Review
Oncology
Maximilian J. Mair, Marjolein Geurts, Martin J. van den Bent, Anna S. Berghoff
Summary: WHO grade II-III gliomas are rare primary brain tumors with longer median survival compared to grade IV glioblastoma. Treatment involves maximal safe resection and adjuvant therapies, with challenges in conducting clinical trials due to rarity and long follow-up times. The 2016 WHO Classification introduced a molecular diagnostic framework for more homogenous subgroups. Available evidence for adjuvant treatment was generated pre-molecular era, emphasizing the need for further research in this field.
CANCER TREATMENT REVIEWS
(2021)
Article
Pathology
Sakun Santisukwongchote, Chinnachote Teerapakpinyo, Piyamai Chankate, Piti Techavichit, Atthaporn Boongird, Sith Sathornsumetee, Samasuk Thammachantha, Pornsuk Cheunsuchon, Jantima Tanboon, Paul Scott Thorner, Shanop Shuangshoti
Summary: This study successfully achieved integrated diagnosis of diffuse gliomas in adult Thai patients using a simplified approach combining clinical, morphological, immunohistochemical, and fewer molecular tests, saving 50% of testing costs. The demographic data and tumor subtypes were similar to series from other regions of the world.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Neurosciences
Derek Wong, Tae Hoon Lee, Amy Lum, Valerie Lan Tao, Stephen Yip
Summary: In this study, the transcriptomic and proteomic profiles of low-grade gliomas (LGG) were investigated using RNA-seq data and tandem mass-spectrometry analysis. The results showed that gene expression in LGG subtypes was mainly influenced by IDH mutations and 1p19q co-deletion. Proteomic analysis identified subtype-specific proteins that could be used to classify the LGG subtypes.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sang Ik Park, Chong Hyun Suh, Jeffrey P. Guenette, Raymond Y. Huang, Ho Sung Kim
Summary: The T2-FLAIR mismatch sign showed high specificity and interobserver agreement for predicting IDHmut-Noncodel, with low sensitivity and some reported false positive cases.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Grace S. Ahn, Kihwan Hwang, Tae Min Kim, Chul Kee Park, Jong Hee Chang, Tae-Young Jung, Jin Hee Kim, Do-Hyun Nam, Se-Hyuk Kim, Heon Yoo, Yong-Kil Hong, Eun-Young Kim, Dong-Eun Lee, Jungnam Joo, Yu Jung Kim, Gheeyoung Choe, Byung Se Choi, Seok-Gu Kang, Jeong Hoon Kim, Chae-Yong Kim
Summary: The addition of concurrent and adjuvant temozolomide did not negatively impact health-related quality of life (HRQoL) and was associated with improved progression-free survival (PFS) for patients with anaplastic gliomas.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Luisa Allwohn, Josy Wolfgang, Julia Onken, David Wasilewski, Siyer Roohani, Daniel Zips, Felix Ehret, David Kaul
Summary: This study analyzes the influence of various tumor and patient characteristics on survival outcomes in patients with oligodendrogliomas (ODG) who have the 1p/19q-codeletion and IDH mutation. The results show that extent of resection, radiotherapy, and chemotherapy are associated with improved progression-free survival (PFS) in WHO grade 2 ODG, while only radiochemotherapy contributes to decreased risk of progression in WHO grade 3 ODG.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Eike Steidl, Katharina Filipski, Pia S. Zeiner, Marlies Wagner, Emmanouil Fokas, Marie-Therese Forster, Michael W. Ronellenfitsch, Iris Dive, Joachim P. Steinbach, Patrick N. Harter, Oliver Baehr
Summary: The classification and treatment of WHO grade II/III gliomas have changed significantly. Molecular markers have been incorporated into the classification, leading to discussions on the importance of grading. Clinical trials have shown benefits of combined radiochemotherapy in improving overall survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura Mancini, Stefano Casagranda, Guillaume Gautier, Philippe Peter, Bruno Lopez, Lewis Thorne, Andrew McEvoy, Anna Miserocchi, George Samandouras, Neil Kitchen, Sebastian Brandner, Enrico De Vita, Francisco Torrealdea, Marilena Rega, Benjamin Schmitt, Patrick Liebig, Eser Sanverdi, Xavier Golay, Sotirios Bisdas
Summary: This study investigated the clinical value of different CEST metrics for glioma classification and found that CEST-derived biomarkers for amides, amines, and their ratio are useful for histomolecular staging in gliomas. The study also revealed that AB/FS CEST mismatch can identify glioma subgroups that may have prognostic and clinical relevance.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Ishan Singhal, Dylan Coss, Wade Mueller, Michael Straza, Max Ostrinsky Krucoff, Fernando Santos-Pinheiro
