Review
Biochemistry & Molecular Biology
Adalberto Merighi, Laura Lossi
Summary: In addition to protein processing, the endoplasmic reticulum (ER) also plays roles in lipid synthesis, molecular transfers, and Ca2+ homeostasis. Proper protein folding and modification in the ER require molecular chaperones and a favorable environment. Disruption in ER conditions or chaperone capacity can lead to the unfolded protein response (UPR), triggering autophagy and potentially causing cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ryosuke Nomura, Nobumasa Takasugi, Hideki Hiraoka, Yuta Iijima, Takao Iwawaki, Yoshito Kumagai, Masatake Fujimura, Takashi Uehara
Summary: Exposure to methylmercury can induce oxidative and endoplasmic reticulum stress, leading to neuronal cell death. This study investigates the time course signaling alterations of the unfolded protein response (UPR) in the most affected brain areas, revealing a potential therapeutic target for treating neuropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sumit Sen Santara, Dian-Jang Lee, Angela Crespo, Jun Jacob Hu, Caitlin Walker, Xiyu Ma, Ying Zhang, Sourav Chowdhury, Karla F. Meza-Sosa, Mercedes Lewandrowski, Haiwei Zhang, Marjorie Rowe, Arthur McClelland, Hao Wu, Caroline Junqueira, Judy Lieberman
Summary: Natural killer (NK) cells can recognize externalized calreticulin (ecto-CRT) as an endogenous ligand for the activating receptor NKp46. Recognition of ecto-CRT by NKp46 triggers NK cell signaling and leads to the elimination of ER-stressed cells. This recognition mechanism plays a crucial role in immune surveillance and cancer prevention.
Review
Cell Biology
Yahao Gao, Changshui Wang, Di Jiang, Gang An, Feng Jin, Junchen Zhang, Guangkui Han, Changmeng Cui, Pei Jiang
Summary: Autophagy is a dynamic process that maintains cell homeostasis by digesting proteins and organelles. Its effect on neural tissue is debated, with some suggesting a protective role and others suggesting it can induce cell death. Oxidative stress, autophagy, and endoplasmic reticulum stress (ERS) are important defense mechanisms in cells under stress. They are integrated and amplified in pathophysiological conditions to promote disease progression. The interactions between oxidative stress, autophagy and ERS in neuronal cell death and survival are reviewed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaohan Zhang, Crystal Young, Yoshiaki Morishita, Kookjoo Kim, Omer O. Kabil, Oliver B. Clarke, Bruno Di Jeso, Peter Arvan
Summary: The thyroid gland's primary functional units are follicles filled with thyroglobulin. Thyroglobulin's appearance is synchronous with vertebrate thyroid follicular architecture and is the most highly expressed thyroid gene and protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yoshiaki Morishita, Aaron P. Kellogg, Dennis Larkin, Wei Chen, Suryakiran Vadrevu, Leslie Satin, Ming Liu, Peter Arvan
Summary: This study found that acute ER stress increases CIDE-A protein levels in thyroid cells, while chronic ER stress results in lower mRNA levels of CIDE-A. Furthermore, CIDE-A mRNA response to a new acute ER stress challenge is reduced in cells surviving chronic ER stress. CIDE-A may be a novel marker associated with a noncanonical ER stress response program.
Article
Neurosciences
T. Havranek, D. Mihalj, Z. Bacova, J. Bakos
Summary: In this study, we investigated the effect of oxytocin on the endoplasmic reticulum (ER) in hippocampal neuronal cells. We found that oxytocin can regulate the expression of ER chaperone components and molecules involved in the unfolded protein response pathway, as well as affect the distribution of intracellular fluorescence signal specific to the ER.
