Article
Oncology
Maria Waltenberger, Denise Bernhardt, Christian Diehl, Jens Gempt, Bernhard Meyer, Christoph Straube, Benedikt Wiestler, Jan J. Wilkens, Claus Zimmer, Stephanie E. Combs
Summary: This article discusses the treatment options for brain metastases, including surgical resection and radiotherapy. The author compares the efficacy of hypofractionated stereotactic radiotherapy (HFSRT) and single fraction stereotactic radiosurgery (SRS) to determine the optimal radiotherapy scheme.
Review
Oncology
Paolo Palmisciano, Gianluca Ferini, Ramlah Khan, Othman Bin-Alamer, Giuseppe E. Umana, Kenny Yu, Aaron A. Cohen-Gadol, Tarek Y. El Ahmadieh, Ali S. Haider
Summary: Pre-operative neoadjuvant stereotactic radiotherapy shows promise as an effective treatment for brain metastases, with comparable rates of local control and overall survival to adjuvant postoperative stereotactic radiotherapy and low rates of treatment-related complications. Ongoing clinical trials aim to further evaluate the long-term outcomes of this treatment approach.
Review
Oncology
Francois Lucia, Ruben Touati, Nicolae Crainic, Gurvan Dissaux, Olivier Pradier, Vincent Bourbonne, Ulrike Schick
Summary: Approximately 30% of cancer patients will develop brain metastases, leading to local recurrence post intracranial stereotactic radiotherapy. Advances in cancer treatments have increased overall survival, but also local failures (LF) after SRS/SRT. Second courses of SRS or SRT may be used to treat LF, with factors affecting efficacy including histology, tumor size, and prior treatments. Prospective studies with more patients are needed to determine the best management of brain metastases recurrence.
Article
Oncology
Naoyuki Kanayama, Toshiki Ikawa, Shingo Ohira, Takero Hirata, Masahiro Morimoto, Kazuhiko Ogawa, Teruki Teshima, Koji Konishi
Summary: This study demonstrates that a significant reduction in brain metastases volume at 6 months post-SRT can predict local control. The dose of 80% of the gross tumor volume (GTV) D80 in the LQ model: alpha/beta = 20 may be a predictive factor for volume reduction.
Review
Oncology
Sujay Rajkumar, Yun Liang, Rodney E. Wegner, Matthew J. Shepard
Summary: Recent studies have shown that pre-operative SRS can reduce the risk of leptomeningeal disease and radiation necrosis after brain metastases surgery. This treatment strategy sterilizes the tumor and minimizes spillage of viable tumor cells during resection, while also decreasing the radiation range during planning and treatment, thus reducing the risk of symptomatic radiation necrosis.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Review
Oncology
Hamoun Rozati, Jiarong Chen, Matt Williams
Summary: This study conducted a systematic review and meta-analysis to assess the overall survival of patients with ten or more brain metastases treated with stereotactic radiosurgery. The results showed that patients with ten or more metastases had statistically worse overall survival compared to the control group. However, there was insufficient information to draw conclusions on toxicity.
Article
Oncology
Valentina Borzillo, Rossella Di Franco, Diana Giannarelli, Fabrizio Cammarota, Esmeralda Scipilliti, Emma D'Ippolito, Angela Petito, Marcello Serra, Sara Falivene, Antonio M. Grimaldi, Ester Simeone, Lucia Festino, Vito Vanella, Claudia Trojaniello, Maria Grazia Vitale, Gabriele Madonna, Paolo A. Ascierto, Paolo Muto
Summary: Combining ipilimumab with stereotactic radiotherapy/radiosurgery could improve local control in patients with melanoma brain metastases. However, the impact and timing of these two methods on patients' outcomes are still unclear.
