Article
Biology
Andonia Petkova-Tuffy, Nina Goedecke, Julio Viotti, Martin Korte, Thomas Dresbach
Summary: The study reveals that NL1 and BDNF act together to play a crucial role in synaptic maturation, including increasing the stability of active zones and recycling of synaptic vesicles, a process that relies on a transsynaptic pathway between them. Using BDNF can mimic the effects of NL1 overexpression on structural and functional maturation, while blocking BDNF signaling can prevent the effects of NL1 on presynaptic maturation.
Article
Pharmacology & Pharmacy
Xiao-Li Zhang, Qi Sun, Zhu-Sheng Quan, Liang Wu, Zi-Ming Liu, Yan-Qi Xia, Qian-Yi Wang, Yue Zhang, Jin-Xia Zhu
Summary: This study found that dopamine promotes the secretion of colonic glial cell-derived neurotrophic factor (GDNF) via D1 receptors on cholinergic neurons, while high concentrations of dopamine inhibit GDNF secretion via D2 receptors on enteric glial cells (EGCs) and/or cholinergic neurons.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tadahiro Numakawa, Haruki Odaka
Summary: BDNF plays a crucial role in various neural functions through the activation of its high-affinity receptor TrkB, and abnormalities in BDNF signaling have been implicated in neurodegenerative diseases such as Alzheimer's disease. Studies have shown the potential involvement of deregulated BDNF signaling in the pathophysiology of AD, and compounds like flavonoids may offer promise as BDNF-targeting therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Wei Ma, Xiaowei Wei, Hui Gu, Dan Liu, Wenting Luo, Songying Cao, Shanshan Jia, Yiwen He, Lizhu Chen, Yuzuo Bai, Zhengwei Yuan
Summary: This study demonstrates that intra-amniotic transplanted BDNF-BMSCs can promote the recovery of defective neural tissue in SBA fetuses, through increasing BDNF expression, alleviating apoptosis of spinal cord cells, promoting neural differentiation, etc. BDNF-BMSCs have better effects than pure BMSCs in inhibiting apoptosis and promoting neural differentiation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Sun
Summary: This study investigated the potential of plasma-derived EVs in protecting against apoptosis of BMSCs, improving angiogenesis, ameliorating myocardial remodeling, and enhancing cardiac function post-MI in rats. Co-culturing with EVs attenuated hypoxia-induced apoptosis of BMSCs in vitro and blunted MI-induced apoptosis in vivo through AKT signaling. The transplantation of BMSCs along with EVs showed significant improvements in cardiac parameters and microRNAs in EVs were identified as potential mediators of these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Deepaneeta Sarmah, Pabbala Veeresh, Aishika Datta, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Pallab Bhattacharya
Summary: The study demonstrates that intrarterially administered mesenchymal stem cells post ischemic stroke provide neuroprotection and can modulate ER stress-induced apoptosis via the BDNF/TrkB signaling pathway.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Cell Biology
Tomoko Ishikura, Hideaki Shiga, Yuka Nakamura, Takako Kanitani, Yasuhito Ishigaki, Takaki Miwa
Summary: This study aimed to determine whether nasally administered murine adipose-derived stem cells (ADSCs) could support olfactory regeneration in vivo. The results showed that ADSCs can promote the repair of olfactory epithelium damage and enhance olfactory perception. This finding indicates that nasally administered ADSCs secreting neurotrophic factors can stimulate the regeneration of olfactory epithelium, thereby improving odor aversion behavior in vivo.
Article
Pharmacology & Pharmacy
Chunxia Chen, Shihai Yan, Zhirong Geng, Zhilin Wang
Summary: The HIF-1 alpha PHD inhibitor IOX2 improves the proliferation and migration of BMSCs by upregulating intracellular Ca2+ and decreasing ROS, thus promoting fracture healing.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Dongdong Fei, Yazheng Wang, Qiming Zhai, Xige Zhang, Yang Zhang, Yang Wang, Bei Li, Qintao Wang
Summary: This study revealed that downregulation of KAT6A in aging bone marrow-derived mesenchymal stem cells resulted in inhibition of the Nrf2/ARE signaling pathway and ROS accumulation, leading to decreased stemness of aging BMSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Guichuan Huang, Jing Zhang, Gang Qing, Daishun Liu, Xin Wang, Yi Chen, Yishi Li, Shuliang Guo
Summary: Increased expression of S100A2 was observed in lung tissues of PF patients, and downregulating this protein alleviated PF progression by inhibiting EMT. Targeting S100A2 may be a promising strategy for treating PF and other EMT-associated diseases.
