Article
Pharmacology & Pharmacy
Yeonggwang Hwang, Hyoung-Chun Kim, Eun-Joo Shin
Summary: Repeated exposure to MCLR enhances KA-induced seizures and neurodegeneration in the hippocampus by increasing membrane GluK2 expression and enhancing oxidative stress and neuroinflammation.
Article
Cell Biology
Malgorzata Tokarska-Schlattner, Laurence Kay, Pascale Perret, Raffaella Isola, Stephane Attia, Frederic Lamarche, Cindy Tellier, Cecile Cottet-Rousselle, Amjad Uneisi, Isabelle Hininger-Favier, Marc Foretz, Herve Dubouchaud, Catherine Ghezzi, Christian Zuppinger, Benoit Viollet, Uwe Schlattner
Summary: AMPK, a key regulator of energy homeostasis, plays important roles in maintaining cardiac function under increased workload conditions. Deletion of AMPK genes in cardiomyocytes did not affect heart function under physiological conditions, but led to alterations in response to increased workload. AMPK deletion also resulted in decreased basal metabolic rate and locomotor activity, along with changes in cardiac mitochondrial function and bioenergetics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tzu-Yu Lin, Chih-Yu Hung, Kuan-Ming Chiu, Ming-Yi Lee, Cheng-Wei Lu, Su-Jane Wang
Summary: Neferine pretreatment showed positive effects in increasing seizure latency, reducing seizure scores, preventing glutamate elevation and neuronal loss, as well as decreasing neuroinflammation in rats with KA-induced seizures, indicating its potential as a therapeutic option in epilepsy treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
N. H. Harbin, D. J. Lustberg, C. Hurst, J. Pare, K. M. Crotty, A. L. Waters, S. M. Yeligar, Y. Smith, N. T. Seyfried, D. Weinshenker, J. R. Hepler
Summary: RGS14 is a protein that plays a multifunctional role in the hippocampus, suppressing excessive signaling and plasticity in neurons and protecting against seizure activity and pathology. It is upregulated following seizure activity to support mitochondrial function and prevent oxidative stress.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Cathryn A. Cutia, Leanna K. Leverton, Xiyu Ge, Rana Youssef, Lori T. Raetzman, Catherine A. Christian-Hinman
Summary: Clinical evidence suggests that there are differential outcomes of comorbid conditions in patients with temporal lobe epilepsy (TLE) based on the lateralization of the seizure focus. This study evaluated the effects of targeting left or right dorsal hippocampus in a model of TLE, and found that it produced different outcomes in granule cell dispersion, body weight gain, and reproductive endocrine dysfunction in female mice. The findings suggest that lateralization of the epileptogenic insult may contribute to similar reproductive endocrine outcomes.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chen-Ling Gan, Yulian Zou, Dongmei Chen, Xindong Shui, Li Hu, Ruomeng Li, Tao Zhang, Junhao Wang, Yingxue Mei, Long Wang, Mi Zhang, Yuan Tian, Xi Gu, Tae Ho Lee
Summary: The overexpression of DAPK1 has been found to increase seizure severity and neuronal cell death in epilepsy patients. Experimental results have shown that targeting DAPK1 can effectively inhibit seizures and apoptosis both in vitro and in vivo. These findings provide important insights into the pathogenesis of epilepsy and suggest a novel therapeutic strategy for treating this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Tae-Jun Song, Choon-Ho Park, Kyu-Ree In, Jong-Bae Kim, Joo Hee Kim, Miran Kim, Hye Jin Chang
Summary: Betulinic acid (BA) is a naturally occurring compound with various biological effects including anti-malarial, anti-inflammatory, anti-cancer, and recently discovered anti-obesity and anti-diabetic activities. BA activates AMPK, leading to reduced blood glucose levels, increased glucose uptake, and enhanced endurance in mice, indicating its therapeutic potential for diabetes.
Article
Biochemistry & Molecular Biology
Shashank Saurav, Sunil Kumar Manna
Summary: This study uncovers the role of Profilin in autophagy induction and discovers the interaction between Profilin and AMPK, leading to autophagy induction and apoptosis.
Article
Biochemistry & Molecular Biology
Hyun-A Seong, Ravi Manoharan, Hyunjung Ha
Summary: The study identified DAXX as an interacting partner of MPK38, which limits obesity-induced metabolic abnormalities in DIO mice by activating MPK38.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Yingchun Xiang, Yumiao Niu, Yacong Xie, Shishuo Chen, Feng Zhu, Weida Shen, Ling-Hui Zeng
Summary: The study investigated the phosphorylation levels of the RhoA/Rho kinase pathway in response to KA treatment, and found that KA induces activation of the pathway leading to inhibition of neurite outgrowth. Pretreatment with fasudil reversed this effect, suggesting that inhibiting the RhoA/Rho kinase pathway may be a potential treatment for seizure-induced neurite injury.
BRAIN AND BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Ming -Shang Pai, Kaw-Chen Wang, Kun-Chieh Yeh, Su-Jane Wang
Summary: The study found that chlorogenic acid can protect rats from kainic acid-induced neurotoxicity and seizures by reducing glutamate levels and maintaining mitochondrial balance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fiona M. Russell, David Grahame Hardie
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in regulating cellular energy balance by promoting ATP production and inhibiting cell growth. It may restrain aberrant growth before tumorigenesis, but support the survival of cancer cells once cancer has arisen.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim, Tae-Cheon Kang
Summary: In this study, we found that the DARPP-32-PP1-AMPAR signaling pathway may play an important role in the latency of seizure onset. Pyridoxal-5'-phosphate phosphatase/chronophin (PLPP/CIN) transiently dephosphorylated DARPP-32 and increased the seizure onset latency, while casein kinase 2 (CK2) phosphorylated DARPP-32 and exacerbated the intensity, duration, and progression of seizures.
Article
Biochemistry & Molecular Biology
Xiaoying Li, Ciqing Yang, Yaping Shi, Lihong Guan, Han Li, Shuanqing Li, Yunxiao Li, Yong Zhang, Juntang Lin
Summary: This study established a mouse model of epilepsy induced by kainic acid and analyzed abnormal neuronal damage and inflammation in the hippocampus. The success rate of the model was found to be 53.8%, indicating its potential for epilepsy research.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Article
Biochemistry & Molecular Biology
Hyun Joo Shin, Eun Ae Jeong, Jong Youl Lee, Hyeong Seok An, Hye Min Jang, Yu Jeong Ahn, Jaewoong Lee, Kyung Eun Kim, Gu Seob Roh
Summary: The deficiency of LCN2 reduces neuronal cell death, BBB leakage, iron overload, and oxidative stress in KA-induced hippocampal cell death, and inhibits related neuroinflammatory responses, indicating a significant role of LCN2 in this process.