Review
Oncology
Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters, Evelien L. J. M. Smits
Summary: Immunotherapy is being investigated as a breakthrough treatment option for glioblastoma, with poly(I:C)/poly-ICLC potentially playing a key role in activating lymphocytes and enhancing immunological responses. Studies show that poly(I:C) or poly-ICLC treatment for glioblastoma has the potential to activate lymphocytes and enhance immune responses.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Clinical Neurology
Gabrielle Metz, Dasantha Jayamanne, Helen Wheeler, Matthew Wong, Raymond Cook, Nicholas Little, Jonathon Parkinson, Marina Kastelan, Chris Brown, Michael Back
Summary: This study assessed the tumor volume reduction in patients with IDH-mutated anaplastic glioma (IDHmutAG) of the insular cortex treated with IMRT. The results showed that IMRT can significantly reduce tumor volume, and residual disease volume does not have a significant negative impact on relapse-free survival.
Article
Clinical Neurology
Pierina Navarria, Federico Pessina, Elena Clerici, Zefferino Rossini, Davide Franceschini, Giuseppe D'Agostino, Ciro Franzese, Tiziana Comito, Mauro Loi, Matteo Simonelli, Elena Lorenzi, Pasquale Persico, Letterio Salvatore, Marco Grimaldi, Lorenzo Bello, Armando Santoro, Maurizio Fornari, Franco Servadei, Marta Scorsetti
Summary: In addition to IDH status, the extent of resection and residual tumor volume have been shown to significantly impact survival. Sequential radio-chemotherapy was found to be the more effective treatment option.
JOURNAL OF NEUROSURGERY
(2021)
Article
Chemistry, Multidisciplinary
Mingze Lu, Haoan Wu, Di Liu, Fei Wang, Yan Wang, Mengjun Wang, Qiannan Cui, He Zhang, Fengchao Zang, Ming Ma, Jun Ma, Fangfang Shi, Yu Zhang
Summary: This study designs a camouflaged nano-reactor that combines chemodynamic therapy and radiotherapy, effectively inhibiting malignant tumors. Experimental results demonstrate that the nano-reactor damages tumor cells through multiple mechanisms and addresses the limitations of chemodynamic therapy and radiotherapy.
Article
Oncology
Nancy Ann Oberheim Bush, Jacob S. Young, Yalan Zhang, Cecilia L. Dalle Ore, Annette M. Molinaro, Jennie Taylor, Jennifer Clarke, Michael Prados, Steve E. Braunstein, David R. Raleigh, Susan M. Chang, Mitchel S. Berger, Nicholas A. Butowski
Summary: For patients with anaplastic oligodendroglioma, initial treatment with adjuvant chemotherapy alone, rather than radiation and chemotherapy, may be a viable option as it is associated with similar overall survival despite shorter progression free survival. Balancing longevity against radiation toxicity is crucial in determining the most suitable treatment approach.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Selena I. Huisman, Arthur T. J. van der Boog, Fia Cialdella, Joost J. C. Verhoeff, Szabolcs David
Summary: This study proposes a new method, the BrainAGE framework, to quantify tissue changes after cranial radiotherapy as accelerated brain aging. The results indicate that patients undergoing radiotherapy experience significant post-radiation accelerated aging, with specific anatomical areas contributing to this aging.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Riccardo Serra, Antonella Mangraviti, Noah L. Gorelick, Tovi Shapira-Furman, Safwan Alomari, Arba Cecia, Namrata Darjee, Henry Brem, Yakir Rottenberg, Abraham J. Domb, Betty Tyler
Summary: This study tested a novel polymeric matrix that gradually releases ACF at the tumor bed while combining it with TMZ and XRT. The combination therapy of ACF, TMZ, and XRT reduced cell viability and induced apoptosis in glioma cells. The release of ACF was measured in vitro and in vivo, and the efficacy was established in an in vivo gliosarcoma model, showing improved median survival and long-term survival.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Oncology
Alessandra Rinah Nogueira Voges, Rodrigo Ubukata, Karina Velloso Braga Yazbek, Otavia Luisa Caballero, Andres Mario Salazar, Cristina de Oliveira Massoco, Maria Lucia Zaidan Dagli
Summary: The study investigated the clinical efficacy, quality of life, and adverse events of poly-ICLC treatment in dogs with advanced cancers. The results showed that the treatment was well tolerated in dogs with some showing clinical benefit and improved quality of life.
