Article
Oncology
Jodi Goldman, Akifumi Hagiwara, Jingwen Yao, Catalina Raymond, Christian Ong, Rojin Bakhti, Elizabeth Kwon, Maguy Farhat, Carlo Torres, Lily G. Erickson, Brandon J. Curl, Maggie Lee, Whitney B. Pope, Noriko Salamon, Phioanh L. Nghiemphu, Matthew Ji, Blaine S. Eldred, Linda M. Liau, Albert Lai, Timothy F. Cloughesy, Caroline Chung, Benjamin M. Ellingson
Summary: In newly diagnosed IDH wild-type GBM patients with measurable enhancing lesions, an enigmatic non-response in rCBV was associated with longer PFS, particularly in MGMT methylated patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Maria del Mar Alvarez-Torres, Elies Fuster-Garcia, Carmen Balana, Josep Puig, Juan M. Garcia-Gomez
Summary: Despite comprehensive treatment with surgery, chemotherapy, and radiotherapy, glioblastoma patients still face a poor prognosis. Extending adjuvant chemotherapy may benefit patients with moderate vascularity and methylated MGMT, but does not show benefits for highly vascular tumors, even in the presence of MGMT methylation.
Review
Biochemistry & Molecular Biology
Yongjun Kou, Feng Geng, Deliang Guo
Summary: This review summarizes the recent progress in understanding lipid metabolism regulation in GBM and discusses novel strategies to induce lipotoxicity in tumor cells by disrupting lipid storage. These findings provide new directions for treating GBM.
Article
Oncology
Jerrold L. Boxerman, Bradley S. Snyder, Daniel P. Barboriak, Kathleen M. Schmainda
Summary: This study aimed to determine whether early change in cerebral blood volume from baseline (Delta CBV) could further stratify the T1 non-progressors according to overall (OS) and progression-free (PFS) survival. The results showed that increasing CBV at 2 weeks was associated with worse PFS and OS, while T1 response status (stable vs. decreasing enhancement) was not. Delta CBV at 2 weeks was also a good prognostic marker for OS-1 and PFS-6. Combining T1 progression and Delta CBV may yield a response assessment paradigm with 3-tiered OS stratification.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Jack M. Shireman, Fatemeh Atashi, Gina Lee, Eunus S. Ali, Miranda R. Saathoff, Cheol H. Park, Sol Savchuk, Shivani Baisiwala, Jason Miska, Maciej S. Lesniak, C. David James, Roger Stupp, Priya Kumthekar, Craig M. Horbinski, Issam Ben-Sahra, Atique U. Ahmed
Summary: Glioblastoma is a primary brain cancer with a near 100% recurrence rate. A molecular circuit involving the interaction between ARL13B and IMPDH2 has been identified, which affects the efficacy of chemotherapy.
Article
Oncology
Tanguy Duval, Jean-Albert Lotterie, Anthony Lemarie, Caroline Delmas, Fatima Tensaouti, Elizabeth Cohen-Jonathan Moyal, Vincent Lubrano
Summary: This study evaluated the sensitivity of quantitative diffusion and perfusion MRI to glioblastoma stem-like cells (GSCs) in the hyperintensities-FLAIR region and found that ADC and rCBV are good predictors of GSC presence and aggressiveness.
Article
Clinical Neurology
Joga Chaganti, Michael Taylor, Hannah Woodford, Timothy Steel
Summary: The study demonstrated significant differences in rCBV and PSR values between HGG and PCNSL patients, suggesting their potential for differentiation of these two types of tumors. Incorporating perfusion in routine MRI of contrast-enhancing lesions could significantly impact patient management.
