Article
Neurosciences
Xiaolu Hu, Lan Yu, Yatong Li, Xiaoxi Li, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Qijun Chen, Xing Wang, Xiaoqing Chen, Yinying Ba, Yaonan Wang, Xia Wu
Summary: This study investigates the inhibitory effect of piperine (PIP) on bacterial metabolism of L-dopa and evaluates the synergistic effect of PIP combined with L-dopa on Parkinson's disease (PD). It is found that the combination of PIP with L-dopa can effectively suppress the bacterial decarboxylation of L-dopa and improve its availability and efficacy in treating PD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Mangala Kumari, Premdass Ramdas, Ammu Kutty Radhakrishnan, Methil Kannan Kutty, Nagaraja Haleagrahara
Summary: Supplementation of α-T3 and γ-T3 improved motor deficits induced by 6-OHDA in Parkinson's disease rats, reducing inflammation, reversing neurodegeneration, and preventing further reduction in SN and STR fiber density.
Article
Biochemistry & Molecular Biology
Zhi Dong Zhou, Wuan Ting Saw, Patrick Ghim Hoe Ho, Zhi Wei Zhang, Li Zeng, Ya Yin Chang, Alfred Xu Yang Sun, Dong Rui Ma, Hong Yan Wang, Lei Zhou, Kah Leong Lim, Eng-King Tan
Summary: This study found that the TH-DA pathway plays a critical role in the pathogenesis of Parkinson's disease. LRRK2 and PINK1 have opposing effects on the TH-DA pathway, and the balance between them affects the survival of DA neurons. Mutations in LRRK2 or PINK1 can disrupt this balance, leading to the demise of DA neurons.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Noor Azzizah Omar, Jaya Kumar, Seong Lin Teoh
Summary: This study assessed the protocol for inducing Parkinson's disease (PD) in adult zebrafish through MPTP injection. The findings suggest that a one-time injection of MPTP with delayed assessment on days 3 to 5 is a good PD model for animal studies.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ana Gomes, Sandra M. Monteiro, Carlos Venacio, Luis Felix
Summary: This study investigated the effects of 24-Epibrassinolide (24-EPI) on 6-hydroxydopamine (6-OHDA)-induced toxicity. The results showed that 6-OHDA caused developmental abnormalities and Parkinson's disease-like symptoms in embryos, which were reversed by 24-EPI. These findings support further investigation of the neuroprotective effects of 24-EPI.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Helena Berlamont, Arnout Bruggeman, Eva Bauwens, Charysse Vandendriessche, Elien Clarebout, Junhua Xie, Sofie De Bruyckere, Griet Van Imschoot, Elien Van Wonterghem, Richard Ducatelle, Patrick Santens, Annemieke Smet, Freddy Haesebrouck, Roosmarijn E. Vandenbroucke
Summary: Research suggests that gastric H. suis infection may have a neuroprotective effect on Parkinson's disease pathology by reducing 6-OHDA-induced cell loss and improving motor function. This effect is potentially mediated through changes in oxidative stress, as indicated by higher expression levels of antioxidant genes in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Bhupesh Vaidya, Pankaj Gupta, Joydev K. Laha, Ipsita Roy, Shyam Sunder Sharma
Summary: This study found that blocking and silencing TRPC5 channels can improve behavioral deficits and molecular changes in Parkinson's disease models. It was also observed that overexpression of TRPC5 channels is associated with the occurrence of Parkinson's disease, providing a new therapeutic approach for the treatment of neurodegenerative diseases and Parkinson's disease.
