Article
Multidisciplinary Sciences
Rafal Chojak, Marta Kozba-Gosztyla, Katarzyna Slychan, Daniel Gajos, Marek Kotas, Michal Tyliszczak, Bogdan Czapiga
Summary: Surgical resection of butterfly glioblastoma is associated with improved overall survival at 6 months compared to biopsy alone. However, there is no strong evidence supporting the superiority of resection over biopsy alone in overall survival at 12 and 18 months.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Jana Lu, Hui Zheng, Victoria Lai
Summary: This pilot study explored the quality of life differences among diverse endocrine surgery patients of different races and surgery types. The results showed that race and surgery type have an impact on quality of life, supporting the need for long-term follow-up studies among patients of diverse races and surgery types.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Surgery
Bhamini Vadhwana, Chelise Carrow, David Bowers, Thomas Groot-Wassink
Summary: The study showed that parathyroidectomy in asymptomatic PHPT patients was significantly associated with improvement in health-related quality of life, including a reduction in anxiety and depression levels. In symptomatic patients, the primary improvement was seen in anxiety and depression levels, suggesting an important cognitive and social aspect of the disease.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Philippe Touraine, Yempabou Sagna, Anders F. Mattsson, Pia Burman, Andre P. Van Beek, Martin Ove Carlsson, Ferah Aydin, Ulla Feldt-Rasmussen, Cecilia Camacho-Hubner
Summary: The effectiveness and safety of GH replacement treatment in adult patients with LCH and GHD were analyzed. The results showed that after 1 year of GH treatment, metabolic variables and quality of life improved in the patients, with no new safety signals.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Oncology
Muayad F. Almahariq, Thomas J. Quinn, Jessica D. Arden, P. T. Roskos, George D. Wilson, Brian Marples, Inga S. Grills, Peter Y. Chen, Daniel J. Krauss, Prakash Chinnaiyan, Joshua T. Dilworth
Summary: This study investigated the use of pulsed radiation therapy (PRT) in the treatment of patients with newly diagnosed glioblastoma (GBM). The results showed that PRT treatment is feasible, effective, and can maintain neurocognitive function and quality of life in patients with GBM. Further validation in larger prospective trials is warranted.
Article
Clinical Neurology
Cristina Smolenschi, Elie Rassy, Johan Pallud, Edouard Dezamis, Razvan Copaciu, Fabrice Parker, Gabriel Garcia, Naima Lezghed, Emeline Colomba, Mohamed Khettab, Sami Ammari, Mohamed Fekhi, Larisa Martanovschi, Lina Benadhou, Steven Knafo, David Guyon, Bianca Cheaib, Frederic Dhermain, Sarah Naomie Dumont
Summary: This study aimed to assess the real-life benefit of bevacizumab in recurrent glioblastoma patients. The results showed significant improvements in overall survival, time to treatment failure, radiological response, and clinical benefit. Therefore, bevacizumab as a therapeutic option has clinical significance for these patients.
JOURNAL OF NEUROLOGY
(2023)
Review
Oncology
Minjie Fu, Zhirui Zhou, Xiao Huang, Zhenchao Chen, Licheng Zhang, Jinsen Zhang, Wei Hua, Ying Mao
Summary: This study aims to provide an evidence map associated with bevacizumab (BEV) therapy for recurrent glioblastoma (rGBM), and the results show that although BEV treatment can improve patients' progression-free survival (PFS) and quality of life, there is insufficient evidence to support its efficacy in prolonging overall survival (OS). BEV combined therapy is more effective than monotherapy, and it is more effective in patients with specific molecular alterations and clinical features. High-quality studies are needed to explore the optimal treatment strategies.
