Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Karol Mierzejewski, Aleksandra Kurzynska, Zuzanna Kunicka, Anna Klepacka, Monika Golubska, Iwona Bogacka
Summary: This study investigated the effect of PPARγ agonists on the expression of inflammatory mediators in the porcine endometrium, showing that they can decrease pro-inflammatory markers and increase anti-inflammatory mediators.
Article
Medicine, Research & Experimental
Jung Seok Hwang, Eunsu Kim, Hyuk Gyoon Lee, Won Jin Lee, Jun Pil Won, Jinwoo Hur, Junichi Fujii, Han Geuk Seo
Summary: The study shows that peroxisome proliferator-activated receptor delta (PPAR delta) inhibits ferroptosis in mouse embryonic fibroblasts (MEFs) derived from cysteine/glutamate transporter (xCT)-knockout mice by regulating catalase expression. The effects associated with PPAR delta are counteracted in the presence of a specific inhibitor of catalase, indicating the importance of catalase for the effect of PPAR delta on ferroptosis triggered by xCT deficiency.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Cell Biology
Aaron M. Gusdon, Nauder Faraday, John S. Aita, Sunil Kumar, Ishan Mehta, HuiMahn A. Choi, Jeffery L. Cleland, Keith Robinson, Louise D. McCullough, Derek K. Ng, Rangaramanujam M. Kannan, Sujatha Kannan
Summary: The findings suggest that OP-101 is well tolerated and may have the potential to reduce inflammation and neuronal injury, leading to decreased morbidity and mortality in severe COVID-19 patients.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Haoyang Zou, Yiyao Gong, Haiqing Ye, Cuiping Yuan, Tiezhu Li, Jie Zhang, Li Ren
Summary: This study summarizes the physiological importance and clinical significance of PPARs and reviews the experimental evidence that natural products mediate metabolic syndrome via PPARs. The majority of currently described natural compounds are mild PPAR-selective agonists with therapeutic effects that are equivalent to synthetic medicines but less harmful adverse effects. Conclusion: PPAR agonists can be combined with natural products to treat and prevent metabolic syndrome.
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In our literature review of 27 relevant studies published between 2000 and 2023, it was found that PPAR alpha and PPAR beta/delta isoforms were upregulated in endometrial cancer cells, while PPAR gamma levels were significantly lower. Interestingly, PPAR agonists were found to be potent anti-cancer therapeutic alternatives. Overall, PPARs seem to play a significant role in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo
Summary: This review discusses the roles of peroxisome proliferator-activated receptors (PPARs) alpha, beta, and gamma in transcriptional regulation, energy metabolism, inflammation regulation, cellular development, and differentiation. PPAR signaling pathways play important roles in the development of viral, bacterial, and parasitic infectious diseases. The review also explores the potential therapeutic uses of PPAR agonists/antagonists in infectious disease treatment.
Review
Oncology
Gang Huang, Wei Jiang, Weiyong Xie, Wei Lu, Weimin Zhu, Zhenhan Deng
Summary: PPARs regulate cartilage homeostasis and reduce inflammation in OA, deficiency of PPARs may accelerate OA progression. PPAR agonists can inhibit catabolic and inflammatory factors synthesis, reducing cartilage lesions development in OA.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Chemistry, Medicinal
Enrico D'Aniello, Pietro Amodeo, Rosa Maria Vitale
Summary: This review provides an overview of discovery, optimization, and structure-activity relationship studies on PPAR modulators from marine sources, as well as the structural and computational studies that led to their identification and/or elucidation, and rationalization of their mechanisms of action.