DNA AND CELL BIOLOGY
(2021)
Review
Neurosciences
Olesja Bondarenko, Mart Saarma
Summary: Neurotrophic factors (NTFs) are essential for neuronal development and survival but face challenges in delivery to the brain due to the blood-brain barrier. Nanoparticles (NPs) show promise in stabilizing and transporting NTFs across the BBB, offering a potential solution to systemic delivery.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Mathias Mahn, Inbar Saraf-Sinik, Pritish Patil, Mauro Pulin, Eyal Bitton, Nikolaos Karalis, Felicitas Bruentgens, Shaked Palgi, Asaf Gat, Julien Dine, Jonas Wietek, Ido Davidi, Rivka Levy, Anna Litvin, Fangmin Zhou, Kathrin Sauter, Peter Soba, Dietmar Schmitz, Andreas Luthi, Benjamin R. Rost, J. Simon Wiegert, Ofer Yizhar
Summary: A mosquito homolog of vertebrate encephalopsin was found to effectively suppress synaptic transmission through a specific signaling pathway, triggering lasting synaptic output inhibition that recovers spontaneously in vitro and in vivo. This discovery opens up new avenues for functional exploration of long-range neuronal circuits in vivo.
Review
Neurosciences
Shu-Hui Dou, Yu Cui, Shu-Ming Huang, Bo Zhang
Summary: This article reviews the abnormal levels of brain-derived neurotrophic factor (BDNF) in various central nervous system (CNS) diseases and suggests that BDNF may play a role in the pathogenesis of these diseases. It also discusses the potential treatment of these diseases by regulating BDNF signaling. The clinical application status of BDNF is briefly introduced.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Yu Yang, Qianqian Liu, Song Deng, Qian Shao, Long Peng, Yuejuan Ling, Yue Huang, Siqi Zheng, Qiaoji Jiang, Dekang Nie, Jian Chen
Summary: The study demonstrates that MSCs overexpressing HO-1 can effectively reduce inflammation and promote recovery in a mouse model of ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Pavel A. Markin, Natalia E. Moskaleva, Svetlana A. Lebedeva, Sergey V. Kozin, Ekaterina M. Grigorevskikh, Larisa G. Kolik, Tatyana A. Gudasheva, Svetlana A. Appolonova
Summary: The study characterizes a novel dipeptide mimetic of the 2nd BDNF loop named GTS-201, which crosses the blood-brain barrier and affects serotonin and dopamine levels in the brain. GTS-201 exhibits psycho-tropic properties and potential therapeutic effects in anxiety and alcohol dependence.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Otorhinolaryngology
Lei Jin, Keyong Li, Xiaoyan Li
ACTA OTO-LARYNGOLOGICA
(2019)
Article
Cell Biology
Dongze Qiu, Xun Chu, Laiqing Hua, Yunke Yang, Keyong Li, Yi Han, Jun Yin, Ming Zhu, Sucheng Mu, Zhan Sun, Chaoyang Tong, Zhenju Song
CELL DEATH & DISEASE
(2019)
Article
Anesthesiology
Yao Chen, Yanyan Hu, Jin Zhang, Yue Shen, Junling Huang, Jun Yin, Ping Wang, Ying Fan, Jianli Wang, Su Lu, Yilin Yang, Lei Yan, Keyong Li, Zhenju Song, Chaoyang Tong, Shilin Du
BMC ANESTHESIOLOGY
(2019)
Article
Environmental Sciences
Anqi Li, Yuan Sun, Tongshuai Wang, Kan Wang, Tuanwei Wang, Wuzhong Liu, Keyong Li, William W. Au, Zubing Wang, Zhao-lin Xia
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Yingtang Shi, Daniel Stornetta, Robert Reklow, Alisha Sahu, Yvonne Wabara, Ashley Nguyen, Keyong Li, Yong Zhang, Edward Perez-Reyes, Rachel Ross, Bradford Lowell, Ruth Stornetta, Gregory Funk, Patrice Guyenet, Douglas Bayliss
Article
Multidisciplinary Sciences
Yingtang Shi, Daniel S. Stornetta, Robert J. Reklow, Alisha Sahu, Yvonne Wabara, Ashley Nguyen, Keyong Li, Yong Zhang, Edward Perez-Reyes, Rachel A. Ross, Bradford B. Lowell, Ruth L. Stornetta, Gregory D. Funk, Patrice G. Guyenet, Douglas A. Bayliss
Summary: It was found that RTN neurons express PACAP at a specific time point after birth to support breathing, while the lack of PACAP in RTN neurons leads to increased apnea. This study reveals key molecular components supporting breathing during a vulnerable period of life.
