Article
Chemistry, Multidisciplinary
Linqiang Mei, Ruxin Xie, Shuang Zhu, Shilong Deng, Haiwei Xu, Xiaotang Fan, Wenyan Yin, Zhanjun Gu
Summary: We investigated the translocation, biotransformation, and biodistribution of CsPbBr3 PNPs in C57BL/6J mice and found that they can accumulate in the hippocampus, leading to Ca overload and severe damage to learning, memory, and cognition behavior. CsPbBr3 PNPs also undergo transformations into soluble and insoluble lead compounds in different physiological environments. The toxicity of CsPbBr3 PNPs is higher than that of soluble Pb(Ac)2 due to sustained release of Pb ions. The neurotoxic effects of Pb-PNPs were attributed to intracellular Ca2+ overload, reactive oxygen species production, and disruption of mitochondrial membrane potential.
Review
Pharmacology & Pharmacy
Rekha K. Narasimhamurthy, Kamalesh D. Mumbrekar, B. S. Satish Rao
Summary: Advancements in radio diagnostic imaging tools and techniques have greatly improved the diagnosis of various pathophysiological conditions, but the effects of low dose radiation on the biological system remain unclear. Current research suggests that low dose radiation may have neurological effects on the central nervous system and further investigation is needed to understand the risks and benefits.
Article
Environmental Sciences
Rekha Koravadi Narasimhamurthy, Babu Santhi Venkidesh, Sangeetha Nayak, Dinesh Reghunathan, Sandeep Mallya, Krishna Sharan, Bola Sadashiva Satish Rao, Kamalesh Dattaram Mumbrekar
Summary: Neurodegenerative disorders pose a serious threat to the global elderly population, and their etiology is often multifactorial. This study investigated the effects of malathion and radiation in mice, and found alterations in signaling pathways and pathways associated with neurodegenerative diseases. Additionally, increased astrogliosis, neuronal cell death, and structural changes in neurons were observed. These findings provide important insights into external factor-driven neurotoxicity and neurodegenerative pathogenesis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, General & Internal
William P. Schmitt, Saurabh Rohatgi, Marcelo Matiello
Summary: A 33-year-old man presented with progressive worsening paresthesia in the arms and legs. The sensory function was impaired in the arms and legs, and there was absence of reflexes in the legs. A diagnostic test was conducted.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Wee Loon Ong, Shun Wong, Hany Soliman, Sten Myrehaug, Chia-Lin Tseng, Jay Detsky, Zain Husain, Pejman Maralani, Lijun Ma, Simon S. Lo, Arjun Sahgal
Summary: Stereotactic body radiation therapy (SBRT) is a standard treatment option for spine metastases, but one of its most feared complications is radiation myelopathy (RM). Limited data is available on RM following spine SBRT, including spinal cord dose constraints and strategies to mitigate the risk.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Review
Clinical Neurology
Eudocia Q. Lee
Summary: Neurologic complications can arise from systemic anti-cancer therapies and radiation therapy, with newer treatments such as CAR-T therapy and immunotherapy posing risks of neurotoxicity. Early recognition and appropriate management are crucial in minimizing neurologic injury, as damage to both central and peripheral nervous systems may not always be reversible.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jovana Bojcevski, Changwen Wang, Haikun Liu, Amir Abdollahi, Ivana Dokic
Summary: This study explored the generation of normal brain 3D organoids from human induced pluripotent stem cells combined with detection of DNA damage repair for developing personalized models to determine normal tissue radiosensitivity. The findings suggest that assessment of DNA damage repair kinetics in hiPSC derived cerebral organoids is feasible and further development may lead to personalized assessment of radiosensitivity in healthy neuronal tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Babu Santhi Venkidesh, Saligrama R. Shankar, Rekha Koravadi Narasimhamurthy, Satish Bola Sadashiva Rao, Kamalesh Dattaram Mumbrekar
Summary: Radiotherapy is an important part of cancer treatment, but it often causes gut dysbiosis and gastrointestinal reactions. This study found that probiotics can alleviate the damage to the gut and brain tissues caused by radiation, potentially playing a significant role in maintaining gut and brain health.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Melissa Lannon, Edward Kachur
Summary: Degenerative cervical myelopathy (DCM) is a common condition caused by narrowing of the spinal canal, leading to spinal cord compression and neurologic dysfunction. Clinicians should be aware of early signs and symptoms to consider surgical intervention for preventing severe deterioration in neurologic function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Clinical Neurology
Jonathan D. Santoro, Kelli C. Paulsen
Summary: This study presents a case of biotinidase deficiency misdiagnosed as neuromyelitis optica spectrum disorders, and reviews previous cases of biotinidase deficiency that met the criteria for neuromyelitis optica spectrum disorder established by Wingerchuck in 2015.
