Article
Oncology
Qiang Ma, Limin Liu, Naiying Sun, Lixiang Gao, Ying Chen, Li Liu, Wenjun Guo, Xingjie Yang
Summary: The present study describes a rare case of glioblastoma with a primitive neuronal component (GBM-PNC), and provides a comprehensive analysis of its clinical, pathological, and differential diagnostic findings. A literature review was conducted to enhance the understanding of GBM-PNC and its distinct characteristics and prognosis. The case report highlights the importance of accurate diagnosis and comprehensive characterization of GBM-PNC for guiding treatment decisions and improving patient outcomes.
Article
Oncology
Natalie Kuesters, Katharina Grupp, Julia-Kristin Grass, Kai Bachmann, Tarik Ghadban, Faik G. Uzunoglu, Michael Tachezy, Daniel Perez, Matthias Reeh, Jakob R. Izbicki, Nathaniel Melling
Summary: The role of CD147 as a prognostic factor in esophageal cancer remains controversial. This study found that CD147 expression was not associated with prognosis in both esophageal adenocarcinoma and squamous cell carcinoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Surgery
Xi Chen, Shi-Liu Hu, Ying Feng, Peng Li, Qin-Sheng Mao, Wan-Jiang Xue
Summary: The study revealed that the expression of FABP3 in gastrointestinal stromal tumors is significantly correlated with tumor size, mitotic index, gross classification, and AFIP-Miettinen risk classification. High expression of FABP3 is significantly associated with poor 5-year overall survival, indicating its prognostic value for patients with GISTs.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Qinglin Zhang, Jiadong Pan, Fangmei An, He Nie, Qiang Zhan
Summary: This study found that decreased expression of SLC39A1 is associated with clinical features and survival rates in early-stage hepatocellular carcinoma (EHCC), with patients showing lower expression having poorer prognosis. The expression level of SLC39A1 may serve as a potential diagnostic and prognostic biomarker for EHCC patients.
Article
Cell Biology
Xingang Zhou, Tingyu Liang, Jinhai Deng, Kenrick Ng, Man Li, Chunxin Lv, Jiamin Chen, Kun Yang, Zhiyuan Ma, Wenping Ma, Peng Wang
Summary: HOXB7 is abnormally overexpressed in diffuse gliomas, especially in glioblastoma and IDH1 wild-type gliomas, indicating poor prognosis. It also serves as a sensitive and specific marker for differentiating oligodendroglioma from astrocytoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexander Yuile, Adrian Lee, Elizabeth A. A. Moon, Amanda Hudson, Marina Kastelan, Samuel Miller, David Chan, Joe Wei, Michael F. F. Back, Helen R. R. Wheeler
Summary: This study found a potential association between PSMA and VEGF expression in glioblastoma. Additionally, it suggests a potential correlation between PSMA expression and overall survival in patients.
Article
Medicine, General & Internal
Michele Paudice, Chiara Maria Biatta, Giulia Scaglione, Alessia Parodi, Serafina Mammoliti, Melita Moioli, Maria Grazia Centurioni, Fabio Barra, Simone Ferrero, Franco De Cian, Katia Mazzocco, Valerio Gaetano Vellone
Summary: Endometrial cancer is a growing disease with an increase in aggressive histotypes. This study investigated potential prognostic markers and found that Bcl-2 and PR may have prognostic significance in high-grade non-endometrioid carcinoma patients.
Article
Biochemistry & Molecular Biology
Cheng-Gong Liao, Xiao-Hua Liang, Yuan Ke, Li Yao, Man Liu, Ze-Kun Liu, Lin He, Yi-Xiao Guo, Huijie Bian, Zhi-Nan Chen, Ling-Min Kong
Summary: This study reveals that active demethylation of CD147 is involved in the metastasis of non-small cell lung cancer (NSCLC), and targeted methylation of CD147 can inhibit the invasion and metastasis of NSCLC, providing a promising therapeutic target for NSCLC.
