Article
Multidisciplinary Sciences
Abbas Saad Alatrany, Wasiq Khan, Abir Hussain, Dhiya Al-Jumeily
Summary: The increasing incidence of Alzheimer's disease (AD) poses socioeconomic challenges. In this study, a hybrid feature selection approach and neural network models are used to predict AD. The approach outperformed existing methods with 99% accuracy and f1-score, providing impactful outcomes for other chronic diseases.
Article
Neurosciences
Sarang Kang, Jungsoo Gim, Jiwoon Lee, Tamil Iniyan Gunasekaran, Kyu Yeong Choi, Jang Jae Lee, Eun Hyun Seo, Pan-Woo Ko, Ji Yeon Chung, Seong-Min Choi, Young Min Lee, Jee Hyang Jeong, Kyung Won Park, Min Kyung Song, Ho-Won Lee, Ki Woong Kim, Seong Hye Choi, Dong Young Lee, Sang Yun Kim, Hoowon Kim, Byeong C. Kim, Takeshi Ikeuchi, Kun Ho Lee
Summary: This study identified two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) in East Asian APOE epsilon 4 non-carrier subjects, located in the PRIG1 and CACNA1A genes. The findings suggest that the discovery of AD-associated variants is possible in non-European ethnic groups, even with fewer subjects and a more homogeneous genetic background.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Multidisciplinary Sciences
Qingqin S. Li, Randall L. Morrison, Gustavo Turecki, Wayne C. Drevets
Summary: Epigenetic mechanisms play a significant role in the etiology of major depressive disorder (MDD), as indicated by a meta-analysis study. The study identified differentially methylated positions (DMPs) and differentially methylated regions (DMRs) associated with MDD, highlighting the involvement of pathways related to neuronal synaptic plasticity, calcium signaling, and inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Huilong Hong, Mei Li, Yijie Chen, Haorang Wang, Jun Wang, Bingfu Guo, Huawei Gao, Honglei Ren, Ming Yuan, Yingpeng Han, Lijuan Qiu
Summary: This study analyzed the phenotypic diversity and genetic basis of epicotyl length (EL) in soybean using 951 cultivars and landraces from different regions. The study identified 180 QTNs and QEIs associated with EL, and predicted 10 candidate genes that may be involved in seed germination and seedling development.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Multidisciplinary Sciences
David O. Enoma, Janet Bishung, Theresa Abiodun, Olubanke Ogunlana, Victor Chukwudi Osamor
Summary: This article discusses the applications and future trends of machine learning algorithms in genome-wide association studies (GWAS) to better understand the effects of population genetic variants. The study found that algorithms such as classification, regression, ensemble, and neural networks have been applied to GWAS and their application areas are comprehensively discussed.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Mathematical & Computational Biology
An Zeng, Huabin Rong, Dan Pan, Longfei Jia, Yiqun Zhang, Fengyi Zhao, Shaoliang Peng
Summary: This study advocates for a data-driven approach by integrating CNN and EL with GA, proposing the CNN-EL-GA method to identify potential neuroimaging and genetic biomarkers for Alzheimer's disease and other brain disorders. This method overcomes limitations related to subjective factors and dependence on prior knowledge, adaptively achieving more robust and effective candidate biomarkers.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
(2021)
Article
Genetics & Heredity
Michal Marczyk, Agnieszka Macioszek, Joanna Tobiasz, Joanna Polanska, Joanna Zyla
Summary: The study evaluated the impact of different integration methods and linkage disequilibrium correction on multiple GSA algorithms, with CERNO and MAGENTA combined with Stouffer method showing the most efficiency. LD correction increased prioritization and specificity of enrichment outcomes for all tested algorithms. The best performance was observed when using Fisher or Stouffer integration with LD correction.
