Article
Oncology
Emilie Le Rhun, Felix Boakye Oppong, Maureen Vanlancker, Roger Stupp, Burt Nabors, Olivier Chinot, Wolfgang Wick, Matthias Preusser, Thierry Gorlia, Michael Weller
Summary: Myelosuppression during temozolomide chemoradiotherapy is associated with the survival of patients with newly diagnosed glioblastoma. Female patients experience more marrow toxicity than males. Lymphopenia is related to the overall survival of patients.
Article
Oncology
Roberto Mapelli, Chiara Julita, Sofia Paola Bianchi, Nicolo Gallina, Raffaella Lucchini, Martina Midulla, Flavia Puci, Jessica Saddi, Sara Trivellato, Denis Panizza, Elena De Ponti, Stefano Arcangeli
Summary: This study found that treatment-related lymphopenia does not adversely affect overall survival in glioblastoma patients. Factors affecting survival included age, sex, extent of surgery, access to chemotherapy, and certain dose parameters. Prospective studies are needed to confirm these findings.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Immunology
Laurence Don Wai Luu, Ling Zhong, Sandeep Kaur, Mark J. Raftery, Ruiting Lan
Summary: The Bordetella genus is divided into classical and non-classical groups. Phosphorylation plays a key role in regulating metabolism and virulence pathways in Bordetella. The phosphorylation of key virulence regulator BvgA may be important in fine-tuning virulence gene expression and distinguishing classical from non-classical Bordetella species.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Dendi Krisna Nugraha, Takashi Nishida, Yuki Tamaki, Yukihiro Hiramatsu, Hiroyuki Yamaguchi, Yasuhiko Horiguchi
Summary: In this study, it was found that the Bvg(-) phase of the pathogenic bacterium Bordetella bronchiseptica survives and proliferates in coculture with the environmental amoeba Acanthamoeba castellanii, while the Bvg(+) phase does not. Furthermore, the amoeba predates on two Bvg(+) phase-specific virulence factors of Bordetella bronchiseptica. These findings suggest that the Bvg(-) phase of the bacterium has an advantage in survival outside mammalian hosts and that it can utilize protists as transient hosts in natural environments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Nalee Kim, Do Hoon Lim, Jung Won Choi, Jung-Il Lee, Doo-Sik Kong, Do-Hyun Nam, Ho Jun Seol
Summary: The study aimed to investigate the outcomes of hypofractionated radiotherapy (HypoRT) in patients with glioblastoma (GBM) receiving concurrent temozolomide. The results showed that HypoRT had comparable progression-free survival and overall survival to conventionally fractionated radiotherapy (ConvRT), and significantly reduced the occurrence of lymphopenia.
YONSEI MEDICAL JOURNAL
(2023)
Article
Immunology
Xuefeng Li, Yee Huang, Jiaying Sun, Xiaoping Yu, Xiangfei Xu, Xuemei Cui, Ke Li, Quanan Ji, Yan Liu, Guolian Bao
Summary: In this study, a stable OMV vaccine was prepared by coating OMVs with chitosan nanoparticles (CNP-OMV). The CNP-OMV showed a homogenous core-shell structure with a size of 139 nm. In vivo and in vitro experiments demonstrated that CNP-OMV significantly enhanced immune protection and anti-infection efficacy against Bordetella bronchiseptica.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Nicholas J. First, Jose Pedreira-Lopez, Manuel R. F. San-Silvestre, Katelyn M. Parrish, Xiao-Hong Lu, Monica C. Gestal
Summary: In this study, it was found that inhibition of VIP/VPAC2 signaling can promote clearance of Bordetella species and reduce bacterial burden. Treatment with VPAC2 antagonists can decrease lung pathology and suggest that T3SS may serve as a therapeutic target for other gram-negative bacteria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Aleksandra Petrovic Fabijan, Verica Aleksic Sabo, Damir Gavric, Zsolt Doffkay, Gabor Rakhely, Petar Knezevic
Summary: This study examined B. bronchiseptica phages for their ability to inhibit bacterial growth and biofilm formation, showing that they have potential in these aspects but are not suitable for therapy due to their temperate nature and lysogenic conversion of the host bacterium.
