Article
Oncology
Jonathan P. S. Knisely, Howard A. Fine
Summary: The Oncology Grand Rounds series aims to provide clinical context to original reports published in the Journal. It includes case presentations, discussions on diagnostic and management challenges, literature reviews, and suggested management approaches by the authors. The goal is to help readers apply key study findings, including those from the Journal of Clinical Oncology, to their own clinical practice.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Yifan Ma, Yue Wang, Chen Nie, Yongzhong Lin
Summary: Through a comprehensive meta-analysis, this study found that targeted therapy combined with radiotherapy and chemotherapy can improve the survival rate and progression-free survival of glioma patients to some extent.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Fan Wang, CaiYan Li, Fei Han, LvAn Chen, Ling Zhu
Summary: The BMAL1 gene plays a crucial role in glioma tolerance for anti-angiogenesis therapy, as its expression is correlated with ANG2 and VEGF levels, microvascular density, and peritumoral edema. In vitro experiments show that silencing BMAL1 decreases VEGF expression, while overexpression promotes ANG2 and VEGF expression.
Article
Oncology
Yueyang Mou, Yaqin Hu, Guolian Xue, Wenjian Zhao, Yang Jiao, Chen Li, Haiyan Cao, Min Chao, Jianping Deng, Penggao Dai, Hongli Zhu, Liang Wang
Summary: ELK3 plays a crucial role in glioma angiogenesis by activating the HIF-1 alpha/VEGF-A signaling axis. It may serve as a prognostic marker for glioma angiogenesis and targeting ELK3 may improve the efficacy of anti-angiogenic therapies.
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Sang-Soo Choi, Haeyoun Choi, In-Cheol Baek, Soon A. Park, Jae-Sung Park, Tai-Gyu Kim, Sin-Soo Jeun, Stephen Ahn
Summary: This case-control study evaluated the association between HLA polymorphism and the risk of glioblastoma development in Koreans. Findings suggest that certain HLA types may affect the development of glioblastoma in Koreans. Further research with larger sample sizes is needed to confirm the role of HLA polymorphisms in the pathogenesis of glioblastoma.
Article
Biochemistry & Molecular Biology
Xiuhong Wei, Bolian Xiao, Liying Wang, Lanlan Zang, Fengyuan Che
Summary: The development of new therapeutic targets for glioma treatment focusing on histone modification-related proteins provides novel insights for current clinical glioma treatment. However, limitations exist in current clinical therapies and future research should focus on potential advances in disease prognosis areas.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Xiaoguang Qiu, Yidong Chen, Zhaoshi Bao, Li Chen, Tao Jiang
Summary: In patients with IDH-wt/TERTp-mut grade II/III gliomas, the combination of radiotherapy and temozolomide followed by adjuvant temozolomide resulted in significantly longer overall survival compared to radiotherapy alone. Female sex was identified as a significant favorable prognostic factor.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Immunology
Baofeng Guo, Shengnan Zhang, Libo Xu, Jicheng Sun, Wai-Lun Chan, Pengfei Zheng, Jinnan Zhang, Ling Zhang
Summary: In this systematic review and meta-analysis, the efficacy and safety of immunotherapy in high-grade glioma (HGG) were evaluated. The study found that immunotherapy extended the overall survival (OS) and progression-free survival (PFS) of the patients, although adverse events were observed. Dendritic cell (DC) vaccine significantly prolonged the OS of HGG patients, while oncolytic viral therapy (VT) showed survival extension only in a subgroup analysis. Immunopotentiation (IP) did not prolong OS, but further investigation is needed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Seth A. Climans, Eva Grunfeld, Warren P. Mason, Kelvin K. W. Chan
Summary: In regions where PCP is rare, routine PCP prophylaxis with trimethoprim-sulfamethoxazole should not be offered as the risks may outweigh the benefits.
Article
Biochemistry & Molecular Biology
Przemyslaw Wielgat, Natalia Wawrusiewicz-Kurylonek, Robert Czarnomysy, Karol Rogowski, Krzysztof Bielawski, Halina Car
Summary: Paired Siglecs play a role in immune homeostasis and potentially pathogenesis. Dexamethasone and temozolomide may modulate immune responses in gliomas, affecting their therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yiting Wei, Shilong Duan, Fanyong Gong, Qiang Li
Summary: This study investigated the molecular mechanisms underlying resistance to the chemotherapeutic agent Temozolomide (TMZ) in glioma cells. The researchers found that the upregulation of the RNA-binding protein FXR1 was associated with TMZ resistance in glioma. Knockdown of FXR1 promoted ferroptosis and overcame TMZ resistance. Additionally, FXR1 was found to bind with GPX4 mRNA and positively regulate GPX4 expression. Inhibition of GPX4 further increased TMZ sensitivity in glioma cells with upregulated FXR1. Targeting the FXR1-GPX4 pathway may be a potential strategy to overcome chemoresistance to TMZ in glioma cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Yong-Wen Deng, Yu-Gao Shu, Sheng-Li Sun
Summary: miR-376a directly targets and inhibits SIRT1 in glioma cells. Downregulation of SIRT1 resulted in decreased YAP1 and VEGF signaling, which led to suppression of glioma cell proliferation, migration, and angiogenesis.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Clinical Neurology
Matteo Riva, Roxanne Wouters, Edmond Sterpin, Roberto Giovannoni, Louis Boon, Uwe Himmelreich, Willy Gsell, Marc Van Ranst, An Coosemans
Summary: The combination of RT with TMZ induces strong immune suppression in high-grade gliomas, which cannot be effectively counteracted by alpha PD1.
Article
Multidisciplinary Sciences
Ping Zhu, Xianglin L. Du, Lu-yu Hwang, David Lairson, Ruosha Li, Yoshua Esquenazi, Jay-Jiguang Zhu
Summary: The optimal time to initiate adjuvant therapy (AT) in elderly patients with glioblastoma (GBM) remains uncertain. Two large-scale datasets from the United States were used to investigate the impact of timing on overall survival (OS) in elderly GBM populations. The study found that initiating AT with a modest delay (27-37 days) or a longer delay (>= 38 days) after craniotomy may be the preferred timing for elderly GBM patients.
SCIENTIFIC REPORTS
(2023)