Review
Oncology
Qinghua Wu, Li You, Eugenie Nepovimova, Zbynek Heger, Wenda Wu, Kamil Kuca, Vojtech Adam
Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nicholas Downes, Henri Niskanen, Vanesa Tomas Bosch, Mari Taipale, Mehvash Godiwala, Mari-Anna Vaeaenaenen, Tiia A. Turunen, Einari Aavik, Nihay Laham-Karam, Seppo Ylae-Herttuala, Minna U. Kaikkonen
Summary: Impaired oxygen homeostasis is a common factor in multiple complex diseases, and the role of noncoding RNAs in this process is not well understood. This study identifies a novel antisense long noncoding RNA that regulates the expression of HIF1A and cellular response to hypoxia by repressing transcriptional elongation and deposition of certain modifications.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Cell Biology
Mykyta Malkov, Chee Teik Lee, Cormac T. Taylor
Summary: Hypoxia and inflammation frequently co-occur in inflammatory diseases, with pro-inflammatory cytokines such as TNF-alpha and IL-1 beta directly impacting HIF signaling pathways. Multi-level crosstalk between inflammatory and hypoxic signaling pathways plays a crucial role in shaping the degree of inflammation at hypoxic sites.
Review
Pharmacology & Pharmacy
Shubham Rastogi, Sara Aldosary, Abdulaziz S. S. Saeedan, Mohd Nazam Ansari, Manjari Singh, Gaurav Kaithwas
Summary: Hypoxia in cancer cells is caused by persistent inflammation and involves the activation of NF-kappa B and HIF-1 alpha. NF-kappa B promotes tumor development and maintenance, while HIF-1 alpha aids cellular proliferation and adaptability to angiogenic signals. The key oxygen-dependent regulator of HIF-1 alpha and NF-kappa B activity is hypothesized to be Prolyl hydroxylase-2 (PHD-2). In non-hypoxic tumor cells, PHD-2 is inactive due to pyruvate-mediated competitive inhibition of 2-oxo-glutarate, leading to the canonical activation of NF-kappa B.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Wen-Sheng Tzeng, Wei-Lin Teng, Pao-Hsien Huang, Tzu-Ching Lin, Feng-Lin Yen, Yow-Ling Shiue
Summary: The study demonstrated that the prepared PTS nanoparticles (PSN) showed better antihepatoma activities in HepG2 cells, especially under hypoxic conditions, and effectively improved the water solubility and drug release of PTS.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Plant Sciences
William Agbemafle, Min May Wong, Diane C. Bassham
Summary: This review summarizes key regulatory mechanisms for modulating autophagy through post-translational modification or transcriptional regulation. Plants activate cellular responses to adapt to changing environmental conditions, one of which is autophagy, where cellular components are delivered to the vacuole for degradation. Autophagy is activated by various conditions, and the pathways controlling its activation are being elucidated. However, there is still much to discover regarding how these factors work together to properly modulate autophagy in response to specific signals.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Adam Albanese, Leonard A. Daly, Daniela Mennerich, Thomas Kietzmann, Violaine See
Summary: The hypoxia signaling pathway allows cells to adapt to decreased oxygen availability, with HIF transcription factors playing a crucial role in inducing the expression of hypoxia-regulated genes. In addition to hydroxylation, other post-translational modifications of HIF also play a crucial role in altering its localization, stability, and activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Gabriela Antonio-Andres, Gustavo U. Martinez-Ruiz, Mario Morales-Martinez, Elva Jimenez-Hernandez, Estefany Martinez-Torres, Tania V. Lopez-Perez, Laura A. Estrada-Abreo, Genaro Patino-Lopez, Sergio Juarez-Mendez, Victor M. Davila-Borja, Sara Huerta-Yepez
Summary: This study reveals that HIF-1 alpha can transcriptionally regulate YY1, and the expression of HIF-1 alpha positively correlates with YY1 in leukemia patients, suggesting that they may serve as therapeutic targets or biomarkers for ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Integrative & Complementary Medicine
Kui-Yuan Peng, Tz-Chong Chou
Summary: Osthole exhibits inhibitory effects on hypoxic colon cancer cells by activating the UPR signaling pathway and inducing apoptosis.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
You-Wu Dai, Xin-Jiang Lu, Rui Jiang, Jian-Fei Lu, Guan-Jun Yang, Jiong Chen
Summary: The study revealed that HIF-1 alpha in ayu plays a crucial role in the immune system by regulating cytokine expression, enhancing phagocytic and bactericidal activities, and improving host defenses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Seongkyeong Yoo, Sanga Choi, Iljin Kim, In-San Kim
Summary: Extracellular vesicles (EVs) play a crucial role in cancer progression and are regulated by hypoxia. Hypoxic EVs contain specific molecules capable of reprogramming recipient cells. Using EVs as drug delivery vehicles shows promise in cancer treatment, but challenges need to be overcome.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Neurosciences
Chaoqun Lin, Shiying Huang, Jianfeng Zhang, Huaitao Yuan, Tuchao Yao, Lukui Chen
Summary: The study found that dl-NBP significantly increases the viability of NSCs and improves their differentiation ability in a hypoxic environment, possibly through the HIF-1 alpha - VEGF pathway.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Thuy-Hang Nguyen, Stephanie Conotte, Alexandra Belayew, Anne-Emilie Decleves, Alexandre Legrand, Alexandra Tassin
Summary: Muscular dystrophies are genetic degenerative muscle disorders characterized by muscle wasting, often accompanied by respiratory impairments and hypoxemia. Hypoxic stress activates compensatory mechanisms, with HIF-1α playing a key role. Alterations in HIF-1α in muscle may impact the pathophysiology of muscular dystrophies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Manon Henry, Anais Burgain, Faiza Tebbji, Adnane Sellam
Summary: This research identified the transcription factors Ahr1 and Tye7 as central regulators of filamentous growth in Candida albicans under hypoxic conditions. These transcription factors directly modulate a set of genes and biological processes to negatively regulate hypoxic filamentation. Additionally, the study found that Ahr1 and Tye7 repress filamentation through different signaling pathways.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)