Review
Chemistry, Medicinal
Yan-Yan Ding, Han Zhou, Bao-Qi Peng-Deng, Bao-Qi Zhang, Zhi-Jun Zhang, Guang-Han Wang, Shao-Yong Zhang, Zheng-Rong Wu, Yi-Rong Wang, Ying-Qian Liu
Summary: Since the isolation of the first natural carbazole alkaloid, murrayanine, from Mwraya Spreng, carbazole alkaloid derivatives have attracted wide attention for their anti-tumor, anti-viral, and anti-bacterial activities. Recent research has shown that carbazole alkaloids and their derivatives exhibit diverse biological activities. This study provides the first comprehensive description of the antifungal and antibacterial activities of carbazole alkaloids in the past decade (2012-2022), including both natural and partially synthesized compounds. The challenges and problems faced by this class of alkaloids are also summarized. This paper will facilitate further exploration of carbazole alkaloids.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Agricultural Engineering
Caroline Sprengel Lima, Matheus Henrique Pereira, Yousmel Aleman Gainza, Herve Hoste, Luis Octavio Regasini, Ana Carolina de Souza Chagas
Summary: Due to its high prevalence and pathogenicity, Haemonchus contortus is a major gastrointestinal nematode in tropical and subtropical regions, causing significant economic losses to sheep and goat breeders in Brazil. Resistance to anthelmintic drugs poses a challenge to parasite control. Pterogyne nitens, a native Brazilian tree with potential ethnopharmacological activity, showed promising anthelmintic properties in inhibiting egg hatch and larval development of H. contortus, suggesting it could be a valuable source of alternative compounds for parasite control.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Mauricio Osorio, Marcela Carvajal, Alejandra Vergara, Estefania Butassi, Susana Zacchino, Carolina Mascayano, Margarita Montoya, Sophia Mejias, Marcelo Cortez-San Martin, Yesseny Vasquez-Martinez
Summary: Prenylated flavonoids are important natural compounds with significant biological activity, particularly in antimicrobial functions. Compounds 11, 12, and 13 showed strong inhibitory activity against human pathogenic fungi and clinical isolated Staphylococcus aureus MRSA, indicating the key structural requirements for antibacterial activity. Additionally, the combination of prenylated flavonoids with commercial antibiotics significantly enhanced the antibacterial activity against drug-resistant bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Ranga Rao Ravu, Melissa R. Jacob, Shabana Khan, Mei Wang, Liang Cao, Ameeta K. Agarwal, Alice M. Clark, Xing-Cong Li
Summary: A new antifungal template based on phloeodictine has been identified, and 34 new synthetic analogues with modifications have been prepared and evaluated. Nineteen compounds showed promising antifungal activities against clinically important fungal pathogens, with low cytotoxicity against mammalian cells. Further preclinical studies on this new class of antifungal compounds are warranted.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Organic
Yan-Ping Liu, Jia-Ming Guo, Zhen Xie, Xin-Yuan Suo, Ze-Yu Liu, Ze-Hua Qiao, Ruo-Qing Guan, Yuan Bian, Lei Qiang, Yan-Hui Fu
Summary: A unique prenylated bicarbazole alkaloid, clausanisumine, with notable anti-HIV activity was isolated from the fruits of Clausena anisum-olens, along with two biogenetically related known monomer carbazole alkaloids. The compound exhibited remarkable anti-HIV-1 reverse transcriptase effects, suggesting its potential for developing new anti-HIV drugs.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Parasitology
Aline Coqueiro, Daniara Cristina Fernandes, Amanda Danuello, Luis Octavio Regasini, Elaine Monteiro Cardoso-Lopes, Maria Claudia Marx Young, Luce Maria Brandao Torres, Vicente Paulo Campos, Dulce Helena Siqueira Silva, Vanderlan da Silva Bolzani, Denilson Ferreira de Oliveira
Summary: Although new nematicides have emerged, there is still high demand for less toxic and more efficient products to control plant-parasitic nematodes. As a result, increased research on natural secondary metabolites from plants to develop new nematicides has been observed. In this study, extracts from eleven Brazilian plant species were screened, and the extract from Piterogyne nitens showed potent nematostatic activity. The alkaloid fraction obtained from the ethanol extract of P. nitens was more active, and three isoprenylated guanidine alkaloids isolated from this fraction showed similar activity, indicating their potential for the development of new products to control Meloidogyne incognita.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ning Han, Jie Li, Feifei Zhao, Yangyang Li, Jun Wang, Xiaolan Dai, Dongping Zeng, Wenguang Xiong, Zhenling Zeng
Summary: In this study, isopropoxy benzene guanidine (IBG) was found to attenuate the effects caused by Streptococcus suis infection by killing the bacteria and reducing its pathogenicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Shaochun Shi, Jichong Li, Xuemei Zhao, Qingbo Liu, Shao-Jiang Song
Summary: Prenylated flavonoids, with a combination of flavonoid skeleton and lipophilic prenyl side-chain, have shown great potential in various biological activities, making them valuable in medicinal chemistry research and treatment of multi-factorial diseases in clinic.
