Article
Reproductive Biology
Anna Lange-Consiglio, Emanuele Capra, Deborah Giuliani, Simone Canesi, Federico Funghi, Giampaolo Bosi, Marina Cretich, Roberto Frigerio, Valentina Galbiati, Fausto Cremonesi
Summary: The study investigates the use of extracellular vesicles (EVs) secreted by the female genital tract in equine species to mimic in vitro fertilization processes. The results suggest that EVs could play a role in cell trafficking during equine semen hyperactivation and may facilitate the development of equine reproductive biotechnologies.
Article
Multidisciplinary Sciences
Ilhan Bok, Ido Haber, Xiaofei Qu, Aviad Hai
Summary: Magnetoelectric materials have the potential to revolutionize biomedical technologies, particularly in sensing biophysical processes in the brain. Recent studies have demonstrated wireless brain stimulation using magnetoelectric nanoparticles. This study presents a strain-based finite element magnetoelectric model to quantify magnetization in response to neural electric fields, providing a foundation for validating magnetoelectric nanoparticles for biomedical applications.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
David Eriksson, Artur Schneider, Anupriya Thirumalai, Mansour Alyahyay, Brice de la Crompe, Kirti Sharma, Patrick Ruther, Ilka Diester
Summary: Researchers from Freiburg University have developed an ultraflexible fiber-based 3D light delivery system for electrophysiology and optogenetic manipulation in freely moving animals. By combining thin optical fibers with silicon probes, they achieved high-quality recordings and ultrafast multichannel optogenetic inhibition. They also developed a multi-channel optical commutator and general-purpose patch-cord for flexible experiments. Their framework enables simultaneous laminar recordings, 3D optogenetic stimulation, connectivity inference, and behavioral quantification in freely moving animals, paving the way for large-scale photo tagging and controlled interrogation of rapid neuronal communication.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jose C. Mateus, Sean Weaver, Dirk van Swaay, Aline F. Renz, Julian Hengsteler, Paulo Aguiar, Janos Voeroes
Summary: This research utilizes electron beam lithography and photolithography to create microstructures that control neuronal connectivity, and demonstrates the formation of functional synapses in vitro.
Article
Multidisciplinary Sciences
M. Angeles Rabadan, Estanislao Daniel De La Cruz, Sneha B. Rao, Yannan Chen, Cheng Gong, Gregg Crabtree, Bin Xu, Sander Markx, Joseph A. Gogos, Rafael Yuste, Raju Tomer
Summary: This article presents a new modular neuronal network system that allows for more complex studies of cortical neuronal ensemble dynamics. It enables quantitative in vitro modeling of brain diseases and systematic drug discovery.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Morgan E. Urdaneta, Nicolas G. Kunigk, Jesus D. Penaloza-Aponte, Seth Currlin, Ian G. Malone, Shelley I. Fried, Kevin J. Otto
Summary: Intracortical recordings can be used to control external devices via brain-machine interfaces (BMI), but stability is limited over time due to factors like foreign body response (FBR). Manufacturing advancements have allowed for the development of high-density recording electrodes, but their long-term stability and neuronal cell loss at different cortical depths are unknown. By using a silicon-substrate microelectrode array implanted in rats, we found that the stability of intracortical recordings varied across cortical depth, with electrodes around L4-L5 being the most stable. Additionally, we discovered that neuronal cell loss varied across cortical layers, with L2/3 and L4 electrodes experiencing the largest loss.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Weikun Huang, Tongzhi Wu, Cong Xie, Christopher K. Rayner, Craig Priest, Heike Ebendorff-Heidepriem, Jiangbo (Tim) Zhao
Summary: The article discusses the importance of calcium ions in intra- and inter-cellular signaling, particularly in insulin secretion. Various sensors for detecting calcium ions are described, with a focus on emerging approaches and challenges in the field.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Thanh Lan Chu, Garima Tripathi, Sang Ho Bae, Byong-Taek Lee
Summary: The combination of chitosan/gelatin (CG) enriched with decellularized liver extracellular matrix powder (dLECM) was optimized to enhance wound healing and reduce postoperative complications. The CG-E4 sponge scaffold showed fast post-operative recovery, higher blood absorption, and faster clotting time, demonstrating its potential as a hemostatic material in surgeries.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Dan Wang, Xiangzhao Ai, Yaou Duan, Nianfei Xian, Ronnie H. Fang, Weiwei Gao, Liangfang Zhang
Summary: A neuronal membrane-coated nanosponge (Neuron-NS) has been developed as an effective approach for detoxifying neurotoxins. These nanosponges can detoxify neurotoxins regardless of their molecular structures, overcoming the challenge posed by toxin structural diversity.
