Article
Psychiatry
Marie-Louis Wronski, Charlotte Hohnemann, Fabio Bernardoni, Klaas Bahnsen, Arne Doose, Dominic Arold, Katrin Borucki, Laura M. Holsen, Elizabeth A. Lawson, Franziska Plessow, Kerstin Weidner, Veit Roessner, Stefan Diestel, Joseph A. King, Maria Seidel, Stefan Ehrlich
Summary: This study provides first evidence for the relevance of specific amygdala substructure reductions regarding cognitive symptom severity in AN and points toward novel mechanistic insight into the relationship between hypoleptinemia and rumination, which might involve the amygdaloid complex.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Nutrition & Dietetics
Zaneta Malczyk, Wojciech Roczniak, Bogdan Mazur, Jaroslaw Kwiecien, Katarzyna Ziora, Karolina Gorska-Flak, Joanna Oswiecimska
Summary: The study found that pancreatic efficiency of lipase secretion in girls with anorexia nervosa was normal, but the kinetics of this enzyme secretion were disturbed, potentially due to disorders in the functioning of the adipose-insular and islet-acinar axes.
Article
Health Care Sciences & Services
Andrea Amerio, Andrea Escelsior, Eleonora Martino, Antonella Strangio, Andrea Aguglia, Matteo Marcatili, Benedetta Conio, Samir Giuseppe Sukkar, Daniele Saverino
Summary: The aim of this study was to evaluate the correlation between circulating SIRT1 and leptin, ghrelin, body mass index (BMI), and IgG reactive to hypothalamic antigens in anorexia nervosa (AN). Results showed that serum SIRT1 levels were increased in AN patients and decreased with the duration of illness. There was a negative correlation between SIRT1 and leptin/BMI, and a positive correlation between SIRT1 and ghrelin/IgG specific for hypothalamic antigens. These findings suggest that SIRT1 may serve as a clinical/biochemical parameter related to AN.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Psychology, Multidisciplinary
Regina C. Casper
Summary: Anorexia nervosa is a disorder characterized by voluntary food restriction and severe weight loss in female adolescents. The process of incorporating the starved thin body into the self-concept is insufficiently researched. Starvation-induced increased urge to move and restlessness may contribute to the development of AN. Leptin administration has shown potential in alleviating AN symptoms, but full recovery requires addressing psychological conflicts through psychotherapy.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Medicine, General & Internal
Karina W. Davidson, Michael J. Barry, Carol M. Mangione, Michael Cabana, David Chelmow, Tumaini Rucker Coker, Esa M. Davis, Katrina E. Donahue, Carlos Roberto Jaen, Martha Kubik, Li Li, Gbenga Ogedegbe, Lori Pbert, John M. Ruiz, Michael Silverstein, James Stevermer, John B. Wong
Summary: Eating disorders are psychiatric conditions that disturb eating or eating-related behaviors and impair physical and psychosocial functioning. The prevalence of these disorders is relatively high, and they are associated with various health problems. This article evaluates the benefits and harms of screening for eating disorders in adolescents and adults with a normal or high body mass index, and concludes that there is insufficient evidence to determine the balance of benefits and harms.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Editorial Material
Psychology, Clinical
Scott J. Crow
Summary: In this issue of International Journal of Eating Disorders, Walsh et al. review the research comparing atypical anorexia nervosa (atypical AN) and AN. Most differences observed were related to weight, while psychopathology and complications were similar. The findings suggest that atypical AN and AN are not fundamentally different, emphasizing the need for further research. The high prevalence of atypical AN in clinical settings highlights the importance of continuing research.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Nutrition & Dietetics
Katarzyna Jowik, Monika Dmitrzak-Weglarz, Natalia Pytlinska, Anna Jasinska-Mikolajczyk, Agnieszka Slopien, Marta Tyszkiewicz-Nwafor
Summary: This study evaluated the plasma levels of APE-13 and ASP, as well as related metabolic and psychometric parameters, in patients with anorexia nervosa. The findings suggest that APE-13 and ASP may serve as biomarkers for anorexia nervosa, and their levels are associated with eating behavior, emotional behavior, and the severity of psychopathological symptoms of eating disorders.
