Article
Oncology
Jing-Ying Xu, Jun-Ni Chen, Jian Lei, Min Hu, San-Gang Wu, Juan Zhou
Summary: This study evaluated the value of local treatment in stage IVB cervical cancer patients and found that the addition of local surgery or radiotherapy to chemotherapy can improve survival outcomes.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Kenji Kuroda, Takahiro Toyokawa, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Hiroaki Tanaka, Shigeru Lee, Kazuya Muguruma, Masakazu Yashiro, Masaichi Ohira
Summary: This study investigated the correlation between systemic inflammatory response and long-term outcomes in gastric cancer patients and identified potential markers in stage II/III patients. The study found that maximum serum C-reactive protein (CRPmax) was an independent prognostic factor for overall survival and relapse-free survival, while maximum white blood cell count (WBCmax) and infectious complications were not. These findings suggest that CRPmax could be a promising prognostic indicator for stage II/III gastric cancer patients undergoing curative resection.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
William Tyler Turchan, Sean P. Pitroda, Ralph R. Weichselbaum
Summary: Radiotherapy and immunotherapy are most effective in treating cancer in the setting of low-volume disease. Further investigation of radio-immunotherapy in metastatic patients should focus upon patients with oligometastatic disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Bogdan Badic, Marie Morvan, Lucille Queneherve, Servane Bouzeloc, Tiphaine Kermarrec, Jean-Baptiste Nousbaum, Noemi Reboux
Summary: Pancreatic cancer is a deadly digestive cancer, and its incidence has been increasing in recent decades. A retrospective study analyzed data from 2117 patients in a digestive tumor registry and identified prognostic factors for survival, including age, surgery, chemotherapy, radiotherapy, and metastasis location. The study provides valuable insights into the management and treatment options for pancreatic cancer.
Article
Oncology
Walburga Yvonne Joko-Fru, Mirko Griesel, Nikolaus Christian Simon Mezger, Lucia Haemmerl, Tobias Paul Seraphin, Jana Feuchtner, Henry Wabinga, Guy N'da, Assefa Mathewos, Bakarou Kamate, Judith Nsonde Malanda, Freddy Houehanou Rodrigue Gnangnon, Gladys Chebet Chesumbai, Anne Korir, Cesaltina Lorenzoni, Annelle Zietsman, Margaret Ziona Borok, Biying Liu, Christoph Thomssen, Paul McGale, Ahmedin Jemal, Donald Maxwell Parkin, Eva Johanna Kantelhardt
Summary: This study aims to describe the cancer-directed therapy received by patients with breast cancer in sub-Saharan Africa, compare these results with the NCCN Harmonized Guidelines, and evaluate the impact on survival. The study found that access to adequate therapy and early-stage diagnosis were the most important determinants of survival for breast cancer patients in sub-Saharan Africa.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Review
Medicine, General & Internal
Lucian Mocan
Summary: Gastric cancer is the fifth most common cancer worldwide, with surgery being the only curative treatment. Early detection and screening combined with neoadjuvant therapy can reduce the incidence of gastric cancer, but patients are often diagnosed at an advanced stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Daniel J. Herr, David A. Elliott, Gillian Duchesne, Kristian D. Stensland, Megan E. V. Caram, Christina Chapman, Jennifer A. Burns, Brent K. Hollenbeck, Jordan B. Sparks, Chris Shin, Alexander Zaslavsky, Alexander Tsodikov, Ted A. Skolarus
Summary: This study aims to examine the 10-year clinical outcomes of patients with localized prostate cancer undergoing radiation therapy within a national healthcare system. The results showed improved survival rates for high-risk disease, providing important benchmarks for clinical decision-making.
