Article
Oncology
Pei Yi Lee, Kellynn Qi Xuan Oen, Grace Rui Si Lim, Juanda Leo Hartono, Mark Muthiah, Daniel Q. Huang, Felicia Su Wei Teo, Andrew Yunkai Li, Anselm Mak, Nisha Suyien Chandran, Chris Lixian Tan, Peiling Yang, E. Shyong Tai, Kay Wei Ping Ng, Joy Vijayan, Yee Cheun Chan, Li Ling Tan, Martin Beng-Huat Lee, Horng Ruey Chua, Wei Zhen Hong, Eng Soo Yap, Dawn K. Lim, Yew Sen Yuen, Yiong Huak Chan, Folefac Aminkeng, Alvin Seng Cheong Wong, Yiqing Huang, Sen Hee Tay
Summary: In this case-control study, lower NLR (<3) was associated with increased occurrence of irAEs, while higher NLR values were correlated with worse clinical outcomes in cancer patients treated with immune checkpoint inhibitors.
Article
Neurosciences
Xin Guo, Hengxing Jiao, Tiantian Zhang, Yuelin Zhang
Summary: A meta-analysis found a significant association between a high pre-treatment and pre-operative neutrophil-to-lymphocyte ratio (NLR) and low survival in patients with glioblastoma. Sub-group analysis showed lower heterogeneity when a cut-off value of 4 was used. The study also suggested that factors such as age and extent of surgical resection contribute to the observed heterogeneity.
Review
Oncology
Tibera K. Rugambwa, Omar Abdihamid, Xiangyang Zhang, Yinghui Peng, Changjing Cai, Hong Shen, Shan Zeng, Wei Qiu
Summary: This study aimed to investigate the correlation between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) and the treatment outcomes of immune checkpoint inhibitors (ICIs). The results showed that patients with lower NLR and PLR were more likely to achieve clinical benefit and better treatment response, while higher NLR and PLR were associated with poorer treatment outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Hulya Albayrak
Summary: This study found that the neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) can be important indicators for evaluating the treatment of psoriasis patients. The SII showed strong positive correlations with the NLR, NMR, and PLR. TNF-α blockers such as Adalimumab, etanercept, and infliximab were found to be especially effective on PLR, NLR, and NMR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ahmet Bilgehan Sahin, Erdem Cubukcu, Birol Ocak, Adem Deligonul, Sibel Oyucu Orhan, Sahsine Tolunay, Mustafa Sehsuvar Gokgoz, Sibel Cetintas, Gorkem Yarbas, Kazim Senol, Mehmet Refik Goktug, Zeki Burak Yanasma, Ulviyya Hasanzade, Turkkan Evrensel
Summary: The study indicates that PIV is a better predictor for predicting the efficacy of neoadjuvant chemotherapy and survival in breast cancer patients, outperforming NLR, MLR, and PLR.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Fang Tang, Xiaoshuai Zhang, Bicheng Zhang, Bo Zhu, Jun Wang
Summary: This study developed two nomogram models for distinguishing disease severity and predicting prognosis in COVID-19 patients. The results indicate that immune response phenotyping based on blood indicators can effectively identify high-risk clinical cases.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
James Broadley, Robb Wesselingh, Udaya Seneviratne, Chris Kyndt, Paul Beech, Katherine Buzzard, Cassie Nesbitt, Wendyl D'Souza, Amy Brodtmann, Tomas Kalincik, Helmut Butzkueven, Terence J. O'Brien, Mastura Monif
Summary: This study suggests that NLR on initial hospital admission blood tests may provide important prognostic information for cases of seropositive AE. High NLR was associated with higher odds of first line treatment failure, while increased MLR was not associated with any short or long-term outcome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pawel Jarmuzek, Piotr Defort, Marcin Kot, Edyta Wawrzyniak-Gramacka, Barbara Morawin, Agnieszka Zembron-Lacny
Summary: Cytokines play a critical role in tumor cell development and multiplication, but their involvement in glioblastoma (GBM) is still not well understood. This study evaluated the inflammatory profile and identified potential molecular signatures specific to GBM. The results showed elevated neutrophils and neutrophil-to-lymphocyte ratio (NLR) in GBM patients, with an inverse correlation between neutrophil count and survival time. Pro-inflammatory cytokines IL-1 beta, IL-6, and IL-8 were significantly higher in GBM, while TNF alpha and HMGB1 were lower. IL-6 and IL-8 had the highest diagnostic potential for clinical prognosis, with a three-fold higher probability of GBM development above certain threshold values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jang Hyun Park, Heung Kyu Lee
Summary: Glioblastoma multiforme (GBM) is an aggressive tumor in the central nervous system, and its survival is affected by hypoxia, which promotes drug resistance and inhibits immune responses. Traditionally, hypoxia studies have focused on blood vessels and tumor cells, excluding the immune system. However, recent evidence suggests the important role of immunosurveillance in tumor hypoxia. This review discusses the clinical, pathological, and immunological perspectives of hypoxia in GBM.