Summary: This article describes two rare cases of patients with coexisting distinct glial tumors in opposite hemispheres. Pathological confirmation of each lesion is crucial in the management of such non-contiguous tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kurt A. Jaeckle, Karla Ballman, Martin van den Bent, Caterina Giannini, Evanthia Galanis, Paul D. Brown, Robert B. Jenkins, J. Gregory Cairncross, Wolfgang Wick, Michael Weller, Kenneth D. Aldape, Jesse G. Dixon, S. Keith Anderson, Jane H. Cerhan, Jeffrey S. Wefel, Martin Klein, Stuart A. Grossman, David Schiff, Jeffrey J. Raizer, Frederick Dhermain, Donald G. Nordstrom, Patrick J. Flynn, Michael A. Vogelbaum
Summary: The study demonstrated that patients treated with temozolomide alone had significantly shorter progression-free survival (PFS) compared to those receiving radiotherapy. Patients not receiving radiotherapy also had shorter PFS, but there was no significant difference in overall survival. There were no significant differences between groups in terms of adverse events and neurocognitive decline.
Review
Oncology
Jasmin Jo, David Schiff
Summary: Treatment recommendations for grade 3 gliomas depend on their histopathologic and molecular phenotype. The current treatments involve surgery, radiation therapy, and chemotherapy. The addition of temozolomide after radiation therapy improves outcomes for non-codeleted grade 3 IDH mutant astrocytoma. For codeleted oligodendroglioma, the recommended treatment includes procarbazine, CCNU, and vincristine regimen. Novel agents targeting IDH mutation and its metabolic effects are being investigated to further improve patient outcomes.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Review
Clinical Neurology
Benjamin T. Whitfield, Jason T. Huse
Summary: In the past decade, advancements in molecular profiling have significantly impacted the way cancer types, including primary brain tumors, are diagnosed, classified, and managed. Molecular alterations have allowed for a more refined classification of brain tumors, deviating from the traditional reliance on morphological characteristics. This shift towards molecular classification is evident in the 2021 WHO classification of central nervous system tumors. This review focuses on the recent updates regarding the classification of adult-type diffuse gliomas, which are highly infiltrative and mostly incurable malignancies of the central nervous system. The refinement of molecular criteria holds promise for improving the diagnosis, prognostication, and eventual treatment of these devastating tumors.
Article
Pathology
Dario de Biase, Giorgia Acquaviva, Michela Visani, Gianluca Marucci, Antonio De Leo, Thais Maloberti, Viviana Sanza, Enrico Di Oto, Enrico Franceschi, Antonella Mura, Moira Ragazzi, Silvia Serra, Elisabetta Froio, Alessandra Bisagni, Alba A. Brandes, Annalisa Pession, Giovanni Tallini
Summary: The study developed a next-generation sequencing panel to simultaneously define 1p/19g codeletion and IDH1/IDH2 mutation status, providing a reliable and cost-effective alternative for molecular diagnostics in gliomas.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Article
Oncology
Tokunori Kanazawa, Kentaro Ohara, Yohei Kitamura, Masato Nakaya, Kazunari Yoshida, Hikaru Sasaki
Summary: Chemotherapy in 1p/19q-codeleted lower grade gliomas leads to histological changes such as sparse glial background and abundant foamy cell infiltration. The increasing rate of CD68+ cells post-chemotherapy is inversely correlated with patient prognosis, while not with tumor response. Glioma stem cells (GSCs) in conjunction with M2 macrophages are responsible for resistance to and recurrence after alkylating agent chemotherapy in 1p/19q-codeleted gliomas.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Jad Zreik, Panagiotis Kerezoudis, Mohammed Ali Alvi, Yagiz U. Yolcu, Sani H. Kizilbash
Summary: Despite the inclusion of 1p/19q codeletion as a required diagnostic component for oligodendrogliomas in the 2016 WHO classification, study findings revealed persistent regional disparities in reported testing and identified new disparities in race/ethnicity that may impact patient management. Patients who underwent reported testing were more likely to receive adjuvant treatment, highlighting the importance of comprehensive testing for better treatment outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Khe Hoang-Xuan, Martina Deckert, Andres J. M. Ferreri, Julia Furtner, Jaime Gallego Perez-Larraya, Roger Henriksson, Andreas F. Hottinger, Benjamin Kasenda, Florence Lefranc, Alexander Lossos, Catherine McBain, Matthias Preusser, Patrick Roth, Roberta Ruda, Uwe Schlegel, Riccardo Soffietti, Carole Soussain, Martin J. B. Taphoorn, Valerie Touitou, Michael Weller, Jacoline E. C. Bromberg
Summary: The management of primary central nervous system lymphoma (PCNSL) is a controversial topic in neuro-oncology. The European Association of Neuro-Oncology (EANO) formed a multidisciplinary task force to update the evidence-based guidelines and include immunosuppressed patients. The guideline provides consensus considerations and recommendations for the treatment of PCNSL, including intraocular manifestations and specific management of the elderly.