Article
Endocrinology & Metabolism
Luciana Martel-Duguech, Jens Otto L. Jorgensen, Marta Korbonits, Gudmundur Johannsson, Susan M. Webb
Summary: This study investigated the current practices of AGHD management throughout Europe, revealing that despite guideline recommendations, GH replacement for AGHD is still unavailable or not fully reimbursed in all European countries. Knowledge among non-endocrine professionals and healthcare administrators regarding AGHD is low, highlighting the need for improvement in postgraduate AGHD curriculum training to optimize care for adults with GHD.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Andrea Magali Gonzalez-Mora, Patricia Garcia-Lopez
Summary: Hormonal factors, specifically estrogen receptors (ERs), may play a role in the development and treatment of glioblastoma. Understanding the function of ERs could lead to the development of more effective therapies for this aggressive brain tumor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yuen Teng, Chaoyue Chen, Yang Zhang, Jianguo Xu
Summary: This study suggests that MRI texture analysis combined with LDA algorithm has the potential to be utilized in distinguishing the subtypes of high-grade gliomas.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Madeleine Johansson, Fabrizio Ricci, Janin Schulte, Margaretha Persson, Olle Melander, Richard Sutton, Viktor Hamrefors, Artur Fedorowski
Summary: Postural orthostatic tachycardia syndrome (POTS) is associated with lower growth hormone (GH) levels, which are inversely related to impairment of daily life activities in POTS patients. Additionally, higher supine diastolic blood pressure is inversely associated with GH levels in both POTS and healthy individuals.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Joshua D. Palmer, Gordon Chavez, Wesley Furnback, Po-Ya Chuang, Bruce Wang, Christina Proescholdt, Chao-Hsiun Tang
Summary: This study is the largest real-world study of patient-reported quality of life in GBM and TTFields treatment to date. It shows unsurprising negative associations between quality of life and disease progression and older age, as well as more novel, positive associations between quality of life and longer time since diagnosis and time using TTFields therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Min Zhao, Kai Li, Hongchuan Niu, Yuanli Zhao, Changyu Lu
Summary: This study used case data analysis to examine changes in hormone levels before and after surgery in patients with pituitary adenoma and investigated the influence of various factors on endocrine function. The findings show that surgical intervention effectively improves endocrine disorders in these patients, with preoperative management of hormone levels facilitating postoperative remission. Multiple surgeries and an extended interval between hormone retesting and surgery can affect postoperative cortisol secretion function.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Per Wagstroem, Asa Nilsdotter-Augustinsson, Mats Nilsson, Janne Bjoerkander, Charlotte Dahle, Sofia Nystroem
Summary: Individuals with immunoglobulin G deficiency (IgGsd) often experience fatigue, which is closely related to the need for immunoglobulin replacement therapy (IgRT) and dysregulation of inflammatory markers. Low quality of life and high levels of fatigue were observed in IgGsd patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Amir El Rahal, Debora Cipriani, Christian Fung, Marc Hohenhaus, Lukas Sveikata, Jakob Straehle, Mukesch Johannes Shah, Henrik Dieter Heiland, Juergen Beck, Oliver Schnell
Summary: This study investigated risk factors, treatment options, and outcomes for tumor-associated hydrocephalus in glioblastoma patients over a 10-year period. Ventricular system opening during a previous tumor resection was identified as a risk factor for communicating hydrocephalus. Ventricular shunting improved hydrocephalus symptoms in 95% of patients and led to restoration of Karnofsky Performance Score.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Andrew B. Lassman, Stephanie L. Pugh, Tony J. C. Wang, Kenneth Aldape, Hui K. Gan, Matthias Preusser, Michael A. Vogelbaum, Erik P. Sulman, Minhee Won, Peixin Zhang, Golnaz Moazami, Marian S. Macsai, Mark R. Gilbert, Earle E. Bain, Vincent Blot, Peter J. Ansell, Suvajit Samanta, Madan G. Kundu, Terri S. Armstrong, Jeffrey S. Wefel, Clemens Seidel, Filip Y. de Vos, Sigmund Hsu, Andres F. Cardona, Giuseppe Lombardi, Dmitry Bentsion, Richard A. Peterson, Craig Gedye, Veronique Bourg, Antje Wick, Walter J. Curran, Minesh P. Mehta
Summary: The use of depatux-m in newly diagnosed glioblastomas (GBMs) with epidermal growth factor receptor gene amplification (EGFR-amp) did not improve overall survival (OS), but showed a longer progression-free survival. There were safety risks associated with the treatment, leading to treatment discontinuation for some patients.
