期刊
JOURNAL OF NEURAL TRANSMISSION
卷 117, 期 9, 页码 1119-1122出版社
SPRINGER WIEN
DOI: 10.1007/s00702-010-0452-1
关键词
VEGF; FGF-2; Plasma; Family history; Mood disorders
资金
- NCNP
- Health and Labor Sciences Research
- Japan Society for the Promotion of Science (JSPS)
- JST, CREST
We investigated the plasma levels of VEGF and FGF-2, important factors for regulation of neuroplasticity such as neurogenesis, in patients in remission from major depressive disorders (MDD). The plasma VEGF levels were significantly higher in the MDD patients than in the matched control subjects, while no significant difference in plasma FGF-2 levels was found. In particular, the MDD patients with family history of psychiatric disorders, but not patients without such a family history, showed significantly higher values of plasma VEGF than the controls. Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD.
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