Article
Oncology
Mark P. van Opijnen, C. Mircea S. Tesileanu, Linda Dirven, Pim B. van der Meer, Maarten M. J. Wijnenga, Arnaud J. P. E. Vincent, Marike L. D. Broekman, Hendrikus J. Dubbink, Johan M. Kros, Sjoerd G. van Duinen, Marion Smits, Pim J. French, Martin J. van den Bent, Martin J. B. Taphoorn, Johan A. F. Koekkoek
Summary: IDHwt hLGG patients and IDHwt glioblastoma patients have similar incidence proportions of epilepsy during the entire disease course. However, the former has a significantly higher incidence of epilepsy before diagnosis and a significantly longer time between first seizure and diagnosis, indicating a distinct clinical course between the two subtypes.
Article
Rehabilitation
Ellen M. P. van Coevorden-van Loon, Herwin H. L. D. Horemans, Majanka H. Heijenbrok-Kal, Rita J. G. van den Berg-Emons, Robert Rozenberg, Arnaud J. P. E. Vincent, Gerard M. Ribbers, Martin J. van den Bent
Summary: This study aimed to evaluate physical fitness and its association with fatigue in patients with low grade glioma. The results showed that muscle strength and cardiorespiratory fitness were significantly decreased in these patients, and lower cardiorespiratory fitness was independently associated with higher levels of physical fatigue.
DISABILITY AND REHABILITATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Noemie S. Minczeles, Eelke M. M. Bos, Reinoud C. C. de Leeuw, Johan M. M. Kros, Mark W. W. Konijnenberg, Jacoline E. C. Bromberg, Wouter W. W. de Herder, Clemens M. F. Dirven, Johannes Hofland, Tessa Brabander
Summary: In patients with progressive meningiomas for whom surgery or external radiotherapy is no longer an option, peptide receptor radionuclide therapy (PRRT) was shown to have a role in controlling tumor growth and improving progression-free survival and overall survival.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Oncology
Matthias Preusser, Martin J. van den Bent
Article
Oncology
L. Bleeker, M. C. M. Kouwenhoven, I. de Heer, B. I. Lissenberg-Witte, A. H. Gijsbers, H. J. Dubbink, J. M. Kros, J. M. M. Gijtenbeek, E. Kurt, C. C. D. van der Rijt, A. T. Swaak-Kragten, F. Y. de Vos, H. L. van der Weide, P. J. French, M. J. van den Bent, P. Wesseling, J. E. C. Bromberg
Summary: This study evaluated the toxicity and efficacy of the Dutch treatment protocol for adult medulloblastoma patients. The results showed that combined chemo-radiotherapy can improve the survival of adult medulloblastoma patients.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Oncology
Maximilian J. Mair, Rupert Bartsch, Emilie Le Rhun, Anna S. Berghoff, Priscilla K. Brastianos, Javier Cortes, Hui K. Gan, Nancy U. Lin, Andrew B. Lassman, Patrick Y. Wen, Michael Weller, Martin van den Bent, Matthias Preusser
Summary: Antibody-drug conjugates (ADCs) have shown efficacy in various cancers, but their activity in the central nervous system (CNS) may be limited by the blood-brain barrier. This review summarizes the available clinical data on ADCs against primary and secondary brain tumors and ongoing trials. It also discusses the physical, biological, and molecular determinants of ADCs' CNS activity and potential strategies to improve drug delivery to brain tumors.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Andrew B. Lassman, Martin J. van den Bent
Article
Oncology
Philipp Karschnia, Antonio Dono, Jacob S. Young, Stephanie T. Juenger, Nico Teske, Levin Haeni, Tommaso Sciortino, Christine Y. Mau, Francesco Bruno, Luis Nunez, Ramin A. Morshed, Alexander F. Haddad, Michael Weller, Martin van den Bent, Juergen Beck, Shawn Hervey-Jumper, Annette M. Molinaro, Nitin Tandon, Roberta Ruda, Michael A. Vogelbaum, Lorenzo Bello, Oliver Schnell, Stefan J. Grau, Susan M. Chang, Mitchel S. Berger, Yoshua Esquenazi, Joerg-Christian Tonn
