Article
Biochemistry & Molecular Biology
Rui-zhi Tan, Jian-chun Li, Bing-wen Zhu, Xiao-ru Huang, Hong-lian Wang, Jian Jia, Xia Zhong, Jian Liu, Li Wang, Hui-yao Lan
Summary: Neuropeptide Y (NPY) is produced by the nerve system and may contribute to the progression of CKD. The present study found a protective role for NPY in AKI and demonstrated its therapeutic potential. NPY was constitutively expressed in blood and resident kidney macrophages, and its loss was associated with AKI. Lack of NPY resulted in worsened renal necroinflammation and dysfunction, while treatment with exogenous NPY inhibited cisplatin-induced AKI. Mechanistically, NPY protected the kidney by inactivating M1 macrophages through the Y1R-NF-KB-Mincle-dependent mechanism. NPY may be a novel therapeutic agent for AKI.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elisabetta Profumo, Elisa Maggi, Marzia Arese, Claudio Di Cristofano, Bruno Salvati, Luciano Saso, Rita Businaro, Brigitta Buttari
Summary: This study reveals that neuropeptide Y (NPY) can modulate the phenotype and functions of human macrophages, promoting their transition to a reparative phenotype that has therapeutic effects on atherosclerosis. NPY reduces lipid droplet accumulation and enhances autophagosome formation in macrophages. Additionally, NPY increases the activation of the antioxidant signaling pathway in macrophages, protecting cells from further damage in the inflammatory pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Daniela Carnevale, Giuseppe Lembo
Summary: Our body continuously interacts with the external environment through the nervous system and the immune system to maintain homeostasis; the integration of these two systems provides a unique opportunity to regulate the body's internal balance.
CARDIOVASCULAR RESEARCH
(2021)
Review
Immunology
Masato Tamari, Aaron M. Ver Heul, Brian S. Kim
Summary: Traditionally seen as a mere structural barrier, the skin is now recognized as a complex immunological barrier involved in antimicrobial immunity and wound healing, housing a sophisticated sensory network to sense various stimuli. Recent studies suggest that the skin's nervous system is integrated with the immune system to encode specific sensations into protective behaviors, showcasing a dynamic and systemic organ with coordinated physical, immunological, and neural functions.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Article
Biochemistry & Molecular Biology
Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Ryoichi Mori, Isao Shimokawa
Summary: The study found that neuropeptide Y (NPY) plays an important role in regulating adipocyte-macrophage crosstalk, and deficiency of NPY can alleviate obesity and NAFLD induced by a high fat diet.
Review
Allergy
Martin Steinhoff, Fareed Ahmad, Atul Pandey, Angeliki Datsi, Ayda AlHammadi, Sara Al-Khawaga, Aysha Al-Malki, Jianghui Meng, Majid Alam, Joerg Buddenkotte
Summary: Atopic dermatitis is a common chronic inflammatory skin disease, and its pathogenesis involves the dysregulation of neuroimmune circuits. Abnormal neuroimmune circuits can lead to inflammation, pruritus, pain, and skin barrier dysfunction. Understanding neuroimmune circuits and neuronal signaling is crucial for controlling the pathological mechanisms of atopic dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Neurosciences
Nicolas Jacquelot, Gabrielle T. Belz, Cyril Seillet
Summary: The Earth's rotation creates biological clocks that regulate physiological processes and immune system. Neuroimmune interactions play a role in rhythmic activity of immune cells, and disruption of these rhythms can lead to chronic inflammation in murine models.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Andy Tran, Wenyuan He, Jim T. C. Chen, Leigh Wellhauser, Kathyrn E. Hopperton, Richard P. Bazinet, Denise D. Belsham
Summary: Consumption of a diet high in saturated fatty acids can lead to hypothalamic neuroinflammation, dysregulation of neuronal function, and induction of orexigenic neuropeptide Y (Npy). Intracellular metabolism of palmitate and metabolites like ceramide and phospholipids play a crucial role in mediating the effects of palmitate on Npy expression.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cell Biology
Dasiel O. Borroto-Escuela, Mariana Pita-Rodriguez, Ramon Fores-Pons, Miguel A. Barbancho, Kjell Fuxe, Manuel Narvaez
Summary: The study demonstrates that coactivation of GALR2 and NPYY1R in the ventral hippocampus induces sustained antidepressant effects and promotes cell proliferation. This coactivation may enhance the formation of GALR2/NPYY1R heteroreceptor complexes in the ventral hippocampus, leading to a transformation of cell proliferation towards a neuronal lineage through the activation of the ERK pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cell Biology