NEUROSCIENCE LETTERS
(2023)
Review
Immunology
Mingming Shi, Yan Chai, Jianning Zhang, Xin Chen
Summary: Neuronal death and inflammatory response are common pathological features in neurological diseases. The accumulation of misfolded/unfolded proteins in the endoplasmic reticulum (ER) leads to ER stress, which has been implicated in almost all neurological diseases. The unfolded protein response is activated to restore proteostasis, but if the damage is irreversible, it triggers intracellular cascades of death and inflammation. Targeting ER stress has emerged as a potential therapeutic approach for neurological diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yu-Jeong Ahn, Hyun-Joo Shin, Eun-Ae Jeong, Hyeong-Seok An, Jong-Youl Lee, Hye-Min Jang, Kyung-Eun Kim, Jaewoong Lee, Meong-Cheol Shin, Gu-Seob Roh
Summary: Exendin-4 (Ex-4) pretreatment showed neuroprotective effects in a mouse model of kainic acid (KA)-induced seizures, reversing the reduction of GLP-1R expression and attenuating seizure score, hippocampal neuronal death, and neuroinflammation. It also significantly reduced hippocampal lipocalin-2 protein levels and alleviated blood-brain barrier leakage, while stimulating the expression of phosphorylated cyclic adenosine monophosphate response element-binding protein (p-CREB). These findings suggest that Ex-4 pretreatment may protect against KA-induced neuronal damage by regulating GLP-1R/CREB-mediated signaling pathways.
Article
Neurosciences
Shuang Wu, Yan-Feng Zhang, Yue Gui, Tian Jiang, Cheng-Mei Zhou, Jing-Yi Li, Jia-Le Suo, Yong-Nan Li, Rui-Lin Jin, Shu-Lei Li, Jia-Yue Cui, Bai-Hong Tan, Yan-Chao Li
Summary: In this study, a new method for detecting neuronal death using two membrane-bound dyes, rhodamine R6 and DiOC6(3), was reported. The staining pattern produced by this method is similar to Fluoro-Jade B in kainic acid-damaged brains in mice. The increased staining of rhodamine R6 and DiOC6(3) is associated with increased levels of phospholipids and free cholesterol in the perinuclear cytoplasm of damaged neurons.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Oncology
Mariola Gimla, Agnieszka Pyrczak-Felczykowska, Marcelina Malinowska, Aleksandra Hac, Magdalena Narajczyk, Irena Bylinska, Tristan A. Reekie, Anna Herman-Antosiewicz
Summary: UA derivative 5 shows superior activity in inhibiting the growth and proliferation of pancreatic cancer cells. It induces ER stress and calcium ion release, leading to cell vacuolization. In a xenograft model, it effectively suppresses tumor growth without causing toxicity to the kidneys or liver.
CANCER CELL INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Duc-Vinh Pham, Prakash Shrestha, Thi-Kem Nguyen, Junhyeung Park, Mahesh Pandit, Jae-Hoon Chang, Soo Young Kim, Dong-Young Choi, Sung Soo Han, Inho Choi, Gyu Hwan Park, Jee-Heon Jeong, Pil-Hoon Park
Summary: MSC3D enhances the survival and functional capabilities of MSCs by decreasing the activation of NLRP3 inflammasomes through alleviation of ER stress in an autophagy-dependent manner. Downregulation of NLRP3 inflammasome signaling plays a critical role in the enhanced therapeutic efficacy of MSC spheroids.
Article
Engineering, Biomedical
Jueun Jeon, Been Yoon, Anup Dey, Seok Ho Song, Yuce Li, Hyeyeon Joo, Jae Hyung Park
Summary: To enhance the immunogenicity of Doxorubicin (DOX), researchers developed a ROS-responsive self-immolative polymer (R-SIP) that efficiently destroys redox homeostasis in cancer cells. The DOX-encapsulated R-SIP (DR-SIP) induces immunogenic cell death and promotes dendritic cell maturation. In vivo studies showed that DR-SIP significantly inhibits tumor growth.