Editorial Material
Medicine, General & Internal
Daniel O'Meara, Lea Sheward, Sydney Hartman-Munick, Jessica Addison, Aya Abu-El-Haija
Summary: This passage describes a 17-year-old girl with a history of anxiety and anorexia nervosa who presented with a range of physical discomfort symptoms and was found to have multiple electrolyte imbalances.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nutrition & Dietetics
Heather M. McDonald, Tony Lin, Lulu L. C. D. Bursztyn
Summary: A young woman presented with significant weight loss and malnutrition due to decreased food intake, initially diagnosed with ARFID but later found to have a suprasellar and pineal germinoma. While there have been cases of germinomas misdiagnosed as anorexia nervosa, this is the first reported case of a multifocal germinoma presenting as ARFID. The criteria for diagnosing ARFID do not include body image distortion, potentially leading to misdiagnosis.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Genetics & Heredity
Triinu Peters, Jochen Antel, Roaa Naaresh, Bjoern-Hergen Laabs, Manuel Foecker, Nicola Albers, Judith Buehlmeier, Anke Hinney, Lars Libuda, Johannes Hebebrand
Summary: Genetic correlations indicate a coexisting genetic predisposition to low leptin levels and risk for anorexia nervosa. Mendelian randomization analyses suggest a causal effect of lower leptin levels on a higher risk of AN, especially in females. However, there is no clear causal effect of AN on leptin levels. These findings imply that low endogenous leptin synthesis may be a risk factor for developing AN, pending confirmation in larger GWAS datasets.
FRONTIERS IN GENETICS
(2021)
Article
Psychology, Clinical
Youngjung Kim, Jonathan Hersch, Lindsay P. Bodell, Janet Schebendach, Tom Hildebrandt, B. Timothy Walsh, Laurel E. S. Mayer
Summary: This study found that higher leptin levels after weight restoration in AN patients are associated with better weight maintenance outcomes, suggesting leptin may be a potential biomarker for improving clinical prognosis.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2021)
Article
Endocrinology & Metabolism
Federico Bigazzi, Carlotta Francesca De Pasquale, Sandra Maestro, Carmen Corciulo, Beatrice Dal Pino, Francesco Sbrana, Tiziana Sampietro
Summary: Anorexia nervosa (AN) patients exhibit elevated LDL-C levels due to their malnutrition, which increases the risk of cardiovascular disease. We investigated PCSK9 levels in AN patients to gain insight into metabolic changes.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Medicine, General & Internal
Leah Puckett, Daniela Grayeb, Vishnupriya Khatri, Kamila Cass, Philip Mehler
Summary: Anorexia nervosa is a complex and deadly psychiatric disorder characterized by co-occurring psychiatric diseases and physiological changes affecting various organ systems. Early recognition and treatment are crucial to prevent serious consequences for patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Gregory L. Hundemer, Anna Clarke, Ayub Akbari, Ann Bugeja, David Massicotte-Azarniouch, Greg Knoll, Daniel T. Myran, Peter Tanuseputro, Manish M. Sood
Summary: In this case-control study, individuals with eating disorders were more likely to have outpatient electrolyte abnormalities compared to matched controls. Unexplained electrolyte abnormalities may serve as markers for potential underlying eating disorders, indicating the need for screening.
Article
Nutrition & Dietetics
Alessio Maria Monteleone, Jacopo Troisi, Gloria Serena, Alessio Fasano, Riccardo Dalle Grave, Giammarco Cascino, Francesca Marciello, Simona Calugi, Giovanni Scala, Giulio Corrivetti, Palmiero Monteleone
Summary: Alterations in the gut microbiome and fecal metabolites were found in anorexia nervosa (AN), with differences seen between those with restricting AN (ANR) and binge-purging AN (ANBP) types. ANBP patients showed significant differences in microbial abundances and metabolites compared to ANR patients. Despite small sample size, this study confirms the occurrence of distinct gut dysbiosis in ANR and ANBP, showcasing different connections between gut microorganisms and fecal metabolites in the two AN types.
Article
Pharmacology & Pharmacy
Karin M. Egberts, Manfred Gerlach, Christoph U. Correll, Paul L. Plener, Uwe Malzahn, Peter Heuschmann, Stefan Unterecker, Maike Scherf-Clavel, Hans Rock, Gisela Antony, Wolfgang Briegel, Christian Fleischhaker, Alexander Hage, Tobias Hellenschmidt, Harmut Imgart, Michael Kaess, Andreas Karwautz, Michael Kolch, Karl Reitzle, Tobias Renner, Su-Yin Reuter-Dang, Christian Rexroth, Gerd Schulte-Korne, Frank M. Theisen, Susanne Walitza, Christoph Wewetzer, Stefanie Fekete, Regina Taurines, Marcel Romanos
Summary: Despite limited knowledge about the benefit-risk ratio in clinical practice, a study monitoring children and adolescents treated with antidepressants and/or antipsychotics found that off-label use did not significantly increase the risk of serious adverse drug reactions. This suggests that closely monitored clinical settings can provide valuable insights bridging the gap between randomized controlled trials and real-world clinical settings.
