Article
Plant Sciences
Martiniano Maria Ricardi, Niklas Wallmeroth, Cecilia Cermesoni, Dietmar Gerald Mehlhorn, Sandra Richter, Lei Zhang, Josephine Mittendorf, Ingeborg Godehardt, Kenneth Wayne Berendzen, Edda von Roepenack-Lahaye, York-Dieter Stierhof, Volker Lipka, Gerd Juergens, Christopher Grefen
Summary: The final step in secretion is membrane fusion facilitated by SNARE proteins that reside in opposite membranes. The formation of a trans-SNARE complex between one R and three Q coiled-coiled SNARE domains drives the final approach of the membranes providing the mechanical energy for fusion. Biological control of this mechanism is exerted by additional domains within some SNAREs.
Article
Biochemistry & Molecular Biology
Guzalia F. Zakirjanova, Arthur R. Giniatullin, Chulpan R. Gafurova, Artem I. Malomouzh, Nikita S. Fedorov, Arthur N. Khaziev, Andrei N. Tsentsevitsky, Alexey M. Petrov
Summary: This study investigates the effects of enzymatic cholesterol oxidation on neuromuscular transmission in mice diaphragms. The results show that cholesterol oxidation disrupts lipid-ordering in synaptic membranes, decreases synaptic delay and exocytosis probability, enhances neurotransmitter and dye release, and inhibits extracellular acetylcholine accumulation. Additionally, cholesterol oxidation affects the mode of exocytosis and may be related to lipid raft disruption.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Cell Biology
Marianna Decet, Patrik Verstreken
Summary: Autophagy is a crucial catabolic pathway for maintaining cellular homeostasis by degrading defective proteins and organelles. In neurons, the orchestrated progression of autophagy takes place in distinct subcellular compartments. Autophagy is essential for proper synaptic function and neuronal survival, particularly in the face of challenges like distance from the soma and oxidative stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shiyi Wei, Fei Wu, Jing Liu, Wenliang Ji, Xiulan He, Ran Liu, Ping Yu, Lanqun Mao
Summary: This study provides the first direct evidence of neurotoxicity induced by nanoplastics, using single-vesicle electrochemistry. The researchers observed cellular uptake of polystyrene nanoplastics, leading to cell viability loss and reductions in vesicular catecholamine content, exocytotic activity, neurotransmitter release, and fusion pore opening-closing speed. Mechanistic investigations suggest that nanoplastics disrupt F-actin assemblies. This research offers important insights into how nanoplastics affect neurotransmitter secretion and neural functions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Carolina Montenegro-Venegas, Debarpan Guhathakurta, Eneko Pina-Fernandez, Maria Andres-Alonso, Florian Plattner, Eckart D. Gundelfinger, Anna Fejtova
Summary: This study reveals that the protein bassoon organizes the release of neurotransmitters by regulating synaptic phosphorylation and cAMP homeostasis. Synapses lacking bassoon exhibit decreased release competence of synaptic vesicles and increased resting pool of vesicles. Furthermore, the CDK5/PDE4/cAMP signaling pathway plays a crucial role in the regulation of neurotransmitter release.
Article
Biochemistry & Molecular Biology
Guan-Ting Liu, Gaga Kochlamazashvili, Dmytro Puchkov, Rainer Mueller, Carsten Schultz, Albert Mackintosh, Dennis Vollweiter, Volker Haucke, Tolga Soykan
Summary: This study reveals the regulatory role of neuronal endosomes in synaptic activity and identifies the importance of endosomal lipid PI(3)P in presynaptic vesicle cycling and neurotransmission.
Article
Biochemistry & Molecular Biology
Akiko Suzuki, Chihiro Iwaya, Kenichi Ogata, Hiroki Yoshioka, Junbo Shim, Isei Tanida, Masaaki Komatsu, Norihiro Tada, Junichi Iwata
Summary: Sjogren's syndrome is a chronic autoimmune disease characterized by immune cell infiltration of the exocrine glands. Deficiency in enzymes involved in the ubiquitin modification pathway leads to a Sjogren's syndrome-like phenotype, and activation of GATE16 is crucial for exocytosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Xiaohuan Xia, Yi Wang, Ying Qin, Shu Zhao, Jialin C. Zheng
Summary: This article reviews the role of exosomes in regulating neurotransmission. Exosomes can modulate synaptic activity and neural plasticity by transferring biomolecules. The article also proposes exosomes as novel neurotransmitters and discusses future directions in neurotransmission research.
