期刊
JOURNAL OF NATURAL PRODUCTS
卷 78, 期 3, 页码 534-538出版社
AMER CHEMICAL SOC
DOI: 10.1021/np500598x
关键词
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资金
- Smithsonian Institution Competitive Grants Program for Science
- Marine Science Network Postdoctoral Fellowship
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
A combined biodiversity- and bioassay-guided natural products discovery approach was used to explore new groups of marine cyanobacteria for novel secondary metabolites with ecologically relevant bioactivities. Phylogenetic analysis of cyanobacterial collections from Belize revealed a new taxon not previously well explored for natural products. The new alkaloid 5-hydroxy-4-(chloromethyl)-5,6,7,8-tetrahydroquinoline (1), named carriebowlinol, and the known compound lyngbic acid (2) were isolated from a nonpolar extract and identified by NMR and MS techniques. Compounds 1 and 2 inhibited the growth of pathogenic and saprophytic marine fungi, and 1 inhibited the growth of marine bacteria, suggesting an antimicrobial ecological function.
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