PHARMACOPSYCHIATRY
(2022)
Article
Clinical Neurology
Stefanie Fekete, Christine Kulpok, Regina Taurines, Karin Egberts, Julia Geissler, Manfred Gerlach, Dorothee Malonga Makosi, Jochem Koenig, Michael S. Urschitz, Irmgard Toni, Antje Neubert, Marcel Romanos
Summary: This study examined the occurrence of serious adverse drug reactions (sADR) of psychotropic drugs in pediatric inpatients and explored the potential preventability through a web-based pediatric drug information system (PDIS). The study found that many sADRs could have been prevented through PDIS, resulting in potential cost savings.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Endocrinology & Metabolism
Teresa Lau, Jessica Cook, Rami Archid, Andreas Stengel, Stephan Zipfel, Isabelle Mack
Summary: This meta-analysis examined the effects of pre-operative lifestyle interventions (PLI) on body mass index (BMI) one year after bariatric surgery. The results showed that PLI was more effective in reducing BMI before surgery compared to usual care. However, one year post-surgery, both groups had comparable BMI reductions, and the impact of pre-operative BMI reduction on post-operative BMI was uncertain.
Article
Psychology, Applied
Anne Herrmann-Werner, Rebecca Erschens, Maximilian Fries, Hannah Wehner, Stephan Zipfel, Teresa Festl-Wietek
Summary: Taking patients' medical history correctly is crucial for diagnosis and treatment. Medical students experience stress when taking patients' medical history in different levels of fidelity, with physiological stress being higher with real patients. Medical students should learn how to cope with stress in such situations.
Article
Pharmacology & Pharmacy
Stefanie Fekete, Tim Guentzel, Karin Egberts, Julia Geissler, Antje Neubert, Manfred Gerlach, Marcel Romanos, Regina Taurines
Summary: This retrospective study examined the frequency of serious adverse drug reactions (sADRs) to antipsychotics in children and adolescents with multiple disabilities and mental disorders (CAMD). It also explored the potential preventability of these sADRs through therapeutic drug monitoring (TDM) and the potential socio-economic benefits of TDM.
PHARMACOPSYCHIATRY
(2023)
Article
Psychology, Clinical
Alexander Ferdinand Meier, Almut Zeeck, Svenja Taubner, Thorsten Gablonski, Inga Lau, Romi Preiter, Hannes Glaeser, Stephan Zipfel, Wolfgang Herzog, Beate Wild, Hans-Christoph Friederich, Gaby Resmark, Katrin Giel, Martin Teufel, Markus Burgmer, Andreas Dinkel, Stephan Herpertz, Bernd Loewe, Sefik Tagay, Joern von Wietersheim, Martina De Zwaan, Armin Hartmann
Summary: This study aimed to explore the use of mentalization-enhancing interventions (MEIs) in psychotherapeutic treatments for patients with anorexia nervosa and their association with patients' capacity to mentalize in sessions. The results showed a moderate correlation between the amount of MEIs used and patients' in-session reflective functioning, but no relation to change in BMI or eating disorder symptoms.
PSYCHOTHERAPY RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Steffen Philipp Ruf, Larissa Hetterich, Nazar Mazurak, Caroline Rometsch, Anna-Maria Jurjut, Stephan Ott, Anne Herrmann-Werner, Stephan Zipfel, Andreas Stengel
Summary: Patients with chronic pain, especially those with somatoform pain disorders, may benefit from mirror therapy in terms of reducing pain intensity and modulating physiological parameters. This study showed that mirror therapy led to a reduction in pain intensity and increased sensitivity to cold stimuli among patients with somatoform pain disorders. It also revealed a decrease in the low-frequency band of heart rate variability, indicating a potential effect on autonomic nervous system regulation. However, further studies with larger sample sizes and control groups are needed to validate these findings.
BEHAVIORAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Jacopo Pruccoli, Isabelle Mack, Bea Klos, Sandra Schild, Andreas Stengel, Stephan Zipfel, Katrin Elisabeth Giel, Kathrin Schag
Summary: This study investigated the contribution of mental health and eating behavior variables in predicting weight changes in obese patients, as well as the mediating effect of eating disorder pathology. The results showed that these variables predicted weight changes, mediated by eating disorder pathology.