Review
Oncology
Tyler Gutschenritter, Vyshak A. Venur, Stephanie E. Combs, Balamurugan Vellayappan, Anoop P. Patel, Matthew Foote, Kristin J. Redmond, Tony J. C. Wang, Arjun Sahgal, Samuel T. Chao, John H. Suh, Eric L. Chang, Richard G. Ellenbogen, Simon S. Lo
Summary: This article discusses the use of novel treatment techniques such as hypofractionated stereotactic radiotherapy (HSRT) and pre-operative SRS for large brain metastases, which can improve local control rates and reduce the occurrence of LMD and RN.
Article
Oncology
Laure Kuntz, Clara Le Fevre, Delphine Jarnet, Audrey Keller, Philippe Meyer, Christophe Mazzara, Helene Cebula, Georges Noel, Delphine Antoni
Summary: This retrospective study analyzed the data of patients who received at least two courses of SRT between 2010 and 2020. The results showed that NDFS and OS after SRT were influenced by various factors, including the number of treatments, patient condition, salvage WBRT, and metastasis velocity.
Review
Oncology
Maxime Loo, Jean-Baptiste Clavier, Justine Attal Khalifa, Elisabeth Moyal, Jonathan Khalifa
Summary: Brain metastases are a common complication for cancer patients, with stereotactic radiosurgery considered a cornerstone treatment. The ideal dose and fractionation schedule remain unknown, with ongoing debates regarding the use of hypofractionated schedules and the linear-quadratic model. Recent studies have shown the importance of radiation schedule in immunomodulatory responses. Efficacy and toxicity data suggest that hypofractionated schedules may offer benefits in terms of reducing toxicity and improving local control rates compared to single-fraction treatment.
Article
Clinical Neurology
Diana A. Roth O'Brien, Sydney M. Kaye, Phillip J. Poppas, Sean S. Mahase, Anjile An, Paul J. Christos, Benjamin Liechty, David Pisapia, Rohan Ramakrishna, A. G. Wernicke, Jonathan P. S. Knisely, Susan C. Pannullo, Theodore H. Schwartz
Summary: This study evaluated the real-world local recurrence of all brain metastasis patients referred for adjuvant stereotactic radiosurgery (SRS) and identified predictors of SRS timing. The timing of SRS was found to be associated with local recurrence rate and LRFS, with receiving SRS within 4 weeks postoperatively potentially reducing the recurrence rate.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Mandara M. Harikar, Tejas Venkataram, Paolo Palmisciano, Gianluca Scalia, Matias Baldoncini, Salvatore Massimiliano Cardali, Giuseppe E. Umana, Gianluca Ferini
Summary: This study compared the efficacy of fractionated stereotactic radiotherapy (FSRT) with staged stereotactic radiosurgery (SSRS) in patients with brain metastases larger than 2 cm. The results showed that both treatment modalities were comparable, but FSRT was associated with lower 12-month overall survival and higher rate of salvage radiotherapy. Further research is needed to support these findings.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Naoya Nagai, Yutaro Koide, Yurika Shindo, Shingo Hashimoto, Hiroyuki Tachibana, Takeshi Kodaira, Shunichi Ishihara, Shinji Naganawa
Summary: The aim of this study was to compare the clinical benefits of stereotactic radiosurgery (SRS) in patients with >10 brain metastases (BM) to those with 2-10 BM. The results showed that SRS had non-inferior overall survival (OS) and intracranial progression-free survival (PFS) in patients with >10 BM compared to those with 2-10 BM. Therefore, SRS could be a viable treatment option for selected patients with >10 BM.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Aristotelis Kalyvas, Enrique Gutierrez-Valencia, Ruth Lau, Xiang Y. Y. Ye, Philip J. J. O'Halloran, Nilesh Mohan, Christine Wong, Barbara-Ann Millar, Normand Laperriere, Tatiana Conrad, Alejandro Berlin, Mark Bernstein, Gelareh Zadeh, David B. B. Shultz, Paul Kongkham
Summary: Neurosurgery is an important treatment modality for large brain metastases, and postoperative stereotactic radiosurgery is the standard adjuvant treatment. Pachymeningeal failure is a newly described entity that occurs in postoperative patients treated with adjuvant SRS. This study aimed to identify risk factors for pachymeningeal failure in patients treated with neurosurgery + SRS.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Oncology
Marion Tonneau, Raphaelle Mouttet-Audouard, Florence Le Tinier, Xavier Mirabel, David Pasquier
Summary: SBRT appears to be a safe, effective, and rapid treatment option for palliative patients, as shown by a study on five patients treated with SBRT for IMM.