Yan Zhu, Shixin Duan, Mei Wang, Zhili Deng, Ji Li
Summary: The nervous system and immune system have been interacting since the embryo stage to regulate each other's development and resist harmful stimuli. However, oversensitive neural response and uncontrolled immune attack can cause various diseases, especially in barrier organs. The interaction between the nervous system and immune system exacerbates these neuroimmune-related diseases, making it challenging to find the exact causes and develop effective treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
W. Bradley Rittase, John E. Slaven, Yuichiro J. Suzuki, Jeannie M. Muir, Sang-Ho Lee, Milan Rusnak, Grace Brehm, Dmitry T. Bradfield, Aviva J. Symes, Regina M. Day
Summary: Total body irradiation (TBI) can lead to death due to inadequate production of blood cells. Radiation causes white blood cell apoptosis, while red blood cells undergo hemolysis due to hemoglobin denaturation. The release of iron into the plasma after RBC lysis results in a secondary toxic event. This study investigated the accumulation of iron in the spleens of mice following TBI and the effects of the radiation mitigator captopril. The results showed that iron accumulates in the spleen after TBI, leading to changes in iron binding and transport proteins and triggering apoptosis and possible ferroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Isabel M. Guijarro, Moises Garces, Pol Andres-Benito, Belen Marin, Alicia Otero, Tomas Barrio, Margarita Carmona, Isidro Ferrer, Juan J. Badiola, Marta Monzon
Summary: This study aims to evaluate the impact of anti-inflammatory treatment with dexamethasone on various cytokines released by neuroglial cells in natural scrapie, exploring their role in neuroinflammation. It highlights the complex interactions among neuro modulator peptides and offers a global approach to understanding neuroinflammatory processes in prion diseases. The study suggests an impairment of communication between microglial and astroglial populations mediated by cytokines, particularly IL-1, and proposes a new pathway to target for modifying the harmful effects of neuroinflammation.
Article
Clinical Neurology
Keun Woo Park, Hyunwoo Ju, Il-Doo Kim, John W. Cave, Yang Guo, Wei Wang, Zhuhao Wu, Sunghee Cho
Summary: The study found that monocyte-derived macrophages (MDMs) play a role in the progressive stroke-induced injury and repair processes. Manipulating monocyte entry at different stroke stages may be an effective immune-based strategy to limit injury propagation in chronic stroke.
Article
Cell Biology
Nouran Abualsaud, Lindsay Caprio, Susana Galli, Ewa Krawczyk, Lamia Alamri, Shiya Zhu, G. Ian Gallicano, Joanna Kitlinska
Summary: Neuropeptide Y (NPY) plays a role in regulating cellular motility and invasiveness in pediatric malignancy neuroblastoma (NB) through the Y5 receptor (Y5R) signaling pathway. Y5R is highly expressed in migratory cells in NB tissues and cell cultures, accumulating in regions of high RhoA activity and dynamic cytoskeleton remodeling. These findings suggest that Y5R could be a target for anti-metastatic therapies in NB and other cancers expressing this receptor.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Cameron H. Flayer, Caroline Perner, Caroline L. Sokol
Summary: The immune system uses structural and functional recognition to combat infectious and non-infectious threats, including generating antigen-specific immunity, tissue repair, and Type 2 immune responses. Neuropeptides and DAMPs play a role in immune cell activities, and the decision tree model explores their interactions to guide immune responses.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Neurosciences
Lisa Meszaros, Markus J. Riemenschneider, Heiko Gassner, Franz Marxreiter, Stephan von Hoersten, Alana Hoffmann, Juergen Winkler
Summary: The study demonstrates that the MBP29-h α-syn mouse model mimics important characteristics of the MSA-C subtype, providing a powerful preclinical tool for evaluating future interventional strategies.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Clinical Neurology
Maike Hartlage-Rubsamen, Alexandra Bluhm, Sandra Moceri, Lisa Machner, Janett Koppen, Mathias Schenk, Isabel Hilbrich, Max Holzer, Martin Weidenfeller, Franziska Richter, Roland Coras, Geidy E. Serrano, Thomas G. Beach, Stephan Schilling, Stephan von Horsten, Wei Xiang, Anja Schulze, Steffen Rossner
Summary: Parkinson's disease is a progressive neurodegenerative disorder characterized by degeneration of dopaminergic neurons and aggregation of alpha-synuclein. The catalysis of pyroglutamate form of alpha-synuclein by QC may contribute to enhanced aggregation in human synucleinopathies. Studies showed the presence of pGlu79-alpha-synuclein in brain samples of PD and dementia with Lewy body subjects, with a spatial co-occurrence with the enzyme QC.