Article
Cell Biology
Keyong Li, Stephen B. G. Abbott, Yingtang Shi, Pierce Eggan, Elizabeth C. Gonye, Douglas A. Bayliss
Summary: The study investigates the intrinsic ionic mechanisms underlying the characteristic metronomic firing activity of RTN neurons, implicating the role of TRPM4 in supporting pacemaker-like firing. TRPM4-dependent oscillatory activity and action potential discharge are modulated by extracellular acidification and serotonin (5-HT).
Article
Surgery
Wuzhou Hong, Yuan Zhou, Yongfeng Cao, Fan Feng, Zefeng Liu, Keyong Li, Le Xie
Summary: A continuum robotic system has been developed for maxillary sinus surgery, incorporating an anatomical constraint-based optimization control strategy. The system's accuracy and capability to reach deep-seated targets in a constrained anatomical space have been evaluated through simulations and experiments, demonstrating the feasibility of the proposed method. Additionally, a preliminary porcine study was conducted to assess the instruments' capability.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2022)
Article
Engineering, Biomedical
Fan Feng, Yuan Zhou, Wuzhou Hong, KeYong Li, Le Xie
Summary: The study developed a flexible joint using selective laser melting technology and designed a shallow neural network-based kinematic modeling approach for a continuum surgical robot. Human model and animal experiments were conducted to assess the robot's force capability and dexterity through master-slave teleoperation. The results verified that the designed robot can achieve transoral laryngeal surgical field exposure without laryngoscope assistance and is capable of performing vocal fold tissue biopsy in living animals.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)
Article
Neurosciences
Keyong Li, Yingtang Shi, Elizabeth C. Gonye, Douglas A. Bayliss
Summary: The study demonstrates the involvement of TRPM4 channels in large subthreshold membrane potential oscillations underlying tonic action potential discharge in the locus coeruleus and suprachiasmatic nucleus. Blocking TRPM4 inhibits the oscillations and contributes to shaping the distinctive electroresponsive properties of these brain regions.
Article
Energy & Fuels
Zonglin Li, Hong Li, Wenhou Li, Jiaopeng Sun, Keyong Li
Summary: The Upper Paleozoic coal-bearing rock series are mainly distributed in the Benxi, Taiyuan, and Shanxi formations. Mudstones and coals are frequently formed in tidal flat deposits. The rocks are thicker on the western, eastern, and northern sides, thinner in the middle, and gradually thinner from north to south. The majority of the coal comprises excellent source rocks, while all limestones are poor source rocks and most mudstones are good-excellent source rocks. The studied source rocks are at the postmature-dry gas stage.
Article
Geochemistry & Geophysics
Haiyan Wu, Ting Liang, Chao Gao, Yanjun Wu, Hongxia Cao, Jun Yu, Fenfei Bai, Jianbo Sun, Keyong Li, Yanqin Guo
Summary: A study was conducted on the Yan'an gas field to examine the natural gas reserves, diagenetic evolution, and different diagenesis environments. The results showed the lithology of the reservoir and the filling materials, as well as the carbon and oxygen isotope values and Sr-87/Sr-86 values. The stratigraphic development indicated a cyclical trend, and the fluid inclusions revealed the sources of fluids in the sedimentation and diagenesis process.
Article
Emergency Medicine
Zhong-shu Kuang, Yi-lin Yang, Wei Wei, Jian-li Wang, Xiang-yu Long, Ke-yong Li, Chao-yang Tong, Zhan Sun, Zhen-ju Song
WORLD JOURNAL OF EMERGENCY MEDICINE
(2020)
Article
Computer Science, Information Systems
Yan Wang, Lisheng Jin, Keyong Li, Baicang Guo, Yi Zheng, Jian Shi
Proceedings Paper
Computer Science, Hardware & Architecture
Ke Li, Haowei Huang, Xiaofeng Gao, Fan Wu, Guihai Chen
PROCEEDINGS OF THE 48TH INTERNATIONAL CONFERENCE ON PARALLEL PROCESSING (ICPP 2019)
(2019)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)