Article
Urology & Nephrology
Yan Zhu, Chao Xue, Jihong Ou, Zhijuan Xie, Jin Deng
Summary: The study found that l-carnitine therapy significantly increased plasma l-carnitine concentrations, improved response to erythropoiesis-stimulating agents, decreased required doses in hemodialysis patients, and maintained hemoglobin and hematocrit levels. Further high-quality randomized controlled trials are needed to confirm these findings and explore the long-term outcomes.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Review
Nutrition & Dietetics
Vali Musazadeh, Hanie Alinejad, Niloofar Kouhi Esfahani, Zeynab Kavyani, Majid Keramati, Neda Roshanravan, Erfan Mosharkesh, Parvin Dehghan
Summary: This umbrella meta-analysis investigates the efficacy of L-carnitine on lipid profiles in adults. The results show that L-carnitine supplementation can significantly improve total cholesterol, triglycerides, low-density lipoprotein-cholesterol levels, and increase high-density lipoprotein-cholesterol levels.
FRONTIERS IN NUTRITION
(2023)
Review
Health Care Sciences & Services
Hyunwoo Oh, Chan Hyuk Park, Dae Won Jun
Summary: This meta-analysis study evaluated the effectiveness of L-carnitine in the treatment of chronic liver disease and found that L-carnitine supplementation significantly lowered ALT and AST levels and normalized ALT levels in patients with chronic liver disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Multidisciplinary Sciences
Mohd Falihin Mohd Shukri, Mohd Noor Norhayati, Salziyan Badrin, Azidah Abdul Kadir
Summary: LC supplementation has a certain effectiveness in the treatment of patients with PCOS, improving body mass index and lipid levels.
Review
Medicine, General & Internal
Gabriel Voltani Guedes, Marcos Ferreira Minicucci, Suzana Erico Tanni
Summary: The use of L-carnitine does not significantly reduce 28-day mortality in septic shock patients, with low-quality evidence supporting this conclusion.
Review
Multidisciplinary Sciences
Api Chewcharat, Pol Chewcharat, Weitao Liu, Jacqueline Cellini, Elizabeth A. Phipps, Jill A. Melendez Young, Sagar U. Nigwekar
Summary: This study found through meta-analysis that supplementing with levocarnitine can reduce the incidence of dialysis-related hypotension among hemodialysis patients and may also improve muscle cramps. The recommended dose for oral supplementation is above 4,200 mg/week for a duration of at least 12 weeks.
Review
Nutrition & Dietetics
Dong-Dong Wang, Tian-Yun Wang, Yang Yang, Su-Mei He, You-Mei Wang
Summary: The study found that l-carnitine can reduce body mass in type 2 diabetes mellitus patients, while no significant effects were observed with acetyl-l-carnitine or propionyl-l-carnitine. To achieve 80% of the maximal effect, a minimum of 2 grams of l-carnitine daily for at least 2 weeks was required.
FRONTIERS IN NUTRITION
(2021)
Article
Psychiatry
Li-Juan Nie, Jun Liang, Feng Shan, Bao-Shi Wang, Yuan-Yuan Mu, Xie-Hai Zhou, Qing-Rong Xia
Summary: The endogenous L-carnitine and its derivative acetyl-L-carnitine play a role in antidepressant effects and may serve as potential biomarkers for diagnosing MDD. The levels of serum LC and ALC are significantly reduced in patients with MDD, with potential diagnostic value. Furthermore, changes in LC and ALC concentrations could differentiate between effective and ineffective treatment of depression, indicating their potential as novel biomarkers.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Fisheries
Phillip M. Tjale, Abdallah Ghonimy, Dong M. Zhang, Qiu J. Wang, Yu K. Chen, Yue Ma, Zhi X. Guo, Yun L. Zhao, Mohammed Hamdy Farouk
Summary: This review illustrates the effects of metal ion toxicity on the activity of (L)-carnitine (LC), as well as the mediating effect of dietary fibers. The interaction between metal ions and LC molecules or its metabolic system can disrupt LC activity and homeostasis. Dietary fibers can mitigate metal ion toxicity and enhance LC absorption. The review provides insights into the understanding of LC metabolism in monogastrics and fish.
AQUACULTURE RESEARCH
(2022)
Review
Nutrition & Dietetics
Mohammad Zamani, Naseh Pahlavani, Mahlagha Nikbaf-Shandiz, Niloufar Rasaei, Rasool Ghaffarian-Ensaf, Omid Asbaghi, Farideh Shiraseb, Samira Rastgoo
Summary: L-carnitine supplementation can decrease fasting blood glucose, hemoglobin A1c, and insulin resistance.
FRONTIERS IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
X-L Wu, B. Ji, S-D Yao, L-L Wang, Z-Y Jiang
Summary: Music-based interventions have a positive impact on patients with chronic kidney disease undergoing hemodialysis, as they can reduce pain and anxiety, as well as lower heart rate and blood pressure levels.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Pediatrics
Fatemeh Hamedi-Kalajahi, Meysam Zarezadeh, Sayed Yousef Mojtahedi, Sakineh Shabbidar, Dariyoosh Fahimi, Hossein Imani
Summary: L-carnitine supplementation in children on hemodialysis can lead to reductions in ApoB levels and ApoB/ApoA1 ratio, significantly decrease serum LDL-C and TC levels, and increase serum FC levels. Long-term studies on L-carnitine therapy for children receiving hemodialysis with significant dyslipidemia are recommended for more conclusive results.
PEDIATRIC NEPHROLOGY
(2021)
Review
Immunology
Samira Rastgoo, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Niloufar Rasaei, Yasaman Aali, Mohammad Zamani, Farideh Shiraseb, Omid Asbaghi
Summary: L-carnitine supplementation has beneficial effects on improving inflammatory conditions by reducing the levels of inflammatory markers. This systematic review and meta-analysis included 48 randomized controlled trials with a total of 3255 participants to investigate the impact of L-carnitine supplementation on inflammation in adults. The results showed that L-carnitine supplementation significantly reduced the levels of C-reactive protein, interleukin-6, tumor necrosis factor-a, malondialdehyde, total antioxidant capacity, alanine transaminase, and aspartate transaminase, indicating its anti-inflammatory properties.
INFLAMMOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Yuji Ueno, Asami Saito, Junichiro Nakata, Koji Kamagata, Daisuke Taniguchi, Yumiko Motoi, Hiroaki Io, Christina Andica, Atsuhiko Shindo, Kenta Shiina, Nobukazu Miyamoto, Kazuo Yamashiro, Takao Urabe, Yusuke Suzuki, Shigeki Aoki, Nobutaka Hattori
Summary: The study investigated white-matter microstructural changes and cognitive decline in hemodialysis patients using novel dMRI techniques. Long-term treatment with l-carnitine may alleviate white-matter microstructural damage and improve cognitive impairment in this population.
Article
Biology
Yasmina K. Mahmoud, Ahmed A. Ali, Heba M. A. Abdelrazek, Tahany Saleh Aldayel, Mohamed M. Abdel-Daim, Menna Allah El-Menyawy
Summary: Although fipronil induced cognitive deficits and oxidative stress, L-arginine and L-carnitine had ameliorative effects on these effects, suggesting they could be potential candidates for mitigating pesticide-induced neurotoxicity.