Article
Chemistry, Applied
Dzung N. Bui, Ly T. T. Nguyen, Le-Thu T. Nguyen, Ngoc T. N. Ngo, Phuong T. Tran, Hieu T. Nguyen, Linh T. N. Dang, Lien-Hoa D. Nguyen, Binh T. D. Trinh
Summary: Two new xanthones, oblongixanthones I and J, were isolated from the twigs of Garcinia oblongifolia. Both compounds showed strong inhibition towards alpha-glucosidase and moderate effects against PTP1B.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Restituto Tocmo, Bryan Le, Amber Heun, Jan Peter van Pijkeren, Kirk Parkin, Jeremy James Johnson
Summary: Xanthones from mangosteen exhibit anti-inflammatory and anti-oxidative effects. The study isolated seven prenylated xanthones from mangosteen fruit pericarp extracts, with Garcinone D (GarD) showing dual protection against intestinal epithelial barrier dysfunction through AhR and Nrf2 pathways.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Applied
Dan Zheng, Hong Zhang, Jia-Ming Jiang, Yu-Yu Chen, Shi-Jie Wan, Zhi-Xiu Lin, Hong-Xi Xu
Summary: Several potential antibacterial compounds were isolated from Garcinia esculenta, with (+/-) garciesculenxanthone C (1) showing the best antibacterial activity against Staphylococcus aureus and exhibiting bactericidal effects.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Lei Yang, Dan Zhang, Jia-Bao Li, Xi Zhang, Nan Zhou, Wen-Yue Zhang, Hui Lu
Summary: Two new prenylated xanthones, mangoxanthones A-B (1-2), were isolated from Garcinia mangostana, along with four known compounds. Compound 1 showed moderate inhibitory activities against alpha-glucosidase and alpha-amylase, and molecular docking predicted its binding sites. Initial structure-activity relationship discussions were conducted.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Zhongnan Wu, Xiaoyong Dai, Wenzhi Wang, Xianfang Zhang, Jiawei Chen, Jing Liu, Laiqiang Huang, Yaolan Li, Shuixing Zhang, Guocai Wang, Yubo Zhang
Summary: The fruits of Garcinia oblongifolia are well-known for their unique taste and high nutritional value. In this study, new compounds with potential health benefits were isolated from the fruits, and one of them showed strong cytotoxicity against nasopharyngeal carcinoma cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Xue Tan, Xiaoyang Han, Haida Teng, Qingqing Li, Yu Chen, Xinxiang Lei, Guangzhong Yang
Summary: Two novel natural tocotrienol derivatives were isolated from the fruit of Garcinia paucinervis, with their structures and configurations determined. These compounds feature unique structures and exhibit antiproliferative and anti-inflammatory activities.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Yan-Song Ye, Yao-Tao Duan, Zhuo Zhou, Khamphanh Thepkaysone, Bounleuane Douangdeuane, Gang Xu
Summary: Thirty-five diverse polyphenols, including nine new compounds, were isolated from Garcinia gracilis. These compounds showed cytotoxic activity and induced apoptosis in human tumor cells.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Medicinal
Zhi-Hong Xu, Yang Luo, Yu-Feng Qiu, Xing-Wei Yang, Tian Lan
Summary: A study on the dry fruits of Garcinia xanthochymus led to the discovery of four new prenylated acylphloroglucinols, xanthochymusones J-M (1-4), as well as the known compounds garciniagifolone A (5) and garcinialiptone A (6). The structures were determined using NMR and MS spectroscopic data. Compound 1, similar to hulupinic acid, is derived from the oxidation and ring contraction of prenylated acylphloroglucinol. The compounds were evaluated for their inhibitory activities against human hepatocellular carcinoma cell lines, and compounds 4 and 5/6 showed moderate cytotoxic activities against Hep G2 cells.
Article
Chemistry, Applied
Mirielle C. Nauman, Restituto Tocmo, Bhaskar Vemu, Jacob P. Veenstra, Jeremy J. Johnson
Summary: Xanthones from the purple mangosteen fruit have been shown to inhibit CDK2/CyclinE1 and dose-dependently inhibit the viability of prostate cancer and breast cancer cells. Gamma-mangostin and alpha-mangostin are the strongest inhibitors among the compounds evaluated.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Nguyen Thi Thu Ha, Nguyen Van Tuyen, Nguyen Thanh Tra, Le Thi Tu Anh, Ninh The Son, Mac Litaudon, Pham Van Cuong, Bui Huu Tai, Phan Van Kiem
Summary: Three new xanthones were isolated from Garcinia mckeaniana stems, and they exhibited weak cytotoxic activity against several cell lines.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Thu Huong Tran, Van Thong Nguyen, Huyen Tram Le, Hoang Minh Nguyen, Thu Ha Tran, Thao Do Thi, Xuan Cuong Nguyen, Manh Tuan Ha
Summary: Xanthones isolated from Garcinia mangostana pericarps showed promising biological and pharmacological activities, with new compounds identified and characterized using NMR, HRESIMS, and ECD spectra. The compounds displayed significant DPPH scavenging capacity and moderate cytotoxic effects against human cancer cell lines in vitro.