FRONTIERS IN GENETICS
(2021)
Article
Dermatology
Ryosuke Okuno, Yu Inoue, Yuichi Hasebe, Toshio Igarashi, Mika Kawagishi-Hotta, Takaaki Yamada, Seiji Hasegawa
Summary: Research has found that some individuals have a genetic predisposition to skin aging, which may be associated with single nucleotide polymorphisms (SNPs). A genome-wide association study on Japanese women revealed that 5 SNPs within the COL5A3 gene were associated with wrinkles at the outer corners of the eyes, and 8q24.11 was associated with nasolabial folds. These SNPs have not been reported in other populations and may serve as markers for genetic predisposition to wrinkles and sagging.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Genetics & Heredity
Aliza P. Wingo, Yue Liu, Ekaterina S. Gerasimov, Jake Gockley, Benjamin A. Logsdon, Duc M. Duong, Eric B. Dammer, Chloe Robins, Thomas G. Beach, Eric M. Reiman, Michael P. Epstein, Philip L. De Jager, James J. Lah, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey, Thomas S. Wingo
Summary: This study identified 11 genes that may play a role in Alzheimer's disease (AD) by affecting brain protein abundance, through a proteome-wide association study. Eight of these genes are new AD risk genes not identified before by AD GWAS, providing new insights into AD pathogenesis. This research offers promising targets for further mechanistic and therapeutic studies on AD.
Article
Multidisciplinary Sciences
Abbas Dehghan, Rui Climaco Pinto, Ibrahim Karaman, Jian Huang, Brenan R. Durainayagam, Mohsen Ghanbari, Areesha Nazeer, Qi Zhong, Sonia Liggi, Luke Whiley, Rima Mustafa, Miia Kivipelto, Alina Solomon, Tiia Ngandu, Takahisa Kanekiyo, Tomonori Aikawa, Carola I. Radulescu, Samuel J. Barnes, Goncalo Graca, Elena Chekmeneva, Stephane Camuzeaux, Matthew R. Lewis, Manuja R. Kaluarachchi, M. Arfan Ikram, Elaine Holmes, Ioanna Tzoulaki, Paul M. Matthews, Julian L. Griffin, Paul Elliott
Summary: Genome-wide association studies have identified genetic loci associated with the risk of Alzheimer's disease (AD). In this study, we used metabolomics to investigate the molecular mechanisms underlying these associations. We found an association between lactosylceramides and AD-related single-nucleotide polymorphisms in the ABCA7 gene. We also observed altered concentrations of certain lipids in brain tissue from knockout mice, suggesting that these lipid abnormalities may contribute to the risk of AD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Tatsuhiko Naito, Kosuke Inoue, Kyuto Sonehara, Ryuta Baba, Takaya Kodama, Yu Otagaki, Akira Okada, Kiyotaka Itcho, Kazuhiro Kobuke, Shinji Kishimoto, Kenichi Yamamoto, Takayuki Morisaki, Yukihito Higashi, Nobuyuki Hinata, Koji Arihiro, Noboru Hattori, Yukinori Okada, Kenji Oki
Summary: This study identified 10 loci associated with the risk of primary aldosteronism (PA) in the Japanese population, and 5 significantly associated loci in a cross-ancestry meta-analysis. The strongest association was found with a variant of the WNT2B gene, highlighting the involvement of the Wnt/beta-catenin pathway in PA pathogenesis.
Article
Genetics & Heredity
Jeremy Schwartzentruber, Sarah Cooper, Jimmy Z. Liu, Inigo Barrio-Hernandez, Erica Bello, Natsuhiko Kumasaka, Adam M. H. Young, Robin J. M. Franklin, Toby Johnson, Karol Estrada, Daniel J. Gaffney, Pedro Beltrao, Andrew Bassett
Summary: A genome-wide AD meta-analysis identified 37 risk loci, including new associations near CCDC6, TSPAN14, NCK2, and SPRED2. By fine-mapping SNPs and using functional annotation, 21 SNPs with >50% probability of being causally involved in AD risk were identified. Protein interaction networks and tissue-specific expression helped prioritize genes, leading to the discovery of likely causal genes.
Article
Computer Science, Interdisciplinary Applications
Xinyue Wang, Xiaoqian Jiang, Jaideep Vaidya
Summary: The paper proposes two algorithms for generating synthetic SNPs that are indistinguishable from real SNPs. Through game theoretic analysis, it demonstrates the possibility of incentivizing honest behavior by the server. Extensive experiments show that the proposed method can ensure efficient and trustworthy outsourcing of logistic regression for GWAS.
