Article
Biochemistry & Molecular Biology
Adriana Kubis-Kubiak, Benita Wiatrak, Agnieszka Piwowar
Summary: Recent research has highlighted the complexity of Alzheimer's disease and the involvement of a wide range of clinical manifestations and cellular and biochemical disturbances. The past decade has seen a focus on metabolic disturbances in early pathology, with attention to the potential role of the S100 protein family in neuronal metabolism and neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Leyla Sahin, Ozge Selin Cevik, Kenan Cevik, Celal Guven, Eylem Taskin, Sayad Kocahan
Summary: This study investigated the protective effects of mild treadmill exercise on acute sleep deprivation rats, finding that exercise can alleviate memory impairment but there is a lack of correlation between hippocampal gene expression levels and memory impairment.
Article
Geriatrics & Gerontology
Jelena B. Stanojevic, Milica Zeljkovic, Milorad Dragic, Ivana R. Stojanovic, Tihomir V. Ilic, Ivana D. Stevanovic, Milica B. Ninkovic
Summary: This study investigates the effect of intermittent theta burst stimulation (iTBS) on a rat model with STZ-induced sAD-like pathology. The results show that iTBS treatment reduces oxidative and nitrosative stress parameters, decreases A beta-(1-42) and APP levels, and increases antioxidant capacity. Additionally, iTBS attenuates STZ-induced astrogliosis. These findings provide experimental evidence for the beneficial effects of iTBS in attenuating oxidative stress and reactive astrogliosis in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Immunology
Manickam Rajkumar, Soundarapandian Kannan, Ramasundaram Thangaraj
Summary: The study demonstrates that Voglibose has potent neuroprotective effects against the ICV-STZ-induced AD model, improving cognitive function. The treatment with Voglibose showed decreased acetylcholinesterase and malondialdehyde activity, enhanced antioxidant enzyme activity, reduced inflammation-related factors, and attenuated amyloid-beta aggregation.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marika Lanza, Rossella Basilotta, Salvatore Cuzzocrea, Maria Bulzomi, Salvatore Oddo, Giovanna Casili, Emanuela Esposito
Summary: The prevalence of obesity worldwide is rapidly increasing and is considered a leading cause of death. Added sugar consumption is one of the main factors contributing to this, as it is associated with a higher risk of obesity, heart disease, diabetes, and brain illnesses such as Alzheimer's disease (AD). Excess sugar can worsen oxidative damage and brain inflammation, which are neuropathological signs of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Caroline Bitencourt Soares, Leticia Rossi Dare, Karine Ramires Lima, Luiza Freitas Lopes, Alexandre Garcia Dos Santos, Helen Lidiane Schimidt, Felipe Pivetta Carpes, Ana Lloret, Jose Vina, Pamela Billig Mello-Carpes
Summary: The study found that long-term multicomponent exercise training can prevent amyloid-beta neurotoxicity in the hippocampus, reducing oxidative stress, restoring antioxidant capacity, increasing glutathione levels, and ultimately preventing recognition memory deficits.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Virendra Tiwari, Akanksha Mishra, Sonu Singh, Sandeep Kumar Mishra, Kiran Kumari Sahu, Parul, Mahesh J. Kulkarni, Rakesh Shukla, Shubha Shukla
Summary: The study demonstrated that the tricyclic antidepressant protriptyline significantly reduced neurodegeneration, oxidative stress, and glial activation, improving the learning and memory retention in streptozotocin-induced rat model of Alzheimer's disease. Protriptyline also improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFXB and GFAP expression, suggesting its potential as a multi-target molecule for the development of effective new treatments in neurodegenerative disorders.
Article
Medicine, Research & Experimental
Masoud Rahmati, Maryam Keshvari, Wenqing Xie, Guang Yang, Hongfu Jin, Hengzhen Li, Farzaneh Chehelcheraghi, Yusheng Li
Summary: In this study, the combined effect of resistance training (RT) and Urtica dioica extract (Ud) was investigated in preventing memory disorders and hippocampal tissue changes caused by aging in rats. The results showed that RT and Ud supplementation alleviated karyopyknosis in hippocampal tissue and improved cognitive function. These interventions also increased the levels of antioxidant enzymes and neurotrophic factors in the hippocampus, while protecting against oxidative stress and hippocampal damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Xudong Huang
Summary: Alzheimer's disease (AD) is a pandemic that causes significant social and economic burden, and currently, there is no effective treatment available. Experimental studies have shown that imbalances in cerebral iron and copper levels are related to the neuropathological hallmarks of AD. Targeting iron-dependent cell death, known as ferroptosis, may be a promising therapeutic strategy for AD. Additionally, the role of copper-dependent cell death, known as cuproptosis, in AD neurodegeneration requires further investigation. This concise review aims to stimulate further research in oxidative stress-mediated ferroptosis and cuproptosis in AD.