Article
Biochemistry & Molecular Biology
Romeo D. Tadjouate Nago, Paul Nayim, Armelle T. Mbaveng, James D. Simo Mpetga, Gabin T. Mbahbou Bitchagno, Badawe Garandi, Pierre Tane, Bruno N. Lenta, Norbert Sewald, Mathieu Tene, Victor Kuete, Augustin Silvere Ngouela
Summary: The study found that the local botanical Imperata cylindrica in Cameroon has strong antibacterial activity. Seven compounds were isolated from the methanol extract, including three previously unreported compounds, showing significant antibacterial effects against multidrug-resistant bacteria. Compound 2 exhibited the strongest antibacterial activity against Staphylococcus aureus.
Article
Chemistry, Applied
Dan Zheng, Hong Zhang, Jia-Ming Jiang, Yu-Yu Chen, Shi-Jie Wan, Zhi-Xiu Lin, Hong-Xi Xu
Summary: Several potential antibacterial compounds were isolated from Garcinia esculenta, with (+/-) garciesculenxanthone C (1) showing the best antibacterial activity against Staphylococcus aureus and exhibiting bactericidal effects.
NATURAL PRODUCT RESEARCH
(2021)
Article
Microbiology
Fidelia Ijeoma Uche, Xiaozhen Guo, Jude Okokon, Imran Ullah, Paul Horrocks, Joshua Boateng, Chenggang Huang, Wen-Wu Li
Summary: This study investigates the in vitro and in vivo antiplasmodial activities of BBIQ alkaloids and their analogues, showing promising results with significant anti-parasitic effects at low concentrations. Cycleanine and its semisynthetic analogues demonstrate improved potency and selectivity, with potential as leads for further drug development.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Pedro Salas-Ambrosio, Antoine Tronnet, Pierre Verhaeghe, Colin Bonduelle
Summary: Antimicrobial peptides are natural macromolecules made of amino acids and have the potential to be novel therapeutic agents. Polypeptide polymer analogues of AMPs show great potential as biomaterials with biomimetic and bioactive structures.
Article
Chemistry, Applied
Nathalie Ruiz Mostacero, Maria Victoria Castelli, Andrea Carla Cutro, Axel Hohmann, Joao Marcos Batista Jr, Maysa Furlan, Julieta Valles, Cecilia Luisa Fulgueira, Silvia Noeli Lopez
Summary: Peperomia obtusifolia is a herbaceous perennial plant used in traditional medicine for treating snake bites and cleansing the skin. Compound 2 isolated from its extracts demonstrated antibacterial activity against Gram-positive bacteria, particularly community acquired methicillin-resistant Staphylococcus aureus and a vancomycin-resistant Enterococcus faecalis strain. The interaction of compound 2 with the bacterial membrane was confirmed, leading to membrane damage and antibacterial effect.
NATURAL PRODUCT RESEARCH
(2021)
Article
Infectious Diseases
Alessia Catalano, Antonio Rosato, Lara Salvagno, Domenico Iacopetta, Jessica Ceramella, Giuseppe Fracchiolla, Maria Stefania Sinicropi, Carlo Franchini
Summary: Triclocarban is a widely used antimicrobial agent with potential environmental impact. Researchers have been studying the synthesis and biological activity of new compounds to replace TCC, and some analogues have shown higher antimicrobial activity against bacteria such as Staphylococcus aureus and Enterococcus faecalis. Compound 2bG also exhibited interesting bactericidal action despite being less active than others.
Review
Infectious Diseases
Mazdida Sulaiman, Khoshnur Jannat, Veeranoot Nissapatorn, Mohammed Rahmatullah, Alok K. Paul, Maria de Lourdes Pereira, Mogana Rajagopal, Monica Suleiman, Mark S. Butler, Mohammed Khaled Bin Break, Jean-Frederic Weber, Polrat Wilairatana, Christophe Wiart
Summary: This review identified 141 alkaloids with antibacterial and/or antifungal activities from Asian angiosperms, and analyzed their distribution, molecular weights, solubility, and modes of action. Several alkaloids exhibited high activity and are potential lead molecules for development.