Article
Oncology
Khe Hoang-Xuan, Martina Deckert, Andres J. M. Ferreri, Julia Furtner, Jaime Gallego Perez-Larraya, Roger Henriksson, Andreas F. Hottinger, Benjamin Kasenda, Florence Lefranc, Alexander Lossos, Catherine McBain, Matthias Preusser, Patrick Roth, Roberta Ruda, Uwe Schlegel, Riccardo Soffietti, Carole Soussain, Martin J. B. Taphoorn, Valerie Touitou, Michael Weller, Jacoline E. C. Bromberg
Summary: The management of primary central nervous system lymphoma (PCNSL) is a controversial topic in neuro-oncology. The European Association of Neuro-Oncology (EANO) formed a multidisciplinary task force to update the evidence-based guidelines and include immunosuppressed patients. The guideline provides consensus considerations and recommendations for the treatment of PCNSL, including intraocular manifestations and specific management of the elderly.
Article
Oncology
Emilie Le Rhun, Felix Boakye Oppong, Martin van den Bent, Wolfgang Wick, Alba A. Brandes, Martin J. B. Taphoorn, Michael Platten, Ahmed Idbaih, Paul M. Clement, Matthias Preusser, Vassilis Golfinopoulos, Thierry Gorlia, Michael Weller
Summary: This study retrospectively analyzed the incidence of lomustine-induced thrombocytopenia and its impact on treatment exposure and survival in patients with recurrent glioblastoma. The results showed that thrombocytopenia induced by lomustine is a major limitation to adequate exposure to lomustine chemotherapy and is associated with inferior progression-free survival, particularly in patients with MGMT promoter-methylated tumors.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Maximilian J. Mair, Anna S. Berghoff, Priscilla K. Brastianos, Matthias Preusser
Summary: Meningiomas are the most frequently diagnosed intracranial neoplasms and surgical resection is the common treatment method. However, there is limited research on pharmacotherapy for meningiomas.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Marie Morfouace, Peter Horak, Simon Kreutzfeldt, Aleksandra Stevovic, Teresa de Rojas, Evgeniya Denisova, Barbara Hutter, Francisco Bautista, Anne -Sophie Defachelles, Jeff White, Julio Oliveira, Bernd Kasper, Matthias Preusser, Vassilis Golfinopoulos, Stefan Pfister, Winette Van der Graaf, Eva Wardelmann, Patrick Shenjere, Stefan Froehling, Martin G. McCabe
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
David Capper, Guido Reifenberger, Pim J. French, Leonille Schweizer, Michael Weller, Mehdi Touat, Simone P. Niclou, Philipp Euskirchen, Christine Haberler, Monika E. Hegi, Sebastian Brandner, Emilie Le Rhun, Roberta Ruda, Marc Sanson, Ghazaleh Tabatabai, Felix Sahm, Patrick Y. Wen, Pieter Wesseling, Matthias Preusser, Martin J. van den Bent
Summary: The mainstay of treatment for adult patients with gliomas, glioneuronal and neuronal tumors consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic cancers, targeted treatments are a part of the standard of care, however, the predictive significance of most of these targets in central nervous system (CNS) tumors remains less well-studied.
Editorial Material
Oncology
Matthias Preusser, Martin J. van den Bent
Article
Oncology
Elisabeth S. Bergen, Alexander Friedrich, Peter Scherleitner, Pedro Ferreira, Barbara Kiesel, Georg Widhalm, Barbara Kiesewetter, Franziska Eckert, Gerald W. Prager, Matthias Preusser, Anna S. Berghoff
Summary: The prognosis of brain metastases from hepatopancreatobiliary tumors is very limited, with poor outcomes. Negative prognostic factors identified include performance status, age, and leptomeningeal carcinomatosis.
