Article
Cardiac & Cardiovascular Systems
Manovriti Thakur, Carolina Victoria Cruz Junho, Sarah Maike Bernhard, Marc Schindewolf, Heidi Noels, Yvonne Doering
Summary: Arterial and venous thrombosis are significant causes of morbidity and mortality worldwide. The association between thrombotic complications and cardiovascular and chronic inflammatory diseases is well-established. Inflammation and immunothrombosis, the initiation of thrombotic events, are gaining attention, but still not fully understood. However, the clinical relevance of aberrant immunothrombosis, known as thromboinflammation, is evident by the increased risk of thrombosis and cardiovascular events in patients with inflammatory or infectious diseases. This review focuses on the interrelationships and functions between NETs and other mediators in cardiovascular disease, as well as neutrophil phenotype, function, and NET formation in chronic kidney disease. Therapeutic targeting of NETs-induced immunothrombosis is also discussed as a potential intervention beyond current treatment options.
CIRCULATION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Chloe Douglas, Jennifer T. Roem, Joseph L. Flynn, Susan A. Furth, Bradley M. Warady, Susan Halbach
Summary: Using data from the CKiD Study, this study found that younger children with chronic kidney disease are more likely to have unrecognized and untreated hypertensive blood pressure, highlighting the need for efforts to improve blood pressure control in this population.
Article
Cardiac & Cardiovascular Systems
Constance C. F. M. J. Baaten, Sonja Vondenhoff, Heidi Noels
Summary: The endothelium plays a crucial role in maintaining and regulating vascular integrity. In patients with chronic kidney disease, endothelial cell dysfunction contributes to increased cardiovascular complications due to the proinflammatory, prothrombotic, and uremic environment caused by declining kidney function. This review discusses the functioning of endothelial cells in healthy conditions, the phenotypic changes in chronic kidney disease patients, and the relationship between endothelial cell dysfunction and cardiovascular risk in chronic kidney disease. Additionally, it considers potential pharmacological interventions to improve endothelial health.
CIRCULATION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Paolo Verdecchia, Fabio Angeli, Gianpaolo Reboldi
Summary: This study found that chronic kidney disease and left ventricular hypertrophy are important modifiers of the prognostic value of the circadian blood pressure changes. The night-to-day systolic blood pressure ratio was independently associated with outcomes, but lost its association when chronic kidney disease and left ventricular hypertrophy were considered. The night-to-day systolic blood pressure ratio provided less information and did not improve the information provided by chronic kidney disease and left ventricular hypertrophy.
Review
Food Science & Technology
Carolla El Chamieh, Sophie Liabeuf, Ziad Massy
Summary: Patients with chronic kidney disease have a higher prevalence of cardiovascular disease due to various CKD-related risk factors, including uremic toxins. Understanding the role of the most toxic compounds and their mechanisms in cardiovascular disease can aid in the development of targeted treatments.
Article
Cardiac & Cardiovascular Systems
Ravi B. Patel, Jozine M. Ter Maaten, Joao Pedro Ferreira, Finnian R. McCausland, Sanjiv J. Shah, Patrick Rossignol, Scott D. Solomon, Muthiah Vaduganathan, Milton Packer, Aliza Thompson, Norman Stockbridge, Faiez Zannad
Summary: Patients with chronic cardiovascular or metabolic diseases often have comorbid kidney disease, leading to worse long-term outcomes. Certain novel treatments have shown beneficial effects on both cardiac and kidney outcomes, sparking interest in formally acknowledging and defining composite cardio-kidney outcomes in future cardiovascular trials.
Review
Biochemistry & Molecular Biology
Sanne L. Maas, Marjo M. P. C. Donners, Emiel P. C. van der Vorst
Summary: Chronic kidney disease (CKD) is a significant health problem that affects hypertensive and diabetic patients. CKD patients have increased cardiovascular disease (CVD) morbidity and mortality due to accelerated atherosclerosis development. The role of ADAM10 and ADAM17 in CKD and CVD and their impact on CKD-induced CVD remain to be elucidated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Julio A. Lamprea-Montealegre, Priya Joshi, Abigail S. Shapiro, Erin Madden, Krista Navarra, O. Alison Potok, L. Parker Gregg, Tanya Podchiyska, Amy Robinson, Mary K. Goldstein, Carmen A. Peralta, Simerjot K. Jassal, Sankar D. Navaneethan, Dena E. Rifkin, Virginia Wang, Michael G. Shlipak, Michelle M. Estrella
Summary: The C-3 initiative aims to improve the detection and treatment of chronic kidney disease (CKD) through a multi-modal approach in three major academic medical centers. The first phase focuses on establishing the infrastructure for universal CKD detection in primary care, using a triple-marker screen.