Article
Biochemistry & Molecular Biology
Carmen Lammi, Martina Bartolomei, Carlotta Bollati, Lorenzo Cecchi, Maria Bellumori, Emanuela Sabato, Vistoli Giulio, Nadia Mulinacci, Anna Arnoldi
Summary: The study showed that two extra virgin olive oil phenolic extracts can modulate DPP-IV activity, with main components capable of reducing the activity.
Article
Chemistry, Multidisciplinary
Pegah Shokoohimehr, Bogdana Cepkenovic, Frano Milos, Justus Bednar, Hossein Hassani, Vanessa Maybeck, Andreas Offenhaeusser
Summary: The further development of neurochips requires high-density and high-resolution recordings over a long period of time. A combination of vertical nanostraws with nanocavities is proposed, allowing tight coupling with neurons and achieving high sensitivity and synaptic resolution in recording.
Review
Biochemistry & Molecular Biology
Yufei Yan, Jiefei Zeng, Linhao Xing, Changyong Li
Summary: Hepatic fibrosis is characterized by the accumulation of extracellular matrix in the liver due to persistent injury. Understanding the cellular and molecular mechanisms controlling the fibrotic response is crucial for developing clinical strategies to prevent fibrosis progression. Activation of hepatic stellate cells plays a key role in promoting ECM synthesis, and various external signals contribute to this process.
Article
Chemistry, Multidisciplinary
Yinan Yang, Ke Xu, Shouliang Guan, Jianfei Ding, Jinfen Wang, Ying Fang, Huihui Tian
Summary: This study reports ultraflexible and multidirectional neural probes encapsulated in a biocompatible polymer alloy with controllable dissolution kinetics. These probes can be reliably implanted into target brain regions, including deep and difficult-to-access areas. Chronically implanted probes enable long-term, multidirectional recordings from hundreds of neurons, making them a promising tool for large-scale neural circuit dissection in the brain.
Article
Cell & Tissue Engineering
Nina Doorn, Eline J. H. van Hugte, Ummi Ciptasari, Annika Mordelt, Hil G. E. Meijer, Dirk Schubert, Monica Frega, Nael Nadif Kasri, Michel J. A. M. van Putten
Summary: Human induced pluripotent stem cell-derived neuronal networks can be used to study neurological disorders, but it is difficult to understand the underlying cellular mechanisms. Computational modeling can help with this, but existing models lack detail and validation. Researchers have developed a biophysical model that accurately simulates healthy neuronal networks and used it to study a patient with Dravet syndrome, showing that sodium channel dysfunctions alone are not enough to replicate the phenotype.
Article
Neurosciences
Silvia Ravera, Martina Bartolucci, Daniela Calzia, Alessandro M. Morelli, Isabella Panfoli
Summary: The study evaluated the aerobic metabolism of mitochondria and extra-mitochondrial structures in bovine isolated myelin, rod outer segments, and mitochondria-enriched fractions. It was found that myelin and outer segments were more efficient in oxygen consumption and ATP synthesis than mitochondria, suggesting ATP export is limited by extracellular ATP concentration. Additionally, myelin and outer segments were able to synthesize ATP at a later time compared to mitochondria after exposure to respiratory substrates, indicating a potential buffering effect of membrane phospholipids on the proton gradient produced by the electron transport chain.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Engineering, Biomedical
Shiran Shustak, Lilah Inzelberg, Stanislav Steinberg, David Rand, Moshe David Pur, Inbar Hillel, Shlomit Katzav, Firas Fahoum, Maarten De Vos, Anat Mirelman, Yael Hanein
JOURNAL OF NEURAL ENGINEERING
(2019)
Article
Neurosciences
Lilah Inzelberg, Yael Hanein
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Biology
El Yasmin Bar, Sivan Kanner, Ari Barzilai, Yael Hanein
Article
Neurosciences
Mike Hemberger, Mark Shein-Idelson, Lorenz Pammer, Gilles Laurent
Article
Optics
Y. Blau, O. Bar-On, Y. Hanein, A. Boag, J. Scheuer
Article
Biotechnology & Applied Microbiology
Vedran Derek, David Rand, Ludovico Migliaccio, Yael Hanein, Eric Daniel Glowacki
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Neurosciences
Elor Arieli, Ron Gerbi, Mark Shein-Idelson, Anan Moran
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Engineering, Biomedical
Ieva Vebraite, Moshe David-Pur, David Rand, Eric Daniel Glowacki, Yael Hanein