Editorial Material
Biochemistry & Molecular Biology
Kirit Singh, Kelly M. Hotchkiss, Ian F. Parney, John De Groot, Solmaz Sahebjam, Nader Sanai, Michael Platten, Evanthia Galanis, Michael Lim, Patrick Y. Wen, Giuseppe Minniti, Howard Colman, Timothy F. Cloughesy, Minesh P. Mehta, Marjolein Geurts, Isabel Arrillaga-Romany, Annick Desjardins, Kirk Tanner, Susan Short, David Arons, Elizabeth Duke, Wolfgang Wick, Stephen J. Bagley, David M. Ashley, Priya Kumthekar, Roel Verhaak, Anthony J. Chalmers, Anoop P. Patel, Colin Watts, Peter E. Fecci, Tracy T. Batchelor, Michael Weller, Michael A. Vogelbaum, Matthias Preusser, Mitchel S. Berger, Mustafa Khasraw
Summary: A breakthrough in drug discovery for glioblastoma necessitates the consecutive collection of central nervous system tissue through window of opportunity trials.
Article
Veterinary Sciences
Helena Rylander, Dylan M. Djani, Starr Cameron
Summary: This paper investigates the clinical presentation, treatment, and recovery process of a 15-month-old neutered Wirehaired Pointer mixed-breed dog with bacterial meningitis, emphasizing the importance of cerebrospinal fluid culture for diagnosis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Microbiology
Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Stephanie Longet, Egbert Mundt, Stephane Paul
Summary: Bordetella pertussis and Bordetella bronchiseptica are responsible for whooping cough in humans and chronic cough in dogs, respectively. Both can evade host immune responses, but this ability is more pronounced in B. bronchiseptica. Collaborative efforts between veterinary and human medical fields are essential to control these infections.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Article
Microbiology
Jasmina M. Luczo, Illiassou Hamidou Soumana, Katie L. Reagin, Preston Dihle, Elodie Ghedin, Kimberly D. Klonowski, Eric T. Harvill, Stephen M. Tompkins
Summary: This study demonstrates that B. bronchiseptica efficiently colonizes the nasal cavity and displaces the commensal microbiota, thereby preventing influenza A virus infection. B. bronchiseptica-mediated interference can also alter host immune responses and infection outcomes. These findings suggest the potential for respiratory pathogen-mediated interference to control influenza A virus replication in the upper respiratory tract.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Cansheng Yuan, Lingling Zhao, Lu Tong, Lin Wang, Zhuang Ke, Ying Yang, Jian He
Summary: This study investigated the degradation of picolinic acid (PA) by a reference strain of Bordetella genus. The study found that the organization of the pic gene cluster in strain RB50 is similar to that of Alcaligenes faecalis. The enzyme PicC(RB50) was able to efficiently transform 3,6-dihydroxypicolinic acid to 2,5-dihydroxypyridine. These findings provide new insights into the biodegradation of PA by Bordetella pathogens.
Article
Microbiology
Monica C. Gestal, Laura K. Howard, Kalyan K. Dewan, Eric T. Harvill
Summary: Infectious diseases are a significant health issue in the United States, and finding more effective vaccine strategies is crucial. Bordetella bacteria suppress host immunity to establish persistent colonization, but disrupting these mechanisms could result in stronger immune responses. Current Bordetella vaccines provide only short-term protection, while a universal vaccine could reduce the burden of infection. Research reveals that disrupting bacterial immunomodulatory pathways can generate stronger and more protective immune responses.