Article
Veterinary Sciences
Tomoko Takahashi, Hitoshi Shiozawa, Teita Ishizaki, Kazuki Okada, Hirotaka Kondo
Summary: This case report describes a female French bulldog with oligodendroglioma that invaded the nasal cavity and metastasized to cervical lymph nodes. Hypo-fractionated radiation therapy successfully relieved symptoms, but the tumor eventually metastasized to multiple organs.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2023)
Article
Oncology
Alexandra Diggs, Tiffany Y. Sia, Yongmei Huang, Allison Gockley, Alexander Melamed, Fady Khoury-Collado, Caryn St. Clair, June Y. Hou, Dawn L. Hershman, Jason D. Wright
Summary: This study analyzed the utilization of adjuvant chemotherapy and radiation therapy in patients with stage II and III uterine leiomyosarcoma (uLMS). The results showed that the use of chemotherapy is increasing while the use of radiation therapy is decreasing. Radiation therapy is associated with improved survival in both stage II and III disease, but there is no association between adjuvant chemotherapy and survival in stage II patients.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Oncology
Li Yanchu, Pu Rong, Cao Rong, Zhang Li, Yang Xiaoyan, Wang Feng
Summary: High-grade gliomas are aggressive brain tumors that are difficult to treat. Ozone therapy has shown promising results in preclinical studies and clinical trials for various cancers, but there have been limited studies on gliomas. Optimizing the dosage and timing of ozone therapy remains a challenge. This study provides an overview of ozone therapy in high-grade gliomas, including its mechanisms of action and clinical evidence.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Keith C. Bible, Electron Kebebew, James Brierley, Juan P. Brito, Maria E. Cabanillas, Thomas J. Clark, Antonio Di Cristofano, Robert Foote, Thomas Giordano, Jan Kasperbauer, Kate Newbold, Yuri E. Nikiforov, Gregory Randolph, M. Sara Rosenthal, Anna M. Sawka, Manisha Shah, Ashok Shaha, Robert Smallridge, Carol K. Wong-Clark
Summary: The guidelines for the management of anaplastic thyroid cancer (ATC) aim to provide evidence-based recommendations to inform clinical decision-making, encompassing diagnosis, treatment goals, locoregional and advanced disease approaches, palliative care, surveillance, and ethical considerations.
Review
Biochemistry & Molecular Biology
Sasha J. Beyer, Miranda Tallman, Sachin R. Jhawar, Julia R. White, Jose G. Bazan
Summary: Many patients with non-metastatic breast cancer receive adjuvant radiation therapy after surgery based on randomized trials, but for patients with low recurrence risks, de-intensification of therapy may be appropriate. Intensifying the dose may be necessary for aggressive breast cancers. Genomic assays are being studied as potential biomarkers to guide adjuvant radiation therapy decision-making.
Article
Medicine, General & Internal
Jiawei Dong, Fang Wang, Yuyun Xu, Xin Gao, Hongtao Zhao, Jiheng Zhang, Nan Wang, Zhihui Liu, Xiuwei Yan, Jiaqi Jin, Hang Ji, Ruiqi Cheng, Lihai Wang, Zhaowen Qiu, Shaoshan Hu
Summary: This study proposes a method that combines magnetic resonance imaging (MRI) and photodynamic therapy (PDT) for the treatment of glioma. By creating 3D models and accurately localizing hyperperfused areas of the tumor, PDT can be precisely targeted to improve treatment effectiveness. The study also identifies proteins associated with poor prognosis in glioma patients in these hyperperfused areas.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Amber L. O. King, Victor Lee, Beverly Yu, Fatima N. Mirza, Cheryl K. Zogg, Daniel X. Yang, Thuy Tran, Jonathan Leventhal, Yi An
Summary: This study aims to explore national patterns and associations of adjuvant radiation therapy (RT) use for stage III melanoma. The results show an increase in the use of adjuvant RT for stage III melanoma in recent years and identify demographic, social, clinical, and hospital-specific factors associated with patients receiving adjuvant RT. Further research is needed to improve guidance on the utilization of RT in melanoma.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Frank S. Lieberman, Meihua Wang, H. Ian Robins, Christina Tsien, Walter J. Curran, Maria Werner-Wasik, Ryan P. Smith, Christopher Schultz, Alan C. Hartford, Peixin Zhang, Minesh P. Mehta
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Meeting Abstract
Oncology
M. P. Mehta, V. Gondi, M. Ahluwalia, P. D. Brown
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Medicine, General & Internal