Article
Oncology
Georgia Levidou, Pawel Gajdzis, Nathalie Cassoux, Piotr Donizy, Christos Masaoutis, Malgorzata Gajdzis, Sophie Gardrat, Alexandros Pergaris, Eougken Danas, Jerzy Klijanienko, Stamatios Theocharis
Summary: HDACs, especially HDAC-2, may play a significant role in the development and progression of uveal melanoma, with potential implications for patient prognosis. This study evaluated the expression of HDAC-1, -2, -4, and -6 in UM cases and found associations with tumor characteristics and patient survival.
Review
Oncology
Robert Ondrussek, Barbora Kvokackova, Karolina Krystofova, Svetlana Brychtova, Karel Soucek, Jan Bouchal
Summary: CD9 is a crucial regulator of cell adhesion in the immune system, playing important physiological roles in hematopoiesis, blood coagulation, and infections. It is involved in leukocytes' transendothelial migration, which may be hijacked by cancer cells during invasion and metastasis. CD9 affects cancer progression and therapy resistance through its presence on cell surface and exosome membranes. The expression of CD9 is generally associated with good patient outcomes, but there are exceptions in breast, ovarian, melanoma, pancreatic, and esophageal cancer, possibly due to different antibodies or cancer heterogeneity. Studies on tetraspanin CD9's role in tumor suppression or promotion are inconclusive, requiring further mechanistic experiments.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yujia Xiong, Mingxuan Li, Yutao Shen, Tianshun Ma, Jiwei Bai, Yazhuo Zhang
Summary: This study reveals that high PALB2 expression is associated with poor prognosis in skull base chordoma patients and promotes the malignant phenotypes of chordoma cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xiang An, Wenlong Lin, Huan Liu, Weixiang Zhong, Xiuming Zhang, Yimin Zhu, Xiaojian Wang, Jun Li, Qinsong Sheng
Summary: The study found heterogeneous expression patterns of ACE2 protein in the gastrointestinal tract, with a punctate distribution in hepatic cells. Compared to adjacent non-tumor tissues, ACE2 protein expression was significantly increased in colon, stomach, and pancreatic cancer tissues but decreased in liver cancer tissues. The expression level of ACE2 protein was not correlated with patient survival in gastrointestinal cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Hu Sun, Bing Chen, Hao Zhao, Hui Zhang, Wei Song, Yinghao Gu
Summary: This study found that high expression of LOXL1 is closely associated with the malignant progression of glioblastoma (GBM) and predicts a poor prognosis. Overexpression of LOXL1 promotes migration and invasion of GBM cells, promoting the malignant progression of the disease.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Kun Li, Guangqing Tan, Xin Zhang, Weiyu Lu, Jingyi Ren, Yuewen Si, Enoch Appiah Adu-Gyamfi, Fangfang Li, Yingxiong Wang, Biao Xie, Meijiao Wang
Summary: EIF4G1 is identified as a potential prognostic biomarker and therapeutic target for breast cancer, as it may regulate the tumor microenvironment and affect metastasis and overall survival in breast cancer patients.
