Article
Chemistry, Physical
Mehdi Yoosefian, Batool Tajaddini, Saeid Ahmadzadeh, Maryam Zeraati-Moghani, Zahra Pakdin-Parizi
Summary: Drinking excessive alcohol can cause chronic diseases and serious problems such as heart disease, high blood pressure, stroke, digestive problems, and liver disease. A molecular dynamics simulation study found that ethanol blocks calcium channels and interferes with calcium ion passage. Furthermore, calcium ions have a greater tendency to interact with residues inside the protein channel in the presence of ethanol.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Sibaji K. Sanyal, Mayanka Awasthi, Peeyush Ranjan, Sunita Sharma, Girdhar K. Pandey, Suneel Kateriya
Summary: Calcium (Ca2+) signaling is important in regulating cellular processes. The potential in Chlamydomonas triggers flagellar Ca2+ currents, leading to membrane depolarization and changes in flagellar waveform. The identity of the voltage-gated calcium channels (VGCCs) involved in this process is unknown. In this study, potential VGCCs from algae were identified and their physiological roles predicted. Experimental evidence showed that VGCC4 localized to the eyespot and flagella of Chlamydomonas and interacted with channelrhodopsins (ChRs). Our findings suggest that VGCCs, including VGCC4, may be involved in regulating Chlamydomonas' photobehavioral response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemical Research Methods
G. M. Archana, R. C. Arunkumar, R. V. Omkumar
Summary: This study reports the presence of L-type VGCC subunit proteins in HEK-293 cells and develops simple methods for its assay. The activity of L-VGCC in HEK-293 cells can be detected through endogenous expression, eliminating the need for transfection. Different experimental methods were used to detect the activity, and the antagonist nifedipine was found to block the activity. These findings offer commercially viable assays for drug screening.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yangmei Li, Chao Chang, Zhi Zhu, Lan Sun, Chunhai Fan
Summary: The dysfunction of voltage-gated calcium channels leading to a deficiency in Ca2+ fluxes is associated with calcium channelopathies such as epilepsy and periodic paralysis. By using resonant terahertz waves, researchers have demonstrated enhanced selectivity and conductance of Ca2+, potentially offering therapeutic interventions in correcting calcium channel deficiencies and inducing apoptosis in tumor cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Maria Clara Gravielle
Summary: GABA(A) receptors are pentameric ion channels crucial for inhibitory transmissions in the central nervous system, with their function regulated by various factors such as receptor subtypes and calcium channels. Dysfunctional alterations of these receptors are associated with neuropsychiatric disorders and influence their plasticity.
Review
Biochemistry & Molecular Biology
Tomasz Boczek, Ludmila Zylinska
Summary: The activity of specific populations of neurons in different brain areas plays a critical role in decision-making processes related to synaptic transmission, adaptations to external signals, and the maintenance of neural function. The endocannabinoid system (ECS) is identified as a vital control system in the central nervous system (CNS), allowing for rapid responses to synaptic processes and inducing long-term changes. Endocannabinoids are bioactive lipid mediators that act primarily through two receptors, CB1R and CB2R, which can regulate downstream Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Robert J. Lauerer, Holger Lerche
Summary: This review summarizes the importance of VGCC in the central nervous system and its association with epilepsy-related genes, providing guidance for disease-specific therapies when applicable.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Sergio Hidalgo, Jorge M. Campusano, James J. L. Hodge
Summary: Schizophrenia has up to 80% heritability and is linked to specific genes such as CACNA1C, CACNA1I, and CACNA1G. Through research on fruit flies, it was found that loss of Ca(v)2 function may lead to sleep and behavioral deficits, as well as reduced cognitive abilities.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Orthopedics
Philip Poillot, Joseph W. Snuggs, Christine L. Le Maitre, Jacques M. Huyghe
Summary: This study identifies the presence of multiple voltage-gated ion channels (VGICs) in the intervertebral disc (IVD), with evidence supporting the role of L-type voltage-gated calcium channels (VGCCs) in mechanotransduction. These findings highlight the importance of further research in this area to fully elucidate the mechanotransduction pathways in the IVD and improve treatment strategies for IVD degeneration.