Meeting Abstract
Oncology
M. P. Mehta, V. Gondi, M. Ahluwalia, P. D. Brown
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Medicine, General & Internal
Jean-Louis Vincent, Bruno Francois, Igor Zabolotskikh, Mradul Kumar Daga, Jean-Baptiste Lascarrou, Mikhail Y. Kirov, Ville Pettila, Xavier Wittebole, Ferhat Meziani, Emmanuelle Mercier, Suzana M. Lobo, Philip S. Barie, Mark Crowther, Charles T. Esmon, Jawed Fareed, Satoshi Gando, Kenneth J. Gorelick, Marcel Levi, Jean-Paul Mira, Steven M. Opal, Joseph Parrillo, James A. Russell, Hidehiko Saito, Kazuhisa Tsuruta, Takumi Sakai, David Fineberg, Romina Bertuzzi, Rinaldo Bellomo, Marianne Chapman, David Ernest, Jason Fletcher, Craig French, John Gowardman, Yahya Shehabi, Bala Venkatesh, James Walsham, Sanjiv Vij, Didier Chochrad, Jacques Creteur, Jacques Devriendt, Alain-Michel Dive, Thierry Dugernier, Frederic Foret, Eric Hoste, Philippe Jorens, Marc Simon, Herbert Spapen, Fernando Dias, Antonio Freire, Suzana Margarth Lobo, Georgi Simeonov, Chavdar Stefanov, Pierre Aslanian, Luc Berthiaume, Claudio Martin, Dean Chittock, Anil Dhar, Christopher Doig, Gwynne Jones, Richard Hall, John Boyd, Phil Shin, Gordon Wood, Ryan Zarychanski, Guillermo Agamenon Quinteros, Vladimir Gasparovic, Ino Husedzinovic, Martin Balik, Ivo Burget, Pavel Dlouhy, Jan Pachl, Sari Karlsson, Raili Laru-Sompa, Ilkka Parviainen, Esko Ruokone, Markus Skrifvars, Julien Bohe, Jean Dellamonica, Alexandre Duguet, Jacques Durand-Gasselin, Maud Fiancette, Olivier Joannes-Boyau, Jean-Yves Lefrant, Alain Mercat, Saad Nseir, Jean-Pierre Quenot, Jean Reignier, Carole Schwebel, Gernot Marx, Kai Zacharowski, Apostolos Armaganidis, Apostolos Komnos, Csaba Fejer, Jayaprakash Appajigol, Sarat Kumar Behera, Shivprasad ChandraShekhar, Sanmay Chowdhury, Pradeep Micheal D'costa, Hari Shankar Shivkumar Gupta, Shivakumar Iyer, Zafer A. Khan, Minesh Mehta, Sudharshan Murthy, Sambit Sahu, Reshma Tewari, Yaron Bar-Lavie, Gennady Bregman, Jonathan Cohen, Arie Eden, Sharon Einav-Bromiker, Daniel Jakobson, Adi Nimrod, Albertus Beishuizen, Richard Gerritsen, Peter Pickkers, Wim Rozendaal, F. J. Schoonderbeek, Angelique Spoelstra-de Man, Arthur R. H. van Zanten, Jan G. Zijlstra, Ross Freebairn, Seton Henderson, Colin McArthur, Paul Young, Manuel Jesus Mayorga, Alina S. Agafina, Natalia Bubnova, Alexey Gritsan, Evgenia Kameneva, Sergey P. Katasonov, Nina M. Khasanova, Mikhail Y. Kirov, Lilly Kruberg, Vladimir V. Kulabukhov, Konstantin Lebedinskii, Yuri A. Spesivtsev, Zarko Rankovic, Sang Bum Hong, Min-Ja Kim, Gee Young Suh, Chul-Gyu Yoo, Antonio