Article
Oncology
Yuan Li, Hao Huang, Yulan Zhu, Bin Xu, Junjun Chen, Yingting Liu, Xiao Zheng, Lujun Chen
Summary: This study found that METTL3 expression is increased in pancreatic cancer tissues and is associated with the progression and prognosis of the disease. Additionally, METTL3 expression is related to tumor-infiltrating immune cells and m(6)A modification and metabolism in pancreatic cancer tissues.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Geriatrics & Gerontology
Jinghui Liu, Chen Li, Yuan Wang, Peigang Ji, Shaochun Guo, Yulong Zhai, Na Wang, Miao Lou, Meng Xu, Min Chao, Yang Jiao, Wenjian Zhao, Fuqiang Feng, Yan Qu, Shunnan Ge, Liang Wang
Summary: The study found that more aggressive treatment regimens may prolong survival for elderly patients with glioblastoma (GBM), while further research and prospective randomized clinical trials are needed to determine the appropriate management, especially for patients with MGMT promoter methylation.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Liang Wang, Haiyan Cao, Ying Zhong, Peigang Ji, Fan Chen
Summary: This study reveals the important role of m6A modifications in GBM tumor microenvironment (TME) cell infiltration and stemness characteristics. The m6A modification patterns are correlated with TME cell infiltration characteristics, stemness characteristics, tumor clinical outcome, immune infiltration, and stemness. Assessing the m6A modification pattern of individual tumors can enhance our understanding of TME infiltration and stemness characteristics and contribute to the development of immunotherapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Fan Chen, Xuan Xie, Min Chao, Haiyan Cao, Liang Wang
Summary: This review summarizes the impact of m6A RNA methylation on cancer progression and immune cell infiltration in the glioblastoma microenvironment, as well as its potential role in novel immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiang-Xu Wang, Haiyan Cao, Yulong Zhai, Shi-Zhou Deng, Min Chao, Yaqin Hu, Yueyang Mou, Shaochun Guo, Wenjian Zhao, Chen Li, Yang Jiao, Guolian Xue, Liying Han, Hong-Mei Zhang, Liang Wang
Summary: This study found that different immune subtypes have a significant impact on the survival of glioma patients. Patients with a high immune response subtype had a shorter survival, and the immune microenvironment of these patients showed enhanced immune cell infiltration. Furthermore, 132 genes related to glioma immunity were identified, and the expression levels of seven core genes were significantly correlated with the prognosis of glioma patients. These findings could be used to stratify glioma patients based on immune subgroup analysis and guide clinical treatment regimens.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
Fan Chen, Xuan Xie, Liang Wang
Summary: The lymphatic system plays an important role in the circulatory system, with functions including immune defense, maintaining internal environment stability, and regulating tissue pressure. Recent studies have confirmed the presence of lymphatic vessels lined with endothelial cells in the CNS, particularly in the meninges. These discoveries have significant clinical implications for infectious diseases, autoimmunity, and tumor immunology.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Yuan Xie, Liqun He, Yanyu Zhang, Hua Huang, Fan Yang, Min Chao, Haiyan Cao, Jianhao Wang, Yaling Li, Lingxue Zhang, Lele Xin, Bing Xiao, Xinxin Shi, Xue Zhang, Jiefu Tang, Lene Uhrbom, Anna Dimberg, Liang Wang, Lei Zhang
Summary: Inhibiting the Wnt signaling pathway can increase Temozolomide (TMZ) delivery and sensitize glioma to chemotherapy. Transcriptome analysis revealed that Wnt signaling inhibition enhances vascular transcytosis by upregulating PLVAP and downregulating MFSD2A. Additionally, Wnt signaling inhibition also enhances caveolae-mediated transcytosis in tumor endothelial cells (ECs). These findings suggest that Wnt signaling regulates MFSD2A-dependent TMZ delivery through a caveolae-mediated pathway, highlighting Wnt signaling as a promising therapeutic target for GBM treatment.
Article
Oncology
Jinghui Liu, Chen Li, Yuan Wang, Peigang Ji, Shaochun Guo, Yulong Zhai, Na Wang, Meng Xu, Julei Wang, Liang Wang
Summary: This study assessed the clinicopathological features and outcomes of secondary gliosarcomas (SGS) through retrospective analysis of data. The results showed that initial diagnosis of GBM was a poor prognostic factor for SGS. Patients with initial non-GBM diagnosis who underwent gross total resection and chemoradiation had better overall survival outcomes. Patients initially diagnosed with GBM who received both chemoradiotherapy and active therapy after disease progression to SGS had significantly longer overall survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biophysics