Article
Oncology
Jin Shang, Xiao Han, Haoran Zha, Haitao Tao, Xiaoyan Li, Fang Yuan, Guangying Chen, Lijie Wang, Junxun Ma, Yi Hu
Summary: Immune checkpoint blockade (ICB) therapy shows promising anti-tumor effects in pancreatic cancer, and changes in baseline SII and neutrophil-lymphocyte ratio (NLR) are important prognostic factors for patients, but their clinical utility requires further investigation in prospective studies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Zhaoqing Tang, Yuan Gu, Zhongyi Shi, Lingqiang Min, Ziwei Zhang, Peng Zhou, Rongkui Luo, Yan Wang, Yuehong Cui, Yihong Sun, Xuefei Wang
Summary: Responses to preoperative chemotherapy in gastric adenocarcinoma patients vary greatly. While previous studies have focused on the tumor microenvironment, little is known about the relationship between systemic immunity and chemotherapy response. In this study, we analyzed serum samples from patients with gastric adenocarcinoma using an antibody-based proteomics panel and assessed their tumor microenvironment using multiple methods. We found that both local and systemic immune features are associated with treatment response. A pretreatment serum protein scoring system was established for response prediction, highlighting the underestimated role of systemic immunity in gastric cancer treatment.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
David A. Barrington, Corinne Calo, Jae Baek, Morgan Brown, Vincent Wagner, Lynette Gonzalez, Allison Huffman, Jason Benedict, Kristin Bixel
Summary: This study investigates the effectiveness of immunotherapy in patients with recurrent endometrial cancer and finds that pre-treatment NLR is associated with overall survival. NLR holds promise as a predictive biomarker for survival after immunotherapy treatment for patients with recurrent endometrial cancer.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Chester Kao, Eric Powers, Yuan Wu, Michael B. Datto, Michelle F. Green, John H. Strickler, Neal E. Ready, Tian Zhang, Jeffrey M. Clarke
Summary: In this study of 88 NSCLC patients, tumor mutational burden (TMB), PD-L1, and NLR were found to be modest biomarkers for response to immune checkpoint inhibitors. TMB was the strongest predictor, but combining all three biomarkers improved the prediction of treatment response.