Review
Biochemistry & Molecular Biology
Lin Peng, Huixia Yang, Yao Ye, Zhi Ma, Christina Kuhn, Martina Rahmeh, Sven Mahner, Antonis Makrigiannakis, Udo Jeschke, Viktoria von Schonfeldt
Summary: PPARs play vital roles in pregnancy, and dysfunctions of PPARs may lead to various related pregnancy diseases such as recurrent miscarriage and preeclampsia. This review discusses the impact of regulating PPARs on trophoblast physiological conditions and explores the underlying mechanisms of PPARs in controlling pregnancy-related processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Iason Psilopatis, Kleio Vrettou, Eleni Nousiopoulou, Kostas Palamaris, Stamatios Theocharis
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, causing severe menstrual irregularities, skin conditions, and insulin resistance-associated health problems. Peroxisome proliferator-activated receptors (PPARs) have been investigated for their role in PCOS, but studies have reached contradictory conclusions about PPAR expression in PCOS. However, natural agents have shown promise as alternative treatments for PCOS. Overall, PPARs appear to play a significant role in PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Claudia Sagheddu, Miriam Melis, Anna Lisa Muntoni, Marco Pistis
Summary: Shared pathophysiological mechanisms are found in different neurological and neuropsychiatric conditions. PPARs may play a neuroprotective role, suggesting that repurposing these drugs could be a potential treatment for diseases affecting the central nervous system.
Article
Biochemical Research Methods
Haiying Ran, Wei Sun, Liting Wang, Xiaoyang Wang, Haili Yu, Jiajia Chen, Fang Liu, Zhiyin Chao, Qi Pu, Yang Liu, Youlong Zeng, Zhangfu Li, Ying Wan, Jiangbei Yuan
Summary: Lipid droplets (LDs) are organelles composed of non-polar lipids surrounded by a phospholipid monolayer. Their excessive accumulation is linked to the development of diseases. In this study, it was found that lipopolysaccharide (LPS) stimulation reduces LDs content in the mouse liver. The inhibition of the peroxisome proliferator-activated receptors (PPAR) signaling pathway by LPS may be responsible for this reduction.
Article
Microbiology
Xin Zhu, Anshan Shan, Zhi Ma, Wei Xu, Jiajun Wang, Shuli Chou, Baojing Cheng
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Pathology
Ajaib S. Paintlia, Manjeet K. Paintlia, Bruce W. Hollis, Avtar K. Singh, Inderjit Singh
AMERICAN JOURNAL OF PATHOLOGY
(2012)
Article
Behavioral Sciences
Angela Allen, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2013)
Article
Behavioral Sciences
Taylor Hatchard, Jaimee J. Ting, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2014)
Article
Cell Biology
Darren J. Yip, Chelsea P. Corcoran, Matias Alvarez-Saavedra, Adriana DeMaria, Stephen Rennick, Alan J. Mears, Michael A. Rudnicki, Claude Messier, David J. Picketts
DEVELOPMENTAL CELL
(2012)
Article
Neurosciences
Andra M. Smith, Claude Messier
FRONTIERS IN HUMAN NEUROSCIENCE
(2014)
Article
Geriatrics & Gerontology
Delyana Miller, Michle Gagnon, Vincent Talbot, Claude Messier
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2013)
Review
Geriatrics & Gerontology
Delyana I. Miller, Vanessa Taler, Patrick S. R. Davidson, Claude Messier
NEUROBIOLOGY OF AGING
(2012)
Article
Neurosciences
Reno M. Gandhi, Cary S. Kogan, Claude Messier, Lindsey S. MacLeod
Review
Neurosciences
J. J. Boulanger, C. Messier
Article
Health Care Sciences & Services
Delyana Ivanova Miller, France Aube, Vincent Talbot, Michele Gagnon, Claude Messier
TELEMEDICINE AND E-HEALTH
(2014)
Article
Neurosciences
Reno M. Gandhi, Cary S. Kogan, Claude Messier
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Neurosciences
Alexandria Beland-Millar, Masaki Takimoto, Taku Hamada, Claude Messier
Article
Behavioral Sciences
Jenna J. Boulanger, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Psychology, Educational
Delyana I. Miller, Patrick S. R. Davidson, Dwayne Schindler, Claude Messier
JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
(2013)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)