Artigas Raventos, Ricard Ferrer, Rita Galeiras Vazquez, Marianela Hernandez, Enrique Piacentini, Alejandro Hugo Rodriguez Oviedo, Miguel Sanchez Garcia, Ming-Cheng Chan, Kuo-Chen Cheng, Chong-Jen Yu, Jane Eddleston, Fang Gao Smith, Peter MacNaughton, Ingeborg Welters, Karen Allen, Grant Bochicchio, Richard Carlson, Stephanie Eaton, Ryan Fink, Carmine Gianatiempo, Rajat Kapoor, Gary Kinasewitz, Firas Koura, Kenneth Krell, Niels Martin, Santosh Nepal, Stephen M. Pastores, Ithan Peltan, John Pullman, Allan Seibert, Jason Smith, Steven Tennenberg, Andrew Wilhelm, Brian Zeno, Pam Allton, David Carruthers, Osamu Matsuki, Toshihiko Kayanoki
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2019)
Meeting Abstract
Oncology
Nicole Willmarth, Scott Elder, Avery Fine, Manmeet Singh Ahluwalia, Jill Barnholtz-Sloan, Priscilla Kaliopi Brastianos, Daniel Brat, Minesh P. Mehta, Robin Page, Ralph DeVitto, Debbie Robins
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Erica Hlavin Bell, Minhee Won, Jessica L. Fleming, Aline P. Becker, Joseph P. McElroy, Edward G. Shaw, Minesh P. Mehta, David G. Brachman, Stanley Z. Gertler, Albert D. Murtha, Christopher J. Schultz, David B. Johnson, Nadia N. Laack, Grant Kirton Hunter, Ian R. Crocker, Arnab Chakravarti
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Isabel Arrillaga, Sylvia Kurz, Ashley Sumrall, Nicholas A. Butowski, Rebecca A. Harrison, John Frederick De Groot, Nicole A. Shonka, Frank S. Lieberman, Yazmin Odia, Rohinton Tarapore, Krystal Merdinger, Joshua E. Allen, Wolfgang Oster, Minesh P. Mehta, Timothy Francis Cloughesy, Andrew S. Chi, Andrew B. Lassman, Tracy Batchelor, Patrick Y. Wen
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tej Ishaan Mehta, Caleb Heiberger, Stephanie Kazi, Mark Brown, Simcha Weissman, Kelvin Hong, Minesh Mehta, Douglas Yim
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2020)
Article
Oncology
D. Jay Wieczorek, Rupesh Kotecha, Matthew D. Hall, Martin C. Tom, Stephen Davis, Manmeet S. Ahluwalia, Michael W. McDermott, Minesh P. Mehta, Alonso N. Gutierrez, Ranjini Tolakanahalli
Summary: This study compared the plan quality metrics of manual forward planning (MFP) and Elekta Fast Inverse Planning (FIP) for stereotactic radiosurgery (SRS) in patients treated with Gamma Knife (R). The results showed that FIP plans demonstrated a statistically significant improvement in target coverage, conformity index, and gradient index compared to MFP plans, while there was no significant difference in beam-on time and delivery parameters between the two planning methods.
