Searching for the human genetic factors standing in the way of universally effective vaccines

Sex-based differences in immune function and responses to vaccination

(2015) S. L. Klein et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Genetics of gene expression in immunity to infection

(2014) Benjamin P Fairfax et al.   CURRENT OPINION IN IMMUNOLOGY

The African Genome Variation Project shapes medical genetics in Africa

(2014) Deepti Gurdasani et al.   NATURE

Common variants associated with general and MMR vaccine–related febrile seizures

(2014) Bjarke Feenstra et al.   NATURE GENETICS

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Associations between Single Nucleotide Polymorphisms in Cellular Viral Receptors and Attachment Factor-Related Genes and Humoral Immunity to Rubella Vaccination

(2014) Iana H. Haralambieva et al.   PLoS One

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

HLA genotypes and rubella vaccine immune response: Additional evidence

(2014) Inna G. Ovsyannikova et al.   VACCINE

Identifying Recent Adaptations in Large-Scale Genomic Data

(2013) Sharon R. Grossman et al.   CELL

Characterizing Vaccine Responses Using Host Genomic and Transcriptomic Analysis

(2013) Daniel O'Connor et al.   CLINICAL INFECTIOUS DISEASES

Responses to booster hepatitis B vaccination are significantly correlated with genotypes of human leukocyte antigen (HLA)-DPB1 in neonatally vaccinated adolescents

(2013) Tzu-Wei Wu et al.   HUMAN GENETICS

A genome-wide association study identifies polymorphisms in the HLA-DR region associated with non-response to hepatitis B vaccination in Chinese Han populations

(2013) Liping Pan et al.   HUMAN MOLECULAR GENETICS

Designing Tomorrow's Vaccines

(2013) Gary J. Nabel   NEW ENGLAND JOURNAL OF MEDICINE

Novel Genetic Analysis for Case-Control Genome-Wide Association Studies: Quantification of Power and Genomic Prediction Accuracy

(2013) Sang Hong Lee et al.   PLoS One

The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches

(2012) Iana H Haralambieva et al.   Expert Review of Vaccines

Power in GWAS: lifting the curse of the clinical cut-off

(2012) S van der Sluis et al.   MOLECULAR PSYCHIATRY

Genome-wide efficient mixed-model analysis for association studies

(2012) Xiang Zhou et al.   NATURE GENETICS

Epidemic Pertussis in 2012 — The Resurgence of a Vaccine-Preventable Disease

(2012) James D. Cherry   NEW ENGLAND JOURNAL OF MEDICINE

Evolution, revolution and heresy in the genetics of infectious disease susceptibility

(2012) A. V. S. Hill   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination

(2012) Kinga K. Smolen et al.   VACCINE

Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from Mozambique

(2012) Holly D. Clifford et al.   VACCINE

Distinguishing vaccine efficacy and effectiveness

(2012) Eunha Shim et al.   VACCINE

Consistency of HLA associations between two independent measles vaccine cohorts: A replication study

(2012) Inna G. Ovsyannikova et al.   VACCINE

Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies

(2011) Dalin Li et al.   GENETIC EPIDEMIOLOGY

The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity

(2011) Inna G. Ovsyannikova et al.   HUMAN GENETICS

The Association of CD46, SLAM and CD209 Cellular Receptor Gene SNPs with Variations in Measles Vaccine-Induced Immune Responses: A Replication Study and Examination of Novel Polymorphisms

(2011) Inna G. Ovsyannikova et al.   HUMAN HEREDITY

A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region

(2011) E. Png et al.   HUMAN MOLECULAR GENETICS

Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

(2011) Michael T Osterholm et al.   LANCET INFECTIOUS DISEASES

Effects of vitamin A and D receptor gene polymorphisms/haplotypes on immune responses to measles vaccine

(2011) Inna G. Ovsyannikova et al.   Pharmacogenetics and Genomics

Improved NYVAC-Based Vaccine Vectors

(2011) Karen V. Kibler et al.   PLoS One

Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination

(2011) Iana H. Haralambieva et al.   VACCINE

Genetic polymorphisms in host antiviral genes: Associations with humoral and cellular immunity to measles vaccine

(2011) Iana H. Haralambieva et al.   VACCINE

Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: Persistence, dampening, and extinction of associations found after a first dose

(2011) Robert M. Jacobson et al.   VACCINE

The concept of vaccination failure

(2011) U. Heininger et al.   VACCINE

Vaccinomics and Personalized Vaccinology: Is Science Leading Us Toward a New Path of Directed Vaccine Development and Discovery?

(2011) Gregory A. Poland et al.   PLoS Pathogens

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

Association between Single‐Nucleotide Polymorphisms inMal/TIRAPandInterleukin‐10Genes and Susceptibility to InvasiveHaemophilus influenzaeSerotype b Infection in Immunized Children

(2010) Shamez N. Ladhani et al.   CLINICAL INFECTIOUS DISEASES

New genetic associations detected in a host response study to hepatitis B vaccine

(2010) S Davila et al.   GENES AND IMMUNITY

2′-5′-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine

(2010) Iana H. Haralambieva et al.   HUMAN IMMUNOLOGY

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Host genetic factors in hepatitis B infection, liver cancer and vaccination response: A review with a focus on Africa

(2010) Branwen J. Hennig et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Genome-wide comparisons of variation in linkage disequilibrium

(2009) Y. Y. Teo et al.   GENOME RESEARCH

Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes

(2009) Inna G. Ovsyannikova et al.   HUMAN GENETICS

Parental origin of sequence variants associated with complex diseases

(2009) Augustine Kong et al.   NATURE

Genome-wide and fine-resolution association analysis of malaria in West Africa

(2009) Muminatou Jallow et al.   NATURE GENETICS

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

(2009) Yoichiro Kamatani et al.   NATURE GENETICS

Replication of rubella vaccine population genetic studies: Validation of HLA genotype and humoral response associations

(2009) Inna G. Ovsyannikova et al.   VACCINE

Personalized vaccines: the emerging field of vaccinomics

(2008) Gregory A Poland et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Genetic Basis for Adverse Events after Smallpox Vaccination

(2008) David M. Reif et al.   JOURNAL OF INFECTIOUS DISEASES

Mast cell activators: a new class of highly effective vaccine adjuvants

(2008) James B McLachlan et al.   NATURE MEDICINE

Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection

(2008) Branwen J. Hennig et al.   PLoS One

Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: Preliminary results

(2008) Neelam Dhiman et al.   VACCINE

Vaccine immunogenetics: Bedside to bench to population

(2008) Gregory A. Poland et al.   VACCINE

Immunity against HIV/AIDS, Malaria, and Tuberculosis during Co-Infections with Neglected Infectious Diseases: Recommendations for the European Union Research Priorities

(2008) Diana Boraschi et al.   PLoS Neglected Tropical Diseases