期刊
JOURNAL OF NEURAL TRANSMISSION
卷 119, 期 4, 页码 455-456出版社
SPRINGER WIEN
DOI: 10.1007/s00702-011-0736-0
关键词
Parkinson disease; Clinical phenotypes; CSF biomarkers; Total-tau/A beta-42
CSF biomarker studies were performed in 6 patients each with tremor-dominant (TD) and non-tremor-dominant (NT) Parkinson disease (PD) patients, 27 Alzheimer disease (AD) and 17 age-matched controls. In both NT-PD and AD patients total tau levels and the cortex tau/A beta-42 were significantly increased compared to both TD-PD patients and controls (p < 0.01). These data in a small cohort confirm previous studies, corroborating the opinion that CSF levels of tau protein and the index total-tau/A beta-42 may be potential markers of the severity of neurodegeneration in PD.
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