CLINICAL LUNG CANCER
(2021)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Boyuan Huang, Xuesong Li, Yuntao Li, Jin Zhang, Zhitao Zong, Hongbo Zhang
Summary: Glioblastoma multiforme (GBM) is the most common and aggressive malignant tumor in the central nervous system. Immunotherapy has shown promising results in the treatment of GBM, but future developments will require an integrated approach with various treatment modalities and specific targeted therapies for the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Medicine, General & Internal
Yassmeen Abu Alsaud, David O'Reilly, Fergus Shanahan, Richard Bambury, Seamus O'Reilly
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Jana K. McHugh, Gozie Offiah, Sean Daly, Nazmy El Beltagi, Michael Kevin Barry, Seamus O'Reilly, Terri P. McVeigh
Summary: This study highlights an unmet need for dedicated Cancer Genetics training for postgraduate specialty trainees in ROI.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Letter
Medicine, General & Internal
Niall T. Hennessy, Sinead Toomey, Virginie Gautier, Sophie O'Reilly, Eoghan de Barra, Emer O. Hanrahan, Bryan T. Hennessy
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
David O. Reilly, Ronan McLaughlin, Cian Ronayne, Anne Marie De Frein, Bojan Macanovic, Ryan W. Chu, Sinead A. Noonan, Roisin M. Connolly, Derek G. Power, Richard M. Bambury, Seamus O. Reilly, Dearbhaile Catherine Collins
Summary: This study investigates the cost and reimbursement of systemic anticancer therapies in the UK and ROI, and finds that many approved treatments are not currently reimbursed and the cost is not associated with survival benefit.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Hailey K. Carroll, Stephen Moore, Abdul R. Farooq, Shahid Iqbal, Danial K. Hadi, Seamus O'Reilly
Summary: This study examined the professional, psychosocial, and financial impact of the COVID-19 pandemic on non-EEA doctors working in Ireland. The results revealed that many doctors had a desire to stay in Ireland long-term, but their career progression was affected. Additionally, they faced mental health issues and financial pressure.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Editorial Material
Oncology
Clara Forrest, Deirdre Madden, Martin J. O'Sullivan, Seamus O'Reilly
JCO ONCOLOGY PRACTICE
(2023)
Article
Agricultural Economics & Policy
Claire O'Neill, Mary Brigid McCarthy, Seamus O'Reilly, Frode Alfnes
Summary: This study aims to identify consumer segments based on food consumption practices, and it identifies four new consumer segments based on interests, preferences, and behaviors. The findings provide insight into the sustainability-related food behaviors of consumers and shed light on how sustainability is integrated into their food lifestyles.
BRITISH FOOD JOURNAL
(2023)
Article
Oncology
Nataliya Mar, Yousef Zakharia, Alejandro Falcon, Rafael Morales-Barrera, Begona Mellado, Ignacio Duran, Do-Youn Oh, Stephen K. Williamson, Pablo Gajate, Hendrik-Tobias Arkenau, Robert J. Jones, Min Yuen Teo, Tolga Turan, Robert T. McLaughlin, Hillary M. Peltier, Elizabeth Chong, Harisha Atluri, James P. Dean, Daniel Castellano
Summary: This study evaluated the safety and efficacy of ibrutinib in the treatment of advanced urothelial carcinoma (UC). The results showed that ibrutinib alone had a higher response rate compared to pembrolizumab, while its combination with paclitaxel extended progression-free survival. These data suggest that ibrutinib has potential advantages in the combination therapy for UC.
Article
Respiratory System
Christopher Cronin, Shahid Iqbal, Abdul R. Farooq, Pauline O'Dea, Louise Burke, Seamus O'Reilly, Deirdre O'Mahony, Derek G. Power, Richard M. Bambury, Dearbhaile C. Collins
Summary: This study evaluated the toxicity and disease-specific outcomes of adjuvant chemotherapy in NSCLC patients. The results showed that 29% of patients required hospitalization due to treatment-associated side effects, 56% experienced relapse, and the median recurrence-free survival was 27 months. These findings demonstrate the high rates of recurrence and treatment-related morbidity in NSCLC patients receiving adjuvant chemotherapy.
LUNG CANCER MANAGEMENT
(2023)
Article
Health Policy & Services
Catherine S. Weadick, Rachel J. Keogh, Hailey K. Carroll, Sandra Boldrin, Eibhlin Mulroe, Lucy Murphy, Bryan Sheils, Aisling Barry, Seamus 'Reilly
Summary: In recent years, the terms time and financial toxicities have become common in cancer care. This article introduces another toxicity: climate toxicity. Climate toxicity has a dual impact in cancer care, increasing cancer risk through exposure to carcinogens and contributing to environmental damage due to increased treatment requirements. The article assesses the impact of climate change on patients, climate toxicity caused by healthcare workers and facilities, and suggests mitigation actions.