Article
Chemistry, Organic
Chuan-Yun Xiao, Zhong-Lin Sun, Jiao Huang, Rong-Sheng Li, Jian-Ming He, Simon Gibbons, Dian-Wen Ju, Qing Mu
Summary: This study identified 10 new neolignans from the extract of Piper betle leaves and confirmed their synergistic antibacterial activity with norfloxacin against a drug-resistant strain of Staphylococcus aureus. Computational molecular modeling also suggested the binding of certain compounds to the active site of the NorA efflux pump.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Atanas G. Atanasov, Sergey B. Zotchev, Verena M. Dirsch, Claudiu T. Supuran
Summary: Natural products and their analogues have historically played a significant role in pharmacotherapy, however, they also present challenges. Recent technological and scientific developments are addressing these challenges and revitalizing interest in natural products as drug leads, particularly for combating antimicrobial resistance.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Maria Luiza Zeraik, Ivani Pauli, Luiz A. Dutra, Raquel S. Cruz, Marilia Valli, Luana C. Paracatu, Carolina M. Q. G. de Faria, Valdecir F. Ximenes, Luis O. Regasini, Adriano D. Andricopulo, Vanderlan S. Bolzani
Summary: Two prenyl chalcones were identified as potent inhibitors of LOX-1, with the most active compound showing competitive LOX-1 inhibitory properties. Molecular modeling studies indicated the importance of prenyl moieties for the binding of the inhibitors to the LOX binding site, related to their pharmacological properties.
Article
Food Science & Technology
Anielle de Oliveira, Thaysa Fernandes Moya Moreira, Ana Luisa Silva Pepinelli, Luis Gustavo Medice Arabel Costa, Tamires Barlati Vieira da Silva, Aline Coqueiro, Renata Hernandez Barros Fuchs, Maria Ines Dias, Isabel C. F. R. Ferreira, Lillian Barros, Odinei Hess Goncalves, Livia Bracht, Fernanda Vitoria Leimann
Summary: This study aimed to encapsulate pinhao extract and incorporate it into cookies to increase its bioactivity and bioavailability. Through chemometric analysis, the optimal encapsulation method was determined, selecting gelatin as the encapsulation agent and Ultra-Turrax as the shear mechanism, achieving efficient encapsulation and stability of the extract. Results showed that cookies formulated with encapsulated extract exhibited higher hardness values, potentially affecting consumer sensory perception.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Thamires Rodrigues Freitas, Raul Marques Novais, Igor Andrade Santos, Daniel Oliveira Silva Martins, Amanda Danuello, Vanderlan da Silva Bolzani, Ana Carolina Gomes Jardim, Marcos Pivatto
Summary: In this study, the antiviral activity of two alkaloids, (-)-cassine and (-)-spectaline, from Senna spectabilis against Chikungunya virus (CHIKV) was evaluated. The compounds showed potential as anti-CHIKV drugs, with relatively low toxicity. Further in vitro and in vivo assays are encouraged to explore their efficacy. This study provides the first description of the antiviral activity of these compounds against CHIKV, which could have significant implications for the development of antiviral drug candidates for Chikungunya fever.
PHARMACOLOGICAL REPORTS
(2022)
Article
Food Science & Technology
Mariana Lima Braga, Larissa Caroline Perinoto, Giovana Caroline Tonon, Franciele Leila Giopato Viell, Aline Coqueiro, Flavia Aparecida Cardoso Reitz, Renata Hernandez Barros Fuchs, Evandro Bona
Summary: This study evaluated four coffee brews using CATA and PRT methods, and analyzed the content of caffeine, trigonelline, and chlorogenic acid with HPLC. The results showed that different coffee samples have distinct characteristics and flavor profiles, and coffee brew K was preferred by consumers.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Review
Plant Sciences
Cristiano S. Funari, Daniel Rinaldo, Vanderlan S. Bolzani, Robert Verpoorte
Summary: This review article investigates the response of phytochemists to green chemistry insights since the launch of the Pollution Prevention Act in 1990. Highly cited phytochemistry papers from each year between 1990 and 2019 were sampled to assess the greenness of experimental procedures, particularly regarding the use of solvents. Progress in sustainability was observed in the extraction stage, but not in purification procedures, where hazardous solvents like chloroform and dichloromethane were still commonly used. Potential alternative approaches for more sustainable purification procedures are discussed, along with initiatives for a broader sustainable phytochemical research.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Helena Mannochio-Russo, Wilhan D. G. Nunes, Rafael F. Almeida, Lorena C. Albernaz, Laila S. Espindola, Vanderlan S. Bolzani
Summary: This study investigated secondary metabolites with larvicidal activity from the Malpighiaceae taxon using metabolomic and bioactivity-based methods. The results revealed significant differences in the metabolic profiles of different plant organs and collection sites. By employing a bioguided approach, three larvicidal compounds were isolated. These findings support the use of metabolomic-guided approaches in combination with classical phytochemical techniques for the search of natural larvicidal compounds for vector control.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Parasitology
