Article
Oncology
Soufyan Annakib, Valerie Rigau, Amelie Darlix, Catherine Goze, Hugues Duffau, Luc Bauchet, Marta Jarlier, Michel Fabbro
Summary: This study retrospectively evaluated the clinical outcomes of bevacizumab as rescue treatment for recurrent WHO grades II-III glioma, and found that bevacizumab displayed prolonged activity in a subset of patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Boran Chen, Chaoyue Chen, Jian Wang, Yuen Teng, Xuelei Ma, Jianguo Xu
Summary: This study investigated the diagnostic ability of radiomics-based machine learning in differentiating atypical low-grade astrocytoma (LGA) from anaplastic astrocytoma (AA). Nine diagnostic models were established with promising performances, with the best AUC values being 0.825 for LDA-based models, 0.808 for SVM-based models, and 0.821 for RF-based models. These findings suggest that radiomic-based machine-learning has the potential for reliable diagnostic performance in distinguishing between atypical LGA and AA.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Prit Benny Malgulwar, Carla Danussi, Sharvari Dharmaiah, William Johnson, Anand Singh, Kunal Rai, Arvind Rao, Jason T. Huse
Summary: The study indicates that SIRT2 inhibitor can reverse ATRX-deficient transcriptional changes, inhibit cell migration in glioma cells, and promote senescence markers expression. Additionally, SIRT2 inhibitor can impair the growth of ATRX-deficient glioma stem cells. These findings provide new insights into the strategies for treating ATRX-deficient gliomas.
Article
Oncology
Xu Yang, Yan Zhang, Zhiwei Xue, Yaotian Hu, Wenjing Zhou, Zhiyi Xue, Xuemeng Liu, Guowei Liu, Wenjie Li, Xiaofei Liu, Xingang Li, Mingzhi Han, Jian Wang
Summary: This study found an increased expression of TRIM56 in glioblastoma, which promoted glioma progression by stabilizing cIAP1 through deubiquitination. The interaction between TRIM56 and cIAP1 may play a key role in glioma development. Additionally, TRIM56 could serve as a potential therapeutic molecular target and prognostic indicator for glioblastoma patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tomoki Todo, Hirotaka Ito, Yasushi Ino, Hiroshi Ohtsu, Yasunori Ota, Junji Shibahara, Minoru Tanaka
Summary: A crucial clinical trial demonstrates that repeated tumor-administration of oncolytic herpes virus G47 Increment in residual or recurrent glioblastoma leads to improved survival rates and a safe profile.
Article
Oncology
Adam M. Sonabend, Andrew Gould, Christina Amidei, Rachel Ward, Karyn A. Schmidt, Daniel Y. Zhang, Cristal Gomez, John F. Bebawy, Benjamin P. Liu, Guillaume Bouchoux, Carole Desseaux, Irene B. Helenowski, Rimas Lukas, Karan Dixit, Priya Kumthekar, Victor A. Arrieta, Maciej S. Lesniak, Alexandre Carpentier, Hui Zhang, Miguel Muzzio, Michael Canney, Roger Stupp
Summary: Low-intensity pulsed ultrasound with intravenous microbubbles (LIPU-MB) can safely open the blood-brain barrier and enhance the delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma. This study provides important evidence for further research and the ongoing phase 2 trial combining LIPU-MB with albumin-bound paclitaxel plus carboplatin.
Article
Biochemistry & Molecular Biology
Chih-Hao Lu, Sung-Tai Wei, Jia-Jun Liu, Yu-Jen Chang, Yu-Feng Lin, Chin-Sheng Yu, Sunny Li-Yun Chang
Summary: In this study, a 33-gene signature of glioblastoma (GBM) was identified through gene differential analysis, which may have significant implications in the diagnosis, treatment, prognosis prediction, and therapeutic development for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Weilun Fu, Wenjing Wang, Hao Li, Yuming Jiao, Jiancong Weng, Ran Huo, Zihan Yan, Jie Wang, Hongyuan Xu, Shuo Wang, Jiangfei Wang, Dexi Chen, Yong Cao, Jizong Zhao
Summary: This study used mass cytometry to analyze immune cells in AG patients, demonstrating tumor-driven immune changes and the predominant immune cells in the AG immune microenvironment. The immune milieu in AAmut showed more immunosuppressive characteristics compared to AOD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jonathan P. S. Knisely, Howard A. Fine
Summary: The Oncology Grand Rounds series aims to provide clinical context to original reports published in the Journal. It includes case presentations, discussions on diagnostic and management challenges, literature reviews, and suggested management approaches by the authors. The goal is to help readers apply key study findings, including those from the Journal of Clinical Oncology, to their own clinical practice.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Pathology
Kei Shing Oh, Meera Mahalingam
Summary: This article investigates the relationship between malignant melanoma and primary glioblastoma through literature analysis. It provides an overview of both cancers, case reports, epidemiologic studies, and common genetic abnormalities. From a scientific perspective, the evidence supports an association between melanoma and glioma.