Article
Oncology
Tugce Kutuk, Ranjini Tolakanahalli, Nicole C. McAllister, Matthew D. Hall, Martin C. Tom, Muni Rubens, Haley Appel, Alonso N. Gutierrez, Yazmin Odia, Alexander Mohler, Manmeet S. Ahluwalia, Minesh P. Mehta, Rupesh Kotecha
Summary: This study evaluated dosimetric data for patients treated with PRDR IMRT for recurrent primary CNS malignancies and found that PRDR re-irradiation is a safe and feasible strategy with favorable clinical outcomes and mild toxicities.
Editorial Material
Oncology
Rupesh Kotecha, Minesh P. Mehta
Article
Oncology
Kathryn E. Mittauer, Sreenija Yarlagadda, John M. Bryant, Nema Bassiri, Tino Romaguera, Andres G. Gomez, Robert Herrera, Rupesh Kotecha, Minesh P. Mehta, Alonso N. Gutierrez, Michael Chuong
Summary: This study describes a 5-fraction ablative SMART planning approach for pancreatic cancer that is robust and stable during on-table adaption, due to gradients controlled by a GI PRV technique and the use of rings. These findings are noteworthy given that daily interfraction anatomic GI OAR differences are routine, thus necessitating on-table adaptation. This work supports feasibility towards utilizing a patient-independent, template on-table adaptive approach.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Sarbani Ghosh Laskar, Shwetabh Sinha, Rahul Krishnatry, Cai Grau, Minesh Mehta, Jai Prakash Agarwal
Summary: The discipline of radiation oncology is faced with challenges in terms of accessibility and affordability, particularly in low-income and low-middle-income countries. The distribution of radiation therapy machines and brachytherapy facilities is unequal, while there is also a deficit in simulators, radiation oncologists, and medical physicists. Measures to address these challenges include adopting indigenous technology, promoting public-private partnerships, relaxing custom duties, enhancing human resources training, and conducting innovative research.
JCO GLOBAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Vinai Gondi, Stephanie L. Pugh, Minesh P. Mehta, Wolfgang Tome, Tammie Benzinger, Joseph A. Bovi, Benjamin W. Corn, Shannon E. Fogh, Cliff Grant Robinson, Jeffrey Scott Wefel, Lisa A. Kachnic
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Paul W. Sperduto, Penny Fang, Jing Li, William Breen, Paul D. Brown, Daniel Cagney, Ayal Aizer, James B. Yu, Veronica Chiang, Supriya Jain, Laurie E. Gaspar, Sten Myrehaug, Arjun Sahgal, Steve Braunstein, Penny Sneed, Brent Cameron, Albert Attia, Jason Molitoris, Cheng-Chia Wu, Tony J. C. Wang, Natalie A. Lockney, Kathryn Beal, Jessica Parkhurstm, John M. Buatti, Ryan Shanley, Emil Lou, Daniel D. Tandberg, John P. Kirkpatrick, Diana Shi, Helen A. Shih, Michael Chuong, Hirotake Saito, Hidefumi Aoyama, Laura Masucci, David Roberge, Minesh P. Mehta
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2019)
Review
Oncology
Rupesh Kotecha, Minesh P. Mehta, Eric L. Chang, Paul D. Brown, John H. Suh, Simon S. Lo, Sunit Das, Haider H. Samawi, Julia Keith, James Perry, Arjun Sahgal
Meeting Abstract
Clinical Neurology
Gourish Mondal, Julieann Lee, Javier Villanueva-Meyer, Jessica Van Ziffle, Courtney Onodera, Patrick Devine, James Grenert, David Samuel, Rong Li, Laura Metrock, Lee-way Jin, Reuben Antony, Mouied Alashari, Samuel Cheshier, Nicholas Whipple, Carol Bruggers, Corey Raffel, Nalin Gupta, Cassie Kline, Alyssa Reddy, Anu Banerjee, Matthew Hall, Minesh Mehta, Ziad Khatib, Ossama Maher, Carole Brathwaite, Melike Pekmezci, Joanna Phillips, Andrew Bollen, Tarik Tihan, Arie Perry, David Solomon
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2019)