Article
Biochemistry & Molecular Biology
Philippe Delmotte, Jane Q. Yap, Debanjali Dasgupta, Gary C. Sieck
Summary: Airway inflammation and pro-inflammatory cytokines play a significant role in the development of respiratory diseases. In this study, we investigated the potential of the chemical chaperone 4-PBA to mitigate TNFα-induced ER stress in hASM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Physical
Di Li, Siqi Liu, Yang Ma, Shixian Liu, Yahui Liu, Jianxun Ding
Summary: The immune system plays a vital role in the occurrence and development of cancer. Immunotherapy offers a promising approach to treat and cure cancer. During immunotherapy, the immunogenic cell death (ICD) of tumor cells activates innate and adaptive immune responses by releasing tumor-associated antigens and damage-associated molecular patterns. This review summarizes the progress in using biomaterials to induce ICD and discusses their potential application in cancer immunotherapy.
Article
Multidisciplinary Sciences
Natsuko Imakita, Masahiro Kitabatake, Noriko Ouji-Sageshima, Atsushi Hara, Shoko Morita-Takemura, Kei Kasahara, Akihiro Matsukawa, Akio Wanaka, Keiichi Mikasa, Toshihiro Ito
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Tadahiro Shimomura, Masayoshi Kawakami, Kouko Tatsumi, Tatsuhide Tanaka, Shoko Morita-Takemura, Tadaaki Kirita, Akio Wanaka
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2019)
Article
Neurosciences
Taeko Ito, Kouko Tatsumi, Yasumitsu Takimoto, Tadashi Nishimura, Takao Imai, Toshiaki Yamanaka, Noriaki Takeda, Akio Wanaka, Tadashi Kitahara
Article
Neurosciences
Shoko Takemura, Mamoru Nagano, Ayami Isonishi, Tatsuhide Tanaka, Kouko Tatsumi, Mariko Yamano, Yoichi Minami, Yasufumi Shigeyoshi, Akio Wanaka
NEUROSCIENCE LETTERS
(2020)
Article
Immunology
Shohei Takagi, Saki Murayama, Katsuhiro Torii, Shoko Takemura-Morita, Erkin Kurganov, Sumiharu Nagaoka, Akio Wanaka, Seiji Miyata
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Article
Anatomy & Morphology
Shoko Takemura, Ayami Isonishi, Tatsuhide Tanaka, Hiroaki Okuda, Kouko Tatsumi, Mariko Yamano, Akio Wanaka
BRAIN STRUCTURE & FUNCTION
(2020)
Article
Multidisciplinary Sciences
Kazuya Nishimura, Tatsuhide Tanaka, Shoko Takemura, Kouko Tatsumi, Akio Wanaka
Summary: The study highlights the role of SNX25 in regulating proinflammatory cytokine expression in macrophages through inhibition of the NF-kappa B signal.
Article
Neurosciences
Tatsuhide Tanaka, Nobuhiko Ohno, Yasuyuki Osanai, Sei Saitoh, Truc Quynh Thai, Kazuya Nishimura, Takeaki Shinjo, Shoko Takemura, Kouko Tatsumi, Akio Wanaka
Summary: Single oligodendrocytes in the central nervous system produce myelin sheaths around multiple axons, and interfascicular oligodendrocytes (IOs) in the corpus callosum of adult mice have morphologically polarized cell bodies with processes of different thicknesses for myelinating axons. The myelin sheaths originating from specific IOs have biased thicknesses and are associated with axonal diameter. Despite potential axonal regulation of myelin sheath thickness, a single axon may also independently influence myelin thickness.
Article
Neurosciences
Naoki Iwasa, Takeshi K. Matsui, Naohiko Iguchi, Kaoru Kinugawa, Naritaka Morikawa, Yoshihiko M. Sakaguchi, Tomo Shiota, Shinko Kobashigawa, Mari Nakanishi, Masaya Matsubayashi, Riko Nagata, Sotaro Kikuchi, Tatsuhide Tanaka, Nobuyuki Eura, Takao Kiriyama, Tesseki Izumi, Kozue Saito, Hiroshi Kataoka, Yuichi Saito, Wataru Kimura, Akio Wanaka, Yuhei Nishimura, Eiichiro Mori, Kazuma Sugie
Summary: This study utilized cerebral organoids derived from human induced pluripotent stem cells to evaluate the impact of ischemic stroke on human cerebral tissue. Pathway analysis revealed significant relationships between various metabolic pathways and the complement and coagulation cascades. Key markers of neuronal cells in response to OGD/R were identified as the fatty acids-related PPAR signaling pathway and pyruvate kinase isoform M2 (PKM2).