ADVANCES IN ANATOMIC PATHOLOGY
(2023)
Article
Oncology
Andres Ramos-Fresnedo, Michael W. Pullen, Carlos Perez-Vega, Ricardo A. Domingo, Oluwaseun O. Akinduro, Joao P. Almeida, Paola Suarez-Meade, Lina Marenco-Hillembrand, Mark E. Jentoft, Bernard R. Bendok, Daniel M. Trifiletti, Kaisorn L. Chaichana, Alyx B. Porter, Alfredo Quinones-Hinojosa, Terence C. Burns, Sani H. Kizilbash, Erik H. Middlebrooks, Wendy J. Sherman
Summary: This study aimed to compare the survival outcomes between molecular GBM (molGBM) and histological GBM (histGBM). The results showed that molGBM had a longer progression-free survival (PFS) compared to histGBM, but similar overall survival (OS).
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Christina I. Tsien, Stephanie L. Pugh, Adam P. Dicker, Jeffrey J. Raizer, Martha M. Matuszak, Enrico C. Lallana, Jiayi Huang, Ozer Algan, Nimisha Deb, Lorraine Portelance, John L. Villano, John T. Hamm, Kevin S. Oh, Arif N. Ali, Michelle M. Kim, Scott M. Lindhorst, Minesh P. Mehta
Summary: This study evaluated whether reirradiation (re-RT) and concurrent bevacizumab (BEV) improve overall survival (OS) and/or progression-free survival (PFS) compared to BEV alone in recurrent glioblastoma (GBM). The results showed that the combination of re-RT and BEV significantly improved PFS, but had no difference in OS.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Thara Tunthanathip
Summary: Malignant transformation of low-grade astrocytoma has a poor prognosis. This study identified supratentorial tumor, midline shift greater than 5mm, and non-total resection as risk factors for malignant transformation.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Oncology
Yuen Teng, Chaoyue Chen, Yang Zhang, Jianguo Xu
Summary: This study suggests that MRI texture analysis combined with LDA algorithm has the potential to be utilized in distinguishing the subtypes of high-grade gliomas.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Otto M. Henriksen, Adam E. Hansen, Aida Muhic, Lisbeth Marner, Karine Madsen, Soren Moller, Benedikte Hasselbalch, Michael J. Lundemann, David Scheie, Jane Skjoth-Rasmussen, Hans S. Poulsen, Vibeke A. Larsen, Henrik B. W. Larsson, Ian Law
Summary: This study compared the diagnostic yield of dynamic contrast-enhanced (DCE) perfusion MRI and O-(2-[F-18]-fluoroethyl)-L-tyrosine ([F-18]FET) PET in patients with recurrent high-grade gliomas. The results showed that DCE BV imaging had good overall diagnostic accuracy, but lower than [F-18]FET PET. Combining both techniques can improve specificity and risk stratification of the lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhongxu An, Vivek Tiwari, Jeannie Baxter, Michael Levy, Kimmo J. Hatanpaa, Edward Pan, Elizabeth A. Maher, Toral R. Patel, Bruce E. Mickey, Changho Choi
MAGNETIC RESONANCE IN MEDICINE
(2019)
Review
Clinical Neurology
Pawan K. Singh, Edward Pan
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vivek Tiwari, Tomoyuki Mashimo, Zhongxu An, Vamsidhara Vemireddy, Sara Piccirillo, Pegah Askari, Keith M. Hulsey, Shanrong Zhang, Robin A. de Graaf, Toral R. Patel, Edward Pan, Bruce E. Mickey, Elizabeth A. Maher, Robert M. Bachoo, Changho Choi
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Oncology
Vivek Tiwari, Elena Daoud, Kimmo J. Hatanpaa, Ang Gao, Song Zhang, Zhongxu An, Sandeep K. Ganji, Jack M. Raisanen, Cheryl M. Lewis, Pegah Askari, Jeannie Baxter, Michael Levy, Ivan Dimitrov, Binu P. Thomas, Marco C. Pinho, Christopher J. Madden, Edward Pan, Toral R. Patel, Ralph J. DeBerardinis, A. Dean Sherry, Bruce E. Mickey, Craig R. Malloy, Elizabeth A. Maher, Changho Choi