AGEING RESEARCH REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Belinda Yau, Samantha Hocking, Sofianos Andrikopoulos, Melkam A. Kebede
Summary: It has been found that there are various populations of insulin secretory granules in pancreatic I3 cells, each with unique characteristics, highlighting the importance of targeting distinct ISG populations in anti-diabetic therapies.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Hematology
Harry Chanzu, Joshua Lykins, Subershan Wigna-Kumar, Smita Joshi, Irina Pokrovskaya, Brian Storrie, Gunnar Pejler, Jeremy P. Wood, Sidney W. Whiteheart
Summary: Serglycin (SRGN) is an intragranular, sulfated proteoglycan that affects granule composition and function in hematopoietic cells. Deletion of SRGN alters platelet alpha-granule composition with a reduction in basic proteins, while not affecting alpha-granule morphology or number. However, SRGN deficiency impairs thrombin-induced exocytosis of platelet factor 4 (PF4) and influences shedding of platelet membrane proteins.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Cell Biology
I. -Ying Kuo, Chih-Hsiung Hsieh, Wan-Ting Kuo, Chih-Peng Chang, Yi-Ching Wang
Summary: Cells in the tumor microenvironment require a class of checkpoints to regulate various secretion and transport processes. Recent studies have shown that Rab proteins mediate communication between diverse cargoes and substrates through vesicular trafficking and secretion pathways in the tumor microenvironment. This review focuses on the role and regulation of vesicular secretion pathways in the tumor microenvironment, and describes the latest research advances and future directions.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Monica C. Quinones-Frias, J. Troy Littleton
Summary: The SYT family of proteins play crucial roles in regulating membrane trafficking at neuronal synapses, participating in synchronous and asynchronous fusion of synaptic vesicles and preventing spontaneous release. Changes in SYT isoforms can alter the fusion of synaptic vesicles and regulate trafficking of other subcellular organelles. However, the exact mechanisms by which SYTs interact with lipids and other effectors are still under investigation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
John Jacob Peters, Jeremy Leitz, Juan A. Oses-Prieto, Alma L. Burlingame, Axel T. Brunger
Summary: Regulated delivery of AMPA receptors to the postsynaptic membrane is essential for synaptic strength modification, particularly long-term potentiation (LTP). In this study, AMPA-containing vesicles (ACVs) were isolated from mouse brains, characterized, and two distinct populations of ACVs were identified based on size and molecular composition. These findings provide insights into the molecular mechanisms of AMPAR delivery and vesicle trafficking related to LTP.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Chong Yan, Jie Jiang, Yuan Yang, Xiaoqi Geng, Wei Dong
Summary: This review highlights the roles of VAMP2 protein in the presynaptic cytoplasm, as well as its interaction with other fusion-related proteins. VAMP2 plays a crucial role in mediating synaptic vesicle fusion and neurotransmitter release during the fusion process.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Osamu Katsumata-Kato, Megumi Yokoyama, Junko Fujita-Yoshigaki
Summary: This study found that newly formed parotid gland granules have secretory ability, and the secretion of procathepsin B can be used to distinguish granule secretion from cell leakage. These newly formed granules have secretory ability prior to membrane remodeling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Robert D. Burgoyne, Lee P. Haynes
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Sravan Pandalaneni, Vijaykumar Karuppiah, Muhammad Saleem, Lee P. Haynes, Robert D. Burgoyne, Olga Mayans, Jeremy P. Derrick, Lu-Yun Lian
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Cell Biology
Dayani Rajamanoharan, Hannah V. Mccue, Robert D. Burgoyne, Lee P. Haynes
MOLECULAR BIOLOGY OF THE CELL
(2015)
Article
Neurosciences
Xi Chen, Hannah V. McCuef, Shi Quan Wong, Sudhanva S. Kashyap, Brian C. Kraemer, Jeff W. Barclay, Robert D. Burgoyne, Alan Morgan
MOLECULAR NEURODEGENERATION
(2015)
Editorial Material
Cell Biology
Alan Morgan, Robert D. Burgoyne
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2015)
Review
Cell Biology
Robert D. Burgoyne, Alan Morgan
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Hannah V. McCue, Xi Chen, Jeff W. Barclay, Alan Morgan, Robert D. Burgoyne
SCIENTIFIC REPORTS
(2015)
Article
Biochemistry & Molecular Biology
Pryank Patel, Gerald R. Prescott, Robert D. Burgoyne, Lu-Yun Lian, Alan Morgan
Article
Multidisciplinary Sciences
Paul A. C. Todd, Hannah V. Mccue, Lee P. Haynes, Jeff W. Barclay, Robert D. Burgoyne
SCIENTIFIC REPORTS
(2016)
Article
Genetics & Heredity
James R. Johnson, Mark R. Edwards, Huw Davies, Daniel Newman, Whitney Holden, Rosalind E. Jenkins, Robert D. Burgoyne, Robert J. Lucas, Jeff W. Barclay
Article
Biochemistry & Molecular Biology
Nordine Helassa, Svetlana V. Antonyuk, Lu-Yun Lian, Lee P. Haynes, Robert D. Burgoyne
HUMAN MOLECULAR GENETICS
(2017)
Article
Genetics & Heredity
James R. Johnson, Mark R. Edwards, Huw Davies, Daniel Newman, Whitney Holden, Rosalind E. Jenkins, Robert D. Burgoyne, Robert J. Lucas, Jeff W. Barclay
Article
Neurosciences
Shi Quan Wong, Matthew G. Pontifex, Marie M. Phelan, Chandra Pidathala, Brian C. Kraemer, Jeff W. Barclay, Neil G. Berry, Paul M. O'Neill, Robert D. Burgoyne, Alan Morgan
NEUROBIOLOGY OF DISEASE
(2018)
Article
Biochemical Research Methods
Shi Quan Wong, Alistair Jones, Steven Dodd, Douglas Grimes, Jeff W. Barclay, Anthony G. Marson, Vincent T. Cunliffe, Robert D. Burgoyne, Graeme J. Sills, Alan Morgan
JOURNAL OF NEUROSCIENCE METHODS
(2018)
Meeting Abstract
Biophysics
Nordine Helassa, Svetlana V. Antonyuk, Lu-Yun Lian, Lee P. Haynes, Robert D. Burgoyne
BIOPHYSICAL JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)