Article
Surgery
Sa-Hong Min, Yongjoon Won, Kanghaeng Lee, Sang Il Youn, Guowei Kim, Young Suk Park, Sang-Hoon Ahn, Joong Do Park, Hyung-Ho Kim
Summary: Radical gastrectomy with metastasectomy may have a potential role in stage IV gastric cancer patients. Laparoscopic gastrectomy with metastasectomy in selected stage IV gastric cancer patients is safe and feasible.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Andras Piffko, Benedikt Asey, Lasse Duehrsen, Inka Ristow, Johannes Salamon, Harriet Wikman, Cecile L. Maire, Katrin Lamszus, Manfred Westphal, Thomas Sauvigny, Malte Mohme
Summary: Non-small cell lung cancer is the leading cause of cancer-related death globally, with an increasing incidence of brain metastases in NSCLC patients. This study identified systemic metastatic load and number of brain metastases as significant factors affecting overall survival in resectable NSCLC patients. Factors such as age, absence of other systemic metastases, and number of brain metastases were found to impact survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Nan-Nan Ji, Xiao-Wen Wu, Qian Cao, Rui Liu, Wei Tu, Yue-Can Zeng, Zhi-Hui Li
Summary: Through studying the data of patients with liver metastases from gastric cancer, it is found that cancer-directed surgery (CDS) can prolong the survival of patients.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Riccardo Giampieri, Luca Cantini, Michela Del Prete, Alessandro Bittoni, Enrica Giglio, Alessandra Mandolesi, Elena Maccaroni, Andrea Lanese, Tania Meletani, Maria Baleani, Renato Bisonni, Marina Scarpelli, Rossana Berardi
Summary: Despite advancements in novel drugs, patients with metastatic gastric cancer still face poor prognosis. This retrospective study of 184 patients found that factors such as lung metastases, intestinal histology, second line chemotherapy, and locoregional treatment were associated with improved overall survival and progression-free survival. This highlights the potential benefits of locoregional treatments in patients with limited metastases, offering a chance for extended survival in individuals with a typically shorter life expectancy.
Article
Oncology
Adrienne B. Shannon, Richard J. Straker, Luke Keele, Douglas L. Fraker, Robert E. Roses, John T. Miura, Giorgos C. Karakousis
Summary: The study found that in patients with gastric adenocarcinoma receiving neoadjuvant chemotherapy, retrieving at least 23 nodes during gastrectomy may improve the 5-year overall survival rate. Therefore, it is important to maintain adequate lymph node retrieval postoperatively for better prognostic prediction.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Xiaoyu Li, Dashan Ai, Yun Chen, Qi Liu, Jiaying Deng, Hongcheng Zhu, Ying Wang, Yue Wan, Yue Xie, Yanan Chen, Weiwei Chen, Jianhong Fan, Xiaoshen Wang, Xueguan Lu, Hongmei Ying, Xiayun He, Chaosu Hu, Kuaile Zhao
Summary: The study revealed different lymph node metastatic patterns in hypopharyngeal, pharyngoesophageal junction, and cervical esophageal cancers, with the latter having combined patterns of the former two. Involved field irradiation was found to be feasible in chemoradiotherapy for pharyngoesophageal junction cancers.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Giorgio Fiore, Leonardo Tariciotti, Giulio Andrea Bertani, Dario Gagliano, Antonio D'Ammando, Antonella Maria Ampollini, Luigi Schisano, Stefano Borsa, Mauro Pluderi, Marco Locatelli, Manuela Caroli
Summary: Brain metastases (BMs) are the most common malignant intracranial lesions, occurring in up to 40% of patients with solid tumors. There is a lack of evidence supporting the superiority of surgery or stereotactic radiosurgery (RS) as first-line treatment for solitary and oligometastatic brain disease. This systematic review with meta-analysis aims to provide a quantitative synthesis of the results of studies comparing the efficacy and safety of surgery and RS for localized metastatic brain disease. Evaluation: 7/10.