Yang Jiao, Tao Zhang, Chao Fan, Haiyan Cao, Min Chao, Liying Han, Weirui Zhang, Lei Mao, Ruigang Liu, Canhua Xu, Liang Wang
Summary: In this study, an improved magnetic induction tomography (MIT) data acquisition system was used to monitor traumatic brain injury (TBI) and distinguish different injury levels. The experiment used a pneumatically controlled cortical impactor to strike the parietal lobe of anesthetized rabbits and establish different TBI models. The MIT data acquisition system continuously monitored the brain for an hour and successfully observed targets with increased conductivity in the reconstructed images, indicating that MIT may facilitate early TBI monitoring and distinguish varying degrees of injuries.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Oncology
Kaiyue Xu, Kaiqian Zhang, Jiying Ma, Qianqian Yang, Ge Yang, Tingting Zong, Guowei Wang, Bo Yan, Jule Shengxia, Chao Chen, Liang Wang, Huijuan Wang
Summary: This study identified the elevated expression of CKAP4 in glioblastoma multiforme (GBM) and investigated its role in the development of the disease. CKAP4 was found to influence the malignant behavior of GBM through the regulation of the FOXM1 signaling pathway. The CKAP4-based prognostic model developed in this study could potentially guide individualized treatment decisions for glioma patients.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Neuroimaging
Weirui Zhang, Yang Jiao, Tao Zhang, Xuechao Liu, Jianan Ye, Yuyan Zhang, Bin Yang, Meng Dai, Xuetao Shi, Feng Fu, Liang Wang, Canhua Xu
Summary: A cerebral contrast-enhanced electrical impedance tomography perfusion method was developed for the early detection of acute ischemic stroke during thrombolytic therapy. The method utilized stable and highly conductive contrast agents and showed significant improvement in detection ability compared to other agents tested. This method accurately detected the location and area of cerebral infarction lesions and can be applied as a rapid, bedside imaging method for suspected ischemic stroke patients.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Shaochun Guo, Ruili Han, Fan Chen, Peigang Ji, Jinghui Liu, Yulong Zhai, Min Chao, Wenjian Zhao, Yang Jiao, Chao Fan, Tao Huang, Na Wang, Shunnan Ge, Yan Qu, Yuan Wang, Liang Wang
Summary: Traumatic brain injury (TBI) is a global challenge associated with premature death and long-term disability. Analyzing the TBI rate and mortality trend can provide valuable diagnosis and treatment suggestions for the development of public health strategies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Yuan Wang, Shaochun Guo, Na Wang, Jinghui Liu, Fan Chen, Yulong Zhai, Yue Wang, Yang Jiao, Wenjian Zhao, Chao Fan, Yanrong Xue, GuoDong Gao, Peigang Ji, Liang Wang
Summary: This study retrospectively analyzed the experience of a tertiary neurosurgical center in China over eight years in treating glioma patients with awake brain mapping. The results showed that awake brain mapping is a feasible and safe method for reducing the risk of neurological deficits, increasing extent of resection (EOR), and extending survival time. The MoCA test results indicated that brain mapping plays a critical role in preserving neurocognitive function during tumor resection.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yueyang Mou, Yaqin Hu, Guolian Xue, Wenjian Zhao, Yang Jiao, Chen Li, Haiyan Cao, Min Chao, Jianping Deng, Penggao Dai, Hongli Zhu, Liang Wang
Summary: ELK3 plays a crucial role in glioma angiogenesis by activating the HIF-1 alpha/VEGF-A signaling axis. It may serve as a prognostic marker for glioma angiogenesis and targeting ELK3 may improve the efficacy of anti-angiogenic therapies.
Article
Clinical Neurology
Yulong Zhai, Peigang Ji, Meng Xu, Min Chao, Na Wang, Jinghui Liu, Yuan Wang, Shaochun Guo, Chao Fan, Zhicheng Fan, Yunpeng Kou, Haiyan Cao, Yan Qu, Liang Wang
Summary: The study analyzed primary CNS tumors diagnosed pathologically in a single center in China from 2003 to 2019. The major tumor types identified were meningiomas, tumors of neuroepithelial tissue, and pituitary adenomas. The study found that grade 4 tumors of neuroepithelial tissue were more common in the temporal lobe, a finding that was rarely reported in previous articles.
WORLD NEUROSURGERY
(2023)
Article
Neurosciences
Wenxing Cui, Yingwu Shi, Baocheng Zhao, Jianing Luo, Gang Zhu, Hao Guo, Bao Wang, Chen Yang, Zhihong Li, Liang Wang, Yan Qu, Shunnan Ge
Summary: This study investigated the correlation between quantitative cranial CT parameters and coagulopathy in patients with traumatic brain injury (TBI). The results showed that ICH/C volume was the main predictor for coagulopathy.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