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Kouko Tatsumi, Kaoru Kinugawa, Ayami Isonishi, Masahiro Kitabatake, Hiroaki Okuda, Shoko Takemura, Tatsuhide Tanaka, Eiichiro Mori, Akio Wanaka
Summary: Olig2-astrocytes express transporter-related genes, with SLC7A10 being a representative gene. Through laser microdissection, it was confirmed that Olig2-astrocytes express significantly higher levels of SLC7A10 mRNA compared to GFAP-astrocytes, suggesting a specific role of SLC7A10 in Olig2-astrocytes in the adult brain.
Article
Biochemistry & Molecular Biology
Yoshie Kawabe, Tatsuhide Tanaka, Ayami Isonishi, Kazuki Nakahara, Kouko Tatsumi, Akio Wanaka
Summary: Cells in the white matter of the adult brain form linear arrays called linear arrays (LAs), which are parallel to the axon axis. The presence of microglia is important for the characteristic cell localization pattern of LAs. Astrocytes are involved in maintaining the functions of remyelinated white matter.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kazuki Nakahara, Hiroaki Okuda, Ayami Isonishi, Yoshie Kawabe, Tatsuhide Tanaka, Kouko Tatsumi, Akio Wanaka
Summary: In Parkinson's disease, decreased dopamine levels in the striatum lead to abnormal circuit activity in the basal ganglia, resulting in increased output via the substantia nigra pars reticulata. NMDA receptor hyperactivity is a characteristic feature of basal ganglia circuitry under conditions of dopamine depletion. The study focused on Asc-1 as a factor regulating NMDA receptor activity by modulating D-serine and glycine concentration. Different regulation of Asc-1 mRNA expression in basal ganglionic nuclei was observed in response to striatal dopamine concentration, and Asc-1 may be a therapeutic target for motor symptoms in Parkinson's disease.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Article
Immunology
Tatsuhide Tanaka, Hiroaki Okuda, Ayami Isonishi, Yuki Terada, Masahiro Kitabatake, Takeaki Shinjo, Kazuya Nishimura, Shoko Takemura, Hidemasa Furue, Toshihiro Ito, Kouko Tatsumi, Akio Wanaka
Summary: The interaction between peripheral neurons and immune cells is crucial in pain sensation, and Snx25 has been identified as a pain-modulating gene. Conditional deletion of Snx25 in monocytes and macrophages, but not in peripheral sensory neurons, reduced pain responses in mice. Dermal macrophages set the threshold for pain sensitivity through the production and secretion of NGF, and they may cooperate with dorsal root ganglion macrophages in pain perception.
Article
Biochemistry & Molecular Biology
Shoko Takemura, Ayami Isonishi, Noriko Horii-Hayashi, Tatsuhide Tanaka, Kouko Tatsumi, Takashi Komori, Kazuhiko Yamamuro, Mariko Yamano, Mayumi Nishi, Manabu Makinodan, Akio Wanaka
Summary: Accumulating evidence has shown that social stress during the juvenile period affects the activity of the hypothalamic-pituitary-adrenal (HPA) axis in adulthood. In this study, adult mice that experienced social isolation during postnatal day 21-35 (juvenile social isolation (JSI) group) were compared to normally reared mice (control group) to investigate the mechanisms underlying this phenomenon. The JSI group mice showed a weakened HPA response to acute swim stress, and there were morphological changes in the tanycytic endfeet in the median eminence, potentially related to the HPA response.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
K. Tatsumi, A. Isonishi, S. Takemura, T. Tanaka, A. Wanaka
JOURNAL OF NEUROCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)