CLINICAL & EXPERIMENTAL METASTASIS
(2023)
Review
Oncology
Felix Sahm, Sebastian Brandner, Luca Bertero, David Capper, Pim J. French, Dominique Figarella-Branger, Felice Giangaspero, Christine Haberler, Monika E. Hegi, Bjarne W. Kristensen, Kathreena M. Kurian, Matthias Preusser, Bastiaan B. J. Tops, Martin van den Bent, Wolfgang Wick, Guido Reifenberger, Pieter Wesseling
Summary: In the 5th edition of the WHO CNS tumor classification, molecular characteristics have become important diagnostic criteria for many CNS tumor types. This guideline focuses on the methods used for diagnosing gliomas, glioneuronal, and neuronal tumors using informative molecular markers. Various molecular methods are discussed, including next-generation sequencing, methylation profiling, and immunohistochemistry. The guideline also covers the analysis of MGMT promoter methylation status, and provides an overview of the advantages, limitations, and requirements of different assays. The importance of molecular diagnostic testing in neuro-oncology is emphasized, along with discussions on clinical relevance, accessibility, cost, and ethical aspects.
Article
Medicine, General & Internal
Gerald Gartlehner, Eva Schernhammer, Sigurd F. Lax, Matthias Preusser, Herbert Bachler, Harald Tietzer, Maria Kletecka-Pulker, Helga Turnher, Uwe Siebert
Summary: Colorectal cancer screening in Austria is currently opportunistic and the Austrian National Committee for Cancer Screening has developed evidence-based recommendations for an organized nationwide screening program. The recommendations suggest that adults aged 45-75 should undergo either a 10-year screening colonoscopy or biennial fecal immunochemical tests. Screening decisions for individuals aged 65 and older should be based on their overall health, prior screening history, and preferences.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Oncology
Maximilian J. Mair, Agnieszka Maj-Hes, Alina Nussbaumer-Proell, Rainer Puhr, Agnieszka Christenheit, Marlene Troch, Hannah C. Puhr, Angelika M. Starzer, Ariane Steindl, Sabine Eberl, Helmuth Haslacher, Thomas Perkmann, Christoph Minichsdorfer, Gerald W. Prager, Wolfgang W. Lamm, Anna S. Berghoff, Barbara Kiesewetter, Markus Zeitlinger, Matthias Preusser, Markus Raderer
Summary: This study aimed to investigate the preventive effect of azithromycin on COVID-19 infection in cancer patients, but due to low acceptance and low incidence of infection, the study was prematurely closed. Nevertheless, azithromycin had a favorable side effect profile in cancer patients.
INFECTIOUS AGENTS AND CANCER
(2023)
Editorial Material
Oncology
Matthias Preusser, Marjolein Geurts, Johannes A. Hainfellner, Martin J. van den Bent
Correction
Medicine, General & Internal
Gerald Gartlehner, Eva Schernhammer, Sigurd F. Lax, Matthias Preusser, Herbert Bachler, Harald Titzer, Maria Kletecka-Pulker, Helga Turnher, Uwe Siebert
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Oncology
J. M. Berger, A. Alany, L. Berchtold, R. Puhr, A. Friedrich, B. Scheiner, G. W. Prager, M. Preusser, A. S. Berghoff, E. S. Bergen
Summary: This study identified liver and peritoneal metastases as well as portal vein obstruction as prognostic factors after ascites diagnosis in metastatic pancreatic cancer patients. Continuation of systemic therapy after ascites diagnosis was associated with longer overall survival.
Article
Hematology
Stephan Nopp, Florian Moik, Simon Kraler, Cornelia Englisch, Matthias Preusser, Arnold von Eckardstein, Ingrid Pabinger, Thomas F. Luescher, Cihan Ay
Summary: GDF-15 is strongly associated with survival in cancer patients, independent of established risk factors. Although an association was identified with ATE and VTE in univariable analysis, GDF-15 was not independently associated with these outcomes and failed to improve established VTE prediction models.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)