Article
Oncology
Timothy F. Cloughesy, Andrew Brenner, John F. de Groot, Nicholas A. Butowski, Leor Zach, Jian L. Campian, Benjamin M. Ellingson, Laurence S. Freedman, Yael C. Cohen, Noa Lowenton-Spier, Tamar Rachmilewitz Minei, Shifra Fain Shmueli, Patrick Y. Wen
Article
Oncology
Emmanuel C. Mantilla, Jessica Abramowitz, Tu Dan, Edward Pan
ANTICANCER RESEARCH
(2020)
Article
Oncology
Eudocia Q. Lee, Peixin Zhang, Patrick Y. Wen, Elizabeth R. Gerstner, David A. Reardon, Kenneth D. Aldape, John F. deGroot, Edward Pan, Jeffrey J. Raizer, Lyndon J. Kim, Steven J. Chmura, H. Ian Robins, Jennifer M. Connelly, James D. Battiste, John L. Villano, Naveed Wagle, Ryan T. Merrell, Merideth M. Wendland, Minesh P. Mehta
Review
Oncology
Pawan Singh, Emmanuel Mantilla, Josie Sewell, Kimmo J. Hatanpaa, Edward Pan
ANTICANCER RESEARCH
(2020)
Article
Oncology
Sumanth P. Reddy, Jonathan E. Dowell, Edward Pan
CLINICAL & EXPERIMENTAL METASTASIS
(2020)
Review
Clinical Neurology
Tomas Garzon-Muvdi, Destiny D. Bailey, Mark N. Pernik, Edward Pan
FRONTIERS IN NEUROLOGY
(2020)
Letter
Clinical Neurology
Elena V. Daoud, Akshat Patel, Jeffrey Gagan, Jack M. Raisanen, George J. Snipes, Emmanuel Mantilla, Ramya Krothapally, Kimmo J. Hatanpaa, Edward Pan
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pegah Askari, Ivan E. Dimitrov, Sandeep K. Ganji, Vivek Tiwari, Michael Levy, Toral R. Patel, Edward Pan, Bruce E. Mickey, Craig R. Malloy, Elizabeth A. Maher, Changho Choi
Summary: This study introduces a new spectral fitting approach to improve the evaluation of 2-hydroxyglutarate (2HG) content in brain tumors, leading to a higher accuracy in identifying mutations in isocitrate dehydrogenase (IDH).
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Xiaoqing Li, Vamsidhara Vemireddy, Qi Cai, Hejian Xiong, Peiyuan Kang, Xiuying Li, Monica Giannotta, Heather N. Hayenga, Edward Pan, Shashank R. Sirsi, Celine Mateo, David Kleinfeld, Chris Greene, Matthew Campbell, Elisabetta Dejana, Robert Bachoo, Zhenpeng Qin
Summary: The study successfully synthesized gold nanoparticles for increasing blood-brain barrier permeability, demonstrating that transcranial picosecond laser stimulation can regulate BBB permeability, enabling drug delivery without disrupting the structure of the neurovascular unit.
Article
Oncology
Shengnan Yu, Shiyou Wei, Milan Savani, Xiang Lin, Kuang Du, Ilgen Mender, Silvia Siteni, Themistoklis Vasilopoulos, Zachary J. Reitman, Yin Ku, Di Wu, Hao Liu, Meng Tian, Yaohui Chen, Marilyne Labrie, Casey M. Charbonneau, Eric Sugarman, Michelle Bowie, Seethalakshmi Hariharan, Matthew Waitkus, Wen Jiang, Roger E. McLendon, Edward Pan, Mustafa Khasraw, Kyle M. Walsh, Yiling Lu, Meenhard Herlyn, Gordon Mills, Utz Herbig, Zhi Wei, Stephen T. Keir, Keith Flaherty, Lunxu Liu, Kongming Wu, Jerry W. Shay, Kalil Abdullah, Gao Zhang, David M. Ashley
Summary: THIO demonstrates therapeutic efficacy in both human and mouse glioma cell lines by inducing apoptotic cell death and inhibiting cell invasion, stem cell, and proliferation pathways through telomeric DNA damage. In addition, THIO significantly reduces tumor proliferation in PDO models and decreases the tumor size of glioblastoma xenografts and PDX models.
CLINICAL CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Limin Zhou, Yiming Wang, Marco C. Pinho, P. Edward, Yin Xi, Joseph A. Maldjian, Ananth J. Madhuranthakam