JOURNAL OF BIOMEDICAL INFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Thomas Greither, Hermann M. Behre, Holger Herlyn
Summary: Deciphering the functional relationships between genes associated with phenotypic variations can be challenging. In this study, a genome-wide association study (GWAS) linked twelve non-synonymous single-nucleotide polymorphisms (SNPs) to fertility variation in men. These SNPs were located in nine genes that have been previously implicated in male fertility. The study also identified potential biomarkers for the diagnosis of male fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Xiaoyu Liang, Xuewei Cao, Qiuying Sha, Shuanglin Zhang
Summary: The article introduces a novel multivariate method for phenome-wide association studies (PheWAS) and demonstrates its superiority through extensive simulation studies and real-life application. The proposed method involves hierarchical clustering, clustering linear combination, and false discovery rate control steps.
Article
Engineering, Electrical & Electronic
Yangyang Shi, Yuanjin Yu, Qingying Wang, Haitao Li, Xi Chen
Summary: In the gimbal system of SGMSCMG, harmonic drive is used to ensure large output torque and reduce motor volume and weight, but its nonlinear characteristics decrease system performance. A composite control method based on model-based feed-forward and fuzzy integral sliding mode control (FISMC) is proposed to suppress gear wave torque and other disturbances. Simulation and experiments on SGMSCMG validate the effectiveness of the composite method, showing improved torque fluctuation suppression and gimbal system performance.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Ruyu Li, Yu Zhao, Tingting Zhang, Zejin Ju, Xianbing Ji, Yanshuai Cui, Longgang Wang, Haiyan Xiao
Summary: In this paper, stable small Pd nanoparticles were prepared using bitter gourd polysaccharide as reducing agent and stabilizing agent. These nanoparticles exhibit peroxidase-like catalytic property and can be used for H2O2 detection. The method shows a wide linear range and low detection limit. Furthermore, the nanoparticles demonstrate good biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Zisheng Sun, Lingna Kong, Xiaoyan Wang, Yue Lei, Xige Li, Hongwei Tang, Yan Hou, Kun Chang, Zhaorong Chang
Summary: In this study, Fe3O4/C-Bi composites with carbon coating and bismuth added were prepared by step-by-step precipitation, spray carbon coating drying, and high-temperature treatment. The Fe3O4/C-Bi composite materials exhibited excellent electrochemical properties, especially the Fe3O4/C-Bi(5%) electrode, which showed the best performance. The composite materials effectively inhibited hydrogen evolution and passivation of iron electrodes, and AA600 cylindrical iron nickel batteries with Fe3O4/C-Bi(5%) as the active material for iron negative electrodes achieved sealing for the first time.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Materials Science, Multidisciplinary
Yingnan Yang, Yingjie Yang, Chunlin He, Yuezhou Wei, Toyohisa Fujita, Guifang Wang, Shaojian Ma, Wenchao Yang
Summary: In order to effectively separate and recover Co(II) from the leachate of spent lithium-ion battery cathodes, solvent extraction with quaternary ammonium salt N263 in the sodium nitrite system was investigated. The extraction of Co(II) is related to the concentration of NO2-. The maximum extraction efficiency of Co(II) reached 99.16%. After counter-current extraction using the McCabe-Thiele diagram, the extraction efficiency of Co(II) exceeded 99.00% with Co(II) concentration of 2544 mg/L. The back-extraction efficiency of Co(II) achieved 91.41% under specific conditions.
INTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS
(2023)
Article
Ecology
Lintao Huang, Xiaolei Yu, Chengyue Liu, Lei Jiang, Lunju Chen, Wentao Ye, Pan Zhang, Yuyang Zhang, Hui Huang
Summary: Coral outplanting is a potential method for restoring degraded reefs, and the type of nail and coral orientation affect its success. An experiment conducted in Luhuitou Reef, China, showed that using eta nails and upside-down orientation led to the highest coral self-attachment during outplanting.