Article
Nutrition & Dietetics
Waralee Ruankham, Wilasinee Suwanjang, Kamonrat Phopin, Napat Songtawee, Virapong Prachayasittikul, Supaluk Prachayasittikul
Summary: This study discovered that alpha-mangostin protects neuronal cells against oxidative stress by activating the SIRT1/3-FOXO3a pathway, making it a potentially promising therapeutic compound.
FRONTIERS IN NUTRITION
(2022)
Article
Neurosciences
Fatemeh Nabavi Zadeh, Maryam Nazari, Abdollah Amini, Soheila Adeli, Amir Barzegar Behrooz, Javad Fahanik Babaei
Summary: The study aimed to investigate the neuroprotective action of alpha-tocopherol on memory-impaired rats induced by icv-STZ. The results demonstrated that alpha-tocopherol could alleviate cognitive impairment, reduce oxidative stress and mitochondrial dysfunction, and correct neurodegenerative defects.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Huaixing Wang, Zongxiu Zhang, Sorawit Sittirattanayeunyong, Jarin Hongpaisan
Summary: The current data supports the hypothesis of vascular pathogenesis in Alzheimer's disease (AD) development and progression. The APOE4 gene was found to be associated with oxidative stress, vascular endothelial growth factor (VEGF) loss, and endothelial cell density in AD arterioles. In cultured human brain microvascular cells, the presence of ApoE4 protein and amyloid-b (Ab) oligomers led to superoxide production, apoptosis, and increased HIF-1a stability, which were related to the increase in VEGF and cell density. Various inhibitors and antioxidants were able to inhibit this cell over-proliferation. These findings highlight the importance of vascular changes in AD pathogenesis.
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Alzheimer's disease is the principal cause of dementia and is associated with neurodegenerative disorders. Hericium erinaceus, a nutritional mushroom with important antioxidant effects, has shown significant therapeutic effects in a rat model of AD, reducing behavioral changes and hippocampal neuronal degeneration.
Article
Biochemistry & Molecular Biology
Manuel Alejandro Vargas-Vargas, Alfredo Saavedra-Molina, Mariana Gomez-Barroso, Donovan Pena-Montes, Christian Cortes-Rojo, Huerta Miguel, Xochitl Trujillo, Rocio Montoya-Perez
Summary: Iron restriction can reduce oxidative damage, improve muscle function, and lipid profile control in diabetic rats.
Article
Biochemistry & Molecular Biology
Sandeep Kumar, P. V. Akhila, Kitlangki Suchiang
Summary: Alzheimer's disease is a common neurodegenerative disease in aged populations, characterized by abnormal accumulation of amyloid-beta. Hesperidin, a compound found in citrus species, has anti-inflammatory, antioxidant, and neuroprotective effects. This study found that hesperidin can upregulate the expression of the acr-16 gene, activate autophagy, and provide antioxidant effects, thereby prolonging lifespan and protecting against the toxic effects of Alzheimer's disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Larissa Daniele Bobermin, Fernanda Becker Weber, Tiago Marcon dos Santos, Adriane Bello-Klein, Angela T. S. Wyse, Carlos-Alberto Goncalves, Andre Quincozes-Santos
Summary: Sulforaphane, a natural compound, has anti-inflammatory and antioxidant properties. This study found that sulforaphane protects astroglial cells by inhibiting inflammation and oxidative stress, through modulation of multiple molecular mechanisms.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Tiago Marcon dos Santos, Cassiana Siebert, Larissa Daniele Bobermin, Andre Quincozes-Santos, Angela T. S. Wyse
Summary: The study revealed that mild hyperhomocysteinemia may lead to anxiety-like behavior and alterations in locomotion/exploration in rats. Glutamate uptake remained unchanged, but the activities of glutamine synthetase and ATPases were increased. Cell viability was not affected.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Larissa Daniele Bobermin, Romulo Rodrigo de Souza Almeida, Fernanda Becker Weber, Lara Scopel Medeiros, Livia Medeiros, Angela T. S. Wyse, Carlos-Alberto Goncalves, Andre Quincozes-Santos
Summary: The study showed that resveratrol can protect aged astrocytes from LPS-induced toxicity, reduce inflammatory response, and improve astroglial functions. The glioprotective effects of resveratrol on aged astrocytes may be associated with molecular mechanisms such as SIRT1, Nrf2, and HO-1.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Juliana Cavalli, Pollyana Mendonca de Assis, Elaine Cristina Dalazen Goncalves, Larissa Daniele Bobermin, Andre Quincozes-Santos, Nadia Rezende Barbosa Raposo, Marcus Vinicius Gomez, Rafael Cypriano Dutra