Article
Veterinary Sciences
Amanda Collins, Rachel A. Bear, Amritha Mallikarjun, Sarah A. Kane, Jennifer L. Essler, Patricia Kaynaroglu, Rebecca Feuer, Jordan G. Smith, Cynthia M. Otto
Summary: This study investigated the impact of vaccines on the olfactory capabilities and behavior of dogs. Dogs that were initially vaccinated orally and then with intranasal vaccine 28 days later were slower in finding the target odor. The intranasal vaccine did not affect the odor threshold or time spent searching for odor, but behavioral factors were found to be closely related to the time spent finding the target odor.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Meeting Abstract
Hematology
Roni Tamari, Christina Cho, Patrick Hilden, Molly Maloy, Taylor Borrill, Ioannis Politikos, Genovefa A. Papanicolaou, Ann A. Jakubowski, Boglarka Gyurkocza, Brian C. Shaffer, Esperanza B. Papadopoulos, Doris M. Ponce, James W. Young, Parastoo B. Dahi, Gunjan L. Shah, Craig S. Sauter, Hugo Castro-Malaspina, Sergio A. Giralt, Miguel-Angel Perales
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Meeting Abstract
Hematology
Rocco Richards, Leslie Cheteyan, Esperanza B. Papadopoulos, Ann A. Jakubowski, Hugo Castro-Malaspina, Genovefa A. Papanicolaou, Yeon Joo Lee
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Meeting Abstract
Hematology
Carmen Lau, Ioannis Politikos, Sean M. Devlin, Alexandra G. Jacob, Molly Maloy, Kristine Naputo, Aishat Afuye, Valkal Bhatt, Parastoo B. Dahi, Miguel-Angel Perales, Sergio A. Giralt, Richard J. O'Reilly, Doris M. Ponce, Susan E. Prockop, Gunjan L. Shah, Genovefa A. Papanicolaou, Andromachi Scaradavou, Juliet N. Barker
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Infectious Diseases
David J. Epstein, Susan K. Seo, Janice M. Brown, Genovefa A. Papanicolaou
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Infectious Diseases
David J. Epstein, Susan K. Seo, Yao-Ting Huang, Jay H. Park, Virginia M. Klimek, Ellin Berman, Martin S. Tallman, Mark G. Frattini, Genovefa A. Papanicolaou
JOURNAL OF INFECTION
(2018)
Article
Medicine, General & Internal
Drew J. Winston, Kathleen M. Mullane, Oliver A. Cornely, Michael J. Boeckh, Janice Wes Brown, Steven A. Pergam, Igoris Trociukas, Pavel Zak, Michael D. Craig, Genovefa A. Papanicolaou, Juan D. Velez, Jens Panse, Kimberly Hurtado, Doreen A. Fernsler, Jon E. Stek, Lei Pang, Shu-Chih Su, Yanli Zhao, Ivan S. F. Chan, Susan S. Kaplan, Janie Parrino, Ingi Lee, Zoran Popmihajlov, Paula W. Annunziato, Ann Arvin
Article
Immunology
Claudia Rosillo, Ana Maria Avila, Yao-Ting Huang, Sean Devlin, Christina Cho, Juan Montoro, Molly A. Maloy, Genovefa A. Papanicolaou, Pere Barba, Miguel-Angel Perales
TRANSPLANT INFECTIOUS DISEASE
(2018)
Article
Immunology
Seong Jin Kim, Yao-Ting Huang, Julia Foldi, Yeon Joo Lee, Molly Maloy, Sergio A. Giralt, Ann A. Jakubowski, Genovefa A. Papanicolaou
TRANSPLANT INFECTIOUS DISEASE
(2018)
Article
Immunology
Yeon Joo Lee, Melissa Bacchus, Elizabeth Schmidt, Mohit Chawla, Juliet N. Barker, Genovefa A. Papanicolaou
TRANSPLANT INFECTIOUS DISEASE
(2018)
Article
Immunology
Yeon Joo Lee, Dionysios Neofytos, Seong Jin Kim, Leslie Cheteyan, Yao-Ting Huang, Esperanza B. Papadopoulos, Ann A. Jakubowski, Genovefa A. Papanicolaou
TRANSPLANT INFECTIOUS DISEASE
(2018)
Editorial Material
Hematology
Genovefa Papanicolaou
LANCET HAEMATOLOGY
(2018)
Meeting Abstract
Surgery
D. Florescu, M. Grimley, G. Papanicolaou, V. Prasad, E. Vainorius, G. Chittick, T. Brundage, G. Nichols
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Article
Immunology
Yeon Joo Lee, Yao-Ting Huang, Seong Jin Kim, Marina Kerpelev, Victoria Gonzalez, Anna Kaltsas, Genovefa Papanicolaou
CLINICAL INFECTIOUS DISEASES
(2018)
Article
Hematology
Yao-Ting Huang, Seong Jin Kim, Yeon Joo Lee, Daniel Burack, Paige Nichols, Molly Maloy, Miguel-Angel Perales, Sergio A. Giralt, Ann A. Jakubowski, Genovefa A. Papanicolaou
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2017)
Review
Biophysics
C. E. Dandoy, M. I. Ardura, G. A. Papanicolaou, J. J. Auletta
BONE MARROW TRANSPLANTATION
(2017)