Article
Plant Sciences
Zhi-Hong Xu, Robert B. Grossman, Yu-Feng Qiu, Yang Luo, Tian Lan, Xing-Wei Yang
Summary: In this study, 21 new polycyclic polyprenylated acylphloroglucinols (PPAPs) were isolated and characterized from Garcinia xanthochymus. The relative configuration of the C-30 stereocenter was determined using various methods, and the absolute configurations of the new compounds were assigned through spectroscopic analysis. The isolated PPAPs showed moderate antiproliferative activity, with some compounds inducing apoptosis and inhibiting cell migration in hepatocellular carcinoma cells by downregulating the STAT3 signaling pathway.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Johanis Wairata, Edwin Risky Sukandar, Arif Fadlan, Adi Setyo Purnomo, Muhammad Taher, Taslim Ersam
Summary: This study isolated five xanthones from Garcinia forbesii, showing strong antioxidant activity, with Compounds 2 and 5 exhibiting higher activity against alpha-glucosidase, Compound 4 being the most effective against alpha-amylase enzymes, and Compounds 2 and 3 showing inhibitory activity against Plasmodium falciparum. Molecular docking studies confirmed the in vitro activity, and ADMET predictions suggested these compounds as potential candidates for oral drugs.
Article
Biochemistry & Molecular Biology
Simona De Vita, Milena Masullo, Sabrina Grambone, Paloma Bermejo Bescos, Sonia Piacente, Giuseppe Bifulco
Summary: The Nrf2 pathway activation plays a crucial role in maintaining redox homeostasis and regulating inflammation. Xanthones isolated from Garcinia mangostana showed antioxidant properties by disrupting the interaction between Keap1 and Nrf2. Among these compounds, demethylcalabaxanthone exhibited an indirect antioxidant effect.
Article
Chemistry, Medicinal
Qingying Liu, Hao Zheng, Xiaoning Wang, Lu Zhou, Shuqi Wang, Tao Shen, Dongmei Ren
Summary: Caged-polyprenylated xanthonoids, mainly found in Genus Garcinia, are a rare class of natural products. Phytochemical studies on Garcinia oligantha led to the discovery of new compounds with potential anti-cancer effects, particularly in inducing apoptosis in human lung cancer cells.
Article
Chemistry, Applied
Dan Zheng, Hong Zhang, Jia-Ming Jiang, Yu-Yu Chen, Shi-Jie Wan, Zhi-Xiu Lin, Hong-Xi Xu
Summary: Several potential antibacterial compounds were isolated from Garcinia esculenta, with (+/-) garciesculenxanthone C (1) showing the best antibacterial activity against Staphylococcus aureus and exhibiting bactericidal effects.
NATURAL PRODUCT RESEARCH
(2021)
Review
Cell Biology
Wan Najbah Nik Nabil, Zhichao Xi, Zejia Song, Lei Jin, Xu Dong Zhang, Hua Zhou, Paul De Souza, Qihan Dong, Hongxi Xu
Summary: Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G(0) phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis. QCCs are therapeutically challenging due to their resistance to most conventional cancer treatments, and understanding appropriate experimental models and evaluation of QCCs are key questions in the field with direct influence on potential pharmacological interventions. This review focuses on preclinical models and detection methods for QCCs, highlighting the features and scope for application, and aims to provide a framework for selecting appropriate experimental models and investigative methods to identify key players that regulate the survival and activation of QCCs for the development of more effective QCC-targeting therapeutic agents.
Article
Cell Biology
Li Zhang, Zongtao Chai, Siyuan Kong, Jiling Feng, Man Wu, Jiaqi Tan, Man Yuan, Gan Chen, Zhuo Li, Hua Zhou, Shuqun Cheng, Hongxi Xu
Summary: The study revealed that CFL1 is upregulated in HCC and is associated with patient survival. NJXA can inhibit the migration and invasion of HCC cells by downregulating CFL1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Wen-Ping Guo, Qing Min, Wei-Wei Gu, Liang Yu, Xiao Xiao, Wei-Bing Yi, Hong-Liang Li, Bei Huang, Jun-Li Li, Ya-Jun Dai, Jian Xia, Jie Liu, Bei Li, Ben-Hong Zhou, Minglun Li, Hong-Xi Xu, Xuan-Bin Wang, Wen-Yuan Shi
Summary: Over 210,000 medical workers in Hubei, China, have been fighting against COVID-19 since December 2019. A survey of healthcare workers in Wuhan and other cities in Hubei found high prevalence of anxiety, insomnia, depression, and PTSD among them. Healthcare workers in Wuhan and those with doctoral and masters' degrees were found to be at higher risk of anxiety and PTSD. Early intervention for mental health issues in healthcare workers is essential.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Article
Chemistry, Medicinal
Qing-Wei Fang, Wen-Wei Fu, Jin-Ling Yang, Yue Lu, Jiang-Cheng Chen, Pei-Ying Wu, Xue Zhang, Hong-Xi Xu
Summary: In this study, a new compound, crocusatin M, and three new glycosidic compounds, crocusatins N-P, were isolated from the dried stigmas of Crocus sativus. The structures of the new compounds were determined by spectroscopic analysis, with compounds 1 and 4 showing weak anti-inflammatory activities.