ACTA NEUROPATHOLOGICA
(2021)
Article
Biochemistry & Molecular Biology
Anja Schulze-Krebs, Fabio Canneva, Judith Stemick, Anne-Christine Plank, Julia Harrer, Gillian P. Bates, Daniel Aeschlimann, Joan S. Steffan, Stephan von Hoersten
Summary: This study investigated the expression, distribution, and activity of transglutaminases in Huntington disease models, particularly focusing on the role of TG6 in disease progression. Results demonstrated a physical interaction between TG6 and (mutant) huntingtin, as well as the involvement of TG6 in mHTT aggregate formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Alexandra Bluhm, Sarah Schrempel, Stephan von Hoersten, Anja Schulze, Steffen Rossner
Summary: In Parkinson's disease, the aggregation of alpha-synuclein is a neuropathological hallmark, but the mechanisms behind this aggregation are not fully understood. Recent research suggests that oxidative stress induced by metal ions and post-translational modifications can affect the conformation of alpha-synuclein, influencing its propensity for aggregation and neurotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Christoph S. Clemen, Andreas Schmidt, Lilli Winter, Fabio Canneva, Ilka Wittig, Lore Becker, Roland Coras, Carolin Berwanger, Andreas Hofmann, Britta Eggers, Katrin Marcus, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Marcus Kruger, Stephan von Horsten, Ludwig Eichinger, Rolf Schroder
Summary: The study investigated N471D Washc5 knock-in and knock-out mice as models for SPG8. Knock-in mice exhibited mild clinical and laboratory abnormalities, but not a typical SPG8 phenotype. Knock-out mice showing normal WASHC5 levels could not be bred to homozygosity, suggesting essential role of WASHC5 in development.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Psychiatry
Yulia Golub, Valeska Stonawski, Anne C. Plank, Anna Eichler, Oliver Kratz, Regina Waltes, Stephan von Hoersten, Veit Roessner, Christine M. Freitag
Summary: This pilot study investigated alterations in plasma molecular markers (DPPIV, IL-6, TNF-beta, NPY) in children with selective mutism (SM), social anxiety disorder (SAD), and healthy controls. Lower DPPIV levels were correlated with more anxiety symptoms, but no significant difference was found in molecular markers between SAD and SM patients compared to the control group.