RESTORATION ECOLOGY
(2023)
Review
Biology
Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen, Xiao Chen, Yanhao Chen, Yu Chen, Yutian Chen, Zhiyang Chen, Jagadish K. Chhetri, Yingjie Ding, Junlin Feng, Jun Guo, Mengmeng Guo, Chuting He, Yujuan Jia, Haiping Jiang, Ying Jing, Dingfeng Li, Jiaming Li, Jingyi Li, Qinhao Liang, Rui Liang, Feng Liu, Xiaoqian Liu, Zuojun Liu, Oscar Junhong Luo, Jianwei Lv, Jingyi Ma, Kehang Mao, Jiawei Nie, Xinhua Qiao, Xinpei Sun, Xiaoqiang Tang, Jianfang Wang, Qiaoran Wang, Siyuan Wang, Xuan Wang, Yaning Wang, Yuhan Wang, Rimo Wu, Kai Xia, Fu-Hui Xiao, Lingyan Xu, Yingying Xu, Haoteng Yan, Liang Yang, Ruici Yang, Yuanxin Yang, Yilin Ying, Le Zhang, Weiwei Zhang, Wenwan Zhang, Xing Zhang, Zhuo Zhang, Min Zhou, Rui Zhou, Qingchen Zhu, Zhengmao Zhu, Feng Cao, Zhongwei Cao, Piu Chan, Chang Chen, Guobing Chen, Hou-Zao Chen, Jun Chen, Weimin Ci, Bi-Sen Ding, Qiurong Ding, Feng Gao, Jing-Dong J. Han, Kai Huang, Zhenyu Ju, Qing-Peng Kong, Ji Li, Jian Li, Xin Li, Baohua Liu, Feng Liu, Lin Liu, Qiang Liu, Qiang Liu, Xingguo Liu, Yong Liu, Xianghang Luo, Shuai Ma, Xinran Ma, Zhiyong Mao, Jing Nie, Yaojin Peng, Jing Qu, Jie Ren, Ruibao Ren, Moshi Song, Zhou Songyang, Yi Eve Sun, Yu Sun, Mei Tian, Shusen Wang, Si Wang, Xia Wang, Xiaoning Wang, Yan-Jiang Wang, Yunfang Wang, Catherine C. L. Wong, Andy Peng Xiang, Yichuan Xiao, Zhengwei Xie, Daichao Xu, Jing Ye, Rui Yue, Cuntai Zhang, Hongbo Zhang, Liang Zhang, Weiqi Zhang, Yong Zhang, Yun-Wu Zhang, Zhuohua Zhang, Tongbiao Zhao, Yuzheng Zhao, Dahai Zhu, Weiguo Zou, Gang Pei, Guang-Hui Liu
Summary: Aging biomarkers are a combination of biological parameters used to assess age-related changes, track the physiological aging process, and predict the transition into a pathological status. This review summarizes the current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, and proposes that aging biomarkers should be specific, systemic, and clinically relevant.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Computer Science, Interdisciplinary Applications
Mingxin Yao, Ying Wei, Huiyu Wang
Summary: This study tracked the diachronic development of hedges that express doubt and uncertainty in Science research articles from 1997 to 2021. The findings show a significant decrease in the use of such hedges in the past 25 years. This suggests that reducing uncertainty may be an implicit writing strategy correlated with the rising linguistic positivity in academic writing.
Article
Engineering, Chemical
Mengyao Jiang, Jiangnan Huang, Guangxing Yang, Hongjuan Wang, Hao-Fan Wang, Feng Peng, Yonghai Cao, Hao Yu
Summary: Electro-adsorption is a promising technology for wastewater treatment, but its practical application still faces challenges. This study developed a mesoporous carbon monolith (MCM) as an adsorbent, which showed high removal performances for both organic and inorganic contaminants with the aid of an electric field. The low resistance, high specific capacitance, and specific surface area of MCM were beneficial for contaminant transportation and storage, improving the removal performance.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yunjia Liu, Si Lin, Yali Zhu, Xiaoying Gao, Zhipeng Wang, Shenghong Yang, Jian Liu
Summary: A simple polyvinyl alcohol (PVA)-mediated evaporation drying strategy is introduced to uniformly deposit functional constituents on porous foam. PVA enhances the coffee-ring effect and stabilizes various functional constituents, resulting in homogeneous accumulation on the surface periphery of the foam. The deposition thickness is dependent on the feeding amounts of PVA but independent of drying temperature. Furthermore, the formation of core-shell foams is induced by 3D outward capillary flow driven by contact surface pinning and continual interfacial evaporation. The enhanced interfacial photothermal effect and solar desalination performance of PVA/polypyrrole-coated foam are demonstrated.