Article
Oncology
Abigail Pepin, Sarthak Shah, Monica Pernia, Siyuan Lei, Marilyn Ayoob, Malika Danner, Thomas Yung, Brian T. Collins, Simeng Suy, Nima Aghdam, Sean P. Collins
Summary: Prostate SBRT was well tolerated in patients with baseline anticoagulant/antiplatelet medication usage, with low incidence of high grade bleeding toxicities and no significant changes in baseline hematuria and hematochezia scores.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Roseleena Minz, Praveen Kumar Sharma, Arvind Negi, Kavindra Kumar Kesari
Summary: Various clinical reports indicate that prolonged exposure to general anesthetic-induced neurotoxicity leads to behavior changes in memory and cognition. However, engineered miRNAs have shown potential in mitigating neurotoxicity and could be used as prophylactics and therapeutics. Challenges and feasibility of using miRNAs as therapeutic agents are discussed, along with updates on the novel neuro-miRNAs related to therapy against neurotoxicity induced by amyloid beta and Parkinson's disease.
Article
Rehabilitation
Kevin Cipriano, J. Taylor Mansfield, Hannie Batal, Erika Gosai
Summary: This case study describes a 56-year-old woman who developed conus medullaris infarction after intensive lumbar hyperextension exercises, a condition known as surfer's myelopathy. Unlike previous reports, this case was associated with weightlifting. The authors suggest considering this diagnosis in patients with nontraumatic paraplegia following spine hyperextension activities, and propose renaming it as acute hyperextension myelopathy to better reflect the underlying pathophysiology.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Clinical Neurology
B. L. Serrallach, E. S. Schafer, S. K. Kralik, B. H. Tran, T. A. G. M. Huisman, J. N. Wright, L. A. Morgan, N. K. Desai
Summary: Nelarabine, a crucial nucleoside analog for treating T-cell acute lymphoblastic leukemia/lymphoma, has been associated with neurologic adverse events. This study reviewed neuroimaging findings of six pediatric patients with T-cell acute lymphoblastic leukemia who experienced nelarabine-induced toxicity. The neuroimaging findings showed various patterns such as acute toxic leukoencephalopathy, posterior reversible encephalopathy syndrome, involvement of deep gray structures and brainstem, cranial and spinal neuropathy, and myelopathy. The goal of this article was to raise awareness among pediatric neuroradiologists, radiologists, and clinicians about the potential neurotoxicity caused by nelarabine.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Review
Oncology
Sebastian F. Winter, Eugene J. Vaios, Helen A. Shih, Clemens Grassberger, Michael W. Parsons, Melissa M. Gardner, Felix Ehret, David Kaul, Wolfgang Boehmerle, Matthias Endres, Jorg Dietrich
Summary: Proton therapy has advantages over conventional radiotherapy in terms of toxicity profiles and potentially reduces late radiogenic complications. However, the impact of variable biological effectiveness of protons on dose distribution needs further investigation. Clinical trials are underway to establish the long-term treatment outcomes of proton therapy in adults with CNS malignancies.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Article
Oncology
Antonio Omuro, Alba A. Brandes, Antoine F. Carpentier, Ahmed Idbaih, David A. Reardon, Timothy Cloughesy, Ashley Sumrall, Joachim Baehring, Martin van den Bent, Oliver Bahr, Giuseppe Lombardi, Paul Mulholland, Ghazaleh Tabatabai, Ulrik Lassen, Juan Manuel Sepulveda, Mustafa Khasraw, Elodie Vauleon, Yoshihiro Muragaki, Anna Maria Di Giacomo, Nicholas Butowski, Patrick Roth, Xiaozhong Qian, Alex Z. Fu, Yanfang Liu, Von Potter, Alexandros-Georgios Chalamandaris, Kay Tatsuoka, Michael Lim, Michael Weller
Summary: This study showed that TMZ + RT had better efficacy than NIVO + RT in newly diagnosed GBM patients with unmethylated MGMT promoter. However, no new safety signals were detected with NIVO in this study.