Summary: CTK 01512-2 was found to be effective in reducing mechanical hypersensitivity and thermal allodynia in chronic pain conditions. It also increased glial cell viability, suggesting a potential new approach to managing chronic pain. These findings provide new perspectives for the treatment of patients with chronic pain.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Rehabilitation
Natalia Duarte Pereira, Jocemar Ilha, Sarah Monteiro dos Anjos, David Morris
Summary: This study aims to test the effects of lower extremity constraint-induced movement therapy (LE-CIMT) on the real-world use and functional ability of individuals with chronic stroke. The results suggest that LE-CIMT is a feasible intervention that can improve lower extremity use and functionality in these patients.
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
(2022)
Review
Rehabilitation
Gabriel Ribeiro de Freitas, Libak Abou, Aline de Lima, Laura A. Rice, Jocemar Ilha
Summary: This article aims to evaluate the measurement properties of clinical instruments used to assess manual wheelchair mobility in individuals with spinal cord injury. The study identified 29 studies with 21 instruments, showing low methodological quality and evidence quality, as well as inconsistent results for different measurement properties. The Wheelchair Outcome Measure and Wheelchair Skills Test Questionnaire are currently the most promising instruments to be recommended for clinical and research use.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Cell Biology
Vanessa Sovrani, Larissa Daniele Bobermin, Camila Leite Santos, Morgana Brondani, Carlos-Alberto Goncalves, Guilhian Leipnitz, Andre Quincozes-Santos
Summary: Aging is associated with metabolic changes, oxidative and inflammatory damage, altered gene expression, and activity of signaling pathways. The hypothalamus, particularly astrocytes, plays a critical role in homeostatic functions during aging. Resveratrol, an anti-inflammatory and antioxidant molecule, was found to prevent the effects of aging on metabolic, oxidative, inflammatory, and senescence parameters in hypothalamic astrocyte cultures from aged rats. The treatment also upregulated key signaling pathways associated with cellular homeostasis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Adriana D. Tholl, Thamyres C. S. Lima, Scheyla P. B. O. Nogueira, Fabiana Faleiros, Cristina Marques-Vieira, Selma M. F. Viegas, Janaina M. de Souza, Natalia Goncalves, Rosane G. Nitschke, Danielle A. da Cruz, Natalia A. Antunes, Jocemar Ilha
Summary: This study aims to investigate the labour market participation rate and the impact of social and economic characteristics among individuals with spinal cord injury or disease (SCI/D) in Brazil. The study found a relatively low labour market participation rate among rehabilitated individuals with SCI/D in southern Brazil. Higher education level is associated with higher employment rate.
Article
Cell Biology
Julia Pramio, Mateus Grings, Amanda Gasparin da Rosa, Rafael Teixeira Ribeiro, Nicolas Manzke Glanzel, Marian Flores Signori, Manuela Bianchin Marcuzzo, Larissa Daniele Bobermin, Angela T. S. Wyse, Andre Quincozes-Santos, Moacir Wajner, Guilhian Leipnitz
Summary: Isolated sulfite oxidase (ISOD) and molybdenum cofactor (MoCD) deficiencies are genetic diseases characterized by the accumulation of toxic sulfite in the brain tissues, leading to neurological dysfunction and brain abnormalities in newborns. This study found that sulfite administration caused redox imbalance, mitochondrial dysfunction, and altered signaling proteins in the cerebral cortex of rat pups, which may contribute to the neuropathology of ISOD and MoCD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Andre Quincozes-Santos, Larissa Daniele Bobermin, Naithan Ludian Fernandes Costa, Natalie K. Thomaz, Romulo Rodrigo de Souza Almeida, Walter O. Beys-da-Silva, Lucelia Santi, Rafael L. Rosa, Daniela Capra, Juliana M. Coelho-Aguiar, Marcos Fabio DosSantos, Manoela Heringer, Elizabeth O. Cirne-Lima, Jorge Almeida Guimaraes, Lavinia Schuler-Faccini, Carlos-Alberto Goncalves, Vivaldo Moura-Neto, Diogo Onofre Souza
Summary: Zika virus infects glial cells in both the central and peripheral nervous systems, leading to neurological complications and potential neurodevelopmental disorders. Understanding the changes in glial cell functions, including inflammatory response, oxidative stress, mitochondrial dysfunction, calcium and glutamate homeostasis, neural metabolism, and neuron-glia communication, may contribute to the development of preventive and therapeutic strategies against Zika virus-induced neurodegeneration.