Jean-Louis Vincent, Bruno Francois, Igor Zabolotskikh, Mradul Kumar Daga, Jean-Baptiste Lascarrou, Mikhail Y. Kirov, Ville Pettila, Xavier Wittebole, Ferhat Meziani, Emmanuelle Mercier, Suzana M. Lobo, Philip S. Barie, Mark Crowther, Charles T. Esmon, Jawed Fareed, Satoshi Gando, Kenneth J. Gorelick, Marcel Levi, Jean-Paul Mira, Steven M. Opal, Joseph Parrillo, James A. Russell, Hidehiko Saito, Kazuhisa Tsuruta, Takumi Sakai, David Fineberg, Romina Bertuzzi, Rinaldo Bellomo, Marianne Chapman, David Ernest, Jason Fletcher, Craig French, John Gowardman, Yahya Shehabi, Bala Venkatesh, James Walsham, Sanjiv Vij, Didier Chochrad, Jacques Creteur, Jacques Devriendt, Alain-Michel Dive, Thierry Dugernier, Frederic Foret, Eric Hoste, Philippe Jorens, Marc Simon, Herbert Spapen, Fernando Dias, Antonio Freire, Suzana Margarth Lobo, Georgi Simeonov, Chavdar Stefanov, Pierre Aslanian, Luc Berthiaume, Claudio Martin, Dean Chittock, Anil Dhar, Christopher Doig, Gwynne Jones, Richard Hall, John Boyd, Phil Shin, Gordon Wood, Ryan Zarychanski, Guillermo Agamenon Quinteros, Vladimir Gasparovic, Ino Husedzinovic, Martin Balik, Ivo Burget, Pavel Dlouhy, Jan Pachl, Sari Karlsson, Raili Laru-Sompa, Ilkka Parviainen, Esko Ruokone, Markus Skrifvars, Julien Bohe, Jean Dellamonica, Alexandre Duguet, Jacques Durand-Gasselin, Maud Fiancette, Olivier Joannes-Boyau, Jean-Yves Lefrant, Alain Mercat, Saad Nseir, Jean-Pierre Quenot, Jean Reignier, Carole Schwebel, Gernot Marx, Kai Zacharowski, Apostolos Armaganidis, Apostolos Komnos, Csaba Fejer, Jayaprakash Appajigol, Sarat Kumar Behera, Shivprasad ChandraShekhar, Sanmay Chowdhury, Pradeep Micheal D'costa, Hari Shankar Shivkumar Gupta, Shivakumar Iyer, Zafer A. Khan, Minesh Mehta, Sudharshan Murthy, Sambit Sahu, Reshma Tewari, Yaron Bar-Lavie, Gennady Bregman, Jonathan Cohen, Arie Eden, Sharon Einav-Bromiker, Daniel Jakobson, Adi Nimrod, Albertus Beishuizen, Richard Gerritsen, Peter Pickkers, Wim Rozendaal, F. J. Schoonderbeek, Angelique Spoelstra-de Man, Arthur R. H. van Zanten, Jan G. Zijlstra, Ross Freebairn, Seton Henderson, Colin McArthur, Paul Young, Manuel Jesus Mayorga, Alina S. Agafina, Natalia Bubnova, Alexey Gritsan, Evgenia Kameneva, Sergey P. Katasonov, Nina M. Khasanova, Mikhail Y. Kirov, Lilly Kruberg, Vladimir V. Kulabukhov, Konstantin Lebedinskii, Yuri A. Spesivtsev, Zarko Rankovic, Sang Bum Hong, Min-Ja Kim, Gee Young Suh, Chul-Gyu Yoo, Antonio Artigas Raventos, Ricard Ferrer, Rita Galeiras Vazquez, Marianela Hernandez, Enrique Piacentini, Alejandro Hugo Rodriguez Oviedo, Miguel Sanchez Garcia, Ming-Cheng Chan, Kuo-Chen Cheng, Chong-Jen Yu, Jane Eddleston, Fang Gao Smith, Peter MacNaughton, Ingeborg Welters, Karen Allen, Grant Bochicchio, Richard Carlson, Stephanie Eaton, Ryan Fink, Carmine Gianatiempo, Rajat Kapoor, Gary Kinasewitz, Firas Koura, Kenneth Krell, Niels Martin, Santosh Nepal, Stephen M. Pastores, Ithan Peltan, John Pullman, Allan Seibert, Jason Smith, Steven Tennenberg, Andrew Wilhelm, Brian Zeno, Pam Allton, David Carruthers, Osamu Matsuki, Toshihiko Kayanoki
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2019)
Meeting Abstract
Oncology
Nicole Willmarth, Scott Elder, Avery Fine, Manmeet Singh Ahluwalia, Jill Barnholtz-Sloan, Priscilla Kaliopi Brastianos, Daniel Brat, Minesh P. Mehta, Robin Page, Ralph DeVitto, Debbie Robins
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Erica Hlavin Bell, Minhee Won, Jessica L. Fleming, Aline P. Becker, Joseph P. McElroy, Edward G. Shaw, Minesh P. Mehta, David G. Brachman, Stanley Z. Gertler, Albert D. Murtha, Christopher J. Schultz, David B. Johnson, Nadia N. Laack, Grant Kirton Hunter, Ian R. Crocker, Arnab Chakravarti
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tej Ishaan Mehta, Caleb Heiberger, Stephanie Kazi, Mark Brown, Simcha Weissman, Kelvin Hong, Minesh Mehta, Douglas Yim
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2020)
Article
Oncology
D. Jay Wieczorek, Rupesh Kotecha, Matthew D. Hall, Martin C. Tom, Stephen Davis, Manmeet S. Ahluwalia, Michael W. McDermott, Minesh P. Mehta, Alonso N. Gutierrez, Ranjini Tolakanahalli
Summary: This study compared the plan quality metrics of manual forward planning (MFP) and Elekta Fast Inverse Planning (FIP) for stereotactic radiosurgery (SRS) in patients treated with Gamma Knife (R). The results showed that FIP plans demonstrated a statistically significant improvement in target coverage, conformity index, and gradient index compared to MFP plans, while there was no significant difference in beam-on time and delivery parameters between the two planning methods.