WORLD NEUROSURGERY
(2021)
Review
Oncology
Clara Le Fevre, Jean-Marc Constans, Isabelle Chambrelant, Delphine Antoni, Caroline Bund, Benjamin Leroy-Freschini, Roland Schott, Helene Cebula, Georges Noel
Summary: This review presents various imaging techniques and potential imaging biomarkers to differentiate pseudoprogression from true progression, improving diagnostic accuracy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Cecile Alanio, Zev A. Blinder, Renee B. Chang, MacLean P. Nasrallah, Devora Delman, Joey H. Li, Oliver Y. Tang, Logan Y. Zhang, Jiasi Vicky Zhang, E. John Wherry, Donald M. O. Rourke, Gregory L. Beatty
Summary: The study found that T cells in the perivascular regions of recurrent GBM were enriched and activated, and their presence was associated with outcomes, indicating that these T cells may be potential therapeutic targets.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Physics, Applied
Rachel K. Luu, Marcin Wysokowski, Markus J. Buehler
Summary: This paper presents a series of deep learning models for solving complex forward and inverse design problems in molecular modeling and design. By using diffusion models inspired by nonequilibrium thermodynamics and attention-based transformer architectures, a flexible framework to capture complex chemical structures is demonstrated. These models are trained on the QM9 dataset and then generalized to study and design key properties of deep eutectic solvents (DESs). The integrated fully prompt-based multi-task generative pretrained transformer model has the best performance and allows for flexible integration of multiple objectives, suggesting emerging synergies during training.
APPLIED PHYSICS LETTERS
(2023)
Article
Cell Biology
Katharina M. Eyme, Alessandro Sammarco, Roshani Jha, Hayk Mnatsakanyan, Caline Pechdimaljian, Litia Carvalho, Rudolph Neustadt, Charlotte Moses, Ahmad Alnasser, Daniel F. Tardiff, Baolong Su, Kevin J. Williams, Steven J. Bensinger, Chee Yeun Chung, Christian E. Badr
Summary: Deregulated de novo lipid synthesis (DNLS) is a potential target for therapeutic intervention in glioblastoma (GBM), but the mechanisms underlying susceptibility to DNLS-targeted therapies are unknown and brain-penetrant inhibitors of DNLS are lacking.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Hye Jin Yun, Min Li, Dong Guo, So Mi Jeon, Su Hwan Park, Je Sun Lim, Su Bin Lee, Rui Liu, Linyong Du, Seok-Ho Kim, Tae Hwan Shin, Seong-il Eyun, Yun-Yong Park, Zhimin Lu, Jong-Ho Lee
Summary: This study reveals that enhanced glucose-derived de novo serine biosynthesis is a critical metabolic feature of GBM cells under metabolic stress, and highlights the potential to target SSP for treating human GBM.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Kathleen M. Schmainda, Melissa A. Prah, Helga Marques, Eunhee Kim, Daniel P. Barboriak, Jerrold L. Boxerman
Summary: In this study, the effects of bevacizumab or placebo on cerebral blood flow parameters in newly diagnosed glioblastoma patients undergoing standard therapy were evaluated. Bevacizumab significantly changed rCBV but not K-trans early posttreatment, and high pretreatment rCBV predicted improved overall survival in patients treated with bevacizumab.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sinan Sahin, Ersen Ertekin, Tuna Sahin, Yelda Ozsunar
Summary: The study aimed to investigate how the normal appearing white matter (NAWM) in glioblastoma patients changed after chemo-radiotherapy (CRT) using multiparametric MRI. The results showed significant decreases in FA, rCBV, rCBF, and ASL values in perilesional NAWM in the first 3 months post-treatment, followed by a plateau and gradual increase towards pretreatment levels. Similar but milder changes were observed in other NAWM areas, and ADC values also showed a plateau pattern after an initial increase. Further research is needed to explain late pathophysiological changes and the study supports the use of ASL perfusion instead of contrast enhanced perfusion methods based on high correlations observed in the results.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Leland S. Hu, Lujia Wang, Andrea Hawkins-Daarud, Jennifer M. Eschbacher, Kyle W. Singleton, Pamela R. Jackson, Kamala Clark-Swanson, Christopher P. Sereduk, Sen Peng, Panwen Wang, Junwen Wang, Leslie C. Baxter, Kris A. Smith, Gina L. Mazza, Ashley M. Stokes, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Alyx B. Porter, Maciej M. Mrugala, Joseph M. Hoxworth, Teresa Wu, Nhan L. Tran, Kristin R. Swanson, Jing Li
Summary: The study developed a radiogenomics machine learning model to quantify uncertainty and predict EGFR amplification status, aiming to address intratumoral genetic heterogeneity and improve personalized therapeutic paradigms. The model used probability distributions to quantify uncertainty for each sample prediction and implemented transductive learning to reduce overall uncertainty.
