期刊
JOURNAL OF NEURAL ENGINEERING
卷 7, 期 6, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1741-2560/7/6/066003
关键词
-
资金
- National Institute of Biomedical Imaging and Bioengineering (NIBIB) [R01-EB-002091]
- NIBIB American Recovery and Reinvestment Act Administrative Supplement
High-frequency alternating currents (HFAC) have proven to be a reversible and rapid method of blocking peripheral nerve conduction, holding promise for treatment of disorders associated with undesirable neuronal activity The delivery of HFAC is characterized by a transient period of neural firing at its inception, termed the 'onset response' The onset response is minimized for higher frequencies and higher amplitudes but requires larger currents However, the complete block can be maintained at lower frequencies and amplitudes, using lower currents In this in vivo study on whole mammalian peripheral nerves, we demonstrate a method to minimize the onset response by initiating the block using a stimulation paradigm with a high frequency and large amplitude, and then transitioning to a low-frequency and low-amplitude waveform, reducing the currents required to maintain the conduction block In five of six animals, it was possible to transition from a 30 kHz to a 10 kHz waveform without inducing any transient neural firing The minimum transition time was 0 03 s Transition activity was minimized or eliminated with longer transition times The results of this study show that this method is feasible for achieving a nerve block with minimal onset responses and current amplitude requirements
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据