Article
Oncology
Tugce Kutuk, Ranjini Tolakanahalli, Nicole C. McAllister, Matthew D. Hall, Martin C. Tom, Muni Rubens, Haley Appel, Alonso N. Gutierrez, Yazmin Odia, Alexander Mohler, Manmeet S. Ahluwalia, Minesh P. Mehta, Rupesh Kotecha
Summary: This study evaluated dosimetric data for patients treated with PRDR IMRT for recurrent primary CNS malignancies and found that PRDR re-irradiation is a safe and feasible strategy with favorable clinical outcomes and mild toxicities.
Editorial Material
Oncology
Rupesh Kotecha, Minesh P. Mehta
Article
Oncology
Kathryn E. Mittauer, Sreenija Yarlagadda, John M. Bryant, Nema Bassiri, Tino Romaguera, Andres G. Gomez, Robert Herrera, Rupesh Kotecha, Minesh P. Mehta, Alonso N. Gutierrez, Michael Chuong
Summary: This study describes a 5-fraction ablative SMART planning approach for pancreatic cancer that is robust and stable during on-table adaption, due to gradients controlled by a GI PRV technique and the use of rings. These findings are noteworthy given that daily interfraction anatomic GI OAR differences are routine, thus necessitating on-table adaptation. This work supports feasibility towards utilizing a patient-independent, template on-table adaptive approach.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Sarbani Ghosh Laskar, Shwetabh Sinha, Rahul Krishnatry, Cai Grau, Minesh Mehta, Jai Prakash Agarwal
Summary: The discipline of radiation oncology is faced with challenges in terms of accessibility and affordability, particularly in low-income and low-middle-income countries. The distribution of radiation therapy machines and brachytherapy facilities is unequal, while there is also a deficit in simulators, radiation oncologists, and medical physicists. Measures to address these challenges include adopting indigenous technology, promoting public-private partnerships, relaxing custom duties, enhancing human resources training, and conducting innovative research.
JCO GLOBAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Vinai Gondi, Stephanie L. Pugh, Minesh P. Mehta, Wolfgang Tome, Tammie Benzinger, Joseph A. Bovi, Benjamin W. Corn, Shannon E. Fogh, Cliff Grant Robinson, Jeffrey Scott Wefel, Lisa A. Kachnic
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Endocrinology & Metabolism
Brandon S. Imber, Andrew L. Lin, Zhigang Zhang, Krishna Nand Keshavamurthy, Amy Robin Deipolyi, Kathryn Beal, Marc A. Cohen, Viviane Tabar, Lisa M. DeAngelis, Eliza B. Geer, T. Jonathan Yang, Robert J. Young
JOURNAL OF THE ENDOCRINE SOCIETY
(2019)
Article
Oncology
Paul W. Sperduto, Penny Fang, Jing Li, William Breen, Paul D. Brown, Daniel Cagney, Ayal Aizer, James B. Yu, Veronica Chiang, Supriya Jain, Laurie E. Gaspar, Sten Myrehaug, Arjun Sahgal, Steve Braunstein, Penny Sneed, Brent Cameron, Albert Attia, Jason Molitoris, Cheng-Chia Wu, Tony J. C. Wang, Natalie A. Lockney, Kathryn Beal, Jessica Parkhurstm, John M. Buatti, Ryan Shanley, Emil Lou, Daniel D. Tandberg, John P. Kirkpatrick, Diana Shi, Helen A. Shih, Michael Chuong, Hirotake Saito, Hidefumi Aoyama, Laura Masucci, David Roberge, Minesh P. Mehta
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2019)
Review
Oncology
Rupesh Kotecha, Minesh P. Mehta, Eric L. Chang, Paul D. Brown, John H. Suh, Simon S. Lo, Sunit Das, Haider H. Samawi, Julia Keith, James Perry, Arjun Sahgal
