Article
Medicine, Research & Experimental
Constantine J. Georgiou, Zhongli Cai, Noor Alsaden, Hyungjun Cho, Minou Behboudi, Mitchell A. Winnik, James T. Rutka, Raymond M. Reilly
Summary: In this study, convection-enhanced delivery (CED) of 23 +/- 3 nm gold nanoparticles (AuNPs) labeled with the beta-particle-emitting radionuclide 177Lu (177Lu-AuNPs) was found to be highly effective for treating orthotopic U251-Luc human glioblastoma multiforme (GBM) tumors in NRG mice. The cytotoxicity of 177Lu-AuNPs on U251-Luc cells was confirmed through in vitro experiments, while in vivo studies showed that the tumors treated with 177Lu-AuNPs exhibited growth arrest and improved long-term survival compared to control mice. Overall, this study highlights the potential of CED using 177Lu-AuNPs as a promising treatment for GBM patients. Rating: 8/10
MOLECULAR PHARMACEUTICS
(2023)
Review
Nanoscience & Nanotechnology
Ran Chen, Tingting Wang, Jie Song, Daojun Pu, Dan He, Jianjun Li, Jie Yang, Kailing Li, Cailing Zhong, Jingqing Zhang
Summary: Antiviral drugs play a crucial role in fighting viruses, including COVID-19, but their use is often limited by poor oral bioavailability and low efficacy. Studying the metabolism and pharmacokinetic characteristics of AvDs can help improve their effectiveness and combat drug resistance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Oncology
Randy S. D'Amico, Manish K. Aghi, Michael A. Vogelbaum, Jeffrey N. Bruce
Summary: Convection-enhanced delivery (CED) is a method of targeted, local drug delivery to the central nervous system that shows promise for treating glioblastoma (GBM), although the long-term efficacy of the agents studied remains difficult to assess at present.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Helena H. W. B. Hansen, Haotian Cha, Lingxi Ouyang, Jun Zhang, Bo Jin, Helen Stratton, Nam-Trung Nguyen, Hongjie An
Summary: Nanobubbles, suspended gaseous entities in liquids, have versatile biomedical applications such as aiding in drug delivery, serving as imaging agents, and allowing controlled and targeted delivery. This review provides an overview of their preparation, characterization, current research focuses, and their potential impact on the future of biomedicine.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Nanoscience & Nanotechnology
Jamie M. Gleason, Sarah H. Klass, Paul Huang, Tomoko Ozawa, Raquel A. Santos, Miko M. Fogarty, David R. Raleigh, Mitchel S. Berger, Matthew B. Francis
Summary: Lipid and micelle-based nanocarriers have been studied for delivering anticancer drugs to improve their accumulation and uptake in tumor tissue. In this study, a protein-based micelle nanocarrier called IDP-2Yx2A was developed to encapsulate a highly potent but water-insoluble cancer drug, SN38, for delivery into glioblastoma multiforme (GBM) tumors. The results showed promising in vivo efficacy with slowed tumor growth and increased median survival times.
ACS APPLIED BIO MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Kei Xian Tan, Michael K. Danquah, Jaison Jeevanandam, Ahmed Barhoum
Summary: Janus particles have emerged as a novel and smart material for improving pharmaceutical formulation, drug delivery, and therapeutics. They have two distinct compartments that can accommodate opposing pharmaceutical agents and allow for controlled drug release. This article discusses the development of Janus particles and their potential applications in diabetes treatment and antimicrobial therapy. It highlights the advances in synthesizing Janus particles from different materials using various approaches and evaluates their potential for improving conventional drug delivery systems.
Article
Materials Science, Multidisciplinary
Linda Waldherr, Maria Seitanidou, Marie Jakesova, Verena Handl, Sophie Honeder, Marta Nowakowska, Tamara Tomin, Meysam Karami Rad, Tony Schmidt, Joachim Distl, Ruth Birner-Gruenberger, Gord Campe, Ute Schafer, Magnus Berggren, Beate Rinner, Martin Asslaber, Nassim Ghaffari-Tabrizi-Wizsy, Silke Patz, Daniel T. Simon, Rainer Schindl
Summary: The study confirms Gem's significantly greater potency in killing GBM cells compared to temozolomide, and demonstrates the potential of the electronically-driven organic ion pump GemIP for targeted delivery to GBM cells.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Review
Oncology
Satya Siva Kishan Yalamarty, Nina Filipczak, Xiang Li, Md Abdus Subhan, Farzana Parveen, Janaina Artem Ataide, Bharat Ashok Rajmalani, Vladimir P. Torchilin
Summary: Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer that is difficult to treat due to its resistance to traditional cancer treatments. The unique biology of GBM cells and the blood-brain barrier contribute to this resistance. However, there are several treatment options available, including surgery, chemoradiotherapy, adjuvant chemotherapy, immunotherapy, targeted therapies, and tumor-treating fields. Ongoing clinical trials aim to improve outcomes for GBM patients.
