期刊
JOURNAL OF NEURAL TRANSMISSION
卷 116, 期 9, 页码 1071-1077出版社
SPRINGER WIEN
DOI: 10.1007/s00702-009-0268-z
关键词
Phospholipase A(2); Flavonoids; Anthocyanin; Anthocyanidin
资金
- Federal Ministry of Education, Science, Research and Technology, BMBF [0313848C]
Epidemiological studies suggest that nutritional antioxidants may reduce the incidence of neurodegenerative disorders and age-related cognitive decline. Specifically, protection against oxidative stress and inflammation has served as a rationale for promoting diets rich in vegetables and fruits. The present study addresses secretory phospholipase A(2) (sPLA(2)) as a novel candidate effector of neuroprotection conferred by anthocyanins and anthocyanidins. Using a photometric assay, 15 compounds were screened for their ability to inhibit PLA(2). Of these, cyanidin, malvidin, peonidin, petunidin, and delphinidin achieved K (i) values a parts per thousand currency sign18 mu M, suggesting a modulatory role for berry polyphenols in phospholipid metabolism.
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