JOURNAL OF NATURAL MEDICINES
(2022)
Review
Biochemistry & Molecular Biology
Chattarin Ruchawapol, Man Yuan, Si-Min Wang, Wen-Wei Fu, Hong-Xi Xu
Summary: Herpesviruses can cause various diseases and pose a challenge to global health due to drug resistance. Natural products and their derivatives have shown significant efficacy in treating herpesvirus infections, providing a potential alternative therapy with minimal side effects. Further research and application of these natural compounds are warranted.
Correction
Toxicology
Xing Wang, Yu-Jie Lou, Ming-Xing Wang, Yun-Wei Shi, Hong-Xi Xu, Ling-Dong Kong
TOXICOLOGY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Li Zhang, Zhongju Xu, Tao Jiang, Jialu Zhang, Pinxian Huang, Jiaqi Tan, Gan Chen, Man Yuan, Zhuo Li, Haibin Liu, Dengfeng Gao, Lianbo Xiao, Hui Feng, Jiatuo Xu, Hongxi Xu
Summary: Ejiao showed significant efficacy in treating blood-deficient patients, especially women, with improvements in dizziness symptoms and quality of life. The treatment also demonstrated a safety profile with no significant adverse effects observed, making it a promising option for women with blood deficiency.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Simin Chen, Man Yuan, Yingling Zhang, Yu Xu, Hongxi Xu
Summary: The aim of this study was to establish a method for the quality control of Fuzhuan brick tea for stable production. Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry was used to identify Fuzhuan brick tea, and the major components were chosen for further quantitative analysis. Subsequently, a quantification method was developed using ultra-high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry, and its reliability was verified through methodological validation. A total of 30 compounds were identified, including catechins, flavonoids, alkaloids, and fatty acids. The established method was reliable for methodological validation and was applied to the quantitative analysis of Fuzhuan brick tea. This study provides a fundamental basis for the quality control and further studies on the component analysis of Fuzhuan brick tea.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Analytical
Gan Chen, Hong Zhang, Jiaming Jiang, Simin Chen, Hongmei Zhang, Gongmin Zhang, Changwu Zheng, Hongxi Xu
Summary: This study aimed to differentiate mountain-cultivated ginseng by age using LC-MS analysis and machine learning models. The study successfully predicted the age group of ginseng samples based on identified biomarkers.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Anatomy & Morphology
Gong-Min Zhang, Qing Huang, Gan Chen, Man Yuan, Chang-Wu Zheng, Hong-Mei Zhang, Hong-Xi Xu
Summary: A new method was established to determine the age of Panax ginseng, which is important for assessing its market value and medical effects.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Review
Biochemistry & Molecular Biology
Jiaqi Tan, Hongmei Zhang, Li Zhang, Hongxi Xu
Summary: Ginseng has been used as both a traditional medicine and food for thousands of years, but there are concerns in China about the potential adverse effects of long-term or excessive use, known as Shanghuo. This review explores the relationship between ginseng and Shanghuo from the perspectives of traditional Chinese medicine (TCM) and modern science. It is believed that ginseng-induced Shanghuo is mainly driven by the hot property of the drug, and it may be related to energy metabolism and the endocrine, immune, and cardiovascular systems. The study also discusses the potential role of specific compounds in ginseng, such as ginsenosides, in inducing Shanghuo.
Article
Biochemical Research Methods
Xiaomei Luo, Man Yuan, Ping Lu, Xuanlei Zhong, Yibo Zhang, Yang Li, Zhichao Xi, Hongmei Zhang, Songlin Li, Hongxi Xu
PHYTOCHEMICAL ANALYSIS
(2023)
Review
Biochemistry & Molecular Biology
Yee Lin Phang, Song Liu, Changwu Zheng, Hongxi Xu
Summary: Natural products containing a phloroglucinol motif have significant medicinal value and biological activities. Recent studies have focused on synthetic approaches to these compounds, which have been widely used in treatment and clinical trials.
NATURAL PRODUCT REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jia-Ming Jiang, Gan Chen, Yu-Yu Chen, Shi-Jie Wan, Si-Min Chen, Han-Gui Ren, Zhi-Xiu Lin, Hui Feng, Hong Zhang, Hong-Xi Xu
Summary: Antivirulence therapy using Chinese Materia Medica, particularly the compound tanshinone IIB (TNB) found in Salvia miltiorrhiza Bunge, shows promising potential in combating Staphylococcus aureus infections by reducing hemolytic activity and abscess formation in organs through interference with the accessory gene regulator quorum sensing system.