Summary: This study retrospectively analyzed 681 patients with first recurrence of IDH wild-type glioblastomas. It found that re-resection could prolong the survival time of patients, and residual contrast-enhancing tumor of 1 cm³ or less had longer survival than non-surgical management. Complete resection according to the RANO resect classification had a better prognosis. Patients without postoperative deficits who received (radio-)chemotherapy had enhanced survival associations with smaller residual contrast-enhancing tumors. However, resection of non-contrast-enhancing tumor did not prolong survival.
Article
Oncology
Fatemeh Arzanforoosh, Sebastian R. R. van der Voort, Fatih Incekara, Arnaud Vincent, Martin Van den Bent, Johan M. M. Kros, Marion Smits, Esther A. H. Warnert
Summary: Reliable insight into tumor microvasculature is crucial for disease monitoring and treatment response. Vessel size imaging (VSI), an emerging MRI technique, has demonstrated potential in accurately revealing microvasculature information in gliomas. However, its clinical application is limited, which was investigated in this study.
Article
Oncology
Sophie H. A. E. Derks, Joost L. M. Jongen, Edgar L. van der Meer, Li Shen Ho, Cleo Slagter, Arjen Joosse, Maja J. A. de Jonge, Joost W. Schouten, Esther Oomen-de Hoop, Martin J. van den Bent, Astrid A. M. van der Veldt
Summary: Cutaneous melanoma is highly prone to metastasize to the brain, with historically poor survival rates. However, the introduction of novel drugs such as targeted therapies and immune checkpoint inhibitors has significantly improved overall survival in patients with melanoma brain metastasis. This study demonstrates the benefits of stereotactic radiotherapy and immune checkpoint inhibitors, suggesting that ICIs should be the first choice of treatment after a diagnosis of MBM, if feasible.
Article
Oncology
Maarten M. J. Wijnenga, Sybren L. N. Maas, Vera van Dis, C. Mircea S. Tesileanu, Johan M. Kros, Linda Dirven, Hans M. Hazelbag, Hendrikus J. Dubbink, Arnaud J. P. E. Vincent, Pim J. French, Martin J. van den Bent
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Hematology
Daniel P. Noij, Martin van den Bent, Jeanette K. Doorduijn, Nick Wlazlo
Summary: We report a case of a 19-year-old patient who experienced two episodes of donor-derived PCNSL after undergoing allogeneic stem cell transplantation in childhood. Despite failed induction chemotherapy, successful consolidation therapy was achieved through a second allogeneic stem cell transplantation after conditioning with thiotepa, busulfan, and fludarabine.
ACTA HAEMATOLOGICA
(2023)
Review
Medicine, General & Internal
Martin J. van den Bent, Marjolein Geurts, Pim J. French, Marion Smits, David Capper, Jacoline E. C. Bromberg, Susan M. Chang
Summary: The most common adult-type primary CNS tumors are diffuse gliomas, but there are also various rare CNS tumor types. The classification of these tumors is increasingly based on molecular diagnostics. Surgery is the mainstay of treatment for gliomas, and early surgery is recommended for patients with histologically low-grade tumors. Standard treatment for adult-type diffuse glioma consists of radiotherapy and chemotherapy. Targeted treatments and immunotherapy are still in the early stages of development for the treatment of adult-type gliomas.