Article
Chemistry, Medicinal
Eleni Kaisis, Laura J. J. Thei, Gary J. J. Stephens, Mark L. L. Dallas
Summary: Cav2.2 channels are modulated by Ab(1-42) peptides, and this modulation has different effects at different concentrations. This study reveals a potential mechanistic link between amyloid accumulation and Cav2.2 channel modulation.
Review
Cell Biology
Petronel Tuluc, Tamara Theiner, Noelia Jacobo-Piqueras, Stefanie M. Geisler
Summary: Pancreatic islets secrete hormones critical for glucose homeostasis, with insulin from beta-cells being the main hormone for lowering blood glucose levels. Glucagon and somatostatin also play important roles in regulating hormone secretion. High voltage-gated Ca2+ channels are central in the release of pancreatic hormones and play a key role in diabetes.
Article
Multidisciplinary Sciences
Taylor L. Voelker, Silvia G. del Villar, Maartje Westhoff, Alexandre D. Costa, Andrea M. Coleman, Johannes W. Hell, Mary C. Horne, Eamonn J. Dickson, Rose E. Dixon
Summary: CaV1.2 channels in the heart are affected by angiotensin II, a therapeutic target of heart failure drugs and regulator of blood pressure. Angiotensin II causes a decrease in PIP2, which leads to the suppression of CaV1.2 currents. This study found that PIP2 depletion destabilizes CaV1.2 channels and reduces their expression and function. The results suggest that PIP2 plays a crucial role in maintaining cardiac excitability and that angiotensin II-induced PIP2 depletion impairs excitation-contraction coupling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Yiliam Cruz-Garcia, Katalin Barkovits, Michael Kohlhaas, Simone Pickel, Michelle Gulentz, Cornelia Heindl, Kathy Pfeiffer, Petra Eder-Negrin, Christoph Maack, Katrin Marcus, Michaela Kuhn, Erick Miranda-Laferte
Summary: Ca2+ influx through LTCCs in cardiomyocytes plays a crucial role in regulating Ca2+-dependent processes. In this study, proximity labeling and quantitative proteomics were used to identify proteins associated with Ca-v beta(2) in cardiomyocytes. These proteins are involved in diverse cellular functions. Additionally, interaction between Ca-v beta(2) and RyR2 was found to be necessary for the Ca2+-induced Ca2+ release mechanism in cardiomyocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lihua Chen, Lena Al-Harthi, Xiu-Ti Hu
Summary: Combination antiretroviral therapy (cART) can suppress HIV-1 replication, improve immune function, but also induce neurotoxicity. Triumeq, a common cART regimen, was found to affect pyramidal neurons in the rat brain cortex in relation to Ca2+ channels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julien Giribaldi, Jean Chemin, Marie Tuifua, Jennifer R. Deuis, Rosanna Mary, Irina Vetter, David T. Wilson, Norelle L. Daly, Christina I. Schroeder, Emmanuel Bourinet, Sebastien Dutertre
Summary: A novel spider toxin, named Pmu1a, was discovered from the venom of Pterinochilus murinus. It has inhibitory activity on both hNa(V)1.7 and hCa(V)3.2 channels, which are therapeutic targets involved in pain pathways. This finding may lead to the development of compounds targeting these channels for chronic pain treatment.