Article
Nutrition & Dietetics
Ana Ibanez-Caparros, Isabel Sanchez, Roser Granero, Susana Jimenez-Murcia, Magda Rosinska, Ansgar Thiel, Stephan Zipfel, Joan de Pablo, Lucia Camacho-Barcia, Fernando Fernandez-Aranda
Summary: This study compared the clinical, psychopathological, and personality traits between eating disorder (ED) patients who were professional athletes and those who were not. The results showed that professional athlete patients had less body dissatisfaction and psychological distress. No differences were found in treatment outcome among the groups.
Article
Pharmacology & Pharmacy
Michael Frey, Lukasz Smigielski, Elvira Tini, Stefanie Fekete, Christian Fleischhaker, Christoph Wewetzer, Andreas Karwautz, Christoph U. Correll, Manfred Gerlach, Regina Taurines, Paul L. Plener, Uwe Malzahn, Selina Kornbichler, Laura Weninger, Matthias Brockhaus, Su-Yin Reuter-Dang, Karl Reitzle, Hans Rock, Hartmut Imgart, Peter Heuschmann, Stefan Unterecker, Wolfgang Briegel, Tobias Banaschewski, Joerg M. Fegert, Tobias Hellenschmidt, Michael Kaess, Michael Koelch, Tobias Renner, Christian Rexroth, Susanne Walitza, Gerd Schulte-Koerne, Marcel Romanos, Karin Maria Egberts, Paolo Magni
Summary: This study investigated the relationship between drug dose and serum concentration of fluoxetine in children and adolescents and established the therapeutic serum reference range. The study found a positive correlation between dose and serum concentration of fluoxetine and its metabolite, with higher body weight and female sex associated with lower serum concentrations and therapeutic response. Most patients showed marked or minimal improvements during treatment, with no reported adverse effects.
Article
Psychiatry
Simone C. Behrens, Joachim Tesch, Philine J. B. Sun, Sebastian Starke, Michael J. Black, Hannah Schneider, Jacopo Pruccoli, Stephan Zipfel, Katrin E. Giel
Summary: This study utilized virtual reality technology to expose patients with anorexia nervosa to healthy weight, and found that virtual reality exposure is effective in eliciting fear of weight gain in these patients. Repeated exposure showed significant improvement in this fear.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2023)
Article
Psychiatry
Katrin E. Giel, Kathrin Schag, Sebastian M. Max, Peter Martus, Stephan Zipfel, Andreas J. Fallgatter, Christian Plewnia
Summary: This study investigates the feasibility and clinical effects of transcranial direct current stimulation (tDCS)-enhanced inhibitory control training in reducing binge eating episodes. The study finds that tDCS-enhanced inhibitory control training is safe and leads to a significant and sustainable reduction in binge eating frequency in patients with BED.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2023)
Article
Oncology
Jan Ilgen, Mirjam Renovanz, Andreas Stengel, Stephan Zipfel, Norbert Schaeffeler
Summary: Cancer causes psychological distress, and resilience, a psychological adaptive capacity, significantly impacts distress among patients with neuro-oncological disease. Resilience has a significant effect on distress in the acute phase.
Meeting Abstract
Pharmacology & Pharmacy
L. Smigielski, E. Tini, M. Romanos, C. Wewetzer, A. Karwautz, K. Reitzle, C. U. Correll, P. L. Plener, U. Malzahn, P. Heuschmann, S. Unterecker, M. Scherf-Clavel, H. Rock, G. Antony, W. Briegel, C. Fleischhaker, T. Banaschewski, T. Hellenschmidt, H. Imgart, M. Kaess, M. Koelch, T. Renner, S. Y. Reuter-Dang, C. Rexroth, G. Schulte-Koerne, F. Theisen, S. Fekete, R. Taurines, M. Gerlach, K. M. Egberts, S. Walitza
PHARMACOPSYCHIATRY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
E. Tini, L. Smigielski, M. Romanos, C. Wewetzer, A. Karwautz, K. Reitzle, C. U. Correll, P. L. Plener, U. Malzahn, P. Heuschmann, S. Unterecker, M. Scherf-Clavel, H. Rock, G. Antony, W. Briegel, C. Fleischhaker, T. Banaschewski, T. Hellenschmidt, H. Imgart, M. Kaess, M. Kolch, T. Renner, S. Y. Reuter-Dang, C. Rexroth, G. Schulte-Koerne, F. Theisen, S. Fekete, R. Taurines, M. Gerlach, K. M. Egberts, S. Walitza
PHARMACOPSYCHIATRY
(2022)