Article
Cardiac & Cardiovascular Systems
Liam Gaziano, Luanluan Sun, Matthew Arnold, Steven Bell, Kelly Cho, Stephen K. Kaptoge, Rebecca J. Song, Stephen Burgess, Daniel C. Posner, Katja Mosconi, Cassianne Robinson Cohen, Amy M. Mason, Thomas R. Bolton, Ran Tao, Elias Allara, Petra Schubert, Lingyan Chen, James R. Staley, Natalie Staplin, Servet Altay, Pilar Amiano, Phar Volker Arndt, Johan Arnlov, Elizabeth L. M. Barr, Cecilia Bjorkelund, Jolanda M. A. Boer, Hermann Brenner, Edoardo Casiglia, Paolo Chiodini, Jackie A. Cooper, Josef Coresh, Mary Cushman, Rachel Dankner, Karina W. Davidson, Renate T. de Jongh, Chiara Donfrancesco, Gunnar Engstrom, Heinz Freisling, Agustin Gomez de la Camara, Vilmundur Gudnason, Graeme J. Hankey, PerOlof Hansson, Alicia K. Heath, Ewout J. Hoorn, Hironori Imano, Simerjot K. Jassal, Rudolf Kaaks, Verena Katzke, Jussi Kauhanen, Stefan Kiechl, Wolfgang Koenig, Richard A. Kronmal, Cecilie Kyro, Deborah A. Lawlor, Borje Ljungberg, Conor MacDonald, Giovanna Masala, Christa Meisinger, Olle Melander, Conchi Moreno Iribas, Toshiharu Ninomiya, Dorothea Nitsch, Borge G. Nordestgaard, Charlotte OnlandMoret, Luigi Palmieri, Dafina Petrova, Jose Ramon Quiros Garcia, Annika Rosengren, Carlotta Sacerdote, Masaru Sakurai, Carmen Santiuste, Matthias B. Schulze, Sabina Sieri, Johan Sundstrom, Valerie Tikhonoff, Anne Tjonneland, Tammy Tong, Rosario Tumino, Ioanna Tzoulaki, Yvonne T. van der Schouw, W. M. Monique Verschuren, Henry Volzke, Robert B. Wallace, S. Goya Wannamethee, Elisabete Weiderpass, Peter Willeit, Mark Woodward, Kazumasa Yamagishi, Raul ZamoraRos, Elvis A. Akwo, Saiju Pyarajan, David R. Gagnon, Philip S. Tsao, Sumitra Muralidhar, Todd L. Edwards, Scott M. Damrauer, Jacob Joseph, Lisa Pennells, Peter W. F. Wilson, Seamus Harrison, Thomas A. Gaziano, Michael Inouye, Colin Baigent, Juan P. Casas, Claudia Langenberg, Nick Wareham, Elio Riboli, J. Michael Gaziano, John Danesh, Adriana M. Hung, Adam S. Butterworth, Angela M. Wood, Emanuele Di Angelantonio
Summary: The study results suggest that mild-to-moderate kidney dysfunction is causally related to the risk of coronary heart disease in people without manifest cardiovascular disease or diabetes.
Review
Biochemistry & Molecular Biology
Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama
Summary: Uric acid is mainly synthesized in the liver, intestines, and vascular endothelium, with the kidney playing a dominant role in its excretion. Hyperuricemia is significantly associated with the development of the metabolic syndrome, cardiovascular diseases (CVD), and chronic kidney disease (CKD). Lowering uric acid levels may slow the progression of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Hui Yin Lim, Brandon Lui, Mark Tacey, David Barit, Geoffrey Donnan, Harshal Nandurkar, Louise M. Burrell, Prahlad Ho
Summary: Despite cardiovascular diseases and thrombosis being major causes of death in patients with CKD, there remains no effective biomarker to predict thrombotic risk in this population. This study evaluated global coagulation assays in CKD patients and correlated the biomarkers to various clinical outcomes. The results showed that CKD patients have increased coagulation function and potential thrombotic risk factors.
THROMBOSIS RESEARCH
(2023)
Review
Medicine, General & Internal
Katarzyna Czajkowska, Edyta Zbroch, Angelika Bielach-Bazyluk, Katarzyna Mitrosz, Elzbieta Bujno, Katarzyna Kakareko, Alicja Rydzewska-Rosolowska, Tomasz Hryszko
Summary: As the aging population sees a rise in cardiovascular and chronic kidney diseases, mortality rates are increasing, leading to significant public health and economic burdens. Identifying easy prognostic markers and early diagnosis are crucial for effective therapy and reduced morbidity. Mid-regional proadrenomedullin shows promise as a novel biomarker for cardiovascular risk and kidney disease progression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Stacey E. Alexeeff, Kamala Deosaransingh, Noelle S. Liao, Stephen K. Van den Eeden, Joel Schwartz, Stephen Sidney
Summary: The study found that long-term exposure to fine particulate matter is associated with an increased risk of cardiovascular mortality among adults with COPD, especially in low exposure scenarios. The results suggest that current regulations may not be sufficient in protecting individuals with COPD from the negative effects of air pollution.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Peripheral Vascular Disease
Simon Correa, Xavier E. Guerra-Torres, Sushrut S. Waikar, Finnian R. Mc Causland
Summary: In patients with CKD, higher serum magnesium levels are associated with lower systolic and diastolic blood pressure, as well as a reduced risk of hypertension and CKD progression. Further research is needed to investigate whether magnesium supplementation could optimize blood pressure control and prevent disease progression in this population.
Article
Peripheral Vascular Disease
Muhammad B. Khan, Rebecca Scherzer, Cora E. Lewis, Rakesh Malhotra, Joachim H. Ix, Michael G. Shlipak, Orlando M. Gutierrez
Summary: This study examined the associations between urine biomarkers and incident hypertension in young adults, and found that higher levels of urine EGF were associated with a lower risk of developing hypertension and lower increases in blood pressure over a 10-year period.