Article
Biochemistry & Molecular Biology
Laura M. Vecchio, Patricia Sullivan, Amy R. Dunn, Marie Kristel Bermejo, Rong Fu, Shababa T. Masoud, Emil Gregersen, Nikhil M. Urs, Reza Nazari, Poul Henning Jensen, Amy Ramsey, David S. Goldstein, Gary W. Miller, Ali Salahpour
Summary: TH plays a crucial role in Parkinson's disease, increasing TH activity leads to oxidative stress and accumulation of toxic dopamine metabolites in vivo, augmenting toxicity.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Maria Lazarova, Lyubka Tancheva, Radoslav Chayrov, Elina Tzvetanova, Albena Alexandrova, Andrey Popatanasov, Diamara Uzunova, Miroslava Stefanova, Ivanka Stankova, Reni Kalfin
Summary: The newly synthesized amantadine derivative Tyr-Am demonstrated significant neuroprotective and antioxidant properties in a 6-OHDA experimental model of Parkinson's disease, comparable to the standard drug amantadine.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Farideh Iravanpour, Leila Dargahi, Mohsen Rezaei, Masoud Haghani, Reza Heidari, Neda Valian, Abolhassan Ahmadiani
Summary: The study investigated the effects of intranasal insulin treatment in a rat model of Parkinson's disease, showing significant improvements in motor dysfunction and dopaminergic cell death associated with the disease. The findings suggest that intranasal insulin may be a promising therapeutic approach for Parkinson's disease, potentially targeting mitochondrial dysfunction and modulating inflammation in the brain.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu
Summary: Parkinson's disease is an aging-related neurodegenerative disease characterized by movement disorders and deficiency of dopamine. Lewy bodies and abnormal accumulation of neuromelanin are the histopathological hallmarks of Parkinson's disease, leading to cell death of dopamine neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hui-Chen Su, Yuan-Ting Sun, Ming-Yu Yang, Ching-Yuan Wu, Cheng-Ming Hsu
Summary: This study investigated the effect of a compound extracted from Danshen, dihydroisotanshinone I (DT), on Parkinson's disease (PD) using an in vitro-based cell model. The results showed that DT attenuated cell death, suppressed reactive oxygen species (ROS) and caspase-3 levels, and regulated circadian genes in the PD cell model. These findings suggest that DT has potential as a novel therapeutic agent for PD, but further in vivo studies are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mohammad Shabani, Monavareh Soti, Hoda Ranjbar, Reyhaneh Naderi
Summary: Parkinson's disease is characterized by motor disabilities and cognitive impairments. Abscisic acid (ABA) has been found in various brain regions of mammals and has neuroprotective properties. A mouse model of PD was used to investigate the effects of ABA on motor and cognitive disorders. The results showed that ABA significantly improved balance and muscle strength deficits caused by 6-OHDA, but did not improve cognitive impairment or rearing in Parkinsonism mice.
Article
Cell Biology
Daniel Rees, Amy L. Beynon, Mariah J. Lelos, Gaynor A. Smith, Luke D. Roberts, Lyndsey Phelps, Stephen B. Dunnett, Alwena H. Morgan, Rowan M. Brown, Timothy Wells, Jeffrey S. Davies
Summary: The feeding-related hormone, acyl-ghrelin, has a potential protective effect on dopamine neurons in experimental models of Parkinson's disease. However, its effect on dopaminergic neurons in the 6-OHDA rat medial forebrain bundle lesion model is unknown.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Wen-Wen Wang, Ruiyu Han, Hai-Jun He, Jia Li, Si-Yan Chen, Yingying Gu, Chenglong Xie
Summary: Studies show that quercetin can improve mitochondrial quality control, reduce oxidative stress, increase levels of mitophagy markers PINK1 and Parkin, and decrease alpha-synuclein expression in 6-OHDA-treated cells. In vivo, quercetin also helps alleviate PD-like motor behaviors, decrease neuronal death, reduce mitochondrial damage, and control alpha-synuclein accumulation in PD rats. The neuroprotective effect of quercetin is compromised when either Pink1 or Parkin is knocked down.