Article
Chemistry, Multidisciplinary
Jiantang Liang, Lei Li, Hailong Tian, Zhihan Wang, Guowen Liu, Xirui Duan, Meiwen Guo, Jiaqi Liu, Wei Zhang, Edouard C. Nice, Canhua Huang, Weifeng He, Haiyuan Zhang, Qifu Li
Summary: Developing therapies that can effectively target glioblastoma by crossing the blood-brain barrier (BBB) and induce ferroptosis is crucial for improving treatment outcomes. In this study, a versatile biomimetic nanoplatform, L-D-I/NPs, was designed for selective targeting of glioblastoma by binding to low-density lipoprotein receptor-related protein-1 (LRP1) and crossing the BBB, thus inducing ferroptosis in glioblastoma cells. L-D-I/NPs have demonstrated the ability to effectively suppress tumor progression and prolong survival in a mouse glioblastoma model, offering a promising approach for ferroptosis-based therapies.
Review
Pharmacology & Pharmacy
Jiaxi Xie, Cailing Zhong, Tingting Wang, Dan He, Luyang Lu, Jie Yang, Ziyi Yuan, Jingqing Zhang
Summary: Cerebral diseases greatly affect people's daily lives, and natural medicines have the potential to treat these diseases by regulating cerebral metabolism. However, their low bioavailability can be improved through nanotechnology delivery systems. Advanced versions of natural medicines alter their pharmacological activities through structure-based metabolic reactions and enzyme-modulated catalytic reactions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bilal Javed, Xinyi Zhao, Daxiang Cui, James Curtin, Furong Tian
Summary: The study synthesized Lignin-g-p (NIPAM-co-DMAEMA) gold nanogel loaded with curcumin and piperine to treat GBM, which exhibited enhanced anticancer properties, improved drug toxicity and release, and induced apoptosis through endocytic pathways. The experimental evidence suggests that the combinatorial curcumin-piperine gold nanogels have the potential to overcome the limitations of conventional chemotherapeutic treatments for glioma cells.
Article
Microbiology
Sinenhlanhla Mtshali, Byron A. Jacobs
Summary: Physiologically based pharmacokinetic models have gained popularity in drug development and regulatory science. This study validates the model's effectiveness in predicting drug-drug interaction and the pharmacokinetics of antiretroviral and anti-TB drugs through mathematical solving and sensitivity analysis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Jiaqi Liu, Yuting Sun, Xianhuang Zeng, Yang Liu, Chaozhi Liu, Ying Zhou, Yueguang Liu, Guihong Sun, Mingxiong Guo
Summary: This study developed artificial vesicles loaded with ANG-TRP-PK1 peptides for targeted therapy of brain tumors. The peptide-loaded vesicles showed better therapeutic effects and reduced side effects compared to traditional drugs in mouse models.
ADVANCED MATERIALS
(2023)
Article
Medicine, Research & Experimental
Elisa Checa-Chavarria, Eva Rivero-Buceta, Miguel Angel Sanchez Martos, Gema Martinez Navarrete, Cristina Soto-Sanchez, Pablo Botella, Eduardo Fernandez
Summary: This novel therapeutic approach using CPT-ALA shows promising results in targeting GBM cells with improved cytotoxic effects and reduced side effects on healthy tissue. In preclinical studies, CPT-ALA demonstrated significant reduction in intracranial GBM volume without notable toxicity, indicating its potential for improving the success of surgical removal and extending life expectancy by reducing tumor recurrence.
MOLECULAR PHARMACEUTICS
(2021)
Review
Chemistry, Medicinal
Jiao Qu, Qianqian Liu, Guoquan You, Ling Ye, Yiguang Jin, Lingdong Kong, Wenjie Guo, Qiang Xu, Yang Sun
Summary: Andrographolide, a natural lactone with a range of pharmacological actions in traditional Chinese medicine, shows promising potential in treating inflammatory diseases and cancers. Its effects have been studied extensively in preclinical use and clinical trials, highlighting advancements in both disease categories.
MEDICINAL RESEARCH REVIEWS
(2022)