Aline Coqueiro, Daniara Cristina Fernandes, Amanda Danuello, Luis Octavio Regasini, Elaine Monteiro Cardoso-Lopes, Maria Claudia Marx Young, Luce Maria Brandao Torres, Vicente Paulo Campos, Dulce Helena Siqueira Silva, Vanderlan da Silva Bolzani, Denilson Ferreira de Oliveira
Summary: Although new nematicides have emerged, there is still high demand for less toxic and more efficient products to control plant-parasitic nematodes. As a result, increased research on natural secondary metabolites from plants to develop new nematicides has been observed. In this study, extracts from eleven Brazilian plant species were screened, and the extract from Piterogyne nitens showed potent nematostatic activity. The alkaloid fraction obtained from the ethanol extract of P. nitens was more active, and three isoprenylated guanidine alkaloids isolated from this fraction showed similar activity, indicating their potential for the development of new products to control Meloidogyne incognita.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Haroon Ur Rashid, Vanderlan S. Bolzani, Khalid Khan, Luiz Antonio Dutra, Nasir Ahmad, Abdul Wadood
Summary: In this study, a stable three-dimensional structure of alpha-glucosidase was designed through in silico analysis, which may aid in the development of effective antifungal drugs.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Natalia Felix Alves, Dayane Castro Ribeiro, Helena Mannochio-Russo, Suzana Aparecida Silva Queiroz, Guilherme Juliao Zocolo, Vanderlan da Silva Bolzani, Marilia Valli
Summary: Advanced Glycation End Products (AGEs) are compounds formed during hyperglycemic conditions and aging, and are associated with skin aging, loss of elasticity, and chronic diseases such as diabetes and Alzheimer's. Herbal supplements have been shown to have beneficial effects on glycemic control and oxidative stress, reducing the formation of AGEs. This study investigated natural compounds from Talisia esculenta with antiglycation activity, and identified rutin and quercitrin as compounds with significant antiglycation activity. These findings suggest the potential use of these natural compounds as AGEs inhibitors in pharmaceuticals and cosmetics.
REVISTA VIRTUAL DE QUIMICA
(2023)
Article
Chemistry, Multidisciplinary
Fernanda L. Furlan, Makoto Matsushita, Aline Coqueiro, Paulo Henrique Marco, Patricia Valderrama
Summary: In this study, near-infrared spectroscopy was used to investigate the shelf life of ora-pro-nobis leaves in terms of storage time, packaging system, temperature, and sanitization condition. The results showed that unwashed leaves stored in the refrigerator with styrofoam-based packaging covered with PVC film had better preservation over time. The study also suggested that NIR absorptions are associated with various components in ora-pro-nobis leaves and their physiological reactions.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Review
Biodiversity Conservation
Dulce Helena Siqueira Silva, Helena Mannochio-Russo, Joao Henrique Ghilardi Lago, Paula Carolina Pires Bueno, Rebeca Previate Medina, Vanderlan da Silva Bolzani, Wagner Vilegas, Wilhan Donizete Goncalves Nunes
Summary: With the support of FAPESP, Brazil has made significant progress in the research on natural products. The establishment of the Laboratory of Chemistry of Natural Products and the launch of the BIOTA-FAPESP program have contributed to the sustainable exploitation of biodiversity. Through chemical analysis, genetic assessment, and pharmacological research, a deeper understanding of the role of natural products in different biological models has been achieved. The development of omics approaches has provided new avenues for comprehensive research. The program also focuses on environmental protection and the principles of Green Chemistry, and has fostered international collaboration and industry partnerships, making important contributions to the development of the bioeconomy and support for public policies.
Article
Chemistry, Multidisciplinary
Dayane C. Ribeiro, Helena M. Russo, Karina Fraige, Maria L. Zeraik, Claudio R. Nogueira, Patricia B. da Silva, Ana C. Codo, Giovana M. F. Calixto, Alexandra I. de Medeiros, Marlus Chorilli, Vanderlan S. Bolzani
Summary: The study identified four biflavonoids in the extracts of Platonia insignis fruit, with morelloflavone being the main compound responsible for its antioxidant and anti-glycant activities. The ethyl acetate extract from the shell also showed promising antioxidant and anti-inflammatory properties, making it a potential candidate for drug development from natural sources.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2021)
Article
Biochemical Research Methods
Maiara S. Borges, Ana C. Zanatta, Otavio A. Souza, Joao H. Pelissari, Julio G. S. Camargo, Renato L. Carneiro, Cristiano S. Funari, Vanderlan S. Bolzani, Daniel Rinaldo
Summary: This study aimed to establish an HPLC fingerprinting method for soybean seeds using Green Chemistry Principles, a sustainable solvent with low toxicity, and a comprehensive experimental design to reduce the number of experiments.
PHYTOCHEMICAL ANALYSIS
(2021)