Summary: This study introduced a novel fabrication process for soft electrode arrays to record and stimulate neural activity in intact retinas. The development of high capacitance electrodes on a soft substrate was demonstrated, along with ex vivo electrical recording of retina activity using carbon electrodes. Additionally, simultaneous photo-electrical stimulation and electrical recording was achieved with the addition of organic photo-capacitors. Results showed successful electrical activity recordings from intact chick retinas, enabling analysis of photosensitive retinal ganglion cell responses and spontaneous retina waves.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Liraz Gat, Aaron Gerston, Liu Shikun, Lilah Inzelberg, Yael Hanein
Summary: Computer vision is widely used in facial expression investigation, but it has limitations such as providing indirect information and being insensitive to invisible deformations. High density surface electromyography (sEMG) is an alternative method that provides direct information about muscle activation. This study compares CV and sEMG analysis of facial muscle activation and finds similarities in event detection but discrepancies in source identification.
Article
Biology
Pratibha Yadav, Mark Shein-Idelson
Summary: Invertebrates have the unique ability to see polarized light and utilize the polarization information in their natural environments for various functions. Studies suggest that insects can use spatio-temporal polarization information for signaling and host assessment, in addition to navigating using celestial polarization.
CURRENT OPINION IN INSECT SCIENCE
(2021)
Article
Biology
Nitzan Albeck, Daniel I. Udi, Regev Eyal, Arik Shvartsman, Mark Shein-Idelson
Summary: The study found that the Agamid lizard's sleep exhibits two distinct states, similar to the sleep patterns of mammals and birds. These states switch periodically throughout the night and are believed to be related to the lizard's evolutionary history and adaptations. Unlike mammals, the lizard's sleep patterns are not sensitive to temperature variations and are associated with breathing rate, micro-movements, and eye movements.
COMMUNICATIONS BIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Bara Levit, Peter Krebsbach, Chen Bar-Haim, Gerardo Hernandez-Sosa, Yael Hanein
Summary: Contemporary skin electrodes for bio-impedance measurements are inconvenient, and new electrode designs are needed for better usability. This study introduces dry, printed, bio-compatible electrode arrays that measure bio-impedance accurately and stably. The electrodes have unique properties that allow blood pulsation measurement in the face and during muscle activation, with signal stability over many hours.
FLEXIBLE AND PRINTED ELECTRONICS
(2023)
Article
Materials Science, Multidisciplinary
Liron Ben-Ari, Adi Ben-Ari, Cheni Hermon, Yael Hanein
Summary: Finger gesture recognition (FGR) has been extensively studied in recent years for various human-machine interface applications. Surface electromyography (sEMG) is an attractive technique in FGR, but its use has been limited due to the need for cumbersome electrode wiring and electronic instrumentation. This study utilizes a novel approach based on soft 16 electrode array, wireless data acquisition unit, and neural network analysis to achieve gesture recognition under natural conditions. The results demonstrate high accuracy values for both same-session and different-session training and test data, marking an important step towards sEMG based gesture recognition in non-laboratory settings.
FLEXIBLE AND PRINTED ELECTRONICS
(2023)
Article
Engineering, Biomedical
Bara Levit, Shira Klorfeld-Auslender, Yael Hanein
Summary: Facial muscles are crucial for various physiological functions, and dysfunction can have negative impacts on human well-being. Many medical disorders and conditions in fields such as psychology, neurology, psychiatry, and cosmetic surgery are associated with facial muscles. Scientific explorations have revealed intriguing phenomena, including the link between facial muscle activation and expression of emotions. The development of high density electrode arrays based on soft skin technology provides opportunities for mapping facial muscle activation with high signal quality, reduced interference, and improved data resolution.
PROGRESS IN BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Lilah Inzelberg, Moshe David-Pur, Eyal Gur, Yael Hanein
JOURNAL OF NEURAL ENGINEERING
(2020)