Review
Clinical Neurology
Lorena de Oliveira Almeida, Aline de Lima, Giovana Silva Sprizon, Jocemar Ilha
Summary: The study aimed to identify clinical instruments for assessing quality of life (QoL) in individuals with spinal cord injury (SCI) and determine the instruments with the best measurement properties. A total of 77 studies and 49 instruments were included in the review. The results showed that 26 instruments could be recommended, while 23 instruments should not be recommended. The study concluded that generic instruments such as SF-36, SF-12, QWB, WHOQOL-DIS, WHOQOL-BREF, QLI-SCI, QOLP-PD, LS Questions, Lisat-9, and BRFSS have the best measurement properties for assessing QoL in individuals with SCI and are potential best recommendations.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Clinical Neurology
M. Ben, J. V. Glinsky, J. Chu, A. I. Spooren, S. Roberts, L. W. Chen, S. Denis, M. Lorusso, V. Jorgensen, E. J. Gollan, J. Agostinello, C. C. M. Van Laake-Geelen, C. Lincoln, J. M. Stolwijk, C. Bell, S. Paddison, D. Rainey, K. Tranter, J. Ilha, K. Oostra, C. Sherrington, L. A. Harvey
Summary: This study aims to describe the intervention provided in a large multi-centre randomised controlled trial called the SCI-MT Trial. The paper focuses on the rationale and principles of Motor Training for people with spinal cord injuries, and provides a detailed description of the intervention based on the TIDieR checklist.
Article
Clinical Neurology
Joanne V. Glinsky, Jocemar Ilha, Yuan Xiong, Guillermo Gomez, Stephan Rostagnor, Soraya Martin-Manjarres, Keira Tranter, Stephen Muldoon, Eric Weerts, Lisa A. Harvey
Summary: The study aimed to determine the impact of a Massive Open Online Course (MOOC) on physiotherapists' knowledge and management of spinal cord injuries (SCI). Qualitative and quantitative data were collected to answer key questions about the reach of the MOOC, participants' feedback, knowledge improvement, and changes in clinical practice and teaching. The results showed that the MOOC effectively increased physiotherapists' knowledge about SCI management, and participants expressed satisfaction and intentions to change their practice and teaching.
Article
Biochemistry & Molecular Biology
Marina C. Leite, Fabiana Galland, Maria Cristina Guerra, Leticia Rodrigues, Jessica Taday, Priscila T. Monteforte, Hanko Hirata, Carmem Gottfried, Rosario Donato, Soraya Smaili, Carlos-Alberto Goncalves
Summary: The secretion of S100B by astrocytes is triggered by the increase in intracellular Ca2+, which is caused by the mobilization of Ca2+ from the endoplasmic reticulum. The widely used solvent DMSO acts as a secretagogue for S100B, promoting its secretion both in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Vitor Gayger-Dias, Adriana F. K. Vizuete, Leticia Rodrigues, Krista Mineia Wartchow, Larissa Bobermin, Marina Concli Leite, Andre Quincozes-Santos, Andrea Kleindienst, Carlos-Alberto Goncalves
Summary: This article reviews the interpretation of S100B as a marker of brain injury and discusses the mechanisms by which astrocyte-produced S100B reaches the circulatory system. The article emphasizes the concept of S100B as an alarmin and its dual activity as an inflammatory and neurotrophic molecule. Furthermore, it points out the lack of data supporting S100B as a marker of blood-brain barrier rupture and the need to consider the glymphatic system when interpreting serum changes of S100B.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