SCIENTIFIC REPORTS
(2021)
Letter
Clinical Neurology
Stefan Weidauer, Nadja Treusch, Elke Hattingen
CLINICAL NEURORADIOLOGY
(2022)
Article
Neurosciences
Lucie Friedauer, Christian Foerch, Joachim Steinbach, Elke Hattingen, Patrick N. Harter, Moritz Armbrust, Hans Urban, Eike Steidl, Elisabeth Neuhaus, Sophie von Brauchitsch
Summary: This study defines the acute superficial siderosis syndrome and describes its typical imaging and histopathological characteristics. Early recognition of this syndrome may help eliminate the source of bleeding in a timely manner to prevent clinical deterioration.
Article
Clinical Neurology
Alexander Grote, Dieter-Henrik Heiland, Julia Taube, Christoph Helmstaedter, Vidhya M. Ravi, Paulina Will, Elke Hattingen, Jan-Ruediger Schuere, Juri-Alexander Witt, Annika Reimers, Christian Elger, Johannes Schramm, Albert J. Becker, Daniel Delev
Summary: This study identifies a distinct mesial-temporal lobe epilepsy syndrome called "innate inflammatory gliosis only" characterized by chronic inflammation associated with astrocytes. Patients with this syndrome have poor seizure and neuropsychological outcomes after surgery compared to patients with hippocampus sclerosis. The findings suggest that this syndrome requires innovative pharmacotreatment strategies.
Article
Clinical Neurology
Makoto Kiyose, Eva Herrmann, Jenny Roesler, Pia S. Zeiner, Joachim P. Steinbach, Marie-Therese Forster, Karl H. Plate, Marcus Czabanka, Thomas J. Vogl, Elke Hattingen, Michel Mittelbronn, Stella Breuer, Patrick N. Harter, Simon Bernatz
Summary: By using MRI measurements and histopathological analysis, we can predict the primary tumor origin of brain metastases in a non-invasive manner and differentiate different types of brain metastases based on their proliferative status.
Article
Cardiac & Cardiovascular Systems
Martin A. Schaller-Paule, Daniel Fritz, Jan Hendrik Schaefer, Elke Hattingen, Christian Foerch, Alexander Seiler
Summary: This study investigated the distribution pattern of cortical ischemic stroke lesions and found that in hospitalized patients, cortical brain infarcts are predominantly located in brain structures associated with motor control and sensory and language function. Matching underrepresented cerebral cortex regions to symptoms not yet associated with stroke warrants further exploration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Hartmut Vatter, Erdem Gueresir, Ralph Koenig, Gregor Durner, Rolf Kalff, Patrick Schuss, Thomas E. Mayer, Juergen Konczalla, Elke Hattingen, Volker Seifert, Joachim Berkefeld
Summary: Cerebral vasospasm after aneurysmal subarachnoid hemorrhage is often treated with invasive endovascular therapy. However, a prospective randomized multicenter trial found that conservative therapy may lead to better clinical outcomes at 6 months compared to invasive treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
K. Bouhadjer, L. V. Romo, M. J. Brennan, B. M. Kozak, E. Hattingen, A. F. Juliano, H. D. Curtin, K. L. Reinshagen
Summary: Small vestibular aqueducts are more frequently seen in patients without Ménière disease and have no correlation with symptoms such as hearing loss and vertigo.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Review
Clinical Neurology
Stefan Weidauer, Elisabeth Neuhaus, Elke Hattingen
Summary: This article provides an overview of the neuroradiological features, clinical symptoms, and differential diagnostic considerations of the two types of superficial siderosis (SS) of the central nervous system (infratentorial and cortical).
CLINICAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Maximilian Rauch, Jan-Ruediger Schuere, Franziska Lieschke, Fee Keil, Eike Steidl, Se-Jong You, Christian Foerch, Elke Hattingen, Stefan Weidauer, Martin A. Schaller-Paule
Summary: This study re-evaluated the relationship between thalamic infarct localization and clinical symptoms using vascular and functional territorial thalamic maps. The results showed that sensorimotor hemiparesis and neglect were predictive for a specific region of thalamic infarct, while hemisensory syndrome did not allow for specific localization.
CLINICAL NEURORADIOLOGY
(2023)
Article
Pediatrics
Katharina J. Wenger, Caroline E. Koldijk, Elke Hattingen, Luciana Porto, Wiebke Kurre
Summary: This study retrospectively characterized WMSAs in an unselected patient cohort at a large pediatric neuroimaging facility, aiming to learn more about the underlying disorders encountered in everyday clinical practice. The majority of WMSAs were acquired and were non-specific in brain MRI, followed by autoimmune disorders and non-genetic hypoxic and ischemic insults.
Article
Clinical Neurology
Panagiota-Eleni Tsalouchidou, Johann Philipp Zoellner, Annika Kirscht, Christina Julia Mueller, Christopher Nimsky, Maximilian Schulze, Elke Hattingen, Georgios Chatzis, Thomas M. Freiman, Adam Strzelczyk, Sven Fuest, Katja Menzler, Felix Rosenow, Susanne Knake
Summary: This study aimed to identify coexisting structural lesions in patients with epilepsy and known temporal encephaloceles (TEs). Results showed that TEs can occur with other lesions, potentially impacting surgical evaluation and approach. Additionally, TEs may be associated with malformations of cortical development.
Article
Clinical Neurology
P. F. Samp, F. Keil, R. du Mesnil, A. Birkhold, M. Kowarschik, E. Hattingen, J. Berkefeld
Summary: Detailed analysis of dural AVFs using the standardized display of 4D-DSA volumes was feasible and helpful in understanding the angioarchitecture in selected cases. However, limitations such as motion artifacts and suboptimal selection of the injected vessel were observed in some cases.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Correction
Oncology
Thomas Zeyen, Daniel Paech, Johannes Weller, Niklas Schaefer, Theophilos Tzaridis, Cathrina Duffy, Louisa Nitsch, Matthias Schneider, Anna-Laura Potthoff, Joachim Peter Steinbach, Peter Hau, Uwe Schlegel, Clemens Seidel, Dietmar Krex, Oliver Grauer, Roland Goldbrunner, Pia Susan Zeiner, Ghazaleh Tabatabai, Norbert Galldiks, Walter Stummer, Elke Hattingen, Martin Glas, Alexander Radbruch, Ulrich Herrlinger, Christina Schaub
JOURNAL OF NEURO-ONCOLOGY
(2023)
Letter
Clinical Neurology
Rafael Willems, Se-Jong You, Friederike Vollmer, Elke Hattingen, Stefan Weidauer
CLINICAL NEURORADIOLOGY
(2023)
Review
Neurosciences
Reinhold Nafe, Christophe T. Arendt, Elke Hattingen
Summary: The objective of this review article is to provide a comprehensive overview of the major features of human prion diseases, bridging the gap between basic research and clinical aspects. The article highlights current insights into the physiological functions of the prion protein and the process of pathological conversion. It discusses diagnostic, molecular, and clinical aspects of all human prion diseases, including rare diseases and potential transmission of prions from other species.
TRANSLATIONAL NEUROSCIENCE
(2023)