Article
Oncology
Khe Hoang-Xuan, Martina Deckert, Andres J. M. Ferreri, Julia Furtner, Jaime Gallego Perez-Larraya, Roger Henriksson, Andreas F. Hottinger, Benjamin Kasenda, Florence Lefranc, Alexander Lossos, Catherine McBain, Matthias Preusser, Patrick Roth, Roberta Ruda, Uwe Schlegel, Riccardo Soffietti, Carole Soussain, Martin J. B. Taphoorn, Valerie Touitou, Michael Weller, Jacoline E. C. Bromberg
Summary: The management of primary central nervous system lymphoma (PCNSL) is a controversial topic in neuro-oncology. The European Association of Neuro-Oncology (EANO) formed a multidisciplinary task force to update the evidence-based guidelines and include immunosuppressed patients. The guideline provides consensus considerations and recommendations for the treatment of PCNSL, including intraocular manifestations and specific management of the elderly.
Article
Oncology
Philipp Vollmuth, Martha Foltyn, Raymond Y. Huang, Norbert Galldiks, Jens Petersen, Fabian Isensee, Martin J. van den Bent, Frederik Barkhof, Ji Eun Park, Yae Won Park, Sung Soo Ahn, Gianluca Brugnara, Hagen Meredig, Rajan Jain, Marion Smits, Whitney B. Pope, Klaus Maier-Hein, Michael Weller, Patrick Y. Wen, Wolfgang Wick, Martin Bendszus
Summary: This study aimed to assess the reproducibility and standardization of treatment response assessment using artificial intelligence (AI) decision support in MRI. The results showed that AI decision support can provide better evaluation of treatment response in patients with lower-grade gliomas compared to manual measurements.
Article
Oncology
Sied Kebir, Vivien Ullrich, Pia Berger, Celia Dobersalske, Sarah Langer, Laurel Rauschenbach, Daniel Trageser, Andreas Till, Franziska K. Lorbeer, Anja Wieland, Timo Wilhelm-Buchstab, Ashar Ahmad, Holger Froehlich, Igor Cima, Shruthi Prasad, Johann Matschke, Verena Jendrossek, Marc Remke, Barbara M. Gruener, Alexander Roesch, Jens T. Siveke, Christel Herold-Mende, Tobias Blau, Kathy Keyvani, Frank K. H. van Landeghem, Torsten Pietsch, Jorg Felsberg, Guido Reifenberger, Michael Weller, Ulrich Sure, Oliver Bruestle, Matthias Simon, Martin Glas, Bjoern Scheffler
Summary: This study aimed to identify and target tumor cells that can survive, adapt, and expand under primary therapy in glioblastoma. The researchers found that ALDH1A1+/pAKT+ subclones accumulate and acquire drug resistance in response to temozolomide treatment. They propose a combination therapy of temozolomide and AKT inhibitors as a potential treatment strategy.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Emilie Le Rhun, Felix Boakye Oppong, Martin van den Bent, Wolfgang Wick, Alba A. Brandes, Martin J. B. Taphoorn, Michael Platten, Ahmed Idbaih, Paul M. Clement, Matthias Preusser, Vassilis Golfinopoulos, Thierry Gorlia, Michael Weller
Summary: This study retrospectively analyzed the incidence of lomustine-induced thrombocytopenia and its impact on treatment exposure and survival in patients with recurrent glioblastoma. The results showed that thrombocytopenia induced by lomustine is a major limitation to adequate exposure to lomustine chemotherapy and is associated with inferior progression-free survival, particularly in patients with MGMT promoter-methylated tumors.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Clinical Neurology
Sofia Doubrovinskaia, Christoph M. Mooshage, Corinna Seliger, Hanns-Martin Lorenz, Simon Nagel, Pascal Lehnert, Jan Purrucker, Brigitte Wildemann, Martin Bendszus, Wolfgang Wick, Silvia Schoenenberger, Leon D. Kaulen
Summary: This study reports the long-term clinical, laboratory, and imaging characteristics of patients with neurological autoimmunity diagnosed in temporal association (<= 6 weeks) with SARS-CoV-2 vaccinations. The condition of most patients improved following therapy, and re-vaccinations were well tolerated. The results suggest that re-vaccinations should be considered based on individual risk-benefit analysis.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Oncology
Julie J. Miller, L. Nicolas Gonzalez Castro, Samuel McBrayer, Michael Weller, Timothy Cloughesy, Jana Portnow, Ovidiu Andronesi, Jill S. Barnholtz-Sloan, Brigitta G. Baumert, Mitchell S. Berger, Wenya Linda Bi, Ranjit Bindra, Daniel P. Cahill, Susan M. Chang, Joseph F. Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. Mellinghoff, L. Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Hai Yan, Andreas von Deimling, Martin van den Bent, William G. Kaelin, Patrick Y. Wen
Summary: This article discusses the diagnosis and management of IDH-mutant gliomas, as well as new treatment methods and future research directions.
