. Medeiros, James J. Chambers, Richard H. Kramer
ACS CHEMICAL BIOLOGY
(2014)
Article
Chemistry, Multidisciplinary
Loic Donato, Alexandre Mourot, Christopher M. Davenport, Cyril Herbivo, David Warther, Jeremie Leonard, Frederic Bolze, Jean-Francois Nicoud, Richard H. Kramer, Maurice Goeldner, Alexandre Specht
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2012)
Article
Neurosciences
Christopher M. Davenport, Peter B. Detwiler, Dennis M. Dacey
JOURNAL OF NEUROSCIENCE
(2008)
Article
Neurosciences
Joanna D. Crook, Christopher M. Davenport, Beth B. Peterson, Orin S. Packer, Peter B. Detwiler, Dennis M. Dacey
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
P. Austin Nelson, Jennifer R. Sage, Suzanne C. Wood, Christopher M. Davenport, Stephan G. Anagnostaras, Lisa M. Boulanger
Article
Multidisciplinary Sciences
Lawrence Fourgeaud, Christopher M. Davenport, Carolyn M. Tyler, Timothy T. Cheng, Michael B. Spencer, Lisa M. Boulanger
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2010)
Article
Neurosciences
Christopher M. Davenport, Rajit Rajappa, Ljudmila Katchan, Charlotte R. Taylor, Ming-Chi Tsai, Caleb M. Smith, Johannes W. de Jong, Don B. Arnold, Stephan Lammel, Richard H. Kramer
Summary: The study uncovers a hidden form of inhibitory synaptic plasticity that prevents the accumulation of excitatory long-term potentiation (LTP). Induction of excitatory LTP relocates α5-GABARs to inhibitory synapses, interrupting further LTP induction. This dual plasticity between inhibitory and excitatory synapses may be a critical early step in memory preservation.
Article
Biochemistry & Molecular Biology
Christopher M. Davenport, Brett J. W. Teubner, Seung Baek Han, Mary H. Patton, Tae-Yeon Eom, Dusan Garic, Benjamin J. Lansdell, Abbas Shirinifard, Ti-Cheng Chang, Jonathon Klein, Shondra M. Pruett-Miller, Jay A. Blundon, Stanislav S. Zakharenko
Summary: Williams-Beuren syndrome (WBS) is a rare genetic disorder characterized by neurodevelopmental and cognitive deficits. However, individuals with WBS have enhanced musical and auditory abilities. Mouse models of WBS show improved frequency discrimination and frequency coding in the auditory cortex. This is caused by hyperexcitable interneurons in the auditory cortex and the downregulation of the neuropeptide receptor VIPR1, which is replicated by the haploinsufficiency of the WBS gene Gtf2ird1. VIPR1 is reduced in individuals with WBS and in cerebral organoids derived from human induced pluripotent stem cells with the WBS microdeletion. Manipulation of Vipr1 in interneurons mimics or reverses the cellular and behavioral phenotypes of WBS mice, suggesting that the Gtf2ird1-Vipr1 mechanism in auditory cortex interneurons may underlie the superior auditory acuity in WBS.
Article
Neurosciences
Christopher M. Davenport, Peter B. Detwiler, Dennis M. Dacey
VISUAL NEUROSCIENCE
(2007)
Article
Cell Biology
AD Shcherbatko, CM Davenport, JC Speh, SR Levinson, G Mandel, P Brehm
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2001)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)