JOURNAL OF CANCER POLICY
(2023)
Article
Health Policy & Services
Seamus O'Reilly, Hailey Kathryn Carroll, Deirdre Murray, Louise Burke, Triona McCarthy, Robert O'Connor, Claire Kilty, Sonya Lynch, Jennifer Feighan, Maeve Cloherty, Patricia Fitzpatrick, Katrina Falvey, Verena Murphy, Mary Jane O'Leary, Sophie Gregg, Leonie Young, Eilish McAuliffe, Josephine Hegarty, Anna Gavin, Mark Lawler, Paul Kavanagh, Susan Spillane, Terry McWade, Mairead Heffron, Karen Ryan, Paul J. Kelly, Aileen Murphy, Mark Corrigan, H. Paul Redmond, Patrick Redmond, Paul M. Walsh, Paula Tierney, Mengyang Zhang, Kathleen Bennett, Maeve Mullooly
Summary: During the COVID-19 pandemic in Ireland, disruptions to cancer services occurred due to various factors, including prioritization of COVID-19 care, staff redeployment, suspension of screenings and procedures, staff shortages, and concerns among individuals about contracting the virus. A cyber-attack on national health service IT systems further worsened the situation. To address these issues, the Irish Cancer Society formed a working group to assess the impact of the pandemic on cancer patients and services, gather perspectives, and discuss strategies for mitigation. Recommendations included research on long-term pandemic effects, recruitment and retention of cancer workforce, mental health support, improved public health messaging, establishment of a national cancer database, and strengthening of infrastructure for future challenges.
JOURNAL OF CANCER POLICY
(2023)
Article
Gastroenterology & Hepatology
John Reynolds, Shaun R. Preston, Brian O'Neill, Maeve A. Lowery, Lene Baeksgaard, Thomas Crosby, Moya Cunningham, Sinead Cuffe, Gareth Griffiths, Imelda Parker, Signe Lenora Risumlund, Rajarshi Roy, Stephen Falk, George B. Hanna, Frederick R. Bartlett, Alberto Alvarez-Iglesias, Michael P. Achiam, Magnus Nilsson, Guillaume Piessen, Narayanasamy Ravi, Dermot O'Toole, Ciaran Johnston, Raymond S. Mcdermott, Richard C. Turkington, Shajahan Wahed, Sharmila Sothi, Hugo Ford, Martin S. Wadley, Derek Power
Summary: The study compares trimodality therapy and perioperative chemotherapy for adenocarcinoma of the oesophagus and oesophagogastric junction, showing similar 3-year survival rates and outcomes in terms of surgery and quality of life.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Health Care Sciences & Services
Clara Forrest, Keelin O'Donoghue, Dearbhaile C. Collins, Seamus O'Reilly
Summary: By the end of 2022, Ireland will face a record number of outstanding clinical claims, with estimated costs of €3.85 billion. This will add further strain to an already burdened healthcare system. In addition to the financial consequences, clinical claims have negative impacts on all parties involved. Analyzing high-quality patient safety data and learning from previous litigation are essential to understand the reasons behind the increasing claims and costs. Implementing evidence-based recommendations through engagement with stakeholders is necessary to address the contributing factors and measure their impact.
Meeting Abstract
Medicine, General & Internal
Ashwini Shanmugam, Anne M. Molloy, Lawrence Brody, Michael Merrigan, Seamus O'Reilly, Gianpiero L. Cavalleri, Russell McLaughlin, Ross Byrne, Edmund Gilbert
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Oncology
D. J. McMahon, J. P. Gleeson, S. O'Reilly, R. M. Bambury
Summary: Glioblastoma multiforme, the majority of primary gliomas, has a low five-year survival rate. The standard treatment includes maximal safe surgical resection, followed by radiotherapy with concurrent and adjuvant temozolomide. Patients with MGMT-methylated tumors have additional benefits. Ongoing research and improvements in multidisciplinary management provide hope for better outcomes.