Article
Clinical Neurology
Katharina Seystahl, Juliane Schweizer, Mira Katan, Sung Ju Weber, Alessia Hug, Miriam Wanner, Andreas R. Luft, Sabine Rohrmann, Susanne Wegener, Michael Weller
Summary: Cancer is not a risk factor for stroke-associated infections in stroke patients. The incidence, characteristics, and treatment of infections did not differ significantly between stroke patients with and without cancer. However, both cancer and stroke-associated infections were associated with in-hospital mortality.
NEURO-ONCOLOGY PRACTICE
(2023)
Article
Oncology
Angelika Scherm, Franziska Maria Ippen, Peter Hau, Hansjoerg Baurecht, Wolfgang Wick, Jens Gempt, Helge Knuettel, Michael F. Leitzmann, Corinna Seliger
Summary: Glioblastoma is the most common malignant brain tumor in adults, and current standard treatment involves surgery followed by radiochemotherapy. This meta-analysis examined the efficacy of targeted therapies in newly diagnosed glioblastoma patients. The analysis showed that targeted agents did not significantly improve overall survival, but they did provide a benefit in progression-free survival, particularly in patients with an unmethylated MGMT promoter. Inhibition of VEGF with bevacizumab was the most effective in prolonging progression-free survival.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Benjamin M. Ellingson, Patrick Y. Wen, Susan M. Chang, Martin van den Bent, Michael A. Vogelbaum, Gang Li, Shanpeng Li, Jiyoon Kim, Gilbert Youssef, Wolfgang Wick, Andrew B. Lassman, Mark R. Gilbert, John F. de Groot, Michael Weller, Evanthia Galanis, Timothy F. Cloughesy
Summary: This study reviewed past trials in recurrent glioblastoma and identified target objective response rates (ORRs) for different treatments. The study found that ORRs varied depending on the type of therapy, and ORR was significantly correlated with median overall survival (mOS) for chemotherapy, biologic, and immunotherapy trials. Based on this analysis, the study recommends a target ORR >25% and a sample size of >=40 patients for future studies in recurrent glioblastoma.
Article
Clinical Neurology
Tobias Kessler, Georges Sam, Wolfgang Wick, Markus Weiler
Summary: This study assessed the changes in compound muscle action potential (CMAP) amplitudes before and during risdiplam treatment in adult patients with 5q-linked spinal muscular atrophy (SMA). The results showed that the increase in CMAP amplitudes in the median nerve was associated with clinical improvement, suggesting that it could be used as an easy-to-use electrophysiological marker to monitor treatment response.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Niklas Grassl, Isabel Poschke, Katharina Lindner, Lukas Bunse, Iris Mildenberger, Tamara Boschert, Kristine Jahne, Edward W. Green, Ingrid Hulsmeyer, Simone Juenger, Tobias Kessler, Abigail K. Suwala, Philipp Eisele, Michael O. Breckwoldt, Peter Vajkoczy, Oliver M. Grauer, Ulrich Herrlinger, Joerg-Christian Tonn, Monika Denk, Felix Sahm, Martin Bendszus, Andreas von Deimling, Frank Winkler, Wolfgang Wick, Michael Platten, Katharina Sahm
Summary: The treatment of H3K27M-vac in patients with progressive H3K27M(+) diffuse midline glioma demonstrates its safety and immunogenicity, and may improve patients' survival.
Article
Oncology
Christoper Kraemer, Michael Kilian, Yu-Chan Chih, Alexandros Kourtesakis, Dirk C. Hoffmann, Tamara Boschert, Philipp Koopmann, Khwab Sanghvi, Alice De Roia, Stefanie Jung, Kristine Jaehne, Bryan Day, Lenny D. Shultz, Miriam Ratliff, Richard Harbottle, Edward W. Green, Rainer Will, Wolfgang Wick, Michael Platten, Lukas Bunse
Summary: This study identified an antigen that is overexpressed in human gliomas and can induce specific cytotoxic T cell responses through vaccination, indicating its potential therapeutic efficacy in treating glioblastoma.