Article
Oncology
Malin Ljunggren, Caroline E. Weibull, Gabriella Palmer, Emerik Osterlund, Bengt Glimelius, Anna Martling, Caroline Nordenvall
Summary: This population-based study found that women with synchronous metastatic colorectal cancer (mCRC) were less likely to receive metastatic surgery and had slightly higher all-cause mortality compared to men.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Nursing
Soomin Hong, JuHee Lee, Jiyeon Lee, Jong Hee Chang, Chang Gi Park, Tae Hee Kim
Summary: This study aims to identify the characteristics of uncertainty in illness among people with primary malignant brain tumors through a mixed-methods systematic review. The results reveal that the progression of uncertainty in people with primary malignant brain tumors is complex and ambiguous due to physical, psychological, and social risk factors. The proposed model provides directions for nursing practice and future research.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Clinical Neurology
Myung Ji Kim, Hyun Ho Jung, Yong Bae Kim, Jong Hee Chang, Jin Woo Chang, Keun Young Park, Won Seok Chang
Summary: This study retrospectively analyzed data from 453 AVM patients and found that combined neoadjuvant or adjuvant embolization with GKRS treatment had better outcomes compared to GKRS alone, reducing the risk of bleeding during the latency period. Additionally, the study also found that neoadjuvant embolization may be a negative predictive factor for complete obliteration of AVMs more than 36 months after GKRS.
Article
Engineering, Biomedical
Yoon Kyung Cho, Chin Su Koh, Youjin Lee, Minkyung Park, Tae Jun Kim, Hyun Ho Jung, Jin Woo Chang, Sang Beom Jun
Summary: This study designed a brain-machine interface (BMI) system that uses sensory-related neural signals for control and combines it with electrical stimulation as reward. Electrodes were used to record electrocorticographic (ECoG) signals from the whisker-related somatosensory cortex of rats, which were then converted into BMI signals to control the movement of a dot on the screen. The rats were trained for 7 days using operant conditioning with medial forebrain bundle (MFB) electrical stimulation to learn the task of moving the dot towards the desired position.
BIOMEDICAL ENGINEERING LETTERS
(2023)
Article
Clinical Neurology
Chanho Kong, Ji Woong Ahn, Sohyun Kim, Ji Young Park, Young Cheol Na, Jin Woo Chang, Seungsoo Chung, Won Seok Chang
Summary: Focused ultrasound (FUS) is a promising non-invasive medical technology that stimulates the brain. This study investigated the effects of FUS-mediated blood-brain barrier (BBB) opening on hippocampal long-term potentiation (LTP) and cognitive function in a mouse model of Alzheimer's disease. The results showed that FUS-mediated BBB opening increased LTP and improved cognitive function.
Article
Biochemistry & Molecular Biology
Younghee Seo, Sangheon Han, Byeong-Wook Song, Jin Woo Chang, Young Cheol Na, Won Seok Chang
Summary: This study investigated the activation of eNSCs and adult neurogenesis after low-intensity focused ultrasound (LIFUS) treatment, and found that LIFUS could activate eNSCs and promote the generation of adult neurons, suggesting its potential as a treatment for neurological damage and disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yae Won Park, Kyunghwa Han, Sooyon Kim, Hyuk Kwon, Sung Soo Ahn, Ju Hyung Moon, Eui Hyun Kim, Jinna Kim, Seok-Gu Kang, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee
Summary: This study investigated prognostic factors in adult glioma patients with leptomeningeal metastases. It found that chemotherapy and antiangiogenic therapy were associated with longer overall survival, while male sex and initial leptomeningeal metastases were associated with shorter survival.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Won Ick Chang, Hwa Kyung Byun, Joo Ho Lee, Chul-Kee Park, In Ah Kim, Chae-Yong Kim, Jong Hee Chang, Seok-Gu Kang, Sang Hyung Lee, Yuki Kuranari, Ryota Tamura, Masahiro Toda, Chan Woo Wee, Hong In Yoon
Summary: This study investigated the prognostic impact of serum biomarkers in patients with newly diagnosed atypical meningiomas. The findings revealed that tumor size, surgical resection, and postoperative serum markers were associated with the progression/recurrence rate. Further studies are needed to validate their clinical significance and biological background.