Article
Chemistry, Multidisciplinary
Shoujie Li, Xiao Dong, Jianing Mao, Wei Chen, Aohui Chen, Gangfeng Wu, Chang Zhu, Guihua Li, Yiheng Wei, Xiaohu Liu, Jiangjiang Wang, Yanfang Song, Wei Wei
Summary: A nanosheet shell (NS) vertically standing on the Ag hollow fiber (NS@Ag HF) surface formed by electrochemical surface reconstruction is reported. The as-prepared NS@Ag HF exhibited a high CO faradaic efficiency of 97% at an ultra-high current density of 2.0 A cm(-2) with sustained performance for continuous >200 h operation. Experimental and theoretical studies reveal that the promoted surface electronic structures of NS@Ag HF by the nanosheets suppress the competitive hydrogen evolution reaction and facilitate the CO2 reduction kinetics. This work provides a feasible strategy for fabricating robust catalysts for highly efficient and stable CO2 reduction.
Article
Biochemical Research Methods
Zhongyun Lan, Lingyun Li, Yili Sun, Xiangjing Meng, Zhenzhong Shi, Mengyang Du, Hui Wang, Zengchao Sun, Qianqian Cui, Lu Wang, Tengjie Geng, Siyu Zhou, Yi'ang Wang, Fangzheng Hu, Chonggang Duan, Yong Geng, Yongheng Zhu, Yuanyuan Dai
Summary: In this study, a nanobody A-LY01 specific to AXL-IG was successfully screened by immunizing camelid with purified AXL-IG, and it was demonstrated that A-LY01 could specifically recognize full-length AXL on the surface of HEK 293T/17 cells. This study provides strong support for the development of diagnostic reagents and antibody therapeutics targeting AXL.
PROTEIN EXPRESSION AND PURIFICATION
(2023)
Article
Chemistry, Physical
Boyu Wang, Tianyi Qiu, Lin Yuan, Qinglong Fang, Xiaojuan Wang, Xiaolin Guo, Dongdong Zhang, Caifeng Lai, Qi Wang, Yang Liu
Summary: Flexible W/Bi and bismuth tungsten oxide composites based on thermoplastic vulcanizate with doping ratios from 20% to 100% were successfully fabricated. The ray attenuation abilities of the composites were investigated at various X-ray tube voltages and gamma ray energies. The study demonstrated that bismuth tungsten oxide particles exhibited more uniform dispersion within the polymer compared to W/Bi. The shielding parameters, including transmittance, attenuation coefficients, and lead equivalent, were experimentally and numerically investigated.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Review
Plant Sciences
Haonan Xu, Wei Wang, Xinzhuo Li, Yuze Li, Chong Deng, Yi Jiang, Xiaomei Song, Dongdong Zhang
Summary: The genus Kadsura is an important part of traditional Chinese medicine, with lignans as its main active components. This review provides a systematic summary of the traditional use, phytochemistry, pharmacology, toxicology, and other aspects of lignans in genus Kadsura. Over 337 lignans have been isolated from this genus, exhibiting various medicinal effects including antitumor, anti-inflammatory, antibacterial, anti-HIV, anti-platelet aggregation, immunomodulatory, and antioxidant effects. Clarification of its active ingredients, mechanism of action, and establishment of quality standards are needed for further study.
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Engineering, Industrial
Xixi Luo, Xinchun Li, Yang Miang Goh, Xuefeng Song, Quanlong Liu
Summary: This paper aims to enhance text data pre-processing and optimize machine learning algorithms to create an attribute factor-based occupational accident severity prediction framework. The findings indicate that the dataset obtained after addressing the class imbalance issue and improving the text segmentation procedure can be utilized as a training sample to accurately predict injury severity.
Article
Environmental Sciences
Danyang Shi, Zhongwei Yang, Yijun Wei, Jing Miao, Dong Yang, Jing Yin, Haibei Li, Tianjiao Chen, Shuqing Zhou, Junwen Li, Chao Li, Min Jin
Summary: A study conducted at the First Bathing Beach in Qingdao found that people who engage in water sports in recreational marine water may face a high risk of exposure to hazardous antibiotic-resistant bacteria. The study analyzed antibiotic resistance genes (ARGs), pathogenic bacteria, and 16S rRNA sequencing data, and found that sewage was the main source of ARG pollution in the swimming area during the cold season. However, ARG pollution in the swimming area was also driven by other sources, especially in the warm season.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