Article
Automation & Control Systems
Hai Wang, Liheng Shi, Zhihong Man, Jinchuan Zheng, Shihua Li, Ming Yu, Canghua Jiang, Huifang Kong, Zhenwei Cao
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2018)
Article
Biology
Janet Ya-An Chang, Liheng Shi, Michael L. Ko, Gladys Y. -P. Ko
JOURNAL OF BIOLOGICAL RHYTHMS
(2018)
Article
Engineering, Electrical & Electronic
Dongmei Guo, Haiqing Jiang, Liheng Shi, Ming Wang
IEEE PHOTONICS JOURNAL
(2018)
Article
Optics
Liheng Shi, Dongmei Guo, Yifeng Cui, Hui Hao, Wei Xia, Yiping Wang, Xiaoqi Ni, Ming Wang
Article
Instruments & Instrumentation
Liheng Shi, Lingwen Kong, Dongmei Guo, Wei Xia, Xiaoqi Ni, Hui Hao, Ming Wang
REVIEW OF SCIENTIFIC INSTRUMENTS
(2018)
Article
Endocrinology & Metabolism
Janet Ya-An Chang, Fei Yu, Liheng Shi, Michael L. Ko, Gladys Y. -P. Ko
JOURNAL OF DIABETES RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Liheng Shi, Min Zhao, Colette A. Abbey, Shu-Huai Tsai, Wankun Xie, Dylan Pham, Samantha Chapman, Kayla J. Bayless, Travis W. Hein, Robert H. Rosa, Michael L. Ko, Lih Kuo, Gladys Y. -P. Ko
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Cardiac & Cardiovascular Systems
Suchi Raghunathan, Jose Francisco Islas, Brandon Mistretta, Dinakar Iyer, Liheng Shi, Preethi H. Gunaratne, Gladys Ko, Robert J. Schwartz, Bradley K. McConnell
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Article
Optics
Ruixue Zhang, Liheng Shi, Siyu Zhou, Jinxu Zhang, Bin Liu, Guanhao Wu
Summary: This article introduces a dynamic spectroscopic ellipsometer based on a simplified phase-stable dual-comb system, which can measure the online dynamic optical properties of materials. It achieves high precision and combined uncertainty in thin-film sample measurements, and the dynamic performance of the system under high data acquisition rate is investigated.
Article
Optics
Jinxu Zhang, Shilin Xiong, Ruixue Zhang, Siyu Zhou, Xingyu Jia, Liheng Shi, Bin Liu, Qinggai Mi, Guanhao Wu
Summary: This paper proposes a fast synchronous method based on line-field dispersive interferometry for real-time measurement of the thickness and group refractive index distribution of solid plates. By measuring the line-field distribution in an illuminated region through a single step, the method successfully measures the line-field distribution of a three-step silicon wafer within a very short time.
Article
Optics
Siyu Zhou, Ruilin Jiang, Ruixue Zhang, Liheng Shi, Di Zhang, Guanhao Wu
Summary: The dual-comb technique is a powerful tool in industrial inspection and scientific research, capable of achieving high-resolution and broadband spectral measurements. We propose an absolute angular-position measurement method based on dual-comb spectroscopy, which achieves a precision of 0.12 arcsec in a dynamic range of approximately 6660 arcsec. Compared with a commercial auto-collimator, the comparison residuals are kept within +/- 0.3 arcsec for angles over 1000 arcsec.
Article
Optics
Liheng Shi, Yue Wang, Ruixue Zhang, Jinxu Zhang, Yuetang Yang, Yang Li, Jiayang Chen, Siyu Zhou, Guanhao Wu
Summary: Coherence scanning interferometer (CSI) enables 3D imaging with nanoscale precision. However, the efficiency of such a system is limited because of the restriction imposed by the acquisition system. Here, we propose a phase compensation method that reduces the interferometric fringe period of femtosecond-laser-based CSI, resulting in larger sampling intervals. Experimental results show that our method can maintain a root-mean-square axial error of below 2 nm at a high scanning speed of 6.44 μm per frame, enabling fast nanoscale profilometry over a wide area.
Article
Optics
Jinxu Zhang, Liheng Shi, Ruixue Zhang, Jiayang Chen, Guanhao Wu
Summary: This paper proposes an orthogonal polarization common-path film thickness measurement system based on spectral interference ellipsometry. It solves the issue of back-surface reflection and achieves high measurement accuracy.
OPTICS AND LASERS IN ENGINEERING
(2023)
Proceedings Paper
Automation & Control Systems
Liheng Shi, Hai Wang, Yunzhi Huang, Xiaozheng Jin, Shuanglong Yang
2018 37TH CHINESE CONTROL CONFERENCE (CCC)
(2018)
Proceedings Paper
Automation & Control Systems
Hai Wang, Liheng Shi, Zhenghao Li
2017 11TH ASIAN CONTROL CONFERENCE (ASCC)
(2017)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)