FRONTIERS IN PSYCHIATRY
(2021)
Editorial Material
Endocrinology & Metabolism
Rainer H. Straub
NEUROIMMUNOMODULATION
(2022)
Article
Engineering, Biomedical
Ravikumar Vaghela, Andreas Arkudas, Daniel Gage, Carolin Korner, Stephan von Hoersten, Sahar Salehi, Raymund E. Horch, Maximilian Hessenauer
Summary: The AV loop model is a key technique in tissue engineering that addresses the problem of vascular support. This study used a novel intravital microscopy approach to observe the process of vascularization in hydrogels. GelMA proved to be a better matrix compared to fibrin in terms of microvessel formation and network maturation. This study provides a new tool for understanding important events in tissue regeneration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Behavioral Sciences
Alexandra Bluhm, Sarah Schrempel, Sandra Moceri, Jens Stieler, Malte Feja, Stephan Schilling, Anja Schulze, Stephan von Hoersten, Maike Hartlage-Ruebsamen, Franziska Richter, Steffen Rossner
Summary: This study identifies a novel post-translational modification, pGlu79-αSyn, which promotes oligomer formation and neurotoxicity in synucleinopathies. MMP-3 and QC are implicated in the generation of pGlu79-αSyn in brains affected by αSyn pathology.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Ravikumar Vaghela, Andreas Arkudas, Daniel Gage, Carolin Koerner, Stephan von Hoersten, Sahar Salehi, Raymund E. Horch, Maximilian Hessenauer
Summary: Due to limitations in current in vivo experimental designs, our understanding of vascular development and its implications for large-scale tissue engineering is limited. Thus, this study aimed to develop unique in vivo imaging chambers for live visualization of cellular processes in the arteriovenous (AV) loop model in rats. Two different types of chambers were developed and filled with modified gelatin hydrogel. Intravital microscopy (IVM) using fluorescein isothiocyanate (FITC)-labeled dextran and rhodamine 6G dye allowed visualization of leukocyte trafficking and examination of microvascular development in the AV loop for up to 21 days. The combination of these IVM chambers provides a comprehensive understanding of vascular development in the AV loop tissue engineering model.
Article
Neurosciences
Daria Chestnykh, Fabian Grassl, Canice Pfeifer, Jonas Duelk, Chiara Ebner, Mona Walters, Stephan von Hoersten, Johannes Kornhuber, Liubov S. S. Kalinichenko, Markus Heinrich, Christian P. Mueller
Summary: This study aimed to evaluate the impact of the newly developed DRD4 agonist APH199 on anxiety, anhedonia, alcohol reinforcement, and amphetamine-induced symptoms. The results showed that APH199 had minimal effects on behavior in mice, but caused significant psychotic-like responses in amphetamine-sensitized rats. These findings challenge the hypothesis of the therapeutic benefits of DRD4 agonists and highlight the need for further preclinical studies to ensure the safety of antipsychotics with DRD4 stimulating properties.
PSYCHOPHARMACOLOGY
(2023)
Review
Behavioral Sciences
Ivanna K. Timotius, Reinko F. Roelofs, Bar Richmond-Hacham, Lucas P. J. J. Noldus, Stephan Von Hoersten, Lior Bikovski
Summary: This study analyzed common gait parameters derived from 91 peer-reviewed experimental studies using CatWalk XT automated gait assessment tests in mice models of six disorders. The findings suggest that certain gait parameters serve as potential indicators of gait dysfunction across multiple disease models, while others are specific to particular models. This study is important for assisting users of CatWalk XT in similar or related research.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Review
Rheumatology
Michael R. Irwin, Rainer H. Straub, Michael T. Smith
Summary: Sleep has a homeostatic role in immune system regulation and can help control inflammation and pain sensitivity. In rheumatoid arthritis (RA) patients, sleep-wake activity dysregulation due to a misaligned inflammatory profile leads to excessive inflammation and increased pain sensitivity. Understanding these risk mechanisms may offer prevention and treatment opportunities for insomnia in RA, potentially improving pain and disease outcomes.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Georg Pongratz, Rainer H. Straub
Summary: The immune system and neuroendocrine system interact in chronic inflammation, with the sympathetic nervous system playing a dual role of promoting inflammation and exerting anti-inflammatory effects. The goal of neuroendocrine immunologic research is to identify new therapeutic targets and translate theoretical knowledge into clinical benefits for patients.
NEUROIMMUNOMODULATION
(2023)
Article
Biochemistry & Molecular Biology
Judith Sommer, Hanna Ehnis, Tatjana Seitz, Julia Schneider, Andreas B. Wild, Sandra Moceri, Christa Buechler, Aline Bozec, Georg F. Weber, Susanne Merkel, Ruth Beckervordersandforth, Alexander Steinkasserer, Roland Schuele, Jonel Trebicka, Arndt Hartmann, Anja Bosserhoff, Stephan von Hoersten, Peter Dietrich, Claus Hellerbrand
Summary: This study finds that obesity leads to inflammation in visceral adipose tissue, with macrophages playing a significant role. FHL2 expression is enhanced in VAT of obese individuals, and it is involved in the interaction between macrophages and adipocytes, contributing to the development of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)