Article
Neurosciences
Anshuman Singh, Anubha Mudawal, Pratibha Maurya, Rajeev Jain, Saumya Nair, Rajendra K. Shukla, Sanjay Yadav, Dhirendra Singh, Vinay Kumar Khanna, Rajnish Kumar Chaturvedi, Mohana K. R. Mudiam, Rao Sethumadhavan, Mohammad Imran Siddiqi, Devendra Parmar
MOLECULAR NEUROBIOLOGY
(2016)
Article
Neurosciences
Shashi Kant Tiwari, Swati Agarwal, Anurag Tripathi, Rajnish Kumar Chaturvedi
MOLECULAR NEUROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Brashket Seth, Anuradha Yadav, Swati Agarwal, Shashi Kant Tiwari, Rajnish Kumar Chaturvedi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Payal Mandal, Prachi Tewari, Sachin Kumar, Sarika Yadav, Anjaneya Ayanur, Rajnish K. Chaturvedi, Mukul Das, Anurag Tripathi
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Review
Biotechnology & Applied Microbiology
Ankit Tandon, Sangh Jyoti Singh, Rajnish Kumar Chaturvedi
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Instruments & Instrumentation
Ruby Bansal, Brashket Seth, Shashikant Tiwari, Sadaf Jahan, Manisha Kumari, Aditya Bhushan Pant, Rajnish Kumar Chaturvedi, Pradeep Kumar, Kailash Chand Gupta
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Sonu Singh, Akanksha Mishra, Soni Jignesh Mohanbhai, Virendra Tiwari, Rajnish Kumar Chaturvedi, Sukant Khurana, Shubha Shukla
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Neurosciences
Brashket Seth, Anuradha Yadav, Ankit Tandon, Jai Shankar, Rajnish Kumar Chaturvedi
Article
Engineering, Environmental
Ankit Tandon, Sangh Jyoti Singh, Manjeet Gupta, Nivedita Singh, Jai Shankar, Nidhi Arjaria, Shweta Goyal, Rajnish Kumar Chaturvedi
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Review
Clinical Neurology
Anuradha Yadav, Brashket Seth, Rajnish Kumar Chaturvedi
Summary: Brain organoids, as 3D model systems, have been developed to study human brain development and neurological disorders. Despite their limitations, researchers are hopeful that future advancements with brain organoids could provide insights into the generation of neuronal circuitry complexity and reproducible creation of different human brain regions.
Review
Pharmacology & Pharmacy
Ankit Tandon, Sangh J. Singh, Rajnish K. Chaturvedi
Summary: Alzheimer's and Parkinson's are two common neurodegenerative disorders, with existing treatments limited in their ability to halt disease progression. Nanotechnology has enabled the development of novel nano-therapeutics for these diseases, allowing for efficient and targeted drug delivery to the brain. Nanoparticles are also being explored for their role in precise diagnosis, with challenges such as route of administration and toxicity needing to be addressed for successful therapeutic outcomes.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Neurosciences
Anuradha Yadav, Ankit Tandon, Brashket Seth, Shweta Goyal, Sangh Jyoti Singh, Shashi Kant Tiwari, Swati Agarwal, Saumya Nair, Rajnish Kumar Chaturvedi
Summary: Exposure to cypermethrin reduces neural stem cell proliferation, decreases the generation of mature neurons, and increases the number of glial cells and apoptotic cells in the hippocampus, leading to neurogenic imbalance and neurodegeneration, ultimately causing cognitive dysfunction in rats.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Sangh Jyoti Singh, Ankit Tandon, Phoolmala, Tulika Srivastava, Nivedita Singh, Shweta Goyal, Smriti Priya, Rajnish Kumar Chaturvedi
Summary: This study found that bisphenol-A (BPA) negatively affects the proliferation and differentiation of neural stem cells, leading to neurological disorders during brain development. BPA impairs the ubiquitin-proteasome system (UPS) by reducing its activity in neural stem cells, resulting in disrupted neuronal differentiation. However, UPS activation with a bioactive triterpenoid 18 alpha-glycyrrhetinic acid (18 alpha GA) can alleviate BPA-induced neurotoxicity and provide neuroprotection.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Shweta Goyal, Rajnish Kumar Chaturvedi
Summary: Mitochondrial protein import machinery is crucial for maintaining neuronal function and mitochondrial morphology and function, with dysfunctions leading to neurodegenerative diseases. Studies have revealed the significant role of this machinery in diseases like AD and PD.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Swati Agarwal, Anuradha Yadav, Rajnish Kumar Chaturvedi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)