Article
Medicine, General & Internal
Vibhor Krishna, Paul S. Fishman, Howard M. Eisenberg, Michael Kaplitt, Gordon Baltuch, Jin Woo Chang, Wei-Chieh Chang, Raul Martinez Fernandez, Marta del Alamo, Casey H. Halpern, Pejman Ghanouni, Roberto Eleopra, Rees Cosgrove, Jorge Guridi, Ryder Gwinn, Pravin Khemani, Andres M. Lozano, Nathan McDannold, Alfonso Fasano, Marius Constantinescu, Ilana Schlesinger, Arif Dalvi, W. Jeff Elias
Summary: Unilateral pallidal ultrasound ablation can alleviate motor symptoms in patients with Parkinson's disease, but it is associated with adverse events. Larger and longer trials are needed to determine the efficacy and safety of this technique.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Psychiatry
Jhin Goo Chang, Do-Won Kim, Hyun Ho Jung, Won Seok Chang, Chan-Hyung Kim, Se Joo Kim, Jin Woo Chang
Summary: Bilateral thermal capsulotomy with magnetic resonance-guided focused ultrasound (MRgFUS-capsulotomy) is a promising treatment option for treatment-refractory obsessive-compulsive disorder (OCD). This study investigated the effects of MRgFUS-capsulotomy on neural oscillations in OCD patients. The results showed that the high beta band power in certain brain areas decreased at 1 month and remained stable for 6 months after the procedure. The cortical connectivity of the high beta band also gradually decreased over time. Improvement in anxiety and depression symptoms was significantly correlated with changes in high beta band power.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Minkyung Park, Ha-Na Woo, Chin Su Koh, Heesue Chang, Ji Hyun Kim, Keerang Park, Jin Woo Chang, Heuiran Lee, Hyun Ho Jung
Summary: This study investigated the effect of injecting rAAV-shmTOR on the downregulation of mTOR and glial activation. The results showed that peripheral sensitization was gradually attenuated in the shmTOR group, and both p-mTORC1 and p-mTORC2 were downregulated in the DRG. The study suggests the potential application of interfering with the mTOR signaling pathway in pain treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Junwon Park, Chanho Kong, Jaewoo Shin, Ji Young Park, Young Cheol Na, Seung Hee Han, Jin Woo Chang, Seung Hyun Song, Won Seok Chang
Summary: This study aimed to evaluate the effect of photodynamic therapy (PDT) and sonodynamic therapy (SDT) on glioblastoma (GBM), as well as the combination therapy of these two (SPDT). The results showed that PDT had an inhibitory effect on tumor volume, while the SDT group showed a slight increase. Light with sensitizers can inhibit GBM growth, but ultrasound had a weaker effect. Further studies are needed to investigate the safety parameters of ultrasound in GBM treatment.
YONSEI MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Junseong Park, Dongkyu Lee, Jin-Kyoung Shim, Seon-Jin Yoon, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Su -Jae Lee, Seok-Gu Kang
Summary: This study reveals the role of ventricle-derived mesenchymal stem-like cells (vMSLCs) in promoting the invasiveness of GBM tumorspheres. It provides important insights into how GBM cells acquire infiltrative features through vMSLCs.
YONSEI MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Kyung Won Chang, Seung Woo Hong, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
Summary: The blood-brain barrier (BBB) acts as a barrier for molecules in passing from the blood to the brain. Focused ultrasound has emerged as a novel method for temporarily opening the BBB, allowing for delivery or removal of neurodegenerative proteins. This study aimed to review our BBB opening procedure using magnetic resonance guided images and identify specific patterns.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Ji Young Park, Junwon Park, Jiwon Baek, Jin Woo Chang, Young Goo Kim, Won Seok Chang
Summary: This study aimed to investigate the potential therapeutic effects of early administration of baclofen in traumatic brain injury (TBI) mice. The results showed that baclofen treatment significantly reduced lesion volume and inhibited neuroinflammation, glial cell activation, and apoptosis. Furthermore, baclofen improved TBI motor and cognitive abnormalities. These findings suggest that early administration of low dose baclofen could be beneficial for TBI treatment.
SCIENTIFIC REPORTS
(2023)